Entry
Name
biotin synthase;
dethiobiotin:sulfur sulfurtransferase
Class
Transferases;
Transferring sulfur-containing groups;
Sulfurtransferases
BRITE hierarchy
Sysname
dethiobiotin:sulfur-(sulfur carrier) sulfurtransferase
Reaction(IUBMB)
dethiobiotin + sulfur-(sulfur carrier) + 2 S-adenosyl-L-methionine + 2 reduced [2Fe-2S] ferredoxin = biotin + (sulfur carrier) + 2 L-methionine + 2 5'-deoxyadenosine + 2 oxidized [2Fe-2S] ferredoxin [RN:
R01078 ]
Reaction(KEGG)
Substrate
dethiobiotin [CPD:
C01909 ];
sulfur-(sulfur carrier);
S-adenosyl-L-methionine [CPD:
C00019 ];
reduced [2Fe-2S] ferredoxin [CPD:
C22150 ]
Product
biotin [CPD:
C00120 ];
(sulfur carrier);
L-methionine [CPD:
C00073 ];
5'-deoxyadenosine [CPD:
C05198 ];
oxidized [2Fe-2S] ferredoxin [CPD:
C22151 ]
Comment
The enzyme binds a [4Fe-4S] and a [2Fe-2S] cluster. In every reaction cycle, the enzyme consumes two molecules of AdoMet. The first reaction produces 5'-deoxyadenosine and 4,5-secobiotin. Reaction with another equivalent of AdoMet results in abstraction of the C-6 methylene pro-S hydrogen atom from 4,5-secobiotin, and the resulting carbon radical is quenched via formation of an intramolecular C-S bond, thus closing the biotin tetrahydrothiophene ring. The sulfur donor is believed to be the [2Fe-2S] cluster, which is sacrificed in the process, so that in vitro the reaction is a single turnover. In vivo, the [2Fe-2S] cluster can be reassembled by the Isc or Suf iron-sulfur cluster assembly systems, to allow further catalysis.
History
EC 2.8.1.6 created 1999, modified 2006, modified 2011, modified 2014
Pathway
Orthology
Genes
CSAT : 104782851 104785018 104793267
BNA : 106388319 106396693 106421211 111215097
RSZ : 108806463 108846608 130509009
CIC : CICLE_v10020553mg CICLE_v10024062mg CICLE_v10024495mg
MINC : 123195598 123205668 123205680 123205681 123205682 123220139 123220495 123221387
LJA : Lj3g3v3599460.1(Lj3g3v3599460.1)
LANG : 109325861 109353158
PMUM : 103322442 103322476
PEU : 105118204 105127006 105134371
PALZ : 118032077 118055013
SSPL : 121756477 121759567 121801944 121806625
SMIL : 130989705 131024714
PSOM : 113284072 113316212
DOSA : Os08t0540100-01(Os08g0540100)
TAES : 123152220 123159206 123166839
SITA : 101755195 101757458
PVIR : 120669605 120701997 120713049
PHAI : 112888520 112897115
ZOF : 121971409 121976250 122000722 122005011
SMO : SELMODRAFT_114715 SELMODRAFT_165887
BPG : Bathy11g00270(biotin)
MPP : MICPUCDRAFT_23693(JGI:MicpuC2_23693)
NCS : NCAS_0C04410(NCAS0C04410)
TBL : TBLA_0B10120(TBLA0B10120)
TDL : TDEL_0H00860(TDEL0H00860)
KNG : KNAG_0K00320(KNAG0K00320)
CAL : CAALFM_CR01930CA(BIO2)
