KEGG ENZYME: 2.4.2.48

ENZYME: 2.4.2.48

Entry

EC 2.4.2.48                 Enzyme

Name

tRNA-guanine15 transglycosylase;
tRNA transglycosylase (ambiguous);
transfer ribonucleate glycosyltransferase (ambiguous);
tRNA guanine15 transglycosidase;
TGT (ambiguous);
transfer ribonucleic acid guanine15 transglycosylase

Class

Transferases;
Glycosyltransferases;
Pentosyltransferases

Sysname

tRNA-guanine15:7-cyano-7-carbaguanine tRNA-D-ribosyltransferase

Reaction(IUBMB)

guanine15 in tRNA + 7-cyano-7-carbaguanine = 7-cyano-7-carbaguanine15 in tRNA + guanine

Substrate

guanine15 in tRNA;
7-cyano-7-carbaguanine [CPD:C15996]

Product

7-cyano-7-carbaguanine15 in tRNA;
guanine [CPD:C00242]

Comment

Archaeal tRNAs contain the modified nucleoside archaeosine at position 15. This archaeal enzyme catalyses the exchange of guanine at position 15 of tRNA with the base preQ0, which is ultimately modified to form the nucleoside archaeosine (cf. EC 2.6.1.97) [1].

History

EC 2.4.2.48 created 2012

Orthology

K18779

7-cyano-7-deazaguanine tRNA-ribosyltransferase

Genes

PPM:	PPSC2_01065(tgtC)

PPO:	PPM_0191(tgtC)

PVO:	PVOR_07275

PLW:	D5F53_24590

CTH:

Cthe_3185

CTX:	Clo1313_0734

CYJ:	Cyan7822_2821

PAGH:

NIES204_27070

CTM:	Cabther_A0932

MJA:

MJ_0436

MFE:	Mefer_0980

MVU:	Metvu_0178

MFS:	MFS40622_1703

MIF:	Metin_0864

MJH:	JH146_1349

MESG:

MLAUSG7_1612(tgtA)

MESA:

MLASG1_1060(tgtA)

MIG:	Metig_0611

MMP:	MMP0610(tgtA)

MMQ:	MmarC5_0996

MMX:	MmarC6_0282

MMZ:	MmarC7_1632

MMD:

GYY_03425

MMAK:

MMKA1_06590(tgtA)

MMAO:

MMOS7_06540(tgtA)

MMAD:

MMJJ_03740(tgt)

MAE:

Maeo_0878

MVN:	Mevan_1482

MVO:

Mvol_0802

MOK:	Metok_1508

METF:

CFE53_03650

MTH:

MTH_176

MMG:	MTBMA_c06290(tgt) MTBMA_c08930

MWO:	MWSIV6_0592(tgtA)

MTEE:

MTTB_08360

METC:

MTCT_0143

METE:

tca_00160(tgt)

METZ:

METMT2_0639

METK:

FVF72_01400(tgtA)

MTHM:

FZP57_02815(tgtA)

METJ:

FZP68_07845(tgtA)

MST:

Msp_0520

METB:

AW729_03950

MEIS:

PXD04_07065(tgtA)

MRU:	mru_1512(tgtA2)

MSI:

Msm_1557

MEB:	Abm4_1021(tgtA)

MMIL:

sm9_1475(tgtA1)

MEYE:

TL18_06780

MOL:

YLM1_1008

MARO:

MarbSA_20160

METV:

K4897_08655(tgtA)

MEL:	Metbo_0966

MEW:	MSWAN_1284

METH:

MBMB1_0938(tgtA) MBMB1_1276

MFC:	BRM9_0492(tgtA1) BRM9_1112(tgtA2)

MFI:	DSM1535_0473 DSM1535_1766(tgtA)

MCUB:

MCBB_1229(tgtA)

MSUB:

BK009_03940

METN:

BK008_11635

METT:

CIT01_08460 CIT01_09780

METO:

CIT02_01275 CIT02_11675

MEME:

HYG87_10175(tgtA)

MFEG:

GCM10025860_22860

MFV:

Mfer_1280

MKA:	MK0188(tgt)

AFU:

AF_0588

AFG:	AFULGI_00006630

APO:	Arcpr_1823

AVE:	Arcve_0758

AST:	Asulf_00167

FPL:

Ferp_1811

GAC:

GACE_2025

GAH:

GAH_00619

PFU:

PF1046

PFI:

PFC_04465

PHO:	PH1116(PH1116)

PAB:	PAB0740(tgtA)

PYN:

PNA2_1792

PYA:	PYCH_06100

PYS:

Py04_1170

PYC:	TQ32_06140

TKO:

TK0760

TON:

TON_0617

TGA:	TGAM_1141(arcTGT)

TSI:

TSIB_0093

TBA:	TERMP_00914

THE:

GQS_01945

THA:

TAM4_2111

THM:

CL1_0051

TLT:

OCC_06816

THS:

TES1_0575

TNU:

BD01_0733

TEU:

TEU_07720

TGY:	X802_02830 X802_08615

THV:	ADU37_CDS00120

TCH:	CHITON_1477

TPEP:

A0127_01270

TPIE:

A7C91_09125

TGG:	A3K92_05420

TCE:	A3L02_08200

TBS:	A3L01_03790

THH:	CDI07_03710

TSL:	A3L11_07780

TTD:	A3L14_05580 A3L14_07970

TPRF:

A3L09_07825

TRL:	A3L10_02760

TPAF:

A3L08_07040

THY:	A3L12_05185

TIC:	FH039_09455(tgtA)

TCQ:	TIRI35C_1006(tgtA)

THEM:

FPV09_00255(tgtA)

THEI:

K1720_03540(tgtA)

PPAC:

PAP_07820

MBA:	Mbar_A1088

MBY:	MSBRM_3344

MBW:	MSBRW_3634

MBAR:

MSBR2_3297

MBAK:

MSBR3_3298

MAC:	MA_4419(tgt)

MMA:

MM_1101

MMAZ:

MmTuc01_1140

MMJ:	MSMAS_0201

MMAC:

MSMAC_0206

MVC:	MSVAZ_0184

MEK:	MSKOL_0178

MLS:	MSLAZ_2930

METM:

MSMTP_0234

MEF:	MSWH1_0500

MEQ:	MSWHS_0512

MSJ:	MSSAC_4105

MSZ:	MSSIH_3641

MSW:	MSSIT_3696

MTHR:

MSTHT_1729

MTHE:

MSTHC_1559

MHOR:

MSHOH_0253

MFZ:	AOB57_007830(tgtA)

MBU:	Mbur_0941(tgtA)

MMET:

MCMEM_1443

MELO:

J7W08_05930(tgtA)

MMH:

Mmah_0673

MHAZ:

BHR79_10235

MPOT:

BKM01_09935

MEV:	Metev_1733

MZH:	Mzhil_0233

MPY:

Mpsy_1469

MZI:	HWN40_01420(tgtA)

MMAV:

RE476_08830(tgtA)

MSEB:

RE474_05410(tgtA)

MHZ:	Metho_0237

MEHF:

MmiHf6_09200(qtrT1)

MEES:

MmiEs2_11770(qtrT1)

MTP:

Mthe_1660

MCJ:

MCON_0339

MHI:

Mhar_0739

MHU:

Mhun_1120

MRTJ:

KHC33_08525(tgtA)

MLA:

Mlab_1207

MEM:	Memar_1287

MBG:	BN140_2027(tgt3)

MEMA:

MMAB1_2627(tgtA)

MCHK:

MchiMG62_14730

MSUM:

OH143_00660(tgtA)

MRC:	R6Y96_03945(tgtA)

MPI:

Mpet_2091

MEND:

L6E24_10845(tgtA)

MEFW:

F1737_02265(tgtA)

MAQE:

RJ40_12590(tgtA)

MFK:	E2N92_00285(tgtA) E2N92_00740

MOU:	OU421_11415(tgtA)

MESB:

L1S32_03305(tgtA)

MANQ:

