KEGG ENZYME: 2.7.11.7

ENZYME: 2.7.11.7

Entry

EC 2.7.11.7                 Enzyme

Name

myosin-heavy-chain kinase;
ATP:myosin-heavy-chain O-phosphotransferase;
calmodulin-dependent myosin heavy chain kinase;
MHCK;
MIHC kinase;
myosin heavy chain kinase;
myosin I heavy-chain kinase;
myosin II heavy-chain kinase;
[myosin-heavy-chain] kinase;
myosin heavy chain kinase A;
STK6

Class

Transferases;
Transferring phosphorus-containing groups;
Protein-serine/threonine kinases

Sysname

ATP:[myosin heavy-chain] O-phosphotransferase

Reaction(IUBMB)

ATP + [myosin heavy-chain] = ADP + [myosin heavy-chain] phosphate

Reaction(KEGG)

(other) R04023

Substrate

ATP [CPD:C00002];
[myosin heavy-chain]

Product

ADP [CPD:C00008];
myosin heavy-chain phosphate [CPD:C03874]

Comment

The enzyme from Dictyostelium sp. (slime moulds) brings about phosphorylation of the heavy chains of Dictyostelium myosin, inhibiting the actin-activated ATPase activity of the myosin. One threonine residue in each heavy chain acts as acceptor. While the enzyme from some species is activated by actin, in other cases Ca2+/calmodulin are required for activity.

History

EC 2.7.11.7 created 1990 as EC 2.7.1.129, transferred 2005 to EC 2.7.11.7

Orthology

K08240

myosin-heavy-chain kinase

Genes

GAE:

121370341

GSL:	Gasu_35390

TMS:	TREMEDRAFT_34670

PPL:	POSPLDRAFT_96521

DSQ:	DICSQDRAFT_66970

ADL:	AURDEDRAFT_72572

LBC:	LACBIDRAFT_312444

DDI:	DDB_G0282489(mhkD) DDB_G0289115(mhkB) DDB_G0290687(mhkC) DDB_G0291231(mhkA)

DPP:	DICPUDRAFT_48766 DICPUDRAFT_51532 DICPUDRAFT_94172 DICPUDRAFT_95520

DFA:	DFA_01762(mhkA) DFA_04784(mhkD) DFA_09931(mhkC) DFA_11050(mhkB)

TBR:	Tb927.4.4970 Tb927.8.7450

TBG:	TbgDal_IV5150 TbgDal_VIII7690

TCR:	509011.100 510681.20

LMA:	LMJF_25_0680 LMJF_36_4700

LIF:	LINJ_25_0690 LINJ_36_4780

LDO:	LDBPK_250690 LDBPK_364780

LMI:	LMXM_25_0680 LMXM_36_4551

LBZ:	LBRM_25_0510 LBRM_35_4800

LPAN:

LPMP_250690 LPMP_354670

» show all

Reference

1 [PMID:3027076]

Authors

Cote GP, Bukiejko U.

Title

Purification and characterization of a myosin heavy chain kinase from Dictyostelium discoideum.

Journal

J Biol Chem 262:1065-72 (1987)

Reference

2 [PMID:6309772]

Authors

Hammer JA 3rd, Albanesi JP, Korn ED.

Title

Purification and characterization of a myosin I heavy chain kinase from Acanthamoeba castellanii.

Journal

J Biol Chem 258:10168-75 (1983)

Reference

3 [PMID:2822719]

Authors

Rieker JP, Swanljung-Collins H, Collins JH.

Title

Purification and characterization of a calmodulin-dependent myosin heavy chain kinase from intestinal brush border.

Journal

J Biol Chem 262:15262-8 (1987)

Reference

4 [PMID:2549052]

Authors

Ravid S, Spudich JA.

Title

Myosin heavy chain kinase from developed Dictyostelium cells. Purification and characterization.

Journal

J Biol Chem 264:15144-50 (1989)

Reference

5 [PMID:2168881]

Authors

Brzeska H, Lynch TJ, Martin B, Corigliano-Murphy A, Korn ED.

Title

Substrate specificity of Acanthamoeba myosin I heavy chain kinase as determined with synthetic peptides.

Journal

J Biol Chem 265:16138-44 (1990)

Reference

6 [PMID:1321427]

Authors

Ravid S, Spudich JA.

Title

Membrane-bound Dictyostelium myosin heavy chain kinase: a developmentally regulated substrate-specific member of the protein kinase C family.

Journal

Proc Natl Acad Sci U S A 89:5877-81 (1992)
DOI:10.1073/pnas.89.13.5877

Reference

7 [PMID:7822274]

Authors

Futey LM, Medley QG, Cote GP, Egelhoff TT

Title

Structural analysis of myosin heavy chain kinase A from Dictyostelium. Evidence for a highly divergent protein kinase domain, an amino-terminal coiled-coil domain, and a domain homologous to the beta-subunit of heterotrimeric G proteins.

Journal

J Biol Chem 270:523-9 (1995)
DOI:10.1074/jbc.270.2.523

Sequence

[ddi:DDB_G0291231]

Reference

8 [PMID:9539704]

Authors

Szczepanowska J, Ramachandran U, Herring CJ, Gruschus JM, Qin J, Korn ED, Brzeska H.

Title

Effect of mutating the regulatory phosphoserine and conserved threonine on the activity of the expressed catalytic domain of Acanthamoeba myosin I heavy chain kinase.

Journal

Proc Natl Acad Sci U S A 95:4146-51 (1998)
DOI:10.1073/pnas.95.8.4146

Reference

9 [PMID:15545285]

Authors

Egelhoff TT, Croft D, Steimle PA.

Title

Actin activation of myosin heavy chain kinase A in Dictyostelium: a biochemical mechanism for the spatial regulation of myosin II filament disassembly.

Journal

J Biol Chem 280:2879-87 (2005)
DOI:10.1074/jbc.M410803200

Sequence

[ddi:DDB_G0291231]

Other DBs

ExplorEnz - The Enzyme Database:

2.7.11.7

IUBMB Enzyme Nomenclature:

2.7.11.7

ExPASy - ENZYME nomenclature database:

2.7.11.7

BRENDA, the Enzyme Database:

2.7.11.7

CAS:	64763-54-8

DBGET integrated database retrieval system