KEGG   ENZYME: 2.6.1.27
Entry
EC 2.6.1.27                 Enzyme                                 
Name
tryptophan transaminase;
L-phenylalanine-2-oxoglutarate aminotransferase;
tryptophan aminotransferase;
5-hydroxytryptophan-ketoglutaric transaminase;
hydroxytryptophan aminotransferase;
L-tryptophan aminotransferase;
L-tryptophan transaminase
Class
Transferases;
Transferring nitrogenous groups;
Transaminases
Sysname
L-tryptophan:2-oxoglutarate aminotransferase
Reaction(IUBMB)
L-tryptophan + 2-oxoglutarate = (indol-3-yl)pyruvate + L-glutamate [RN:R00684]
Reaction(KEGG)
R00684;
(other) R02700
Substrate
L-tryptophan [CPD:C00078];
2-oxoglutarate [CPD:C00026]
Product
(indol-3-yl)pyruvate [CPD:C00331];
L-glutamate [CPD:C00025]
Comment
A pyridoxal-phosphate protein. Also acts on 5-hydroxytryptophan and, to a lesser extent, on the phenyl amino acids.
History
EC 2.6.1.27 created 1972
Pathway
ec00380  Tryptophan metabolism
ec01100  Metabolic pathways
Orthology
K00838  aromatic amino acid aminotransferase I / 2-aminoadipate transaminase
K14265  tryptophan aminotransferase
Genes
DNM: 101421111
MNG: MNEG_3800
SCE: YGL202W(ARO8)
SEUB: DI49_1777
SPAO: SPAR_G00550
AGO: AGOS_AFR548C AGOS_AGR167W
ERC: Ecym_7228
KLA: KLLA0_A04906g KLLA0_F10021g
KMX: KLMA_20259(ARO8) KLMA_50151(ARO8)
LTH: KLTH0E07678g KLTH0G02002g
VPO: Kpol_278p2
ZRO: ZYRO0C06028g
CGR: CAGL0G01254g
NCS: NCAS_0E00670(NCAS0E00670)
NDI: NDAI_0I02830(NDAI0I02830)
TPF: TPHA_0D03370(TPHA0D03370)
TGB: HG536_0D05130
TDL: TDEL_0D05790(TDEL0D05790)
KAF: KAFR_0D01420(KAFR0D01420)
KNG: KNAG_0B00660(KNAG0B00660)
ZMK: HG535_0B02410 HG535_0F03900
PPA: PAS_chr1-4_0608
DHA: DEHA2A06886g
PIC: PICST_66767(ARO8)
PGU: PGUG_02078 PGUG_04621
SPAA: SPAPADRAFT_60926
LEL: PVL30_001167(ARO8)
CAL: CAALFM_C200340CA(ARO8)
CTP: CTRG_01079
COT: CORT_0A12760
CDU: CD36_15310
CTEN: CANTEDRAFT_94668
YLI: YALI0E20977g
CLU: CLUG_00783
CLUS: A9F13_10g00462
CAUR: CJI96_0000113
SLB: AWJ20_1088(ARO8)
PKZ: C5L36_0A12110 C5L36_0E01100
BNN: FOA43_000076 FOA43_002087
BBRX: BRETT_001037 BRETT_003919
OPA: HPODL_01516 HPODL_01574
SLUD: SCDLUD_001488 SCDLUD_002357
NCR: NCU09116
SMP: SMAC_04612
PAN: PODANSg5646
PBEL: QC761_109500(ARO8_2)
PPSD: QC762_109500(ARO8_2)
PPSP: QC763_109500(ARO8_2)
PPSA: QC764_109500(ARO8_2)
TTT: THITE_2121569
MTM: MYCTH_2294749
CTHR: CTHT_0057710
MGR: MGG_09919 MGG_14221
PPEI: PpBr36_07692 PpBr36_09659
PGRI: PgNI_06329 PgNI_10166
TMN: UCRPA7_6517
SSCK: SPSK_08879
FGR: FGSG_01285
FPU: FPSE_11596
FPOA: FPOAC1_001382
FVN: FVRRES_01575
FVR: FVEG_01416 FVEG_03489
FOX: FOXG_00100 FOXG_05640 FOXG_09911
NHE: NECHADRAFT_50127 NECHADRAFT_51829 NECHADRAFT_74483 NECHADRAFT_94787
FFC: NCS54_00056900 NCS54_00456400 NCS54_00907800 NCS54_01236800
FKR: NCS57_00055100 NCS57_00461400 NCS57_01226300 NCS57_01313200
