KEGG ENZYME: 2.4.1.87

ENZYME: 2.4.1.87

Entry

EC 2.4.1.87                 Enzyme

Name

N-acetyllactosaminide 3-alpha-galactosyltransferase;
alpha-galactosyltransferase;
UDP-Gal:beta-D-Gal(1,4)-D-GlcNAc alpha(1,3)-galactosyltransferase;
UDP-Gal:N-acetyllactosaminide alpha(1,3)-galactosyltransferase;
UDP-Gal:N-acetyllactosaminide alpha-1,3-D-galactosyltransferase;
UDP-Gal:Galbeta1->4GlcNAc-R alpha1->3-galactosyltransferase;
UDP-galactose-acetyllactosamine alpha-D-galactosyltransferase;
UDPgalactose:beta-D-galactosyl-beta-1,4-N-acetyl-D-glucosaminyl-glycopeptide alpha-1,3-D-galactosyltransferase;
glucosaminylglycopeptide alpha-1,3-galactosyltransferase;
uridine diphosphogalactose-acetyllactosamine alpha1->3-galactosyltransferase;
uridine diphosphogalactose-acetyllactosamine galactosyltransferase;
uridine diphosphogalactose-galactosylacetylglucosaminylgalactosylglucosylceramide galactosyltransferase;
beta-D-galactosyl-N-acetylglucosaminylglycopeptide alpha-1,3-galactosyltransferase;
UDP-galactose:N-acetyllactosaminide 3-alpha-D-galactosyltransferase;
UDP-galactose:beta-D-galactosyl-1,4-beta-N-acetyl-D-glucosaminyl-R 3-alpha-D-galactosyltransferase;
UDP-galactose:beta-D-galactosyl-(1->4)-beta-N-acetyl-D-glucosaminyl-R 3-alpha-D-galactosyltransferase

Class

Transferases;
Glycosyltransferases;
Hexosyltransferases

Sysname

UDP-alpha-D-galactose:beta-D-galactosyl-(1->4)-beta-N-acetyl-D-glucosaminyl-R 3-alpha-D-galactosyltransferase

Reaction(IUBMB)

UDP-alpha-D-galactose + beta-D-galactosyl-(1->4)-beta-N-acetyl-D-glucosaminyl-R = UDP + alpha-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-N-acetylglucosaminyl-R (where R can be OH, an oligosaccharide or a glycoconjugate) [RN:R02791]

Reaction(KEGG)

R02791 > R04531 R05978(G) R06145(G) R06169(G);
(other) R11320(G)

Substrate

UDP-alpha-D-galactose [CPD:C00052];
beta-D-galactosyl-(1->4)-beta-N-acetyl-D-glucosaminyl-R

Product

UDP [CPD:C00015];
alpha-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-N-acetylglucosaminyl-R [CPD:C04855]

Comment

Acts on beta-galactosyl-1,4-N-acetylglucosaminyl termini on asialo-alpha1-acid glycoprotein and N-acetyllactosamine (beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine), but not on 2'-fucosylated-N-acetyllactosamine. The non-reducing terminal N-acetyllactosamine residues of glycoproteins can also act as acceptor. Now includes EC 2.4.1.124 and EC 2.4.1.151.

History

EC 2.4.1.87 created 1976, modified 1989, modified 2002 (EC 2.4.1.124 created 1984, incorporated 2002, EC 2.4.1.151 created 1984, incorporated 2002)

Pathway

ec00601

Glycosphingolipid biosynthesis - lacto and neolacto series

ec00603

Glycosphingolipid biosynthesis - globo and isoglobo series

ec01100

Metabolic pathways

Orthology

K00743

N-acetyllactosaminide 3-alpha-galactosyltransferase

K20736

alpha-1,3-galactosyltransferase 2

Genes

HSA:	127550(A3GALT2)

PTR:	104007284(A3GALT2)

PPS:	100975171(A3GALT2)

GGO:	101137879(A3GALT2)

PON:	100431438(A3GALT2)

NLE:	100586880(A3GALT2)

HMH:	116472909(A3GALT2) 116475461(GGTA1)

MCC:	711045(A3GALT2)

MCF:	102136396(A3GALT2)

MTHB:

126930244 126937962

MNI:	105495214(A3GALT2)

CSAB:

103225947(A3GALT2)

CATY:

105594799(A3GALT2)

PANU:

101020613(A3GALT2)

TGE:	112625133(A3GALT2)

RRO:	104655865 104677306(A3GALT2)

RBB:	108537074 108537279(A3GALT2)

