KEGG ENZYME: 2.7.7.86

ENZYME: 2.7.7.86

Entry

EC 2.7.7.86                 Enzyme

Name

cyclic GMP-AMP synthase;
cGAMP synthase;
cGAS

Class

Transferases;
Transferring phosphorus-containing groups;
Nucleotidyltransferases

Sysname

ATP:GTP adenylyltransferase (cyclizing)

Reaction(IUBMB)

ATP + GTP = 2 diphosphate + cyclic Gp(2'-5')Ap(3'-5') (overall reaction) [RN:R10462];
(1a) ATP + GTP = pppGp(2'-5')A + diphosphate;
(1b) pppGp(2'-5')A = cyclic Gp(2'-5')Ap(3'-5') + diphosphate

Reaction(KEGG)

R10462

Substrate

ATP [CPD:C00002];
GTP [CPD:C00044];
pppGp(2'-5')A

Product

diphosphate [CPD:C00013];
cyclic Gp(2'-5')Ap(3'-5') [CPD:C20640];
pppGp(2'-5')A

Comment

Cyclic Gp(2'-5')Ap(3'-5') is a signalling molecule in mammalian cells that triggers the production of type I interferons and other cytokines.

History

EC 2.7.7.86 created 2013, modified 2014

Orthology

K17834

cyclic GMP-AMP synthase

Genes

HSA:	115004(CGAS)

PTR:	462822(CGAS)

PPS:	100990327(CGAS)

GGO:	101146170(CGAS)

PON:	100456001(CGAS)

NLE:	100583298(CGAS)

HMH:	116468920(CGAS)

MCC:	717665(CGAS)

MCF:	102133276(CGAS)

MTHB:

126952121

MNI:	105479453(CGAS)

CSAB:

103243898(MB21D1)

CATY:

105589206(MB21D1)

PANU:

100137406(CGAS)

TGE:	112622071(CGAS)

MLEU:

105544565(MB21D1)

RRO:	104669277(CGAS)

RBB:	108529201(MB21D1)

TFN:	117087450(CGAS)

PTEH:

111547444(CGAS)

CANG:

105513551(MB21D1)

CJC:	100387233(CGAS)

SBQ:	101052976(MB21D1)

CIMI:

108301246(CGAS)

CSYR:

103258632(MB21D1)

MMUR:

105858834 105884657(MB21D1)

LCAT:

123632173(CGAS)

PCOQ:

105807017 105811756(MB21D1)

OGA:	100960993(CGAS)

MMU:	214763(Cgas)

MCAL:

110302572(Cgas)

MPAH:

110328585(Mb21d1)

RNO:	682147(Cgas)

MCOC:

116072532 116073422

ANU:	117693634(Cgas)

MUN:	110560519(Cgas)

CGE:	100754516 100758179(Cgas)

MAUA:

101831922(Cgas) 106021433

PROB:

127217910(Cgas)

PLEU:

114686791(Cgas)

MORG:

121466160(Cgas)

MFOT:

126491081

AAMP:

119809822(Cgas)

NGI:	103744364(Mb21d1)

HGL:	101717623(Mb21d1)

CPOC:

100713978(Cgas)

CCAN:

109694315 109702432

DORD:

106000092(Mb21d1)

DSP:	122113960(Cgas)

PLOP:

125357513(Cgas)

NCAR:

124988764

MMMA:

107144037(Cgas)

OCU:	100349407(CGAS)

OPI:	101520974(CGAS)

TUP:	102474401(MB21D1)

GVR:	103595481(MB21D1)

CFA:	611033(CGAS)

CLUD:

112658300(CGAS)

VVP:	112926356(CGAS)

VLG:	121477532(CGAS)

NPO:	129512979(CGAS)

AML:	100471590(CGAS)

UMR:	103657480(CGAS)

UAH:	113261117(CGAS)

UAR:	123796269(CGAS)

ELK:

111152334

LLV:

125103240

MPUF:

101687874(MB21D1)

MNP:	132017214(CGAS)

MLK:	131834176(CGAS)

NVS:	122899794(CGAS)

ORO:	101374743(MB21D1)

EJU:	114204499(CGAS)

ZCA:	113926618(CGAS)

MLX:	118000892(CGAS)

NSU:	110583453(CGAS)

LWW:	102733539(CGAS)

FCA:	101098056(CGAS)

PYU:	121029669(CGAS)

PCOO:

112862518(CGAS)

PBG:	122489692(CGAS)

PVIV:

125166755(CGAS)

LRUF:

124528966

PTG:	102952381(MB21D1)

PPAD:

109248226(MB21D1)

PUC:

125938635

AJU:	106980198(CGAS)