NTE : NEUTE1DRAFT69237(NEUTE1DRAFT_69237)
BFU : BCIN_12g02450(Bcbio2)
CCAC : CcaHIS019_0202850(BIO2)
LBC : LACBIDRAFT_379847(LbBioB)
ABP : AGABI1DRAFT110110(AGABI1DRAFT_110110)
ABV : AGABI2DRAFT189996(AGABI2DRAFT_189996)
SCM : SCHCO_02612582(SCHCODRAFT_02612582)
AAF : AURANDRAFT_12447 AURANDRAFT_59442(BIOB)
PSOJ : PHYSODRAFT_340219 PHYSODRAFT_526228
ECOO : ECRM13514_0850(bioB)
ECOH : ECRM13516_0805(bioB)
ECW : EcE24377A_0838(bioB)
EDJ : ECDH1ME8569_0728(bioB)
ECOI : ECOPMV1_00778(bioB)
REE : electrica_03544(bioB)
RTG : NCTC13098_05234(bioB)
RIG : AOQ88_02110 AOQ88_02340
CLAP : NCTC11466_03202(bioB)
KIE : NCTC12125_02214(bioB)
KLU : K7B04_00125(bioB) K7B04_12705(bioB)
AHN : NCTC12129_03434(bioB)
METY : MRY16398_39960(bioB)
PSHI : SAMEA2665130_1582(bioB)
YPG : YpAngola_A1425(bioB)
YPI : YpsIP31758_2844(bioB)
SMW : SMWW4_v1c12800(bioB)
SFJ : SAMEA4384070_1366(bioB)
SOF : NCTC11214_05592(bioB)
PAQU : DMB82_0012720(bioB)
DIC : Dpoa569_002269(bioB)
EHD : ERCIPSTX3056_673(bioB)
BAPF : BUMPF009_CDS00306(biob)
BAPG : BUMPG002_CDS00307(biob)
BAPU : BUMPUSDA_CDS00306(biob)
BAPW : BUMPW106_CDS00306(biob)
TPTY : NCTC11468_01253(bioB)
PHEI : NCTC12003_02899(bioB)
PRJ : NCTC6933_01145(bioB)
LRI : NCTC12151_02381(bioB)
HIC : NTHIC486_01757(bioB)
HPIT : NCTC13334_01317(bioB)
HHZ : NCTC10839_00736(bioB)
HAEG : NCTC8502_02050(bioB)
PDAG : 4362423_00514(bioB)
ALIG : NCTC10568_00136(bioB)
ASEG : NCTC10977_01730(bioB)
AVT : NCTC3438_01186(bioB)
RPNE : NCTC8284_03040(bioB_2)
PAET : NCTC13378_01166(bioB)
XFU : XFF4834R_chr03740(bioB)
XPH : XppCFBP6546_09875(bioB)
XHD : LMG31886_04360(bioB)
LLZ : LYB30171_00095(bioB)
VAU : VANGNB10_cI1729c(bioB)
VPL : SA104470976_00860(bioB)
PAEB : NCGM1900_0511(bioB)
PPRC : PFLCHA0_c56440(bioB)
PMUD : NCTC8068_04916(bioB)
PFW : PF1751_v1c50420(bioB)
PPUU : PputUW4_04983(bioB)
PTRT : HU722_0027095(bioB)
PTW : TUM18999_06800(bioB)
PTAE : NCTC10697_00422(bioB)
MSHE : MAALD49_27330(bioB)
PSYC : DABAL43B_2455(bioB)
ABD : ABTW07_1231(bioB) ABTW07_1743(bioB)
AJO : RZ95_05520 RZ95_06985
ALA : BFG52_09465 BFG52_16225
ASJ : AsACE_CH00727(bioB-1) AsACE_p100027(bioB-2)
ALW : FOB21_00300(bioB) FOB21_03355(bioB)
ADS : FPL17_02445(bioB) FPL17_06935(bioB)
ATN : FM020_05620(bioB) FM020_08020(bioB)
ATG : J4G44_07420(bioB) J4G44_07755(bioB)
AGYL : FPL18_13770(bioB) FPL18_14690(bioB)
ATZ : M5E07_06270(bioB) M5E07_08050(bioB)
MCAT : MC25239_00435(bioB)
MCUN : NCTC10297_00930(bioB)
SON : SO_2740(bioB) SO_3925(hydE)
SHE : Shewmr4_2359 Shewmr4_3255
SHN : Shewana3_0706 Shewana3_2519
SHF : CEQ32_02775(bioB) CEQ32_19955
SBJ : CF168_08330(bioB) CF168_17260
SALG : BS332_04465 BS332_20860
SCAA : TUM17387_15690(bioB) TUM17387_33980(hydE)