L1994_07255(tgtA)

MBN:

Mboo_1313

MFO:	Metfor_1670

MPL:

Mpal_1831

MPD:	MCP_1180(tgtA)

MEZ:	Mtc_1497(tgtA)

RCI:	RCIX2688(tgt-2)

HAL:	VNG_1959G(tgtA1)

HSL:	OE_3749R(tgtA)

HANR:

LJ422_07885(tgtA)

HDL:	HALDL1_14740

HHB:	Hhub_3276(tgtA)

HAGS:

JT689_09220(tgtA)

HABO:

JRZ79_07630(tgtA)

HNO:	LT974_13175(tgtA)

HLU:	LT972_01610(tgtA)

HALH:

HTSR_1954(tgtA1)

HHSR:

HSR6_2029(tgtA1)

HSU:	HLASF_1961(tgtA1)

HSF:	HLASA_1947(tgtA1)

HAHS:

HSRCO_2598(tgt)

SALR:

FQU85_06365(tgtA) FQU85_13150

HALR:

EFA46_002245(tgtA)

HJE:	HacjB3_04665

HDO:	MUK72_01460(tgtA)

HALX:

M0R89_03445(tgtA)

HAXZ:

M0R88_03655(tgtA)

HAYC:

NGM10_01970 NGM10_11465(tgtA)

HAXY:

NGM07_09180(tgtA)

SALI:

L593_08885

SAIM:

K0C01_07490(tgtA)

HARA:

AArcS_1165(tgt) AArcS_1595 AArcS_1597(tgt2)

HMA:	rrnAC3258(tgt)

HHI:	HAH_0503(tgt1)

HHN:	HISP_02605

HAB:	SG26_10395

HTA:	BVU17_02475

HALJ:

G9465_17745(tgtA)

HSIN:

KDQ40_11020(tgtA) KDQ40_22875

NPH:	NP_2508A(tgtA)

NMO:	Nmlp_3669(tgtA)

NHO:	HWV23_14775(tgtA)

NSAL:

HWV07_18015(tgtA)

HUT:

Huta_2181

HTI:

HTIA_2061

HALA:

Hrd1104_02875(tgtA)

HASV:

SVXHr_2399(tgtA) SVXHr_2733(tgtA2)

HABN:

HBNXHr_2395(tgtA)

HMU:

Hmuk_1434

HALZ:

E5139_10325(tgtA)

HALL:

LC1Hm_0973(tgtA)

HAZP:

GBQ70_10320(tgtA)

HALI:

BV210_11915

HSN:	DV733_01170 DV733_01180 DV733_03190

HDS:	HSR122_2696(tgt)

HRR:	HZS55_06675(tgtA)

HPEL:

HZS54_07205(tgtA)

HLT:	I7X12_06790(tgtA)

HARC:

HARCEL1_04695 HARCEL1_12085 HARCEL1_12905

SSAI:

N0B31_04305(tgtA)

HAAD:

MW046_01310(tgtA)

HVO:	HVO_2001(tgtA1)

HME:	HFX_2097(tgt)

HGI:	ABY42_09780

HALE:

G3A49_13005(tgtA)

HLS:	KU306_02400(tgtA)

HLN:	SVXHx_2616(tgtA)

HBO:	Hbor_06020

HAQ:	DU484_04520

HAJ:	DU500_04935

HAER:

DU502_02835(tgtA)

HRA:	EI982_10760(tgtA) EI982_16750 EI982_16760

HLM:	DV707_02085

HALM:

FCF25_00300 FCF25_00315 FCF25_02275(tgtA)

HLA:

Hlac_2160

HALP:

DOS48_10425

HALB:

EKH57_05930(tgtA)

HEZZ:

EO776_06595(tgtA)

HALQ:

Hrr1229_011360(tgtA)

HSS:	J7656_10015(tgtA) J7656_11510 J7656_11520

HSAI:

HPS36_00365(tgtA)

HAZZ:

KI388_07410

SRUB:

C2R22_19070

HAE:	halTADL_2549

HALN:

B4589_007885(tgtA)