HHV:	120242942(CGAS)

BTA:	782472(CGAS)

BOM:	102285090(MB21D1)

BIU:	109563704(MB21D1)

BBUB:

102415629(CGAS)

BBIS:

104996886(MB21D1)

CHX:	102187049(MB21D1)

OAS:	114116050(CGAS)

BTAX:

128053541(CGAS)

ODA:	120862886(CGAS)

CCAD:

122422632(CGAS)

MBEZ:

129561080(CGAS)

SSC:	100516408(MB21D1)

CFR:	102523852(CGAS)

CBAI:

105064893(MB21D1)

CDK:	105099837(CGAS)

VPC:	102545127(CGAS)

BACU:

103017021 103017298

BMUS:

118905482(CGAS)

LVE:	103082954(MB21D1)

OOR:	101289557(CGAS)

DLE:	111183240(CGAS)

PCAD:

102985456(CGAS)

PSIU:

116763806(CGAS)

NASI:

112390807(CGAS)

ECB:	100067982(CGAS)

EPZ:	103562297(MB21D1)

EAI:	106827075(CGAS)

MYB:

102243555

MYD:	102775467(MB21D1)

MMYO:

118660304(CGAS)

MLF:	102428890(CGAS)

PKL:	118705992(CGAS)

EFUS:

103284145(CGAS)

MNA:	107531610(MB21D1)

DRO:	112319268(CGAS)

SHON:

118978695(CGAS)

AJM:	119050815(CGAS)

PDIC:

114495020(CGAS)

PHAS:

123821499 123821692(CGAS)

MMF:	118621468(CGAS)

PPAM:

129067109(CGAS)

HAI:	109387546(MB21D1)

RFQ:	117020212(CGAS)

PALE:

102883365(CGAS)

PGIG:

120594970(CGAS)

PVP:	105306113(CGAS)

RAY:	107509280(MB21D1)

TOD:	119251468(CGAS)

SARA:

101553412(MB21D1)

SETR:

126014330(CGAS)

LAV:	100664322(CGAS)

TMU:

101344880

ETF:	101644613(CGAS)

MDO:	100021282(MB21D1)

GAS:	123246481(CGAS)

SHR:	100920386(CGAS)

AFZ:

127561909

PCW:	110217669(MB21D1)

OAA:	100087769(CGAS) 103165103

GGA:	421864(MB21D1)

PCOC:

116240629(CGAS)

MGP:	100549716(CGAS)

CJO:	107312047(CGAS)

TPAI:

128078668(CGAS)

LMUT:

125689730(CGAS)

NMEL:

110396507(MB21D1)

APLA:

101797757(CGAS)

ACYG:

106030386(CGAS)

CATA:

118246113(CGAS)

AFUL:

116487495(CGAS)

TGU:	100224044(CGAS)

LSR:	116183447(CGAS)

SCAN:

103822607(CGAS)

PMOA:

120511371(CGAS)

OTC:	121339126(CGAS)

PRUF:

121358896(CGAS)

GFR:	102042126(MB21D1)

FAB:	101809319(MB21D1)

OMA:	130251656(CGAS)

PHI:	102108130(MB21D1)

PMAJ:

107201290(CGAS)

CCAE:

111925811(CGAS)

CCW:	104694402(CGAS)

CBRC:

103619163(MB21D1)

ETL:	114057629(CGAS)

ZAB:	102069185(CGAS)

ACHL:

103811171(MB21D1)

SVG:	106849522(MB21D1)

MMEA:

130575061(CGAS)

HRT:	120750611(CGAS)

FPG:	101922902(MB21D1)

FCH:	102047663(CGAS)

CLV:	102091030(MB21D1)

EGZ:	104125162(MB21D1)

NNI:	104022036(MB21D1)

PCRI:

104031956(MB21D1)

PLET:

104624433(MB21D1)

EHS:	104502947(MB21D1)

PCAO:

104039501(MB21D1)

ACUN:

113478379(CGAS)

TALA:

104360478(CGAS)

PADL:

103924675(MB21D1)

AFOR:

103896032(MB21D1)

ACHC:

115350836(CGAS)

HALD:

104310548(MB21D1)

HLE:	104830712(MB21D1)

AGEN:

126046073

GCL:

127014782

CCRI:

104154713(MB21D1)

CSTI:

104549935(MB21D1)

CMAC:

104479842(MB21D1)

BREG:

104635071(MB21D1)

FGA:	104079823(MB21D1)

GSTE:

104250724(MB21D1)

LDI:	104347026(MB21D1)

MNB:	103773119(MB21D1)

OHA:	104334473(MB21D1)