SXM : MKD32_03715(hydE) MKD32_08630(bioB)
SCHK : GII14_08745(bioB) GII14_19220(hydE)
SDEO : D0436_04945(hydE) D0436_13445(bioB)
SALH : HMF8227_01333(bioB)
TTU : TERTU_0490(bioB) TERTU_3309
CBS : COXBURSA331_A0933(bioB)
LLG : 44548918_01420(bioB)
LJR : NCTC11533_01414(bioB)
LCJ : NCTC11976_02355(bioB)
LWA : SAMEA4504053_1707(bioB)
LSS : NCTC12082_00520(bioB)
LADL : NCTC12735_00763(bioB)
LANT : TUM19329_19770(bioB)
MISZ : MishRS11D_04680(bioB)
TIB : THMIRHAM_01810(bioB)
TSE : THMIRHAS_01790(bioB)
TZO : THMIRHAT_02010(bioB)
TUN : J9260_06305(bioB) J9260_13570(bioB)
ALV : Alvin_0526 Alvin_1972
ATEP : Atep_12860(bioB) Atep_14490
TTP : E6P07_04525(bioB) E6P07_07730
THIP : N838_16300(hydE) N838_27610(bioB)
CJAP : GWK36_03775 GWK36_06260(bioB)
TFRI : Thiofri_03792(bioB)
TNI : TVNIR_0403(bioB_[H])
THIC : TspCOW1_26740(bioB)
ALCA : ASALC70_01672(bioB)
EMP : EZMO1_0534(bioB1) EZMO1_4078(bioB2)
AEL : NCTC12917_01349(bioB)
CHJ : NCTC10426_00331(bioB)
CDIZ : CEDIAZO_03519(bioB)
NME : NMB1146(bioB-1) NMB1184(bioB-2)
NMM : NMBM01240149_0982(bioB)
NMS : NMBM01240355_1111(bioB)
NMQ : NMBM04240196_1016(bioB)
NMZ : NMBNZ0533_1158(bioB)
NMX : NMA510612_1507(bioB)
NWE : SAMEA3174300_2045(bioB)
NZO : SAMEA4504057_0414(bioB)
NCI : NCTC10296_02319(bioB)
NCZ : NCTC10294_00746(bioB)
NANI : NCTC12227_01693(bioB)
ECOR : SAMEA4412678_1197(bioB)
CHAE : CH06BL_02060(bioB-2)
CNC : CNE_1c01740(bioB) CNE_BB1p09040(bioB)
BMV : BMASAVP1_A3077(bioB)
BML : BMA10229_A2017(bioB)
BPM : BURPS1710b_0570(bioB)
BPL : BURPS1106A_0409(bioB)
BGL : bglu_1g32460 bglu_2p0570
BGU : KS03_5609(bioB) KS03_705(bioB)
BUE : BRPE67_ACDS00850(bioB)
BRH : RBRH_02661 RBRH_03099
PLG : NCTC10937_00561(bioB)
LMIR : NCTC12852_01313(bioB)
BUO : BRPE64_ACDS00880(bioB)
CABK : NK8_00800(bioB) NK8_68480(bioB) NK8_84010(bioB)
VTR : MYVALT_F_02990(bioB)
BTRM : SAMEA390648702130(bioB)
AXX : ERS451415_05011(bioB)
RHF : EUB48_12565(bioB) EUB48_15445(bioB)
HYR : BSY239_2014(bioB) BSY239_2814(bioB)
HPSE : HPF_10135(bioB1) HPF_12635(bioB2)
PKT : AT984_15670 AT984_20800
JAJ : EKL02_00460(bioB) EKL02_06210(bioB)
MUM : FCL38_08375(bioB) FCL38_20135(bioB)
SUTT : SUTMEG_01490 SUTMEG_05900
SUTK : FG381_01115(hydE) FG381_12255(bioB)
SWS : I6J16_03135(bioB) I6J16_04115(hydE)
THI : THI_2351(bioB1) THI_3269(bioB2)
URU : DSM104443_00712(bioB)
UPL : DSM104440_00668(bioB)
ABRE : pbN1_09770(bioB1) pbN1_20230(bioB2)
AZA : AZKH_0994(bioB) AZKH_2513(bioB)
FPHO : SHINM1_001530(bioB)
ERW : ERWE_CDS_06820(bioB)
ERG : ERGA_CDS_06730(bioB)
MLO : mll5831 mll6007 mll9100
MLN : A9174_32780 A9174_34670
MOH : IHQ72_31690(bioB) IHQ72_32480(bioB)
AMIS : Amn_10270 Amn_24760
PHT : BLM14_26630 BLM14_28465
