Entry
Name
Fas-activated serine/threonine kinase;
FAST;
FASTK;
STK10
Class
Transferases;
Transferring phosphorus-containing groups;
Protein-serine/threonine kinases
BRITE hierarchy
Sysname
ATP:[Fas-activated serine/threonine protein] phosphotransferase
Reaction(IUBMB)
ATP + [Fas-activated serine/threonine protein] = ADP + [Fas-activated serine/threonine phosphoprotein]
Reaction(KEGG)
Substrate
ATP [CPD:
C00002 ];
[Fas-activated serine/threonine protein]
Product
ADP [CPD:
C00008 ];
[Fas-activated serine/threonine phosphoprotein]
Comment
This enzyme is activated during Fas-mediated apoptosis. Following Fas ligation, the enzyme, which is constitutively phosphorylated, is dephosphorylated, and it is the dephosphorylated form that causes phosphorylation of TIA-1, a nuclear RNA-binding protein. Phosphorylation of TIA-1 precedes the onset of DNA fragmentation.
History
EC 2.7.11.8 created 2005 (EC 2.7.1.37 part-incorporated 2005)
Orthology
K08290 Fas-activated serine/threonine kinase
Genes
CJC : 100391071 100409995(FASTK)
NVS : 122897905 122905202(FASTK)
EJU : 114198016(FASTK) 114213868
ZCA : 113911331(FASTK) 113925854
CHX : 102186744 108635865(FASTK)
RFQ : 117018039(FASTK) 117025120
SANH : 107657442 107701011
CCAR : 109047574 109088211
CAUA : 113045685 113118459 113118466
CGIB : 127950709 128030564
MASI : 127441421 127442123
SLUC : 116065601 116065877(fastk)
SASA : 106568668 106597078
STRU : 115156573 115170161
OTW : 112227246(fastk) 112260156
OMY : 110509102(fastk) 110529976
SALP : 111957211 111979512
CCLU : 121534771 121554836 121580592
PSPA : 121313456 121314399(fastk)
ARUT : 117394833(fastk) 117399961
» show all
Taxonomy
Reference
Authors
Tian Q, Taupin J, Elledge S, Robertson M, Anderson P.
Title
Fas-activated serine/threonine kinase (FAST) phosphorylates TIA-1 during Fas-mediated apoptosis.
Journal
Sequence
Reference
Authors
Li W, Simarro M, Kedersha N, Anderson P.
Title
FAST is a survival protein that senses mitochondrial stress and modulates TIA-1-regulated changes in protein expression.
Journal
Other DBs
ExplorEnz - The Enzyme Database: 2.7.11.8
ExPASy - ENZYME nomenclature database: 2.7.11.8