NNT:	104399529(MB21D1)

SHAB:

115609556(CGAS)

DPUB:

104301303(MB21D1)

ACAR:

104523863(CGAS)

CPEA:

104393982(MB21D1)

AVIT:

104268341(MB21D1)

CVF:	104295951(MB21D1)

RTD:	128906970(CGAS)

CUCA:

104062712(MB21D1)

TEO:	104384573(MB21D1)

BRHI:

104488787(MB21D1)

AAM:	106492488(MB21D1)

AROW:

112977541(CGAS)

NPD:	112957605(CGAS)

TGT:	104565337(MB21D1)

DNE:	112984436(CGAS)

ASN:	102379168 102388310(CGAS)

AMJ:	102565317(MB21D1) 102576030

CPOO:

109311795(MB21D1) 109321596

GGN:	109298553 109299820(MB21D1)

PSS:	102447277(CGAS) 112544782 112544783 112544784 112546990

CMY:	102930662 102934779(CGAS) 102936464

CCAY:

125624754 125634772(CGAS) 125638726

DCC:	119845281 119853169(CGAS)

CPIC:

101937365(CGAS) 101951637 122172622

TST:	117868382 117875177(CGAS) 117877076

CABI:

116815600(CGAS) 116830189 116835107

MRV:	120389418 120401978(CGAS) 120405307

ACS:	100567354(mb21d1)

ASAO:

132760733(CGAS)

PVT:	110075025(MB21D1)

SUND:

121916199 121919775(CGAS)

CTIG:

120316881

PGUT:

117663498

PMUA:

114593874(CGAS) 114601597

PRAF:

128410255(CGAS) 128418781

ZVI:	118082764(CGAS) 118086762

HCG:	128340948(CGAS)

GJA:	107107013 107123189(MB21D1)

STOW:

125432413 125437822

EMC:	129339358(CGAS)

XLA:	108704160(mb21d1.L) 108717996

XTR:	100488048(cgas)

NPR:	108795988 108795990

RTEM:

120937033 120937034 120937377

BBUF:

120998121(CGAS)

BGAR:

122934311(CGAS)

MUO:	115467235(CGAS) 115467236

GSH:	117358224 117358246

DRE:	100536487 557043(mb21d1)

SRX:	107706136 107718834(mb21d1)

SANH:

107654670 107693606(mb21d1) 107696517

SGH:	107588675 107589446 107591657

CCAR:

109112294 109112296

CAUA:

113056938 113112671 113119289

CGIB:

127934967 127970662 127978745 128026636

PTET:

122323294 122356113(cgasa)

LROH:

127175618(cgasa) 127182416

OMC:	131526076 131552678(cgasa)

PPRM:

120479510(cgas) 120485031

RKG:	130072067(cgasa) 130084207

MAMB:

125275080 125276950(cgasa)

CIDE:

127500875 127524368

MASI:

127412118 127414345 127421380

TROS:

130559752(cgasa) 130567054

TDW:	130415928 130431259(cgasa)

MANU:

129415411(cgasa) 129454934

IPU:	108256977 108263730(cgasa)

IFU:	128600586 128605703(cgasa)

PHYP:

113536320 113545662(cgas)

SMEO:

124375754 124395062(cgasa)

TFD:	113636304(cgasa) 113661383

TVC:	132837560 132847374(cgasa)

AMEX:

103037406(mb21d1) 103045125

CMAO:

118805631 118809941(cgas)

EEE:	113578442 113580312

CHAR:

105911542(cgas) 116223264

LCO:	104930807 104930999 109139339(cgas)

NCC:	104953808 104960303

TBEN:

117478011 117499869(cgas)

PGEO:

117455476 117460018(cgas)

GACU:

117536638 117542351(cgas)

EMAC:

134874564

ELY:	117248427(cgas) 117264086

EFO:	125903006(cgasa) 125905116

PLEP:

121954978(cgasa) 121958065

SLUC:

116047115 116061627(cgas)

ECRA:

117956958 117960151(cgas)

ESP:	116701880 116705125(cgas)

PFLV:

114568181 114571773

GAT:

120826951

PPUG:

119218702

AFB:	129092545(cgasa) 129097087

CLUM:

117739511

MSAM:

119906690 119909717 119917545(cgas)

SCHU:

122864465 122884694(cgasa)

CUD:	121511480(cgasa)

ALAT:

119015120 119033773(cgas)

MZE:	101482018 101485826

ONL:	102078106 106097853 109204785

OAU:	116324850 116326666 120443305(cgas)

OLA:	101161502(cgas)

OML:	112162124(cgas)

CSAI:

133460830 133463703(cgasa)