FMU: J7337_000607 J7337_003508
TRE: TRIREDRAFT_105978 TRIREDRAFT_57322
TRR: M419DRAFT_7300 M419DRAFT_99227
MAW: MAC_07121
MAJ: MAA_00168
PCHM: VFPPC_16183
CMT: CCM_06988
AMUS: LMH87_008267 LMH87_012115
PLJ: VFPFJ_03307
PTKZ: JDV02_001737(ARO8_1)
VAL: VDBG_04940
VDA: VDAG_04481
CFJ: CFIO01_05667 CFIO01_06036 CFIO01_12021
CLUP: CLUP02_05332 CLUP02_15557
CHIG: CH63R_00489
SAPO: SAPIO_CDS0338 SAPIO_CDS3624
ELA: UCREL1_11541
PFY: PFICI_00876 PFICI_05473 PFICI_07657 PFICI_08638
SSL: SS1G_10035
BFU: BCIN_07g04780(Bcaro8)
MBE: MBM_09282
PSCO: LY89DRAFT_633729
GLZ: GLAREA_00731
ANI: ANIA_04156 ANIA_06338 ANIA_08516
AFM: AFUA_2G13630
ACT: ACLA_073980
NFI: NFIA_088830
AOR: AO090020000444 AO090026000245
ANG: An02g00030 An02g05540
AFV: AFLA_006053 AFLA_006709 AFLA_010210
ALUC: AKAW2_21160S(ARO8_1) AKAW2_21604S
ACHE: ACHE_50803A(ARO8_2)
APUU: APUU_51301A(ARO8_2) APUU_80012S
PCS: N7525_001399
PDP: PDIP_79130
POU: POX_a00237 POX_a01329
TMF: EYB26_001982
TRG: TRUGW13939_05336 TRUGW13939_11796
CIM: CIMG_04628
CPW: CPC735_071790
URE: UREG_01826
PBL: PAAG_05743
PBN: PADG_07646
ABE: ARB_01306
TVE: TRV_00012
AJE: HCAG_04617
BGH: BDBG_04597 BDBG_16211
PNO: SNOG_04259
PTE: PTT_08476
BZE: COCCADRAFT_104299
BSC: COCSADRAFT_92370
BOR: COCMIDRAFT_487
AALT: CC77DRAFT_1049425
ARAB: EKO05_0002155
ZTR: MYCGRDRAFT_100367
PFJ: MYCFIDRAFT_57678
FFU: CLAFUR5_06006 CLAFUR5_08181
CBET: CB0940_04616
BCOM: BAUCODRAFT_578314
NPA: UCRNP2_4527 UCRNP2_8015
TML: GSTUM_00008805001
SPO: SPAC56E4.03 SPBC1773.13 SPCC569.07
SOM: SOMG_00046 SOMG_01863
CNE: CNB03000 CNB03180 CNF01590 CNF04620
CNB: CNBB2510 CNBB2710 CNBF0280 CNBF3120
CNG: CNAG_03808 CNAG_03828 CNAG_05820 CNAG_06555
CGI: CGB_A3370W CGB_F4480C
CDEU: CNBG_1526 CNBG_1724
TMS: TREMEDRAFT_34172 TREMEDRAFT_68672 TREMEDRAFT_71644
TASA: A1Q1_00184 A1Q1_05326 A1Q1_05529 A1Q1_06907 A1Q1_07720
CCAC: CcaHIS019_0505270(CcaverHIS019_0505270) CcaHIS019_0701480(CcaverHIS019_0701480) CcaHIS019_0705380(CcaverHIS019_0705380)
PPL: POSPLDRAFT_89909
TVS: TRAVEDRAFT_133162 TRAVEDRAFT_38052 TRAVEDRAFT_56842 TRAVEDRAFT_72661
DSQ: DICSQDRAFT_133615 DICSQDRAFT_135879 DICSQDRAFT_178445 DICSQDRAFT_181832
PCO: PHACADRAFT_207395 PHACADRAFT_250454 PHACADRAFT_253130 PHACADRAFT_28172
SHS: STEHIDRAFT_120086 STEHIDRAFT_137204 STEHIDRAFT_152122 STEHIDRAFT_170511 STEHIDRAFT_58581 STEHIDRAFT_60514 STEHIDRAFT_80491
HIR: HETIRDRAFT_380789 HETIRDRAFT_458781
PSQ: PUNSTDRAFT_104522 PUNSTDRAFT_125467 PUNSTDRAFT_52167
ADL: AURDEDRAFT_112435 AURDEDRAFT_114554 AURDEDRAFT_116968 AURDEDRAFT_130695 AURDEDRAFT_147363 AURDEDRAFT_54486 AURDEDRAFT_75410 AURDEDRAFT_93142
FME: FOMMEDRAFT_165688 FOMMEDRAFT_169725 FOMMEDRAFT_25327 FOMMEDRAFT_61360
GTR: GLOTRDRAFT_131793 GLOTRDRAFT_71756 GLOTRDRAFT_75354 GLOTRDRAFT_98301
