KEGG   ENZYME: 2.7.1.119
Entry
EC 2.7.1.119                Enzyme                                 
Name
hygromycin-B 7''-O-kinase;
hygromycin B phosphotransferase;
hygromycin-B kinase (ambiguous)
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
Sysname
ATP:hygromycin-B 7''-O-phosphotransferase
Reaction(IUBMB)
ATP + hygromycin B = ADP + 7''-O-phosphohygromycin B [RN:R03770]
Reaction(KEGG)
R03770
Substrate
ATP [CPD:C00002];
hygromycin B [CPD:C01925]
Product
ADP [CPD:C00008];
7''-O-phosphohygromycin B
Comment
Phosphorylates the antibiotics hygromycin B, 1-N-hygromycin B and destomycin, but not hygromycin B2, at the 7''-hydroxy group in the destomic acid ring.
History
EC 2.7.1.119 created 1989, modified 2009, modified 2011
Orthology
K17880  hygromycin-B 7''-O-kinase
Genes
XHYFZ025_02925
XASHEP74_01321
SDNSden_2943
SSESsed_4380
SPLSpea_2805
SVOSVI_4227
SPSWSps_05479
SBKSHEWBE_0404
SPSHFM037_27200
SEURFM038_024410
LSDEMK97_14005
TACTSG35_009525
TVDSG34_019720
PSPOPSPO_a1848(hyg)
LCADPXX05_02805
CUUBKK79_15750
ADKAlide2_1935
NENNCHU2750_17050
SHZshn_08510
BJAblr1035(blr1035)
BJUBJ6T_10600
BJPRN69_05170
BRABRADO6829
BBTBBta_0715
BRSS23_67720
AOLS58_06400
BRCBCCGELA001_34480
BRADBF49_7151
BICLMTR13_36535
BROBRAD285_6968
BRKCWS35_10000
BOTCIT37_09125
BRQCIT40_30270
BGQX265_34860
BGZXH91_33225
BSYMCIT39_29375
BBETF8237_13200
BARHWN72_46410
BVZBRAD3257_8692
BELBE61_90630
BDGLPJ38_02350
BSEPHAP48_0012130
BQBJ4P68_0015995
BSEIKMZ68_03295
BBANJ4G43_050905
BCANBcanWSM471_35650
BAUTQA635_04680
BBRAQA636_04155
BGKIC762_32665
BCOUIC761_34840
BPAHQA639_04100
BXNI3J27_37815
BRAZLRP30_02140
BOPAXW83_14650
BVVBHK69_21860
PLIAE4191_15325
PSAPJHX88_06905
PSHQF3W81_08540
SCUSCE1572_39530
BLEBleG1_3378
CSUAIM538_08060
VNECFK40_16370
GAJMY490_17370
LWIUE46_12585
PPYPPE_01320
PPOLX809_07440
PTAHPL003_15155
PBDPBOR_13235
POWIJ21_42000
PXLBS614_06340
PKBB4V02_18125
PAIHASL14_04465
PLUTEI981_15230 EI981_19145
PBACHUB98_20000
AFXJZ786_16100
PMARB0X71_15750
VIJJNUCC6_05980
CSHClosa_2823
NAHF5544_16105
SCOSCO3277(SCE39.27c)
SMASAVERM_4746
SGRFSGFS_069420
SCBSCAB_38991
SVESVEN_5979
SDVBN159_8349
SLVSLIV_21400
SLDT261_3533
SRWTUE45_pSRc_0512(TUE45_pSRTUE45c_0512)
SGSAVL59_19560
SALWCP975_10190
SGMGCM10017557_47320
SLSSLINC_1212
SSIAA7J05_25520
SGVB1H19_24140
SLAUSLA_6338
SALFSMD44_02510(hyg)
STROSTRMOE7_24175
SFKKY5_2295c
SCYAEJ357_44140
SNQCP978_19285
SKACP970_31000
SRKFGW37_32675
SVRCP971_25275
SPHVF9278_29505
SSPBCP982_13355
SPLACP981_22790
SCYGS1361_02065
SDWK7C20_21555
SXNIAG42_00620
SHKJ2N69_10010
SANUK7396_15240
SINEKI385_26640
SLFJEQ17_26470
SDECL3078_27040
SAOVG3H79_26560
SDURM4V62_29520
SAKBK1J60_18325
SCAEIHE65_18645
SCIRSTRCI_000323
SLONLGI35_38975
SDRZNEH16_14175
STUDSTRTU_002915
SCYNN8I84_23005
SOVQZH56_04505
SCOAQU709_39560
SFPQUY26_28585
KAUB6264_19840
ACITHPK19_12600
SPIQOHA34_37355
ACTQOG417_03835 OG417_35105
NOABKM31_23170
NOWGBF35_13400
KRAKrad_2754
SACCEYD13_04715
AOIAORI_1717
AJAAJAP_30905
AMYCCU254_28415
AMYBBKN51_00795
AABA4R43_37900
AMYYYIM_40145
AORISD37_32605
APRTMUY14_01420
AROONQK81_14440
ATHML1857_30105
APRECNX65_11050
AMIAmir_2164
SESPBN6_18860
KALKALB_4352
KBUQ4V64_48445
AHMTL08_06760
ACTIUA75_06520
ACADUA74_06520
PMADBAY61_06195
CROSN8J89_34390
AFSAFR_32445
ASICQ0Z83_062300
DVCDvina_09130
PBFCFX0092_A0744
KBSEPA93_38635
OLEK0B96_00120
 » show all
Reference
1  [PMID:3026811]
  Authors
Zalacain M, Pardo JM, Jimenez A.
  Title
Purification and characterization of a hygromycin B phosphotransferase from Streptomyces hygroscopicus.
  Journal
Eur J Biochem 162:419-22 (1987)
DOI:10.1111/j.1432-1033.1987.tb10618.x
Other DBs
ExplorEnz - The Enzyme Database: 2.7.1.119
IUBMB Enzyme Nomenclature: 2.7.1.119
ExPASy - ENZYME nomenclature database: 2.7.1.119
BRENDA, the Enzyme Database: 2.7.1.119
CAS: 88361-67-5

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