KEGG ENZYME: 2.5.1.103

ENZYME: 2.5.1.103

Entry

EC 2.5.1.103                Enzyme

Name

presqualene diphosphate synthase;
SSL-1 (gene name);
hpnD (gene name)

Class

Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)

Sysname

(2E,6E)-farnesyl-diphosphate:(2E,6E)-farnesyl-diphosphate farnesyltransferase (presqualene diphosphate-forming)

Reaction(IUBMB)

2 (2E,6E)-farnesyl diphosphate = presqualene diphosphate + diphosphate [RN:R00702]

Reaction(KEGG)

R00702

Substrate

(2E,6E)-farnesyl diphosphate [CPD:C00448]

Product

presqualene diphosphate [CPD:C03428];
diphosphate [CPD:C00013]

Comment

Isolated from the green alga Botryococcus braunii BOT22. Unlike EC 2.5.1.21, squalene synthase, where squalene is formed in one step from farnesyl diphosphate, in this alga the intermediate presqualene diphosphate is generated and released by this enzyme. This compound is then converted into either squalene (by EC 1.3.1.96, Botryococcus squalene synthase) or botryococcene (EC 1.3.1.97, botryococcene synthase).

History

EC 2.5.1.103 created 2012

Orthology

K21151

presqualene diphosphate synthase

K21678

presqualene diphosphate synthase

Genes

ACAV:

VI35_08830

AEA:	C2U39_09245

ARV:	C7N77_15940

AES:	C2U30_04565

RPJ:	N234_32515

REH:	H16_B2206(h16_B2206)

CNC:	CNE_2c21840

CUH:	BJN34_33520

REU:	Reut_B4953

RME:	Rmet_4149(crtB)

CTI:	RALTA_B1982(crtB)

CBW:	RR42_s2400

CCUP:

BKK81_26335

CUP:	BKK80_29980

CUU:	BKK79_20630

CPAU:

EHF44_19250(hpnD)

COX:	E0W60_04540(hpnD)

CCAM:

M5D45_21260(hpnD)

CUK:	KB879_16305(hpnD)

CNAN:

A2G96_29210

BMA:

BMAA2102

BMV:	BMASAVP1_1131

BML:	BMA10229_1410

BMAL:

DM55_3713(hpnD)

BMAE:

DM78_4587(hpnD)

BMAQ:

DM76_4408(hpnD)

BMAI:

DM57_14645

BMAF:

DM51_3765(hpnD)

BMAZ:

BM44_3672(hpnD)

BMAB:

BM45_4449(hpnD)

BPS:

BPSS2340

BPM:	BURPS1710b_A1491

BPL:	BURPS1106A_A3163

BPD:	BURPS668_A3277

BPSE:

BDL_5819(hpnD)

BPSM:

BBQ_3759(hpnD)

BPSU:

BBN_5841(hpnD)

BPSD:

BBX_4988(hpnD)

BPZ:	BP1026B_II2521

BPQ:	BPC006_II3109

BPK:	BBK_5126(hpnD)

BPSH:

DR55_5385(hpnD)

BPSA:

BBU_3645(hpnD)

BPSO:

X996_5155(hpnD)

BUT:	X994_4704(hpnD)

BTE:	BTH_II2361

BTQ:	BTQ_3276(hpnD)

BTJ:	BTJ_4308(hpnD)

BTZ:	BTL_5109(hpnD)

BTD:	BTI_4771(hpnD)

BTV:	BTHA_5107(hpnD)

BTHE:

BTN_4770(hpnD)

BTHM:

BTRA_5038(hpnD)

BTHA:

DR62_4874

BTHL:

BG87_5105(hpnD)

BOK:	DM82_3977(hpnD)

BOC:	BG90_4050(hpnD)

BUU:	WS70_28735

BSAV:

WS86_18640

BHG:	I6G56_29180(hpnD)

BUD:	AQ610_31640

BVI:	Bcep1808_3806

BVE:	AK36_4903(hpnD)

BUR:	Bcep18194_B0017

BCM:	Bcenmc03_4554

BCH:	Bcen2424_5681

BCJ:

BCAM2833

BCEN:

DM39_5011(hpnD)

BCEW:

DM40_3398(hpnD)

BCEO:

I35_6713

BAM:

Bamb_4953

BAC:	BamMC406_5506

BMJ:	BMULJ_05351(crtB)

BMU:

Bmul_3173

BMK:	DM80_4551(hpnD)

BMUL:

NP80_3381(hpnD)

BCT:

GEM_5579

BCED:

DM42_5155(hpnD)

BCEP:

APZ15_24785

BDL:	AK34_4972(hpnD)

BPYR:

