KEGG ENZYME: 2.5.1.93

ENZYME: 2.5.1.93

Entry

EC 2.5.1.93                 Enzyme

Name

4-hydroxybenzoate geranyltransferase;
PGT1;
PGT2;
4HB geranyltransferase;
4HB:geranyltransferase;
p-hydroxybenzoate geranyltransferase;
PHB geranyltransferase;
geranyl diphosphate:4-hydroxybenzoate geranyltransferase

Class

Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)

Sysname

geranyl-diphosphate:4-hydroxybenzoate 3-geranyltransferase

Reaction(IUBMB)

geranyl diphosphate + 4-hydroxybenzoate = 3-geranyl-4-hydroxybenzoate + diphosphate [RN:R09040]

Reaction(KEGG)

R09040

Substrate

geranyl diphosphate [CPD:C00341];
4-hydroxybenzoate [CPD:C00156]

Product

3-geranyl-4-hydroxybenzoate;
diphosphate [CPD:C00013]

Comment

The enzyme is involved in shikonin biosynthesis. It has a strict substrate specificity for geranyl diphosphate and an absolute requirement for Mg2+ [2].

History

EC 2.5.1.93 created 2010

Pathway

ec00130

Ubiquinone and other terpenoid-quinone biosynthesis

ec01110

Biosynthesis of secondary metabolites

Orthology

K13565

4-hydroxybenzoate geranyltransferase

Reference

1 [PMID:19392660]

Authors

Ohara K, Muroya A, Fukushima N, Yazaki K

Title

Functional characterization of LePGT1, a membrane-bound prenyltransferase involved in the geranylation of p-hydroxybenzoic acid.

Journal

Biochem J 421:231-41 (2009)
DOI:10.1042/BJ20081968

Sequence

[ag:BAB84122]

Reference

2 [PMID:9640665]

Authors

Muhlenweg A, Melzer M, Li SM, Heide L

Title

4-Hydroxybenzoate 3-geranyltransferase from Lithospermum erythrorhizon: purification of a plant membrane-bound prenyltransferase.

Journal

Planta 205:407-13 (1998)
DOI:10.1007/s004250050337

Sequence

[ag:BAB84122 BAB84123]

Reference

3 [PMID:11744717]

Authors

Yazaki K, Kunihisa M, Fujisaki T, Sato F

Title

Geranyl diphosphate:4-hydroxybenzoate geranyltransferase from Lithospermum erythrorhizon. Cloning and characterization of a ket enzyme in shikonin biosynthesis.

Journal

J Biol Chem 277:6240-6 (2002)
DOI:10.1074/jbc.M106387200

Sequence

[ag:BAB84122 BAB84123]

Other DBs

ExplorEnz - The Enzyme Database:

2.5.1.93

IUBMB Enzyme Nomenclature:

2.5.1.93

ExPASy - ENZYME nomenclature database:

2.5.1.93

BRENDA, the Enzyme Database:

2.5.1.93

All links

Pathway (4)   
   KEGG PATHWAY (4)   
Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Gene (3)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (2)   
Protein sequence (5)   
   UniProt (3)   
   SWISS-PROT (2)   
Protein domain (5)   
   InterPro (5)   
All databases (23)   

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