RBS : RHODOSMS8_03279(bioB)
SFD : USDA257_c49430(bioB)
SAME : SAMCFNEI73_Ch2849(bioB)
EGI : PZN02_002026(bioB) PZN02_006333(bioB)
AVV : RvVAT039_05220(bioB)
AVF : RvVAR031_25160(bioB)
ASAL : CFBP5507_19805(bioB)
RPUS : CFBP5875_19495(bioB)
ALEG : CFBP4996_21130(bioB)
REL : REMIM1_PE00119(bioB)
RHL : LPU83_pLPU83d0029(bioB)
RGA : RGR602_PC01481(bioB)
RJG : CCGE525_27725(bioB) CCGE525_34995(bioB)
BIO : BR141012304_20320(bioB)
BJU : BJ6T_66030 BJ6T_77600
BJP : RN69_32015 RN69_37670
BARH : WN72_11065(bioB) WN72_17325(bioB)
BDG : LPJ38_18720(bioB) LPJ38_35630(bioB)
BSEP : HAP48_0016760(bioB)
BCAN : BcanWSM471_08335(bioB) BcanWSM471_08745(bioB)
MAQU : Maq22A_c08870(bioB)
MMES : MMSR116_03450(bioB)
MTUN : MTUNDRAET4_0204(bioB)
RLAC : QMO75_11475(bioB) QMO75_14180(hydE)
FIL : BN1229_v1_0785(bioB)
FIY : BN1229_v1_0789(bioB)
MLUT : JET14_15000(bioB) JET14_15485(bioB)
CAUF : CSW63_00555(bioB) CSW63_02425(bioB)
BVY : NCTC9239_00177(bioB)
PHP : PhaeoP97_00877(bioB)
PPIC : PhaeoP14_00832(bioB)
PAMI : JCM7686_0973 JCM7686_pAMI8p110
PVER : E3U25_09995(bioB) E3U25_14230(bioB)
LVS : LOKVESSMR4R_00060(bioB)
NRE : BES08_02170 BES08_23035
NOG : GKE62_03350(bioB) GKE62_07835(bioB)
NDR : HT578_04315(bioB) HT578_09180(bioB)
SPHD : HY78_11040 HY78_18145
SBIN : SBA_ch1_21920(bioB_1) SBA_ch1_24720(bioB_2)
SHYD : CJD35_06275(bioB) CJD35_12970(bioB)
SPPH : KFK14_09610(bioB) KFK14_12320(bioB)
SFLA : SPHFLASMR4Y_00815(fbiC)
NGU : QN315_09315(bioB) QN315_18915(bioB)
RPM : RSPPHO_00586(hydEF) RSPPHO_01192(bioB3)
HPO : HMPREF4655_21560(bioB)
HPX : HMPREF0462_1379(bioB)
HCL : NCTC13205_00115(bioB)
HSH : NHP194022_12250(bioB)
HPUL : NCTC13154_00550(bioB)
CJV : MTVDSCj20_1646(bioB)
CFV : CFVI03293_0177(bioB)
CAMP : CFT03427_0186(bioB)
CCOC : CCON33237_1638(bioB)
CLR : UPTC16701_0168(bioB)
CLM : UPTC16712_0166(bioB)
CAMR : CAQ16704_0158(bioB)
CURE : CUREO_0459 CUREO_1312(bioB)
CHYO : CHH_0073 CHH_0163(bioB)
CHV : CHELV3228_0088(bioB)
CPIN : CPIN18020_0531(bioB) CPIN18020_0544
CAMZ : CVIC12175_1596(bioB)
CRX : CRECT_0222(bioB) CRECT_1409
HCJ : HCR_11690(bioB_1) HCR_12860(bioB_2)
GBN : GEOBRER4_18790(bioB)
GSB : GSUB_07485 GSUB_09030
PCA : Pcar_1458(bioB) Pcar_1607(hydE-3) Pcar_1632(hydE-2) Pcar_1722(hydE-1)
PACE : A6070_06025 A6070_07110
PEF : A7E78_01925 A7E78_02235 A7E78_03620
DFI : AXF13_01440 AXF13_07235
DPG : DESPIGER_0970 DESPIGER_1377
DEF : CNY67_08590(bioB) CNY67_09540
DFL : DFE_2983(bioB) DFE_3335
PSYF : N1030_14115(bioB) N1030_15385(hydE)
DSB : LN040_08660(hydE) LN040_10315(bioB)
DMA : DMR_01800 DMR_33650(bioB) DMR_37150
DCB : C3Y92_00485 C3Y92_05080(bioB)
DMS : E8L03_11270(bioB) E8L03_18895(hydE)
