ENZYME: 2.7.1.151 Help
Entry
Name
inositol-polyphosphate multikinase;
IpK2;
IP3/IP4 6-/3-kinase;
IP3/IP4 dual-specificity 6-/3-kinase;
IpmK;
ArgRIII;
AtIpk2alpha;
AtIpk2beta;
inositol polyphosphate 6-/3-/5-kinase
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
BRITE hierarchy
Sysname
ATP:1D-myo-inositol-1,4,5-trisphosphate 6-phosphotransferase
Reaction(IUBMB)
2 ATP + 1D-myo-inositol 1,4,5-trisphosphate = 2 ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate (overall reaction) [RN:
R10065 ];
(1a) ATP + 1D-myo-inositol 1,4,5-trisphosphate = ADP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate [RN:
R05800 ];
(1b) ATP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate = ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate [RN:
R05801 ]
Reaction(KEGG)
Substrate
ATP [CPD:
C00002 ];
1D-myo-inositol 1,4,5-trisphosphate [CPD:
C01245 ];
1D-myo-inositol 1,4,5,6-tetrakisphosphate [CPD:
C11555 ]
Product
ADP [CPD:
C00008 ];
1D-myo-inositol 1,3,4,5,6-pentakisphosphate [CPD:
C01284 ];
1D-myo-inositol 1,4,5,6-tetrakisphosphate [CPD:
C11555 ]
Comment
This enzyme also phosphorylates Ins(1,4,5)P3 to Ins(1,3,4,5)P4, Ins(1,3,4,5)P4 to Ins(1,3,4,5,6)P5, and Ins(1,3,4,5,6)P4 to Ins(PP)P4, isomer unknown. The enzyme from the plant Arabidopsis thaliana can also phosphorylate Ins(1,3,4,6)P4 and Ins(1,2,3,4,6)P5 at the D-5-position to produce 1,3,4,5,6-pentakisphosphate and inositol hexakisphosphate (InsP6), respectively [3]. Yeast produce InsP6 from Ins(1,4,5)P3 by the actions of this enzyme and EC
2.7.1.158 , inositol-pentakisphosphate 2-kinase [4].
History
EC 2.7.1.151 created 2002, modified 2006
Pathway
ec00562 Inositol phosphate metabolism
Orthology
K00915 inositol-polyphosphate multikinase
Genes
TFN : 117082769(IPMK) 117096508
PTEH : 111521921(IPMK) 116418853
NCAR : 124974079 124984625
PCAD : 102975028 102996268(IPMK)
MYD : 102753565 102755711(IPMK)
HAI : 109377792 109380619(IPMK)
ETL : 114060290(IPMK) 114071299
XLA : 108697359(ipmk.S) 447535(ipmk.L)
DRE : 100151036(ipmka) 790916(ipmkb)
SRX : 107708928 107719230 107746459 107747295
SANH : 107654052 107665575 107676374 107695532
SGH : 107549139 107549140 107586076 107593497(ipmk)
CCAR : 109057433 109076380 109084910 109088143 109099711(ipmk)
CAUA : 113056354 113069997 113092381 113111942
CGIB : 127968997 127970767 128025007
PTET : 122355553(ipmkb) 122357115(ipmka)
LROH : 127174195(ipmkb) 127174919(ipmka)
OMC : 131551216(ipmkb) 131551718(ipmka)
PPRM : 120464023(ipmkb) 120468587(ipmka)
RKG : 130080529(ipmkb) 130106377(ipmka)
MAMB : 125254993(ipmkb) 125277244(ipmka)
CIDE : 127523525 127525469
MASI : 127411873 127414416 127423372 127426752
TROS : 130559677(ipmka) 130569635(ipmkb)
TDW : 130431707(ipmka) 130439177(ipmkb)
MANU : 129415696(ipmka) 129420717(ipmkb)
IPU : 108263300(ipmka) 108274002(ipmkb)
IFU : 128605594(ipmka) 128616547(ipmkb)
PHYP : 113527504(ipmk) 113541013
SMEO : 124389178(ipmkb) 124395067(ipmka)
TFD : 113639738(ipmka) 113649376(ipmkb)
TVC : 132841597(ipmkb) 132847287(ipmka)
AMEX : 103031896 103035921(ipmk)
CMAO : 118809173(ipmkb) 118810385(ipmka)
EEE : 113576897 113577017(ipmk)
CHAR : 105893580(ipmkb) 105902260
CSAI : 133419435 133419847
PFOR : 103142515(ipmk) 103144755
ALIM : 106518993 106537088
SASA : 106578945 106589401
STRU : 115156991 115201178
OTW : 112223433 112224288(ipmkb)
OMY : 110491367 110498974(ipmkb)
OGO : 124040045(ipmkb) 124048148
OKE : 118357461(ipmkb) 118368497
SALP : 111967789 111978066
SNH : 120029550(ipmkb) 120046128
CCLU : 121532117 121547349
SFM : 108932688 108939714(ipmk)
AANG : 118217809 118221123(ipmkb)
PSPA : 121321864 121325606
ARUT : 117415049 117418532
DSI : Dsimw501_GD22857(Dsim_GD22857)
ACOZ : 120959437 120959438
AARA : 120900040 120900041
AMER : 121600292 121600293
ASTE : 118503975 118503985
AFUN : 125770915 125770918
AMOU : 128306097 128310532