TFN:	117092920(A3GALT2) 117098733

PTEH:

111550328 111555868(A3GALT2)

CANG:

105501452 105521438(A3GALT2)

CJC:	100390928(GGTA1) 100414894(A3GALT2)

SBQ:	101033629(A3GALT2) 101038827

CIMI:

108285857(GGTA1) 108303978(A3GALT2)

CSYR:

103251189(GGTA1) 103258027(A3GALT2)

MMUR:

105871787(A3GALT2) 105875133

LCAT:

123635805(A3GALT2) 123646481(GGTA1)

PCOQ:

105808631(A3GALT2) 105826396

OGA:	100949731(A3GALT2) 100961603

MMU:	14594(Ggta1) 215493(A3galt2)

MCAL:

110289655 110292229(A3galt2)

MPAH:

110318488 110323213(A3galt2)

RNO:	171553(A3galt2) 246766(Ggta1)

MCOC:

116090066 116096681(A3galt2)

ANU:	117702846 117708202(A3galt2)

MUN:	110548184(A3galt2) 110558641(Ggta1)

CGE:	100754535(Ggta1) 100774283(A3galt2)

MAUA:

101829635(A3galt2) 101835276(Ggta1)

PROB:

127222824(Ggta1) 127225089(A3galt2)

PLEU:

114682033(A3galt2) 114704707(Ggta1)

MORG:

121448691(A3galt2) 121462785(Ggta1)

MFOT:

126491232 126507921

AAMP:

119818014(A3galt2) 119819136(Ggta1)

NGI:	103730905(A3galt2) 103734487

HGL:	101699219(A3galt2) 101705531

CPOC:

100719695 100725746(A3galt2)

CCAN:

109686855(A3galt2) 109692479

DORD:

105988804(A3galt2) 105996167

DSP:	122106733(A3galt2) 122107087(Ggta1)

PLOP:

125347986(Ggta1) 125354883(A3galt2)

NCAR:

124964685 124978089

MMMA:

107141520(A3galt2) 107149291 107152125(Ggta1)

OCU:	100339429 100348435

OPI:	101519151(GGTA1) 101523303(A3GALT2)

TUP:	102483559(A3GALT2) 102502371

GVR:	103582241 103602662(A3GALT2) 103604067

CFA:	487298(A3GALT2) 491357(GGTA1)

CLUD:

112660251(A3GALT2) 112677145(GGTA1)

VVP:	112927838 112931709(A3GALT2)

VLG:	121473075(GGTA1) 121498202(A3GALT2)

NPO:	129505936(GGTA1) 129513917(A3GALT2)

AML:	100479995(A3GALT2) 100482234

UMR:	103666421(A3GALT2) 103670365(GGTA1)

UAH:	113266361 113268332(A3GALT2)

UAR:	123782181(A3GALT2) 123788010(GGTA1)

ELK:	111143712 111145926

LLV:	125083451 125097516

MPUF:

101671456(A3GALT2) 101677189

MNP:	132002155(A3GALT2) 132017359 132024456(GGTA1)

MLK:	131808804(A3GALT2) 131812029(GGTA1) 131833168

NVS:	122899209 122899723(A3GALT2) 122917295(GGTA1)

ORO:	101365724(A3GALT2) 101367788 101371520

EJU:	114212923 114217073(A3GALT2)

ZCA:	113916273(A3GALT2) 113934462(GGTA1)

MLX:	118017738(GGTA1) 118019722(A3GALT2)

NSU:	110575416(A3GALT2) 110581480(GGTA1)

LWW:	102728656(A3GALT2) 102730250

FCA:	101084042(A3GALT2) 493877(GGTA1)

PYU:	121025760(A3GALT2) 121034927(GGTA1)

PCOO:

112862931(A3GALT2) 112864705

PBG:	122475015(GGTA1) 122482124(A3GALT2)

PVIV:

125150313(GGTA1) 125171773(A3GALT2)

LRUF:

124503702 124514376

PTG:	102965067 107180570(A3GALT2)

PPAD:

109255233 109255324 109269868

PUC:	125913696 125927275

AJU:	106973174 106986621

HHV:	120232112(A3GALT2) 120233419(GGTA1)

BTA:	281780(GGTA1) 617693(A3GALT2)

BOM:	102276118(A3GALT2) 102282898

BIU:	109566417 109575981(A3GALT2)

BBUB:

102402563(A3GALT2) 102405485 123333796

BBIS:

104986490(A3GALT2) 104997334

CHX:	102168270 108637492(A3GALT2)