DSA : Desal_0368 Desal_1338 Desal_2977
DHY : DESAM_21599(bioB) DESAM_22764
DAS : Daes_0296 Daes_0593 Daes_0770
PPRF : DPRO_1005 DPRO_2549(bioB)
PSEL : GM415_07265(bioB) GM415_17570(hydE)
PSEF : PSDVSF_13910(hydE_1) PSDVSF_17680(bioB) PSDVSF_31380(hydE_2)
PPOR : JCM14722_10530(hydE) JCM14722_13900(bioB)
PNW : SYK_14420 SYK_19260(bioB) SYK_30820(hydE)
PTHE : LF599_02810(hydE) LF599_16565(bioB)
DSD : GD606_03060(hydE) GD606_11995(hydE)
PBIZ : LWC08_01305 LWC08_11125(hydE) LWC08_12030(bioB) LWC08_13890
DVU : DVU_1767 DVU_2558(bioB)
DVG : Deval_1531 Deval_2359
DOA : AXF15_03275 AXF15_08805
THEW : TDMWS_13850(bioB) TDMWS_19690
DPS : DP0475 DP2376 DP2549
DPR : Despr_0278 Despr_1604
DTO : TOL2_C24670 TOL2_C38290(bioB)
DALK : DSCA_33440 DSCA_39360
DEK : DSLASN_29500(bioB) DSLASN_44770(hydE)
DTI : Desti_1185 Desti_5155
SFU : Sfum_0841 Sfum_1825 Sfum_1844
TID : Thein_0031 Thein_0500
BAZ : BAMTA208_07905(bioB)
BSON : S101395_00965(bioB)
BFD : NCTC4823_00345(bioB)
PARG : PspKH34_16190(bioB)
VIR : X953_02520 X953_06765
BLEN : NCTC4824_04044(bioB)
SAX : USA300HOU_2409(bioB)
SUQ : HMPREF0772_10762(bioB)
SUX : SAEMRSA15_23240(bioB)
SUF : SARLGA251_22070(bioB)
SAUT : SAI1T1_2018000(bioB)
SAUJ : SAI2T2_1018010(bioB)
SAUK : SAI3T3_1018000(bioB)
SAUQ : SAI4T8_1018010(bioB)
SAUV : SAI7S6_1018000(bioB)
SAUW : SAI5S5_1017940(bioB)
SAUX : SAI6T6_1017940(bioB)
SAUY : SAI8T7_1017980(bioB)
SDP : NCTC12225_02662(bioB)
SPIC : SAMEA4384060_0526(bioB)
SSH : NCTC13712_02376(bioB)
BAYD : BSPP4475_01105(bioB)
PPM : PPSC2_13175(bioB1) PPSC2_14270(bioB3)
PPO : PPM_2526(bioB1) PPM_2870(bioB3)
PPOL : X809_29505 X809_30660
PPQ : PPSQR21_026130(bioB) PPSQR21_028400
PPOY : RE92_22430 RE92_23625
PTA : HPL003_20740 HPL003_23075
PSTE : PSTEL_11965 PSTEL_13390
PPEO : ABE82_13530 ABE82_14675
PKB : B4V02_10870 B4V02_11850
PAIH : ASL14_23690 ASL14_25135
PMAE : LMZ02_14940(hydE) LMZ02_21920(bioB)
COHN : KCTCHS21_53490(bioB)
AFAS : NZD89_23180(bioB) NZD89_27820(bioB) NZD89_28360(bioB)
SGG : SGGBAA2069_c18670(bioB)
ECEC : NCTC12421_01485(bioB)
CAC : CA_C0210(bioB) CA_C1631
CAE : SMB_G0215(bioB) SMB_G1656
CAY : CEA_G0215(bioB) CEA_G1645
CPF : CPF_1795(bioB) CPF_2775
CTET : BN906_00132 BN906_01431
CNO : NT01CX_1470(bioB) NT01CX_1484
CBO : CBO2259 CBO3582(bioB)
CBA : CLB_2200(bioB) CLB_3662
CBH : CLC_2183(bioB) CLC_3560
CBY : CLM_2468(bioB) CLM_4074
CBL : CLK_1702(bioB) CLK_3055
CBK : CLL_A0358 CLL_A0721(bioB)
CBB : CLD_0904 CLD_2316(bioB)
CBI : CLJ_B2472(bioB) CLJ_B3911
CBN : CbC4_0638(bioB) CbC4_0656
CBT : CLH_0344 CLH_0685(bioB)
CBF : CLI_2309(bioB) CLI_3807
CBM : CBF_2298(bioB) CBF_3773
CBJ : H04402_02273 H04402_03682
CBEI : LF65_00324 LF65_02077
