Entry
Name
[isocitrate dehydrogenase (NADP+)] kinase;
[isocitrate dehydrogenase (NADP+)] kinase;
ICDH kinase/phosphatase;
IDH kinase;
IDH kinase/phosphatase;
IDH-K/P;
IDHK/P;
isocitrate dehydrogenase kinase (phosphorylating);
isocitrate dehydrogenase kinase/phosphatase;
STK3
Class
Transferases;
Transferring phosphorus-containing groups;
Protein-serine/threonine kinases
BRITE hierarchy
Sysname
ATP:[isocitrate dehydrogenase (NADP+)] phosphotransferase
Reaction(IUBMB)
ATP + [isocitrate dehydrogenase (NADP+)] = ADP + [isocitrate dehydrogenase (NADP+)] phosphate [RN:
R04401 ]
Reaction(KEGG)
Substrate
ATP [CPD:
C00002 ];
[isocitrate dehydrogenase (NADP+)] [CPD:
C04125 ]
Product
ADP [CPD:
C00008 ];
[isocitrate dehydrogenase (NADP+)] phosphate [CPD:
C04564 ]
Comment
The enzyme has no activating compound but is specific for its substrate. Phosphorylates and inactivates EC
1.1.1.42 , isocitrate dehydrogenase (NADP+).
History
EC 2.7.11.5 created 1986 as EC 2.7.1.116, transferred 2005 to EC 2.7.11.5
Orthology
K00906 isocitrate dehydrogenase kinase/phosphatase
Genes
ECOO : ECRM13514_5138(aceK)
ECOH : ECRM13516_4875(aceK)
ELR : ECO55CA74_23115(aceK)
ECW : EcE24377A_4561(aceK)
ECOA : APECO78_00825(aceK)
EDJ : ECDH1ME8569_3872(aceK)
ECOI : ECOPMV1_04388(aceK)
SEM : STMDT12_C43180(aceK)
SETC : CFSAN001921_19500(aceK)
SEEN : SE451236_03955(aceK)
SENH : CFSAN002069_11190(aceK)
SEEH : SEEH1578_07085(aceK)
SENJ : CFSAN001992_12855(aceK)
SEEC : CFSAN002050_03740(aceK)
SEEB : SEEB0189_021435(aceK)
SENC : SEET0819_04720(aceK)
REE : electrica_04791(aceK)
RTG : NCTC13098_06908(aceK_1)
CLAP : NCTC11466_04326(aceK)
KIE : NCTC12125_03485(aceK)
AHN : NCTC12129_04633(aceK)
METY : MRY16398_53480(aceK)
PSHI : SAMEA2665130_2632(aceK)
YPG : YpAngola_A3925(aceK)
YPI : YpsIP31758_0296(aceK)
SMW : SMWW4_v1c44640(aceK)
SERS : SERRSCBI_21570(aceK)
SFG : AV650_00945(aceK) AV650_27785(aceK)
SFJ : SAMEA4384070_4461(aceK)
SOF : NCTC11214_02116(aceK)
PAQU : DMB82_0018065(aceK)
DIC : Dpoa569_000447(aceK)
PHEI : NCTC12003_00428(aceK)
PRJ : NCTC6933_00496(aceK)
XPH : XppCFBP6546_15215(aceK)
XHD : LMG31886_39760(aceK)
PAEB : NCGM1900_5198(aceK)
PPRC : PFLCHA0_c15690(aceK)
PMUD : NCTC8068_01418(aceK)
PFW : PF1751_v1c40420(aceK)
PPUU : PputUW4_03989(aceK)
PTRT : HU722_0021375(aceK)
PTW : TUM18999_40540(aceK)
PTAE : NCTC10697_03047(aceK)
PTN : PTRA_a1652(aceK) PTRA_a2254(aceK)
PSM : PSM_A1236(aceK) PSM_A1686(aceK)
PIA : PI2015_1200 PI2015_1633
PBW : D172_006975 D172_010070
PALN : B0W48_17720 B0W48_18760
PEA : PESP_a1569(aceK) PESP_a2232(aceK)
PART : PARC_a2349(aceK) PARC_a2446(aceK)
PTU : PTUN_a2520(aceK) PTUN_a2544(aceK)
PNG : PNIG_a1741(aceK) PNIG_a2445(aceK)
PTD : PTET_a1428(aceK) PTET_a1941(aceK)
PDJ : D0907_07015 D0907_09320
PAGA : PAGA_a1685(aceK) PAGA_a2307(aceK)
PCAR : PC2016_1357 PC2016_1899
PMAA : CPA52_06270 CPA52_07070
PDV : FFU37_05255(aceK) FFU37_05655(aceK)
PSHO : KQ246_04050(aceK) KQ246_04740(aceK)
SALH : HMF8227_02437(aceK)
RHEI : ATY27_11040 ATY27_18615
TNI : TVNIR_2248(aceK_[H])
AEL : NCTC12917_03028(aceK)
NWE : SAMEA3174300_1420(aceK)
NZO : SAMEA4504057_0557(aceK)
NCI : NCTC10296_00161(aceK)
NANI : NCTC12227_01659(aceK)
BMV : BMASAVP1_A3087(aceK)
BML : BMA10229_A2008(aceK)
BPM : BURPS1710b_0581(aceK)
BPL : BURPS1106A_0419(aceK)
BUE : BRPE67_ACDS00980(aceK)
LMIR : NCTC12852_00395(aceK)
BUO : BRPE64_ACDS01000(aceK)
AXX : ERS451415_00118(aceK)
FIL : BN1229_v1_3574(aceK)
FIY : BN1229_v1_3566(aceK)
» show all
Taxonomy
Reference
Authors
Wang JY, Koshland DE Jr.
Title
The reversible phosphorylation of isocitrate dehydrogenase of Salmonella typhimurium.
Journal
Reference
Authors
Miller SP, Karschnia EJ, Ikeda TP, LaPorte DC.
Title
Isocitrate dehydrogenase kinase/phosphatase. Kinetic characteristics of the wild-type and two mutant proteins.
Journal
Reference
Authors
Singh SK, Matsuno K, LaPorte DC, Banaszak LJ.
Title
Crystal structure of Bacillus subtilis isocitrate dehydrogenase at 1.55 A. Insights into the nature of substrate specificity exhibited by Escherichia coli isocitrate dehydrogenase kinase/phosphatase.
Journal
Reference
Authors
Oudot C, Cortay JC, Blanchet C, Laporte DC, Di Pietro A, Cozzone AJ, Jault JM.
Title
The "catalytic" triad of isocitrate dehydrogenase kinase/phosphatase from E. coli and its relationship with that found in eukaryotic protein kinases.
Journal
Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.7.11.5
ExPASy - ENZYME nomenclature database: 2.7.11.5