AALI : 118465563 118465567
CQU : CpipJ_CPIJ006477 CpipJ_CPIJ016779
CPII : 120416726 128092762
CEL : CELE_ZK795.1(ipmk-1)
BMY : BM_BM7551(Bma-ipmk-1)
HRJ : 124280531 124282260 124282261
SMM : Smp_013210 Smp_125650 Smp_129310
OVI : T265_03185 T265_14432
ATH : AT5G07370(IPK2a) AT5G61760(IPK2BETA)
CSAT : 104708359 104726765 104734760 104739125 104768946
EUS : EUTSA_v10004707mg EUTSA_v10013933mg
BRP : 103837393 103847062 103875176
BNA : 106352393 106366083 106419484 106446077 106451903 111198742
BOE : 106306009 106313593 106318708
RSZ : 108818385 108823938 108829829 108834296 108849844
MINC : 123207183 123215343 123222511
GRA : 105764851 105788652 105801747
GHI : 107886183 107903073 107923660 107946632 107946903 107949622
GAB : 108456443 108459957 108476510
HSYR : 120174290 120187011 120189872 120210066 120210622
VUM : 124822763 124830293 124839639
CCAJ : 109800354 109812939 109812951
LJA : Lj3g3v0463560.1(Lj3g3v0463560.1)
LANG : 109341590 109352161 109354989
QSA : O6P43_014478 O6P43_020727
MDM : 103438670 103454867 114822892
MSYL : 126600736 126626570
PXB : 103950762 103950782 103962654
CSAV : 115698255 115716475 115716479
MESC : 110616457 110631399
PEU : 105110248 105118814 105136604
PALZ : 118028275 118044905
CILL : 122281349 122281447
CAVE : 132176243 132186039 132187254
SPEN : 107007208 107012961
SOT : 102577543(IPMK) 102599548
SSTN : 125860869 125862307
SDUL : 129893835 129896262
CANN : 107851080 107862089
NTA : 107774418 107789213 107815456 107822685
NAU : 109221768 109226836 109240966
SSPL : 121741193 121744570 121779384 121780991 121788318
APAN : 127254805 127263124
HAN : 110873246 110880020 110915991
ECAD : 122588951 122607417
CCAV : 112509590 112511747
CSIN : 114267810 114313245 114313246
BVG : 104887784 104887785 104899432
CQI : 110712170 110723052 110728080 110731880
ATRI : 130801164 130812653
NNU : 104608420 104608955 104608998
PSOM : 113278321 113309840 113310350 113322567 113338775
DOSA : Os02t0523800-01(Os02g0523800)
TAES : 123148742 123161229 123167046
ZMA : 100280570 103626177 103631504 103636799
PVIR : 120655889 120703208
PDA : 103712359 103720079 120111460 120112227
ZOF : 122001418 122001420 122005707
NCOL : 116256086 116256249 116257516
SMO : SELMODRAFT_102174 SELMODRAFT_79570
MPP : MICPUCDRAFT_55246(JGI:MicpuC2_55246)
NCS : NCAS_0B03200(NCAS0B03200)
NDI : NDAI_0A01200(NDAI0A01200)
TPF : TPHA_0C02470(TPHA0C02470)
TBL : TBLA_0H01030(TBLA0H01030)
TDL : TDEL_0F04950(TDEL0F04950)
KAF : KAFR_0B06020(KAFR0B06020)
KNG : KNAG_0A04850(KNAG0A04850)
CAL : CAALFM_C209730CA(IPK2)
NTE : NEUTE1DRAFT60460(NEUTE1DRAFT_60460)
CNG : CNAG_02802 CNAG_06500
CCAC : CcaHIS019_0306550(CcaverHIS019_0306550)
LBC : LACBIDRAFT_246465 LACBIDRAFT_315595
ABP : AGABI1DRAFT121474(AGABI1DRAFT_121474)
ABV : AGABI2DRAFT209575(AGABI2DRAFT_209575)
SCM : SCHCO_02639210(SCHCODRAFT_02639210)
PGR : PGTG_06735 PGTG_14727 PGTG_17699
PSTR : Pst134EA_011190 Pst134EA_011197 Pst134EA_033466 Pst134EA_033467
DDI : DDB_G0271760 DDB_G0281737
EIV : EIN_281880 EIN_327430
» show all
Taxonomy
Reference
Authors
Saiardi A, Erdjument-Bromage H, Snowman AM, Tempst P, Snyder SH
Title
Synthesis of diphosphoinositol pentakisphosphate by a newly identified family of higher inositol polyphosphate kinases.
Journal
Sequence
Reference
Authors
Odom AR, Stahlberg A, Wente SR, York JD.
Title
A role for nuclear inositol 1,4,5-trisphosphate kinase in transcriptional control.
Journal
Reference
Authors
Stevenson-Paulik J, Odom AR, York JD
Title
Molecular and biochemical characterization of two plant inositol polyphosphate 6-/3-/5-kinases.
Journal
Sequence
Reference
Authors
Verbsky JW, Chang SC, Wilson MP, Mochizuki Y, Majerus PW
Title
The pathway for the production of inositol hexakisphosphate in human cells.
Journal
Other DBs
ExPASy - ENZYME nomenclature database: 2.7.1.151