KEGG   ENZYME: 2.4.1.46
Entry
EC 2.4.1.46                 Enzyme                                 
Name
monogalactosyldiacylglycerol synthase;
uridine diphosphogalactose-1,2-diacylglycerol galactosyltransferase;
UDP-galactose:diacylglycerol galactosyltransferase;
MGDG synthase;
UDP galactose-1,2-diacylglycerol galactosyltransferase;
UDP-galactose-diacylglyceride galactosyltransferase;
UDP-galactose:1,2-diacylglycerol 3-beta-D-galactosyltransferase;
1beta-MGDG;
1,2-diacylglycerol 3-beta-galactosyltransferase;
UDP-galactose:1,2-diacyl-sn-glycerol 3-beta-D-galactosyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
Sysname
UDP-alpha-D-galactose:1,2-diacyl-sn-glycerol 3-beta-D-galactosyltransferase
Reaction(IUBMB)
UDP-alpha-D-galactose + a 1,2-diacyl-sn-glycerol = UDP + a 1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol [RN:R02691]
Reaction(KEGG)
R02691
Substrate
UDP-alpha-D-galactose [CPD:C00052];
1,2-diacyl-sn-glycerol [CPD:C00641]
Product
UDP [CPD:C00015];
1,2-diacyl-3-O-(beta-D-galactosyl)-sn-glycerol
Comment
This enzyme adds only one galactosyl group to the diacylglycerol; EC 2.4.1.241, digalactosyldiacylglycerol synthase, adds a galactosyl group to the product of the above reaction. There are three isoforms in Arabidopsis that can be divided into two types, A-type (MGD1) and B-type (MGD2 and MGD3). MGD1 is the isoform responsible for the bulk of monogalactosyldiacylglycerol (MGDG) synthesis in Arabidopsis [4].
History
EC 2.4.1.46 created 1972, modified 2003, modified 2005
Pathway
ec00561  Glycerolipid metabolism
ec01100  Metabolic pathways
Orthology
K03715  1,2-diacylglycerol 3-beta-galactosyltransferase
Genes
ATH: AT2G11810(MGDC) AT4G31780(MGD1) AT5G20410(MGD2)
ALY: 9305384 9308006 9319839
CRB: 17878480 17882958 17892650
CSAT: 104700063 104706388 104717012 104721659 104730134 104736117 104748635 104767934 104770420
EUS: EUTSA_v10013431mg EUTSA_v10022676mg EUTSA_v10024883mg
BRP: 103837651 103851349 103851545 103862083
BNA: 106354743 106366315 106368692 106375399 106392218 106420497 106425766
BOE: 106301258 106316128 106316193 106325403
RSZ: 108824363 108842169 108843682 108853953 130511690
THJ: 104808956 104811011 104819949
CPAP: 110808254 110826136
CIT: 102614331 102616808 102624996
CIC: CICLE_v10007936mg CICLE_v10008213mg CICLE_v10010220mg
PVY: 116108379 116108383 116138108
MINC: 123194445 123195049 123199903
TCC: 18587678 18588847
GRA: 105770833 105773757 105776111 105781160
GHI: 107901653 107953724 107961718 121212595 121217451 121225007 121229214 121232004
GAB: 108450048 108477428 108486783
HSYR: 120126550 120177598 120197448 120218989
DZI: 111284770 111286736 111299430 111303304
EGR: 104436070 104438405 104438611
GMX: 100794727 100804814 100806325 547469(MGD1)
GSJ: 114374435 114385082 114392744 114394029
PVU: PHAVU_001G042600g PHAVU_003G171300g
VRA: 106762909 106766883
VAR: 108323869 108338531
VUN: 114175823 114194729
VUM: 124835426 124837578
CCAJ: 109808150 109817751
APRC: 113846505 113874985
MTR: 11428752 11439263 25500699
TPRA: 123881899 123916063
CAM: 101510704 101515157
PSAT: 127073476 127092901
VVO: 131596322 131633100
LJA: Lj0g3v0327859.1(Lj0g3v0327859.1) Lj4g3v1935530.1(Lj4g3v1935530.1)
ADU: 107461393 107470593 107495613
AIP: 107605453 107623603 107640550
