KEGG ENZYME: 2.4.1.79

ENZYME: 2.4.1.79

Entry

EC 2.4.1.79                 Enzyme

Name

globotriaosylceramide 3-beta-N-acetylgalactosaminyltransferase;
uridine diphosphoacetylgalactosamine-galactosylgalactosylglucosylceramide acetylgalactosaminyltransferase;
globoside synthetase;
UDP-N-acetylgalactosamine:globotriaosylceramide beta-3-N-acetylgalactosaminyltransferase;
galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase;
UDP-N-acetylgalactosamine:globotriaosylceramide beta1,3-N-acetylgalactosaminyltransferase;
globoside synthase;
gUDP-N-acetyl-D-galactosamine:D-galactosyl-1,4-D-galactosyl-1,4-D-glucosylceramide beta-N-acetyl-D-galactosaminyltransferase;
beta3GalNAc-T1;
UDP-N-acetyl-D-galactosamine:alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosylceramide 3III-beta-N-acetyl-D-galactosaminyltransferase;
UDP-N-acetyl-D-galactosamine:alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide 3III-beta-N-acetyl-D-galactosaminyltransferase;
UDP-N-acetyl-D-galactosamine:alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide III3-beta-N-acetyl-D-galactosaminyltransferase

Class

Transferases;
Glycosyltransferases;
Hexosyltransferases

Sysname

UDP-N-acetyl-alpha-D-galactosamine:alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide III3-beta-N-acetyl-D-galactosaminyltransferase

Reaction(IUBMB)

UDP-N-acetyl-alpha-D-galactosamine + alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide = UDP + N-acetyl-beta-D-galactosaminyl-(1->3)-alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide [RN:R05631 R05962]

Reaction(KEGG)

R05631 R05962(G);
(other) R11321(G) R11378(G) R11379(G)

Substrate

UDP-N-acetyl-alpha-D-galactosamine [CPD:C00203];
alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide [CPD:C04737]

Product

UDP [CPD:C00015];
N-acetyl-beta-D-galactosaminyl-(1->3)-alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide

Comment

Globoside is a neutral glycosphingolipid in human erythrocytes and has blood-group-P-antigen activity [4]. The enzyme requires a divalent cation for activity, with Mn2+ required for maximal activity [3]. UDP-GalNAc is the only sugar donor that is used efficiently by the enzyme: UDP-Gal and UDP-GlcNAc result in very low enzyme activity [3]. Lactosylceramide, globoside and gangliosides GM3 and GD3 are not substrates [4]. For explanation of the superscripted '3' in the systematic name, see {iupac/misc/glylp#5.3::GL-5.3.4}.

History

EC 2.4.1.79 created 1976, modified 2006

Pathway

ec00601

Glycosphingolipid biosynthesis - lacto and neolacto series

ec00603

Glycosphingolipid biosynthesis - globo and isoglobo series

ec01100

Metabolic pathways

Orthology

K00719

galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase

Genes

HSA:	8706(B3GALNT1)

PTR:	460824(B3GALNT1)

PPS:	103783664(B3GALNT1)

GGO:	101128316(B3GALNT1)

PON:	100174453(B3GALNT1)

NLE:	100582204(B3GALNT1)

HMH:	116481195(B3GALNT1)

MCC:	703939(B3GALNT1)

MCF:	102122721(B3GALNT1)

MTHB:

126948315

MNI:	105488519(B3GALNT1)

CSAB:

103241387(B3GALNT1)

CATY:

105571923(B3GALNT1)

PANU:

101014119(B3GALNT1)

TGE:	112619482(B3GALNT1)

MLEU:

105530136(B3GALNT1)

RRO:	104665025(B3GALNT1)

RBB:	108513415(B3GALNT1)

TFN:	117079007(B3GALNT1)

PTEH:

111550131(B3GALNT1)

CANG:

105523987(B3GALNT1)

CJC:	100412790(B3GALNT1)

SBQ:	104650882(B3GALNT1)

CIMI:

108310326(B3GALNT1)

CSYR:

103270002(B3GALNT1)

MMUR:

105865205 105881201(B3GALNT1)

LCAT:

123630229(B3GALNT1)

PCOQ:

105815284(B3GALNT1) 105815298

OGA:	100948114(B3GALNT1)

MMU:	26879(B3galnt1)

MCAL:

110291625(B3galnt1)

MPAH:

110320437(B3galnt1)

RNO:	310508(B3galnt1)

MCOC:

116092991(B3galnt1)

ANU:	117707692(B3galnt1)

MUN:	110555067(B3galnt1)

CGE:	100756438(B3galnt1)

MAUA:

101842661(B3galnt1)

PROB:

127232681(B3galnt1)

PLEU:

114691707(B3galnt1)

MORG:

121452942(B3galnt1)

MFOT:

126504866

AAMP:

119826479(B3galnt1)

NGI:	103738016(B3galnt1)

HGL:	101706281(B3galnt1)

CPOC:

100729840(B3galnt1)

CCAN:

109687568(B3galnt1)

DORD:

105985632(B3galnt1)

DSP:	122107279(B3galnt1)

PLOP:

125352009(B3galnt1)

NCAR:

124993439

MMMA:

107151148(B3galnt1)

OCU:

100352272

OPI:	101535578(B3GALNT1)

TUP:	102470507(B3GALNT1)

GVR:	103608030(B3GALNT1)

CFA:	100683634(B3GALNT1)

CLUD:

112645890(B3GALNT1)

VVP:	112933319(B3GALNT1)

VLG:	121477463(B3GALNT1)

NPO:	129498624(B3GALNT1)

AML:	100472542(B3GALNT1)

UMR:	103677240(B3GALNT1)

UAH:	113254148(B3GALNT1)

UAR:	123801336(B3GALNT1)

ELK:

111149669

LLV:

125099839

MPUF:

101670826(B3GALNT1)

MNP:	132012076(B3GALNT1)

MLK:	131824912(B3GALNT1)

NVS:	122908661(B3GALNT1)

ORO:	101362550(B3GALNT1)

EJU:	114209060(B3GALNT1)

ZCA:	113918056(B3GALNT1)

MLX:	118005935(B3GALNT1)

NSU:	110591647(B3GALNT1)

LWW:	102743098(B3GALNT1)

FCA:	101092536(B3GALNT1)

PYU:	121033933(B3GALNT1)

PCOO:

112849744(B3GALNT1)

PBG:	122491774(B3GALNT1)

PVIV:

125174722(B3GALNT1)

LRUF:

124525900

PTG:	102967614(B3GALNT1)

PPAD:

109262073(B3GALNT1)

PUC:

125921190

AJU:

106969458

HHV:	120238283(B3GALNT1)

BTA:	767844(B3GALNT1)

BOM:	102268013(B3GALNT1)

BIU:	109558643(B3GALNT1)

BBUB:

102399951(B3GALNT1)

BBIS:

104988491(B3GALNT1)

CHX:	102172392(B3GALNT1)

OAS:	101104544(B3GALNT1)

BTAX:

128047004(B3GALNT1)

ODA:	120868988(B3GALNT1)

CCAD:

122444977(B3GALNT1)

MBEZ:

129545867(B3GALNT1)

SSC:	397634(B3GALNT1)

CFR:	102520987(B3GALNT1)

CBAI:

105066656(B3GALNT1)

CDK:	105085986(B3GALNT1)

VPC:	102528588(B3GALNT1)

BACU:

103007706(B3GALNT1)

BMUS:

118894474(B3GALNT1)

LVE:	103081769(B3GALNT1) 103082553

OOR:	101281290(B3GALNT1)

DLE:	111174411(B3GALNT1) 111185630 111185631

PCAD:

102984339 102987471(B3GALNT1)

PSIU:

116753608(B3GALNT1)

NASI:

112412096(B3GALNT1)

ECB:	100062101(B3GALNT1)

EPZ:	103556050(B3GALNT1)

EAI:	106841036(B3GALNT1)

MYB:	102245995(B3GALNT1)

MYD:	102751273(B3GALNT1)

MMYO:

118676619(B3GALNT1)

MLF:	102437524 102439809(B3GALNT1)

PKL:	118722297(B3GALNT1)

EFUS:

103286698(B3GALNT1)

MNA:	107539305(B3GALNT1)

DRO:	112307143(B3GALNT1)

SHON:

118987441(B3GALNT1)

AJM:	119046051(B3GALNT1)

PDIC:

114491031(B3GALNT1)

PHAS:

123827240(B3GALNT1)

MMF:	118617221(B3GALNT1) 118636326

PPAM:

129075988(B3GALNT1)

HAI:	109373391(B3GALNT1)

RFQ:	117031627(B3GALNT1)

PALE:

102885235(B3GALNT1)

PGIG:

120598486(B3GALNT1)

PVP:	105305269(B3GALNT1)

RAY:	107513039(B3GALNT1)

MJV:	108396279(B3GALNT1)

TOD:	119257657(B3GALNT1)

SARA:

101549871(B3GALNT1)

SETR:

126012166(B3GALNT1)

LAV:	100672964(B3GALNT1)

TMU:

101351705

ETF:	101642922(B3GALNT1)

DNM:	101433163(B3GALNT1)

MDO:	100015392(B3GALNT1)

GAS:	123240276(B3GALNT1)

SHR:	100914641(B3GALNT1)

AFZ:

127552841

PCW:	110210070(B3GALNT1)

OAA:	100077633(B3GALNT1)

GGA:	425011(B3GALNT1)

PCOC:

116235495(B3GALNT1)

MGP:	100542332(B3GALNT1)

CJO:	107318361(B3GALNT1)

TPAI:

128082487(B3GALNT1)

LMUT:

125697817(B3GALNT1)

NMEL:

110397553(B3GALNT1)

APLA:

106019552(B3GALNT1)

ACYG:

106043526(B3GALNT1)

CATA:

118253127(B3GALNT1)

AFUL:

116492328(B3GALNT1)

TGU:	100228838(B3GALNT1)

LSR:	110476616(B3GALNT1)

SCAN:

103815586(B3GALNT1)

PMOA:

120504195(B3GALNT1)

OTC:	121336527(B3GALNT1)

PRUF:

121353689(B3GALNT1)

GFR:	102040599(B3GALNT1)

FAB:	101809193(B3GALNT1)

OMA:	130256667(B3GALNT1)

PHI:	102106993(B3GALNT1)

PMAJ:

107208685(B3GALNT1)

CCAE:

111933293(B3GALNT1)

CCW:	104688069(B3GALNT1)

CBRC:

103615715(B3GALNT1)

ETL:	114062933(B3GALNT1)

ACHL:

103805940(B3GALNT1)

SVG:	106858074(B3GALNT1)

MMEA:

130586147(B3GALNT1)

HRT:	120757091(B3GALNT1)

FPG:	101912356(B3GALNT1)

FCH:	102056837(B3GALNT1)

CLV:	102087526(B3GALNT1)

EGZ:	104122266(B3GALNT1)

NNI:	104011569(B3GALNT1)

PCRI:

104028548(B3GALNT1)

PLET:

104627882(B3GALNT1)

PCAO:

104047083(B3GALNT1)

TALA:

104363308(B3GALNT1)

PADL:

103925238(B3GALNT1)

AFOR:

103898640(B3GALNT1)

ACHC:

115347025(B3GALNT1)

HALD:

104314644(B3GALNT1)

HLE:	104842551(B3GALNT1)

AGEN:

126039173

GCL:

127020102

CCRI:

104160078(B3GALNT1)

CSTI:

104560631(B3GALNT1)

CMAC:

104475757(B3GALNT1)

MUI:	104539654(B3GALNT1)

BREG:

104642724(B3GALNT1)

FGA:	104080350(B3GALNT1)

GSTE:

104253870(B3GALNT1)

LDI:	104353329(B3GALNT1)

MNB:	103779678(B3GALNT1)

OHA:	104334441(B3GALNT1)

NNT:	104403793(B3GALNT1)

SHAB:

115611651(B3GALNT1)

DPUB:

104301660(B3GALNT1)

PGUU:

104463437(B3GALNT1)

ACAR:

104523712(B3GALNT1)

CPEA:

104387033(B3GALNT1)

AVIT:

104270872(B3GALNT1)

CVF:	104285904(B3GALNT1)

RTD:	128910764(B3GALNT1)

TEO:	104372231(B3GALNT1)

BRHI:

104495474(B3GALNT1)

AAM:	106495105(B3GALNT1)

AROW:

112961979(B3GALNT1)

NPD:	112952483(B3GALNT1)

TGT:	104565268(B3GALNT1)

DNE:	112986451(B3GALNT1)

SCAM:

104140021(B3GALNT1)

ASN:	102381398(B3GALNT1)

AMJ:	102574149(B3GALNT1)

CPOO:

109310352(B3GALNT1)

GGN:	109287747(B3GALNT1)

PSS:	102454980(B3GALNT1)

CMY:	102942089(B3GALNT1)

CCAY:

125643154(B3GALNT1)

DCC:	119860888(B3GALNT1)

CPIC:

101934527(B3GALNT1)

TST:	117882635(B3GALNT1)

CABI:

116823590(B3GALNT1)

MRV:	120372022(B3GALNT1)

ACS:	100564179(b3galnt1)

ASAO:

132770546(B3GALNT1)

PVT:	110078057(B3GALNT1)

SUND:

121927083(B3GALNT1)

VKO:	123025660(B3GALNT1)

PMUA:

114597936(B3GALNT1)

PRAF:

128414722(B3GALNT1)

ZVI:	118093800(B3GALNT1)

HCG:	128349449(B3GALNT1)

GJA:	107107027(B3GALNT1)

STOW:

125437503(B3GALNT1)

EMC:	129332501(B3GALNT1)

MUO:	115478714(B3GALNT1)

GSH:	117366587 117366589 117367012

LOC:	102690089(b3galnt1)

PSPA:

121322566 121323543 121326691

ARUT:

117416799 117423202

LCM:	102358886 102363803

LERI:

129703687

SPU:	115927124 765098

SKO:	102800712 102807352

HRF:

124150667

HRJ:	124259260 124269462 124290859

CRG:	105335519 105335520

CVN:

111119565

CANU:

128166403

OED:	125646280 125655608 125671243

MYI:	110441288 110452220 110453853 110460297 110463413

PMAX:

117335478 117337035

LAK:

112042554

» show all

Reference

1 [PMID:4632917]

Authors

Chien JL, Williams T, Basu S.

Title

Biosynthesis of a globoside-type glycosphingolipid by a -N-acetylgalactosaminyltransferase from embryonic chicken brain.

Journal

J Biol Chem 248:1778-85 (1973)

Reference

2 [PMID:4433547]

Authors

Ishibashi T, Kijimoto S, Makita A.

Title

Biosynthesis of globoside and Forssman hapten from trihexosylceramide and properties of beta-N-acetyl-galactosaminyltransferase of guinea pig kidney.

Journal

Biochim Biophys Acta 337:92-106 (1974)
DOI:10.1016/0005-2760(74)90043-5

Reference

3 [PMID:6425294]

Authors

Taniguchi N, Makita A.

Title

Purification and characterization of UDP-N-acetylgalactosamine: globotriaosylceramide beta-3-N-acetylgalactosaminyltransferase, a synthase of human blood group P antigen, from canine spleen.

Journal

J Biol Chem 259:5637-42 (1984)

Reference

4 [PMID:10993897]

Authors

Okajima T, Nakamura Y, Uchikawa M, Haslam DB, Numata SI, Furukawa K, Urano T, Furukawa K

Title

Expression cloning of human globoside synthase cDNAs. Identification of beta 3Gal-T3 as UDP-N-acetylgalactosamine:globotriaosylceramide beta 1,3-N-acetylgalactosaminyltransferase.

Journal

J Biol Chem 275:40498-503 (2000)
DOI:10.1074/jbc.M006902200

Sequence

[hsa:8706]

Other DBs

ExplorEnz - The Enzyme Database:

2.4.1.79

IUBMB Enzyme Nomenclature:

2.4.1.79

ExPASy - ENZYME nomenclature database:

2.4.1.79

BRENDA, the Enzyme Database:

2.4.1.79

CAS:	62213-46-1

DBGET integrated database retrieval system