CKL : CKL_0605(hydE) CKL_1696(bioB2)
CLJ : CLJU_c22770 CLJU_c38330
CCB : Clocel_0490 Clocel_2372
CLS : CXIVA_03660 CXIVA_15550
CSR : Cspa_c03400(pylB) Cspa_c50510(bioB)
CPAS : Clopa_0793 Clopa_2990
CPAT : CLPA_c06230(bioB) CLPA_c17440(pylB1)
CPAE : CPAST_c06230(bioB) CPAST_c17440(pylB1)
CSB : CLSA_c03330(pylB1) CLSA_c25290(pylB2) CLSA_c43920(bioB)
CAH : CAETHG_0339 CAETHG_1691(hydE)
CLD : CLSPO_c23230(bioB) CLSPO_c37650(hydE)
CACE : CACET_c13430(bioB1) CACET_c17130(bioB2)
CCK : Ccar_14075 Ccar_19090
CBUT : ATN24_03010 ATN24_20060
CTYK : CTK_C22200(bioB) CTK_C26910(hydE)
CEU : A7L45_01970 A7L45_10680
CFM : BJL90_12065 BJL90_19205
CCHV : BTM20_01530 BTM20_04425
CSEP : CP523_03275(hydE) CP523_06940
CDY : F3K33_01520(hydE) F3K33_09485(bioB) F3K33_11680(hydE)
CCOH : SAMEA4530647_1148(thiH_2)
CFER : D4Z93_08190(bioB) D4Z93_10060(hydE)
CGAS : J1C67_02015(hydE) J1C67_06720(bioB)
CLOS : DMR38_08540 DMR38_16190(bioB) DMR38_19130(hydE)
CCAA : KQH81_01210(hydE) KQH81_16830(bioB)
CRW : CROST_026210 CROST_039110(bioB)
CFB : CLFE_008710(bioB) CLFE_024860
CAUN : CLAUR_004790 CLAUR_036150(bioB)
CNN : CNEO_0394 CNEO_2013(bioB)
CGEL : psyc5s11_03180 psyc5s11_54400(bioB)
CTAG : LL095_07705(bioB) LL095_10415(hydE)
CRS : FQB35_00870(bioB) FQB35_03930(hydE)
CPRF : K7H06_03150(hydE) K7H06_12360(hydE) K7H06_17455(bioB)
CRAS : KVH43_00940(hydE) KVH43_05710(bioB)
SARJ : HH195_00455(bioB) HH195_05700(hydE)
OCW : OW730_06490(hydE) OW730_19870(bioB)
CTX : Clo1313_2212 Clo1313_2531
CCL : Clocl_0758 Clocl_1572
HSC : HVS_07980(thiH2) HVS_08735(bioB)
RHER : EHE19_002455(hydE) EHE19_005145(bioB)
RPAY : P0092_18865(bioB) P0092_20630(hydE)
EHA : Ethha_0049 Ethha_1379
RAL : Rumal_0545 Rumal_1686
RUJ : E5Z56_07095(hydE) E5Z56_10740(bioB)
SMAN : C12CBH8_00890(bioB_1) C12CBH8_14190(bioB_2)
PETR : QKW49_17735(hydE) QKW49_20395(hydE)
PALM : RBG61_04290(hydE) RBG61_09540 RBG61_10645(bioB)
AGAT : RWV98_08830(hydE) RWV98_14555(bioB)
DOR : Desor_2671 Desor_3748
DMI : Desmer_0499 Desmer_2937
DCA : Desca_0053 Desca_1533
PTH : PTH_0249(BioB) PTH_0521(BioB) PTH_0983(BioB)
DRU : Desru_0244 Desru_1634 Desru_2192
DKU : Desku_1297 Desku_2317
TFR : BR63_00485(bioB) BR63_18275(hydE)
AACX : DEACI_0592 DEACI_0826 DEACI_4105
TJR : TherJR_0016 TherJR_3005
DGI : Desgi_0921 Desgi_1056 Desgi_3111
HCV : FTV88_0071(bioB) FTV88_1004(hydE)
EMT : CPZ25_003755(bioB) CPZ25_007320(hydE) CPZ25_008720
ELIM : B2M23_09775 B2M23_18025
RRK : H8S51_000415(bioB) H8S51_011590(hydE)
CCOM : I6K69_00255(hydE) I6K69_10070(bioB)
CEV : LK421_05955(hydE) LK421_10450(bioB)
BYL : A4V09_00240 A4V09_04185
BPRO : PMF13cell1_04613 PMF13cell1_05420(bioB)
BLAB : EYS05_01900(bioB) EYS05_03545(hydE)