ABD05_21475

BCON:

NL30_18015

BUB:	BW23_4003(hpnD)

BDF:	WI26_26725

BLAT:

WK25_29570

BTEI:

WS51_10755

BSEM:

WJ12_34030

BPSL:

WS57_00075

BMEC:

WJ16_32505

BSTG:

WT74_32870

BSTL:

BBJ41_27940

BANN:

JFN94_18185(hpnD)

BARI:

NLX30_22945(hpnD)

BAEN:

L3V59_29260(hpnD)

BGL:	bglu_2g22730

BGU:	KS03_3645(hpnD)

BUG:	BC1001_4761

BGF:	BC1003_4525

BGD:	bgla_2g29880

BGO:	BM43_6722(hpnD)

BYI:	BYI23_B013700(hpnD)

BUK:

MYA_3463

BUE:	BRPE67_BCDS00660(hpnD)

BUL:	BW21_4300(hpnD)

BUQ:	AC233_26240

BGP:	BGL_2c29500

BPLA:

bpln_2g29540

BUM:	AXG89_19300

BUI:	AX768_29065

BURK:

DM992_25930(hpnD)

BXE:

Bxe_B0010

BXB:	DR64_5374(hpnD)

BPH:

Bphy_4139

BGE:	BC1002_5088

BPX:	BUPH_01326

BPY:	Bphyt_7027

BUZ:	AYM40_35485

BFN:	OI25_5472(hpnD)

BCAI:

K788_0000711

PSPW:

BJG93_21545(hpnD)

PARA:

BTO02_22405

PARB:

CJU94_28545(hpnD)

PHS:	C2L64_18365(hpnD)

PTER:

C2L65_16200(hpnD)

PGP:	CUJ91_30000(hpnD)

PCJ:	CUJ87_28070(hpnD)

PTS:	CUJ90_23655(hpnD)

PMEG:

FNZ07_04860(hpnD)

PTRO:

G5S35_20790(hpnD)

PGIS:

I6I06_28040(hpnD)

PACP:

FAZ97_23535(hpnD)

PACS:

FAZ98_18970(hpnD)

PEW:	KZJ38_24050(hpnD)

PDIO:

PDMSB3_3367.1(hpnD)

PBRY:

NDK50_21360(hpnD)

PSAA:

QEN71_16440(hpnD)

PKF:	RW095_15090(hpnD)

PBON:

QS306_13705(hpnD)

PPAI:

E1956_24890(hpnD)

PPK:	U875_17030

PPNO:

DA70_09100

PPNM:

LV28_21705

PRB:	X636_17390

PPUL:

RO07_16095

PSPU:

NA29_21055

PAPI:

SG18_00205

PVE:	UC34_07350

POX:	MB84_11685

PTX:	ABW99_02785

PFG:	AB870_18045

PNR:	AT302_26710

PAND:

DRB87_06615(hpnD)

PFIB:

PI93_020490(hpnD)

PCOM:

NTU39_08360(hpnD)

CABA:

SBC2_70720(hpnD)

BUO:	BRPE64_BCDS00790

CABK:

NK8_42300(hpnD)

VCV:	GJV44_p00025

TVL:	FAZ95_23945(hpnD)

TCAR:

U0034_25745(hpnD)

MLIR:

LPB04_14420(hpnD)

TMJ:	P0M04_22835(hpnD)

PMOB:

HG718_04895(hpnD)

KMN:	HW532_17965(hpnD)

PECT:

BN1012_Phect103

RHI:	NGR_a00440(hpnD)

SINO:

SS05631_a45170

ESJ:	SJ05684_a40270

BJA:	blr3002(blr3002)

BJU:	BJ6T_67650

BJP:	RN69_32810

BRA:

BRADO2628

BBT:

BBta_2967

BRS:	S23_49950(hpnD)

AOL:

S58_49910

BRC:	BCCGELA001_13465

BRAD:

BF49_1690

BIC:	LMTR13_28340

BRO:	BRAD285_4713

BRK:	CWS35_18215(hpnD)

BOT:	CIT37_38585(hpnD)

BRQ:	CIT40_09510(hpnD)

BGQ:	X265_25990(hpnD)

BGZ:	XH91_24130(hpnD)

BSYM:

CIT39_08630(hpnD)

BBET:

F8237_05035(hpnD)

BARH:

WN72_16440(hpnD)

BVZ:	BRAD3257_5708

BEL:	BE61_70460

BDG:	LPJ38_18010(hpnD)

BSEP:

HAP48_0030890(hpnD)

BQB:	J4P68_0032150(hpnD)

BSEI:

KMZ68_09710(hpnD)

BBAN:

J4G43_017125(hpnD)

BCAN:

BcanWSM471_14285(hpnD)

BAUT:

QA635_28530(hpnD)

BBRA:

QA636_30420(hpnD)

BGK:	IC762_11720(hpnD)

BCOU:

IC761_24425(hpnD)

BPAH:

QA639_15460(hpnD)

BXN:	I3J27_11365(hpnD)

BROS:

QUH67_11920(hpnD)

BRAZ:

LRP30_12830(hpnD)

RPA:	TX73_019380(hpnD)

RPB:

RPB_1724

RPC:

RPC_1718

RPD:

RPD_3575

RPE:

RPE_1812

RPT:

Rpal_4263

RPX:	Rpdx1_1603

RBK:	E0H22_09830(hpnD)

NWI:

Nwi_2271

NHA:

Nham_2684

OCA:	OCAR_6673(hpnD)

OCG:	OCA5_c13950

OCO:	OCA4_c13950

PCAX:

AFIC_002155(hpnD)

VGO:	GJW-30_1_02140(crtB_2)

TRB:	HB776_13765(hpnD)

TALZ:

RPMA_20060(hpnD)

STAR:

G3545_15490(hpnD)

MEA:	Mex_1p1816

MDI:

METDI2703

MEX:

Mext_1942

MCH:

Mchl_2218

MPO:

Mpop_1833

MZA:	B2G69_17170

MRD:	Mrad2831_5424

MET:

M446_6349

MNO:

Mnod_7144

MOR:	MOC_5999(hpnD)

META:

Y590_09030

MAQU:

Maq22A_c25245(erg9)

MPHY:

MCBMB27_04725

MEE:	DA075_06155(hpnD)

METD:

C0214_10785(hpnD)

METX:

A3862_03555

METS:

DK389_19265(hpnD)

METI:

DK427_24625(hpnD)

MMES:

MMSR116_24435(hpnD)

MTEA:

DK419_24990(hpnD)

MIND:

mvi_55630

MOG:	MMB17_13740(hpnD)

MTAD:

M6G65_20535(hpnD)

BID:

Bind_3154

MSL:

Msil_3241

MTUN:

MTUNDRAET4_2107(hpnD)

MLG:	CWB41_01835(hpnD)

MEDK:

QEV83_07975(hpnD)

BBAR:

RHAL1_00132(hpnD)

HDN:

Hden_0475

HDT:	HYPDE_24878

HMC:	HYPMC_3773

RVA:

Rvan_3019

RLAC:

QMO75_10885(hpnD)

RHZ:	RHPLAN_23290

MSC:

BN69_1680

MBRY:

B1812_03900

MROS:

EHO51_00870(hpnD)

MHEY:

H2LOC_015885(hpnD)

MPAR:

F7D14_11075(hpnD)

MIWA:

SS37A_09940

MTW:	CQW49_11735(hpnD)

MECQ:

MSC49_02510

PSIN:

CAK95_04475

TSO:

IZ6_27210

RBM:

TEF_04820

LIZ:	LGH83_10465(hpnD)

CAUL:

KCG34_23155(hpnD)

PLCG:

RVY76_15990

PALW:

PSAL_001910(hpnD)

LVR:	T8T21_16660

ZMO:

ZMO0870

ZMN:

Za10_0422

ZMM:

Zmob_0427

ZMB:

ZZ6_0425

ZMI:

ZCP4_0441

ZMC:	A265_00436(crtM)

ZMR:	A254_00436(crtM)

ZMP:	Zymop_0395

NOR:	FA702_05045(hpnD)

NHUM:

PQ457_14480(hpnD)

SPHM:

G432_09190

SPAN:

AWL63_21310

SPHA:

D3Y57_13885(hpnD)

SARI:

H5J25_10650(hpnD)

SMOR:

LHA26_10010(hpnD)

SNOS:

K8P63_14020(hpnD)

SABI:

PBT88_02335(hpnD)

HGN:	E6W36_05955

POQ:	KZX46_17585(hpnD)

PMEA:

KTC28_15775(hpnD)

GOX:

GOX2258

GOH:

B932_2744

GOY:	GLS_c24010(hpnD)

GAL:	A0U94_06160

GTI:	FXF46_13815(hpnD)

GSP:	IGS75_12755(hpnD)

GFA:	MKW11_14245(hpnD)

GBE:	GbCGDNIH1_1981

GBH:	GbCGDNIH2_1981

GBC:	GbCGDNIH3_1981

GBS:	GbCGDNIH4_1981

ACR:

Acry_0118

AMV:	ACMV_01430

GDI:

GDI1622

GDJ:

Gdia_1827

GXY:

GLX_17350

GXL:

H845_3227

KNA:	B0W47_08880

KEU:	S101446_02251(crtB)

KSC:	CD178_01161(crtB_1)

KRE:	GWK63_14325(hpnD)

KOI:	LV478_05315(hpnD)

APT:	APA01_01970

APW:	APA42C_01970

APF:	APA03_01970

APU:	APA07_01970

APG:	APA12_01970

APQ:	APA22_01970

APX:	APA26_01970

APZ:	APA32_01970

APK:	APA386B_1685

ASZ:

ASN_2210

ASV:	WG31_01025

AACE:

A0U92_11680

APER:

A0U91_06965

APOM:

CPF11_06315(hpnD)

ATO:	CIW82_01580(hpnD)

AASC:

A4S02_11555

ACET:

DS739_01125(hpnD)

AOT:	AcetOri_orf02400

AOY:	EOV40_001050(hpnD)

ACEK:

FLP30_07010(hpnD)

ABG:	Asbog_02596(hpnD)

KBA:	A0U89_01830

RGI:	RGI145_09720

ROS:	CTJ15_07700(hpnD)

RMUC:

FOB66_09725(hpnD)

RMT:	IAI58_18585(hpnD)

NCH:	A0U93_11935

COQ:	D9V35_08230(hpnD)

COMM:

GN303_08030(hpnD)

NTN:	D5366_10590(hpnD)

NEH:	E3E11_07655(hpnD)

SSAM:

E3D00_09655(hpnD)

SWF:	E3E12_06920(hpnD)

BOB:	GN304_03810(hpnD)

BOMB:

GT348_03335(hpnD)

EBLA:

JGUZn3_04110(hpnD)

LCK:	HN018_00150(hpnD)

KHA:	IFJ82_01375(hpnD)

PARZ:

DTQ13_08065(hpnD)

RAP:	RHOA_2341(hpnD)

ACIM:

GT370_09625(hpnD)

KDP:	N5W20_09460(hpnD)

NGU:	QN315_11445(hpnD)

SHUM:

STHU_15370 STHU_32400

SVC:	STVA_19140 STVA_37720

STEL:

STAQ_34010

AZL:	AZL_014580(crtB)

ALI:	AZOLI_1388

ABS:	AZOBR_p120091

ABQ:	ABAZ39_16790

ABF:	AMK58_16905

ATI:	AL072_11960

AHU:	A6A40_05000

AZT:	TSH58p_22395

AZM:	DM194_04395(hpnD)

AZZ:	DEW08_02165(hpnD)

AOZ:	HUE56_17245(hpnD)

AARE:

D3093_17180(hpnD)

AZS:	E6C72_10485(hpnD)

NAO:	Y958_22680(hpnD)

SKT:	IGS68_10425(hpnD)

SMUC:

JL100_016810(hpnD)

SROE:

JL101_015660(hpnD)

MGY:	MGMSRv2__1219

MGRY:

MSR1_10400(crtB_1)

MAGX:

XM1_1989

MAGN:

WV31_17680

DEX:	HWD60_12245(hpnD)

DVN:	HQ394_07740(hpnD)

MAG:

amb1366

HTQ:	FRZ44_04150

HADH:

FRZ61_04420

TXI:

TH3_01790

THAC:

CSC3H3_02195

MAGQ:

MGMAQ_1492

VSU:	P3M64_01210(hpnD)

THAR:

T8K17_14475(hpnD)

HFL:	PUV54_13175

PBF:	CFX0092_B0150

» show all

Reference

1 [PMID:21746901]

Authors

Niehaus TD, Okada S, Devarenne TP, Watt DS, Sviripa V, Chappell J

Title

Identification of unique mechanisms for triterpene biosynthesis in Botryococcus braunii.

Journal

Proc Natl Acad Sci U S A 108:12260-5 (2011)
DOI:10.1073/pnas.1106222108

Sequence

[ag:AEL16715]

Reference

2 [PMID:26258173]

Authors

Pan JJ, Solbiati JO, Ramamoorthy G, Hillerich BS, Seidel RD, Cronan JE, Almo SC, Poulter CD

Title

Biosynthesis of Squalene from Farnesyl Diphosphate in Bacteria: Three Steps Catalyzed by Three Enzymes.

Journal

ACS Cent Sci 1:77-82 (2015)
DOI:10.1021/acscentsci.5b00115

Other DBs

ExplorEnz - The Enzyme Database:

2.5.1.103

IUBMB Enzyme Nomenclature:

2.5.1.103

ExPASy - ENZYME nomenclature database:

2.5.1.103

BRENDA, the Enzyme Database:

2.5.1.103

DBGET integrated database retrieval system