AHF: 112697606 112701499 112716006 112723333 112755834 112783732
LANG: 109326041 109328766 109339323 109343788 109345964 109354684
PCIN: 129298458 129308040 129320635
QSA: O6P43_002454 O6P43_015794 O6P43_019192 O6P43_023960
FVE: 101295108 101304410
RCN: 112173289 112188707
PPER: 18770365 18793552
PMUM: 103320709 103341171
PAVI: 110752682 110762666
PDUL: 117633726 117635731
MDM: 103401643 103417972 103440567 103442345
MSYL: 126602362 126602396 126611893 126632819
PXB: 103949172 103949703 103949750 103953356 103953874
ZJU: 107407197 107419930
MNT: 21396532 21407637
CSAV: 115695927 115707728
CSV: 101209030 101215352
CMO: 103488358 103496946
BHJ: 120075858 120079310
MCHA: 111004707 111013024
CMAX: 111465534 111493715 111496183
CMOS: 111444335 111450318 111454498
CPEP: 111798450 111799315 111806023
RCU: 8263869 8274155
JCU: 105637529 105641265
HBR: 110636479 110657369 110671192 110671419
MESC: 110600030 110604125 110611819
POP: 18099909 18111074 7465432 7468702
PEU: 105121074 105122665 105130558 105134120
PALZ: 118032612 118050172 118051142 118052055
JRE: 108995671 109000998 109005204 109008297
CILL: 122305199 122308429 122316603 122318578
CAVE: 132165589 132189765
QSU: 111986418 111998614 112024357
QLO: 115974813 115977130
TWL: 119993637 119997838
VVI: 100247378 100248939
VRI: 117912821 117924660
SLY: 101246362 101259856 101263085
SPEN: 107007576 107026350 107028612
SOT: 102578822 102588275 102600797 102600922
SSTN: 125842124 125855119 125875926
SDUL: 129870409 129888914 129889452 129891437
CANN: 107840795 107848737 107877723
LBB: 132603111 132609443 132636984
NTA: 107758934 107778411 107787940(NtMGD1) 107796922 107814929 107815856
NSY: 104220710 104239147 104244772
NTO: 104091472 104102546 104108525
NAU: 109207107 109208351 109234432
INI: 109147300 109168378 109169926 109178727
ITR: 116001911 116007458 116012054 116023241
SIND: 105162237 105164881 105166432
OEU: 111374436 111388678 111398224 111399376 111407920
EGT: 105960665 105975327
SSPL: 121748721 121751961 121752090 121783436 121801630 121805604 121808305
SMIL: 130988223 130989229 131015096
SHIS: 125187479 125193157 125194428 125214688
APAN: 127239996 127251388 127255782 127266408
HAN: 110877347 110899401 110928684 110930343
ECAD: 122599393 122600251
LSV: 111877804 111908547
CCAV: 112501081 112507778 112529284
DCR: 108201943 108206444 108211851 108215641
CSIN: 114256679 114266251 114284431
RVL: 131299857 131317884 131320271
AEW: 130756615 130790928 130793391 130796304
BVG: 104887802 104901921
SOE: 110791699 110805894
CQI: 110708023 110712165 110723048 110725562
ATRI: 130816002 130817586
MOF: 131149884 131150440 131158174
NNU: 104586160 104589849 104592530 104605433
MING: 122066766 122073030 122082450
TSS: 122646141 122652759 122655935 122666759
PSOM: 113282742 113301280 113306106 113355890
OSA: 4331045 4345212 4347099
DOSA: Os02t0802700-01(Os02g0802700) Os08t0299400-01(Os08g0299400) Os09t0423600-01(Os09g0423600)
OBR: 102704776 102712378 102717644
OGL: 127762694 127781561 127784191
BDI: 100822971 100838296 100844719
ATS: 109741872 109755152 109769532
TDC: 119286449 119293432 119301677 119309621 119318371 119323792
TAES: 123082162 123094585 123099670 123112071 123121603 123128831 123139279 123145979 542965
TUA: 125509420 125515215 125553653