RSX: RhiXN_03665 RhiXN_04072
LBC: LACBIDRAFT_191053 LACBIDRAFT_311755
CCI: CC1G_07874 CC1G_11694 CC1G_14996 CC1G_15151
ABP: AGABI1DRAFT113513(AGABI1DRAFT_113513) AGABI1DRAFT75541(AGABI1DRAFT_75541) AGABI1DRAFT75553(AGABI1DRAFT_75553)
ABV: AGABI2DRAFT191531(AGABI2DRAFT_191531) AGABI2DRAFT191838(AGABI2DRAFT_191838) AGABI2DRAFT201971(AGABI2DRAFT_201971)
PCUB: JR316_0005155 JR316_0005698
MPR: MPER_11136
MRR: Moror_12963 Moror_14804 Moror_17465 Moror_3409 Moror_9956
MORE: E1B28_009660 E1B28_010878 E1B28_010888 E1B28_013419
SCM: SCHCO_02482695(SCHCODRAFT_02482695) SCHCO_02616666(SCHCODRAFT_02616666) SCHCO_02623001(SCHCODRAFT_02623001) SCHCO_02626718(SCHCODRAFT_02626718) SCHCO_02681983(SCHCODRAFT_02681983)
CPUT: CONPUDRAFT_100638 CONPUDRAFT_140570 CONPUDRAFT_142726 CONPUDRAFT_151445
SLA: SERLADRAFT_356993(amt1) SERLADRAFT_414134 SERLADRAFT_467467 SERLADRAFT_475830
WSE: WALSEDRAFT_70869
WIC: J056_001316
UMA: UMAG_01804 UMAG_03538
PFP: PFL1_00079 PFL1_02593
SGRA: EX895_003884 EX895_006511
MGL: MGL_2601
MRT: MRET_0487
MSYM: MSY001_0235
PGR: PGTG_01133
PTRC: PtA15_7A469
PSTR: Pst134EA_013486
MLR: MELLADRAFT_103845 MELLADRAFT_115660
SMIN: v1.2.016220.t1(symbB.v1.2.016220.t1)
 » show all
Reference
1  [PMID:5722279]
  Authors
George H, Gabay S.
  Title
Brain aromatic aminotransferase. I. Purification and some properties of pig brain L-phenylalanine-2-oxoglutarate aminotransferase.
  Journal
Biochim Biophys Acta 167:555-66 (1968)
DOI:10.1016/0005-2744(68)90045-4
Reference
2  [PMID:5697992]
  Authors
O'Neil SR, DeMoss RD.
  Title
Tryptophan transaminase from Clostridium sporogenes.
  Journal
Arch Biochem Biophys 127:361-9 (1968)
DOI:10.1016/0003-9861(68)90237-3
Reference
3  [PMID:14285270]
  Authors
TANGEN O, FONNUM F, HAAVALDSEN R.
  Title
SEPARATION AND PURIFICATION OF AROMATIC AMINO ACID TRANSAMINASES FROM RAT BRAIN.
  Journal
Biochim Biophys Acta 96:82-90 (1965)
DOI:10.1016/0005-2787(65)90612-X
Other DBs
ExplorEnz - The Enzyme Database: 2.6.1.27
IUBMB Enzyme Nomenclature: 2.6.1.27
ExPASy - ENZYME nomenclature database: 2.6.1.27
BRENDA, the Enzyme Database: 2.6.1.27
CAS: 9022-98-4

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Pathway (9)   
   KEGG PATHWAY (4)   
   KEGG MODULE (5)   
Chemical substance (6)   
   KEGG COMPOUND (6)   
Chemical reaction (3)   
   KEGG REACTION (2)   
   KEGG RCLASS (1)   
Gene (491)   
   KEGG ORTHOLOGY (2)   
   KEGG GENES (306)   
   KEGG MGENES (38)   
   RefGene (145)   
Protein sequence (19)   
   UniProt (8)   
   SWISS-PROT (6)   
   RefSeq(pep) (5)   
DNA sequence (53)   
   RefSeq(nuc) (7)   
   GenBank (23)   
   EMBL (23)   
Protein domain (9)   
   InterPro (9)   
All databases (590)   

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