OAS:	101103704(A3GALT2) 443282(GGTA1)

BTAX:

128043315(A3GALT2) 128055902(GGTA1)

ODA:	120851938(GGTA1) 120854762(A3GALT2)

CCAD:

122426222(A3GALT2) 122442105(GGTA1)

MBEZ:

129538592(A3GALT2) 129539953(GGTA1)

SSC:	100739829(A3GALT2) 396733(GGTA1P)

CFR:	102516495(A3GALT2) 102516521

CBAI:

105065260

CDK:	105104406 116156821(A3GALT2)

VPC:

102541625

BACU:

103006673

BMUS:

118890621(A3GALT2) 118896871(GGTA1)

LVE:	103079826(A3GALT2) 103089836

OOR:	101277096(GGTA1) 101279702(A3GALT2)

DLE:	111175451(A3GALT2) 111177259(GLT6D1)

PCAD:

102975905(GGTA1) 102996822(A3GALT2)

PSIU:

116755327 116755462(A3GALT2)

NASI:

112411282(GLT6D1) 112413362(A3GALT2)

ECB:	100067589 106782783(A3GALT2)

EPZ:	103555510 103557792(A3GALT2)

EAI:	106824198(GGTA1) 106829012(A3GALT2)

MYB:

102261921

MYD:	102751930 102753567(A3GALT2)

MMYO:

118667122(GGTA1) 118675052(A3GALT2)

MLF:	102418670 102418780(A3GALT2)

PKL:	118724792(A3GALT2)

EFUS:

103300120(A3GALT2)

MNA:	107537664 107542062(A3GALT2)

DRO:	112299104(A3GALT2) 112306460

SHON:

118995989(GGTA1) 118997700(A3GALT2)

AJM:	119046898(GGTA1) 119052438(A3GALT2)

PDIC:

114497325 114497543(A3GALT2)

PHAS:

123819701 123831861(A3GALT2)

MMF:	118627073(A3GALT2) 118630216(GGTA1)

PPAM:

129069035(A3GALT2) 129079304(GGTA1)

HAI:	109383944 109385732 109390838(A3GALT2)

RFQ:	117020071 117027790(A3GALT2) 117032059

PALE:

102885392(A3GALT2) 102892029

PGIG:

120582036(A3GALT2) 120605761(GGTA1)

PVP:	105290602(A3GALT2) 105292696

RAY:	107513619(A3GALT2) 107516315

MJV:	108401813(A3GALT2) 108405129(GGTA1)

TOD:	119232266(GGTA1) 119236484(A3GALT2)

SARA:

101537225(A3GALT2) 101550558

LAV:	100655343 100671107(A3GALT2)

TMU:	101350553 101352341

ETF:	101639145 101661937(A3GALT2)

DNM:	101421783(A3GALT2) 101426740

MDO:	100016068 100016105

GAS:	123233711 123237374(GGTA1)

SHR:	100932826 100933356

AFZ:	127550538 127550540

PCW:	110211311 110211337

OAA:

100089476

PSS:	102447976(A3GALT2)

CMY:

102941601

CCAY:

125623683 125624512

DCC:

119844080

ACS:

103281997

ASAO:

132763594

PVT:

110078804

SUND:

121936010(GLT6D1)

PBI:

103058654

PMUR:

107295054

CTIG:

120308657

TSR:

106542602

PGUT:

117676609

PTEX:

113443868(GLT6D1)

NSS:

113424224

VKO:

123028190

PMUA:

114589231(GLT6D1)

PRAF:

128406401(GLT6D1)

ZVI:	118083828(GLT6D1)

HCG:

128338747

GJA:

107118477

STOW:

125441522

EMC:

129342423

NPR:

108793736

RTEM:

120913257

CHAR:

105894281 105909849 116219872

TRU:	101068483 101078261(a3galt2)

TFS:	130514059 130524001

TNG:	GSTEN00027557G001

LCO:

104919360

NCC:	104957307(a3galt2)

TBEN:

117489403 117489404

CGOB:

115004723 115007798(a3galt2)

PGEO:

117440761 117442178 117442977 117446524 117450555 117450569 117450579 117451297

GACU:

117535151 117535155 117535176 117535187 117548214 117548216 117548217 117549212

EMAC:

134882377 134882712 134882713

ELY:	117256487 117259063 117259076

EFO:	125879807 125879816 125889109

PLEP:

121939462 121945515 121945523 121959687

SLUC:

116037649 116051301 116057313 116067217 116067352

ECRA:

