Entry
Name
(2Z,6E)-farnesyl diphosphate synthase;
(Z)-farnesyl diphosphate synthase;
Z-farnesyl diphosphate synthase
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
BRITE hierarchy
Sysname
geranyl-diphosphate:isopentenyl-diphosphate geranylcistransferase
Reaction(IUBMB)
geranyl diphosphate + isopentenyl diphosphate = diphosphate + (2Z,6E)-farnesyl diphosphate [RN:
R08528 ]
Reaction(KEGG)
Substrate
geranyl diphosphate [CPD:
C00341 ];
isopentenyl diphosphate [CPD:
C00129 ]
Product
diphosphate [CPD:
C00013 ];
(2Z,6E)-farnesyl diphosphate [CPD:
C16826 ]
Comment
Requires Mg2+ or Mn2+ for activity. The product of this reaction is an intermediate in the synthesis of decaprenyl phosphate, which plays a central role in the biosynthesis of most features of the mycobacterial cell wall, including peptidoglycan, linker unit galactan and arabinan. Neryl diphosphate can also act as substrate.
History
EC 2.5.1.68 created 2007, modified 2010
Pathway
ec00900 Terpenoid backbone biosynthesis
ec01110 Biosynthesis of secondary metabolites
Orthology
K12503 short-chain Z-isoprenyl diphosphate synthase
Genes
BMEC : WJ16_28400 WJ16_28955
MMAE : MMARE11_42000(uppS)
MSP : Mspyr1_14790 Mspyr1_40870
MCB : Mycch_1318 Mycch_4074
MPHL : MPHLCCUG_04253(uppS_2)
MVQ : MYVA_1453 MYVA_4488(uppS)
MCHT : MCHIJ_25230(uppS_1)
MPSC : MPSYJ_21920(uppS_1)
MMAT : MMAGJ_05950(uppS_1)
MSEI : MSEDJ_55180(uppS_2)
MSAL : DSM43276_01075(uppS_1)
MTER : 4434518_01019(uppS_1)
CDD : CDCE8392_0836(uppS1)
CDIP : ERS451417_00833(uppS1)
CPP : CpP54B96_0736(uppS1)
CUN : Cul210932_0809(uppS1)
CUQ : Cul210931_0773(uppS1)
CUZ : Cul05146_0831(uppS1)
CUJ : CUL131002_0787(uppS1)
CUS : CulFRC11_0776(uppS1)
CMIN : NCTC10288_01619(uppS1)
CRL : NCTC7448_01598(uppS1)
NOZ : DMB37_15005 DMB37_28775
NWL : NWFMUON74_11170 NWFMUON74_46050(uppS_1)
GPD : GII33_06580 GII33_06810 GII33_06855(uppS) GII33_06870
SANL : KZO11_24220 KZO11_27040
SGRF : SGFS_045600 SGFS_084480
SCYE : R2B67_08800 R2B67_11685
SDV : BN159_3370(uppS1) BN159_7965(uppS2)
STRC : AA958_22585 AA958_24250
SAMB : SAM23877_3798(uppS)
SCZ : ABE83_12315 ABE83_33315
SLE : sle_26800(sle_26800)
SCLF : BB341_09085 BB341_29945
SGS : AVL59_05935 AVL59_18480
SGM : GCM10017557_28670(uppS)
SNR : SNOUR_16240(uppS1) SNOUR_37660(uppS)
SVU : B1H20_23485 B1H20_26065
SALJ : SMD11_2499 SMD11_6329
SQZ : FQU76_01635 FQU76_22405
SKA : CP970_15465 CP970_31335(uppS)
SNK : CP967_11725 CP967_27925
SSEO : D0Z67_18665 D0Z67_28165
STUI : GCM10017668_45800(uppS)
SATA : C5746_26705 C5746_35320
SCAL : I6J39_23230 I6J39_25760
SFB : CP974_18225 CP974_19920
SCIR : STRCI_000701 STRCI_005224
SXT : KPP03845_104791 KPP03845_300035(uppS)
SFP : QUY26_03385(uppS) QUY26_13430
KSK : KSE_47670(uppS2) KSE_73590(uppS3)
KAB : B7C62_21465 B7C62_23840
KIT : CFP65_0189 CFP65_4723
KIS : HUT16_03810(uppS) HUT16_21825
ABRY : NYE86_13300(uppS) NYE86_29995
MSUW : GCM10025863_15510(uppS)
AQK : AKACHI_09460(uppS_2)
FSB : GCM10025867_18950(uppS)
AMAV : GCM10025877_04440(uppS_1)
MALK : MalAC0309_0857(uppS)
LMOI : VV02_09215 VV02_24595
BEI : GCM100_28350(uppS_2)
DSS : GCM25873_16520(uppS_2)
PPC : HMPREF9154_2688(uppS_2)
MIK : FOE78_15730(uppS) FOE78_20030
MICG : GJV80_03230(uppS) GJV80_12455
SGRG : L0C25_04080 L0C25_21465(uppS)
KQI : F1D05_12240 F1D05_17600(uppS)
KSL : OG809_02830 OG809_30090(uppS)
NOA : BKM31_10045 BKM31_51260
NOW : GBF35_31265(uppS) GBF35_44850
NCX : Nocox_25215 Nocox_37150
NGN : LCN96_31400(uppS) LCN96_50110
NFS : OIE67_17455(uppS) OIE67_54345
APRE : CNX65_03565 CNX65_22715
KUT : JJ691_32580 JJ691_53850(uppS_1) JJ691_69100(uppS_3)
ACTA : C1701_07815 C1701_21865
UME : RM788_20410(uppS) RM788_29540
MSAG : GCM10017556_33990(uppS)
MFEU : H1D33_10890 H1D33_25305(uppS)
AIH : Aiant_35630(uppS_1) Aiant_88210(uppS_2)
ACTR : Asp14428_55240(uppS)
ACTL : L3i22_059080 L3i22_100420(uppS)
AOU : ACTOB_004678(uppS) ACTOB_008044
PLK : CIK06_15115(uppS) CIK06_24810
PLAB : C6361_30765(uppS) C6361_35280
PLAT : C6W10_09925 C6W10_35335(uppS)
ATL : Athai_05670(uppS_1) Athai_43130
ASER : Asera_01340(uppS_1) Asera_31500(uppS_2)
PRY : Prubr_00720(uppS_1) Prubr_34260(uppS_2) Prubr_44890
NHY : JQS43_02625 JQS43_23810(uppS)
ANE : ATCC27039_27300(uppS)
ACAP : MANAM107_07160(uppS_1)
» show all
Taxonomy
Reference
Authors
Schulbach MC, Mahapatra S, Macchia M, Barontini S, Papi C, Minutolo F, Bertini S, Brennan PJ, Crick DC.
Title
Purification, enzymatic characterization, and inhibition of the Z-farnesyl diphosphate synthase from Mycobacterium tuberculosis.
Journal
Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.5.1.68
ExPASy - ENZYME nomenclature database: 2.5.1.68