BWX : NQ550_06170(bioB) NQ550_09360(hydE)
BMAS : LK422_02660(hydE) LK422_04020(bioB)
BLAR : LC508_01275(hydE) LC508_24500(bioB)
BLUI : Blut17040_18680(hydE) Blut17040_32800(bioB)
BCOC : BLCOC_36090 BLCOC_45080(bioB)
CSCI : HDCHBGLK_00595 HDCHBGLK_01883(bioB_1) HDCHBGLK_02120(bioB_2)
CHYL : CE91St63_29280(bioB)
BPRL : CL2_04810 CL2_09980
ARF : AR1Y2_2390 AR1Y2_2739
ACAC : EYQ97_04520(hydE) EYQ97_06045(bioB)
ANR : Ana3638_07065(bioB) Ana3638_09435(hydE)
ACEL : acsn021_08620(bioB_1) acsn021_18320(bioB_2)
ACHT : bsdcttw_39480(bioB)
RGN : RGna_12570(hydE) RGna_14200(bioB)
RLR : NQ541_10495(hydE) NQ541_11785(bioB)
DLO : K5I24_03050(bioB) K5I24_12485(hydE)
DFM : NQ560_01520(hydE) NQ560_05070(bioB)
QDO : H9Q78_08080(bioB) H9Q78_13330
WHJ : H9Q79_12695(hydE) H9Q79_15265(bioB)
STOM : QU660_05560(hydE) QU660_05725(bioB)
ERE : EUBREC_0234 EUBREC_0920
CPRO : CPRO_14540(thiH_2) CPRO_16000(bioB)
ANV : RBQ60_08200(bioB) RBQ60_09115(hydE)
CLE : Clole_0350 Clole_2657
CEW : EKH84_05095(bioB) EKH84_16105(hydE)
VGU : HYG85_01655 HYG85_14710(bioB) HYG85_16845(hydE)
VPY : HZI73_04555 HZI73_19925(hydE) HZI73_23365(bioB)
AMIC : Ami3637_10845(bioB)
ABUT : Ami103574_13335(bioB)
ETM : CE91St48_13020 CE91St48_30020
GFE : Gferi_16110 Gferi_20720
CSPO : QNI18_03555(hydE) QNI18_03700(bioB)
PBIF : KXZ80_05615(hydE) KXZ80_06280(bioB)
PSOR : RSJ16_06505 RSJ16_07105
CDF : CD630_02970(bioB) CD630_21550(bioB1)
PDC : CDIF630_00422(bioB1) CDIF630_02386(bioB2)
CDC : CD196_0313 CD196_2018
CDL : CDR20291_0300 CDR20291_2061
PDF : CD630DERM_02970(bioB) CD630DERM_21550(bioB1)
TEM : JW646_02480(hydE) JW646_19745(bioB)
TGC : L0P85_05885(hydE) L0P85_08605(bioB)
TMY : TEMA_02470 TEMA_34010(bioB)
TEB : T8CH_2774(bioB) T8CH_3074
THYR : P4S50_01040(hydE) P4S50_03060(bioB)
EAC : EAL2_c04200 EAL2_c10100(bioB)
FAA : HMPREF0389_00860(bioB) HMPREF0389_01136(hydE)
CMIU : B1H56_02585 B1H56_06410(bioB)
TTE : TTE1073(BioB) TTE1885(BioB2)
TEX : Teth514_0563 Teth514_1130
TMT : Tmath_1315 Tmath_1660
TKI : TKV_c07380(bioB) TKV_c17490(pylB)
CHY : CHY_0889(bioB) CHY_2448
TXY : Thexy_0900 Thexy_2403
AAUT : ACETAC_02105(bioB) ACETAC_07585 ACETAC_08040(hydE)
MTHO : MOTHE_c17460(bioB2)
MTHZ : MOTHA_c18290(bioB2)
HALS : D7D81_05440(hydE) D7D81_08730(hydE) D7D81_09600(bioB)
IFN : GM661_02895(hydE) GM661_06165(hydE) GM661_06930(bioB)
AAR : Acear_1903 Acear_2037
HHL : Halha_0328 Halha_2623
COB : COB47_2173 COB47_2245
CHD : Calhy_0300 Calhy_2532
COW : Calow_2139 Calow_2204
CKI : Calkr_2183 Calkr_2520
CCHA : ELD05_01560(bioB) ELD05_12575(hydE)
CDIA : CaldiYA01_02670(bioB) CaldiYA01_23400
CNAG : OTJ99_000220(hydE) OTJ99_002210(bioB)
CDAN : SOJ16_002531(bioB) SOJ16_002654(hydE)