117943156 117945686 117945922 117948437 117948445

ESP:	116688624 116691062 116694142

PFLV:

114553924 114554441 114554518 114554598 114554673 114556077

GAT:	120834481 120835170

PPUG:

119195871 119230135

AFB:	129105403 129107717

CLUM:

117727569 117730305

PSWI:

130193235 130208894

MSAM:

119885654 119890562

SCHU:

122877865 122886010

CUD:	121503700 121507200 121507410

ALAT:

119018129 119021141

MZE:	101476245(a3galt2)

ONL:	100691157 100696629 100699221 100706236 106098913 109204947

OAU:	116312925 116316519 116323213 116334247 116336518 120440900 120443130

OLA:	101158589 101158846 101159083 101159331 101159492 110014315

OML:	112145436 112161178 112161179 112161180

CSAI:

133448651 133458057

XMA:	102225862(a3galt2)

XCO:	114135833(a3galt2) 114142426

XHE:	116711175 116716720 116718494 116724797 116733252

PRET:

103462901 103464476(a3galt2)

PFOR:

103136623(a3galt2) 103144194

PLAI:

106945815(a3galt2) 106953116

PMEI:

106924734(a3galt2) 106927369

GAF:	122834004 122844420

PPRL:

129353024 129364139

CVG:	107087544 107094052 107098819

CTUL:

119772774 119796323 119796330

GMU:	124857033 124866475

NFU:	107372345 107385258 107385260

KMR:	108229171 108229172 108231546 108231617 108234809 119616584

ALIM:

106513849 106513851 106519097

NWH:	119412395 119412396 119412397 119426969

AOCE:

111574913 111588016(a3galt2)

MCEP:

125005723 125006159

CSEM:

103378785 103385676

POV:	109637219 109638603

SSEN:

122768615 122772585 122773138

HHIP:

117757446 117761542

HSP:	118105204 118112067

SMAU:

118302527 118309924

LCF:	108887790 108899900

SDU:

111224019

SLAL:

111658256

XGL:	120801819 120807446

BPEC:

110168737

MALB:

109958978

BSPL:

114852556 114856414

SASA:

106565705 106582820

STRU:

115150916 115207511

OTW:	112220697 112254318

OMY:	110494632 110527833

OGO:	124003325 124031534

ONE:	115136718 115143428

OKI:	109890162 109910047

OKE:	118388308 118400038

SALP:

111969813 111969849

SNH:	120020412 120065536

CCLU:

121574840 121578734

ELS:

105017413

SFM:	108918234(a3galt2) 108924914

PKI:	111857101 111859140

AANG:

118208254 118208255 118210928

LOC:	102684573(a3galt2)

PSPA:

121306694 121306703 121328869 121329372

ARUT:

117396907 117422694 117422696 117422697 117431939 117964722 117974010 117974011

PSEX:

120530963

LCM:

102357128

CMK:

103181344

RTP:	109918400 109924380

CPLA:

122540228 122541425

HOC:	132832976 132833523

LERI:

129711445

PMRN:

116938936 116939603 116950227 116953205

LRJ:	133347228 133348677 133348848 133354654

» show all

Reference

1 [PMID:4632915]

Authors

Basu M, Basu S.

Title

Enzymatic synthesis of a blood group B-related pentaglycosylceramide by an alpha-galactosyltransferase from rabbit bone marrow.

Journal

J Biol Chem 248:1700-6 (1973)

Reference

2 [PMID:3932335]

Authors

Blanken WM, Van den Eijnden DH.

Title

Biosynthesis of terminal Gal alpha 1----3Gal beta 1----4GlcNAc-R oligosaccharide sequences on glycoconjugates. Purification and acceptor specificity of a UDP-Gal:N-acetyllactosaminide alpha 1----3-galactosyltransferase from calf thymus.

Journal

J Biol Chem 260:12927-34 (1985)

Reference

3 [PMID:6787040]

Authors

Blake DA, Goldstein IJ.

Title

An alpha-D-galactosyltransferase activity in Ehrlich ascites tumor cells. Biosynthesis and characterization of a trisaccharide (alpha-D-galactose-(1 goes to 3)-N-acetyllactosamine).

Journal

J Biol Chem 256:5387-93 (1981)

Other DBs

ExplorEnz - The Enzyme Database:

2.4.1.87

IUBMB Enzyme Nomenclature:

2.4.1.87

ExPASy - ENZYME nomenclature database:

2.4.1.87

BRENDA, the Enzyme Database:

2.4.1.87

CAS:	128449-51-4

DBGET integrated database retrieval system