HALG:

HUG10_09565(tgtA)

HALU:

HUG12_06155(tgtA)

HMP:	K6T50_07365(tgtA)

HRE:	K6T36_07135(tgtA)

HRM:	K6T25_08640(tgtA)

HACB:

Hbl1158_13730(tgtA)

HDF:	AArcSl_0263(tgtA)

HAH:	Halar_1993

HTU:

Htur_0719

HSAL:

JMJ58_05490(tgtA)

HAKZ:

J0X25_10800(tgtA) J0X25_12290

NMG:	Nmag_2676(tgtA)

HXA:	Halxa_3588

NAT:

NJ7G_3961

NPE:	Natpe_3147

NVR:	FEJ81_14805(tgtA)

NPL:	FGF80_12285 FGF80_13845(tgtA)

NAY:	HYG81_13910(tgtA)

HALY:

HYG82_18350 HYG82_18360 HYG82_20000(tgtA)

HJT:	DVR14_05860

HLO:	J0X27_03265(tgtA) J0X27_05370

NGE:	Natgr_1056

HRU:	Halru_0675

SAWL:

NGM29_01750(tgtA) NGM29_19440

HALV:

NGM15_11360(tgtA)

NOU:	Natoc_0816

HLR:	HALLA_08145

HLC:	CHINAEXTREME01480

NAJ:	B1756_06790

NAG:	AArcMg_0720

NAN:	AArc1_2903

NARA:

QQ977_11115(tgtA)

NBG:	DV706_03675

NAS:	GCU68_09815(tgtA) GCU68_16940

HDA:	BB347_00680

MELU:

MTLP_07920

MEAM:

MU439_02540(tgtA)

MEAE:

QEN48_07740(tgtA)

TAC:

Ta1493

TVO:	TVG1580555(TVG1580555)

PTO:

PTO0454

FAC:	FACI_IFERC01G0857

FAI:

FAD_1747

CDIV:

CPM_0489

TAR:	TALC_00617

MAX:	MMALV_05930

MER:	MMINT_14750

MEAR:

Mpt1_c02640(tgtA1)

MEUZ:

KRP56_05120(tgtA)

MARC:

AR505_0637

ABI:

Aboo_0570

ACF:	AciM339_0479

APE:

APE_2017

ACJ:

ACAM_1266

SMR:

Smar_0911

SHC:	Shell_1554

IHO:	Igni_0478 Igni_0817

IIS:	EYM_03435 EYM_04515

DKA:

DKAM_1258

DFD:	Desfe_1359

DMU:	Desmu_1248

TAG:

Tagg_1283

IAG:

Igag_0098

THG:	TCELL_0281

HBU:

Hbut_0469

PFM:	Pyrfu_0098 Pyrfu_0491

PDL:	Pyrde_0066 Pyrde_1365

PABI:

PABY_12560 PABY_21150(tgtA)

PARE:

PYJP_19390(tgtA)

STO:	STK_03270(tgtA)

SOH:	D1869_01245(tgtA)

SSO:	SSO0274(tgtA)

SOL:

Ssol_1251

SSOA:

SULA_1292(tgtA)

SSOL:

SULB_1293(tgtA)

SSOF:

SULC_1291(tgtA)

SSHI:

J5U23_03193

SCAS:

SACC_01920

SAI:

Saci_0659

SACN:

SacN8_03185

SACR:

SacRon12I_03175

SACS:

SUSAZ_02975

SIS:	LS215_1966

SIA:	M1425_1857

SIM:	M1627_1944

SID:

M164_1874

SIY:	YG5714_1943

SIN:	YN1551_0979

SII:

LD85_2086

SIH:

SiH_1803

SIR:

SiRe_1723

SIC:

SiL_1717

SULA:

BFU36_04805

SULE:

GFS03_10220(tgtA)

SULO:

GFS33_02035(tgtA)

SULL:

EWF20_02695(tgtA)

MSE:

Msed_2272

MEMJ:

MJ1HA_2597

MCN:

Mcup_2018

MHK:	DFR87_06845(tgtA)