XMA:	102238245(cgas) 106699738

XCO:	114137781 114156605

XHE:	116713105 116731906

PRET:

103472993 103476464

PFOR:

103137383(mb21d1) 103143458

PLAI:

106938210(mb21d1) 106951929

PMEI:

106911808 106923428

GAF:	122842438(cgasa) 122843138

PPRL:

129359599(cgasa) 129375921

CVG:	107098985 107101098

CTUL:

119774847(cgas) 119790489

GMU:	124859105(cgasa) 124878899

NFU:	107375894(mb21d1)

KMR:	108244627(cgas)

ALIM:

106533424(mb21d1)

NWH:	119430509(cgasa)

AOCE:

111563935 111586938

MCEP:

125018945 125018951 125019502

POV:	109631848(mb21d1)

SSEN:

122786074

HHIP:

117775272(cgas)

HSP:	118118935(cgasa)

SMAU:

118283425(cgasa)

LCF:	108873443(cgasa) 108898898

SDU:	111220892 111227407 111227458(cgas)

SLAL:

111645593 111646355 111646980 111648681 111649430

XGL:	120786458 120796225(cgasa)

BPEC:

110156913(mb21d1)

MALB:

109954004 109961116 109970716

BSPL:

114865590 114870674(cgasa)

SJO:	128373328(cgasa) 128373882

SASA:

106570029 106577085(mb21d1) 106606998

STRU:

115153193 115175959 115193802

OTW:	112229902 112253530(cgasa) 112254417 112264864

OMY:	110489275 110496144 110502447 110528533(cgas)

OGO:	124037217 124041278(cgasa) 124043619

ONE:	115112699 115128993 115131684 115135136

OKI:	109888967 109899102 109903121 109906931

OKE:	118361302 118369685(cgasa) 118398256 118399243

SALP:

111951600 111955989 112080536 112080849

SNH:	120017425(cgas) 120027447 120045881

CCLU:

121553461 121570526 121585758

ELS:	105023252 105027914

SFM:	108927166 108933614

PKI:	111850720 111854243

AANG:

118218464(cgas) 118232887

LOC:	102683757(mb21d1) 107076494

PSPA:

121308405 121316824(cgasa)

ARUT:

117411600(cgas) 117968100 117971567

PSEX:

120516706(cgas)

LCM:	102346272(MB21D1) 102353888

RTP:	109919108(cgas)

CPLA:

122542602

HOC:

132835866

LERI:

129697021

PMRN:

116946569

LRJ:

133353021

BFO:	118419102 118425279

BBEL:

109470647

SKO:	100376890 102805563

DPO:	4812402 6900849

DPE:	6599088 6601652

DMN:

108153688

DMO:	Dmoj_GI13277

BIM:

100743943

BTER:

100644606

BPYO:

122569612

OBB:

114876897

MGEN:

117228555

AEC:

105145568

HST:	105183688 112590534

DQU:

106749942

LHU:

105675429

PGC:

109860398

CGLO:

123267413

DAM:

107044363

TPAL:

117647679

PCHN:

125032947

RSAN:

119406268

CSCU:

111640160

PTEP:

107449532 107453297 107453300

UDV:

129222597

PCAN:

112564288

HRF:	124133238 124133248

HRJ:	124262090 124290754

CRG:	105322102 105322103

CVN:

111114210

CANU:

128162093 128162095

OED:

125666063

EPA:

110240579

ATEN:

116295534 116307849

ADF:	107337790 107349987 107349993 107353078

AMIL:

114948743 114949417 114965664

PDAM:

113670688 113680563 113681850 113681904

SPIS:

111338054 111345036 111345331 111345339 111345504

HMG:

105850432

» show all

Reference

1 [PMID:23258413]

Authors

Sun L, Wu J, Du F, Chen X, Chen ZJ

Title

Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway.

Journal

Science 339:786-91 (2013)
DOI:10.1126/science.1232458

Sequence

[hsa:115004] [mmu:214763]

Reference

2 [PMID:23722158]

Authors

Ablasser A, Goldeck M, Cavlar T, Deimling T, Witte G, Rohl I, Hopfner KP, Ludwig J, Hornung V.

Title

cGAS produces a 2'-5'-linked cyclic dinucleotide second messenger that activates STING.

Journal

Nature 498:380-4 (2013)
DOI:10.1038/nature12306

Other DBs

ExplorEnz - The Enzyme Database:

2.7.7.86

IUBMB Enzyme Nomenclature:

2.7.7.86

ExPASy - ENZYME nomenclature database:

2.7.7.86

BRENDA, the Enzyme Database:

2.7.7.86

DBGET integrated database retrieval system