LPER: 127301516 127305230 127331070
LRD: 124652455 124678127 124678568 124689013 124693403
SBI: 8055186 8055993 8084656
ZMA: 100274282 100281388 100383973
SITA: 101760868 101764122 101764643
SVS: 117841430 117844563 117860076
PVIR: 120645267 120657513 120660703 120679264 120695685 120711695
PHAI: 112873981 112882799 112896381
PDA: 103706476 103707463 103710116 103715894
EGU: 105033793 105039544 105049423 105050115
MUS: 103981301 103985478 103992285 103997383 103999153
ZOF: 121970519 121970748 121970955 121975592 121975845 121992261 121996202 122002492 122006748 122029369 122042030 122043366 122046547 122047891 122050454
DCT: 110103531 110103945 110104020
PEQ: 110023378 110026955
AOF: 109820101 109841163 109844529
MSIN: 131217073 131254857 131258383
NCOL: 116250941 116253683 116261104
ATR: 18435298 18442588
SMO: SELMODRAFT_271007(MGD)
PPP: 112295608 112296119
CRE: CHLRE_13g585301v5
VCN: VOLCADRAFT_58564
MNG: MNEG_3776
CSL: COCSUDRAFT_35261
OLU: OSTLU_119506(mgdA)
OTA: OT_ostta02g01930
BPG: Bathy14g01530(MGDG)
MIS: MICPUN_107335(MGDA)
MPP: MICPUCDRAFT_45255(JGI:MicpuC2_45255)
CME: CYME_CMI271C
GSL: Gasu_39500
CCP: CHC_T00008381001 CHC_T00008619001 CHC_T00009002001
SMIN: v1.2.024400.t1(symbB.v1.2.024400.t1)
PTI: PHATRDRAFT_14125 PHATRDRAFT_9619 PHATR_43938
FCY: FRACYDRAFT_198887 FRACYDRAFT_275442
TPS: THAPSDRAFT_264013 THAPSDRAFT_264314 THAPS_263200
NGD: NGA_0081800(MGD)
AAF: AURANDRAFT_1716 AURANDRAFT_24670
EHX: EMIHUDRAFT_414703 EMIHUDRAFT_467938 EMIHUDRAFT_470522 EMIHUDRAFT_73870
GTT: GUITHDRAFT_118033 GUITHDRAFT_146693 GUITHDRAFT_156659
 » show all
Reference
1  [PMID:4838219]
  Authors
Veerkamp JH.
  Title
Biochemical changes in Bifidobacterium bifidum var. pennsylvanicus after cell-wall inhibition. VI. Biosynthesis of the galactosyldiglycerides.
  Journal
Biochim Biophys Acta 348:23-34 (1974)
DOI:10.1016/0005-2760(74)90089-7
Reference
2  [PMID:5681471]
  Authors
Wenger DA, Petitpas JW, Pieringer RA.
  Title
The metabolism of glyceride glycolipids. II. Biosynthesis of monogalactosyl diglyceride from uridine diphosphate galactose and diglyceride in brain.
  Journal
Biochemistry 7:3700-7 (1968)
DOI:10.1021/bi00850a049
Reference
3  [PMID:10518794]
  Authors
Miege C, Marechal E, Shimojima M, Awai K, Block MA, Ohta H, Takamiya K, Douce R, Joyard J
  Title
Biochemical and topological properties of type A MGDG synthase, a spinach chloroplast envelope enzyme catalyzing the synthesis of both prokaryotic and eukaryotic MGDG.
  Journal
Eur J Biochem 265:990-1001 (1999)
DOI:10.1046/j.1432-1327.1999.00801.x
  Sequence
[ag:CAB56218]
Reference
4  [PMID:15590685]
  Authors
Benning C, Ohta H.
  Title
Three enzyme systems for galactoglycerolipid biosynthesis are coordinately regulated in plants.
  Journal
J Biol Chem 280:2397-400 (2005)
DOI:10.1074/jbc.R400032200
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.46
IUBMB Enzyme Nomenclature: 2.4.1.46
ExPASy - ENZYME nomenclature database: 2.4.1.46
BRENDA, the Enzyme Database: 2.4.1.46
CAS: 37277-55-7

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Pathway (4)   
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Gene (3108)   
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   KEGG GENES (511)   
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