MPRU:

DFR88_06835

MTEN:

GWK48_05310(tgtA)

MJN:	MjAS7_0566

AHO:

Ahos_0803

AMAN:

B6F84_07480

ABRI:

DFR85_07390(tgtA)

ASUL:

DFR86_06535(tgtA)

AAMB:

D1866_11860(tgtA)

ACIH:

HS5_21770

SACD:

HS1genome_0368

SAZO:

D1868_01985(tgtA)

CSTY:

KN1_18910

STEP:

IC006_1769

SMET:

RQ359_000073(tgtA)

SAHS:

HS7_08210

PAI:

PAE0777

PIS:	Pisl_1072 Pisl_2003

PCL:

Pcal_2149

PAS:	Pars_0033 Pars_2160

PYR:

P186_1074

POG:	Pogu_2457 Pogu_2729

TNE:

Tneu_0030

PYW:	PYWP30_00035 PYWP30_02110

CMA:

Cmaq_0024

TTN:	TTX_1934(tgtA) TTX_1975

TUZ:	TUZN_1496 TUZN_1566

VDI:

Vdis_1864

VMO:

VMUT_0301

VSO:	Vsou_02670

TPE:

Tpen_0356

THB:	N186_02800

TCB:	TCARB_1628

THEL:

IG193_05765(tgtA)

ASC:

ASAC_0308

CLG:	Calag_1247

FFO:	FFONT_1048

NMR:

Nmar_1536

NIR:	NSED_08445

NKR:	NKOR_08355

NID:	NPIRD3C_0009(tgtA)

NIN:	NADRNF5_0355(tgtA)

NIW:	Nisw_06235(tgtA)

NCL:	C5F47_08050

NOX:	C5F49_07935

NUE:	C5F50_11275

NIP:	NsoK4_00600(tgtA)

NZT:	NZOSNM25_000253

NCT:	NMSP_0225(tgtA_1)

NIC:	DSQ20_08960

NGA:	Ngar_c32140(tgtA)

NVN:	NVIE_022530(tgtA)

NEV:

NTE_03307

TAA:	NMY3_00824(tgt)

NFN:	NFRAN_1814(tgt)

NCV:	NCAV_0711(tgtA)

CSY:	CENSYa_1646

CSU:	CSUB_C1315

NBV:

T478_1256

TAH:	SU86_004490

NIU:	DSQ19_01565

NDV:	NDEV_0261(tgtA)

CCAI:

NAS2_1317

KCR:

Kcr_1361

BARC:

AOA65_1371(tgtA_1)

BARB:

AOA66_1126(tgtA_2)

NEQ:

NEQ124

NAER:

MJ1_0729

LOKI:

Lokiarch_50690(tgtA_2) Lokiarch_52540(tgtA_3)

LOB:	NEF87_002806

PSYT:

DSAG12_00760(tgtA_2)

» show all

Reference

1 [PMID:10862614]

Authors

Bai Y, Fox DT, Lacy JA, Van Lanen SG, Iwata-Reuyl D

Title

Hypermodification of tRNA in Thermophilic archaea. Cloning, overexpression, and characterization of tRNA-guanine transglycosylase from Methanococcus jannaschii.

Journal

J Biol Chem 275:28731-8 (2000)
DOI:10.1074/jbc.M002174200

Sequence

[mja:MJ_0436]

Other DBs

ExplorEnz - The Enzyme Database:

2.4.2.48

IUBMB Enzyme Nomenclature:

2.4.2.48

ExPASy - ENZYME nomenclature database:

2.4.2.48

BRENDA, the Enzyme Database:

2.4.2.48

All links

Gene (5214)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (470)   
   KEGG MGENES (3838)   
   RefGene (905)   
Protein sequence (3460)   
   UniProt (2074)   
   SWISS-PROT (35)   
   RefSeq(pep) (1351)   
DNA sequence (2256)   
   RefSeq(nuc) (1967)   
   GenBank (155)   
   EMBL (134)   
Protein domain (13)   
   InterPro (13)   
All databases (10943)   

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