PHAR : NCTC13077_00407(bioB)
PIV : NCTC13079_00530(thiH_1)
PEQU : O6R05_04215(hydE) O6R05_06965(bioB)
CAD : Curi_c00860(bioB) Curi_c19190 Curi_c19230
CAZO : G3A45_04220(hydE) G3A45_10845(bioB)
SEDZ : JYG23_02275(hydE) JYG23_05345(bioB)
VAT : B7L28_01390 B7L28_08470
VRM : 44547418_00157(bioB_1) 44547418_00234(bioB_2)
VDN : NCTC11831_00145(bioB_1) NCTC11831_00200(bioB_2)
VNK : VEIT17_01440 VEIT17_02030(bioB)
VRG : OKW85_00820(hydE) OKW85_01145(bioB)
MHW : ACT01_04200 ACT01_07730
MEG : DKB62_07770(bioB) DKB62_08170
MMAX : LCQ47_02020(bioB) LCQ47_09630(hydE)
DHO : Dia5BBH33_16850(bioB_1) Dia5BBH33_16860(bioB_2) Dia5BBH33_16870(bioB_3)
SSG : Selsp_0442 Selsp_1568
SRI : SELR_19500 SELR_pSRC102540(bioB)
MFUN : GXM21_01740(hydE) GXM21_02240(bioB)
SGBI : P3F81_00075(bioB) P3F81_11835(hydE)
PUF : UFO1_0381 UFO1_0382 UFO1_1251
PFT : JBW_03021 JBW_04120 JBW_04241 JBW_04242
MANA : MAMMFC1_01043(bioB_1) MAMMFC1_04187(bioB_3)
STED : SPTER_05860 SPTER_23080(bioB_1) SPTER_23090(bioB_2)
AFN : Acfer_1415 Acfer_1537 Acfer_1846
AIN : Acin_1499(bioB) Acin_1540(bioB) Acin_2229(bioB)
PFAC : PFJ30894_00559(thiH_2) PFJ30894_02091(bioB)
AARG : Aargi30884_17370 Aargi30884_17380
ERM : EYR00_08875(hydE) EYR00_14725(bioB)
TSF : NQ543_05655(hydE) NQ543_09775(bioB)
XCL : G4Z02_00305(hydE) G4Z02_06380(hydE)
MCHI : AN480_15820 AN480_26875
MMAE : MMARE11_23090(bioB)
MHAD : B586_11125 B586_12840
MBAI : MB901379_02222(bioB)
MHEK : JMUB5695_02727(bioB)
MMAM : K3U93_07750 K3U93_10970(bioB) K3U93_21405(bioB)
MKY : IWGMT90018_33640(bioB)
MPHL : MPHLCCUG_02822(bioB)
MTHN : 4412656_02016(bioB)
MAUU : NCTC10437_02639(bioB)
MFLV : NCTC10271_02779(bioB)
MSAL : DSM43276_02382(bioB)
MTER : 4434518_02078(bioB)
CDI : DIP0105(bioB) DIP1124
CDP : CD241_0102(bioB) CD241_1035
CDH : CDB402_0069(bioB) CDB402_0999
CDT : CDHC01_0102(bioB) CDHC01_1035
CDE : CDHC02_0110(bioB) CDHC02_1034
CDR : CDHC03_0076(bioB) CDHC03_1029
CDA : CDHC04_0072(bioB) CDHC04_1040
CDZ : CD31A_0114(bioB) CD31A_1136
CDB : CDBH8_0110(bioB) CDBH8_1107
CDS : CDC7B_0068(bioB) CDC7B_1046
CDD : CDCE8392_0068(bioB) CDCE8392_1026
CDW : CDPW8_0074(bioB) CDPW8_1102
CDV : CDVA01_0069(bioB) CDVA01_0997
CDIP : ERS451417_00077(bioB_1) ERS451417_01039(bioB_2)
CPU : CPFRC_00310(bioB) CPFRC_04565(bioB)
CPL : Cp3995_0062(bioB) Cp3995_0922(bioB2)
CPG : CP316_00365(bioB) CP316_04705(bioB)
CPP : CpP54B96_0065(bioB) CpP54B96_0918(bioB2)
CPK : CP1002_00310(bioB) CP1002_08580(bioB)
CPQ : CPC231_00310(bioB) CPC231_04565(bioB)
CPX : CPI19_00310(bioB) CPI19_06955(bioB)
CPZ : CpPAT10_0061(bioB) CpPAT10_0904(bioB2)
COR : Cp267_0069(bioB) Cp267_0945(bioB2)
COP : CP31_00360(bioB) CP31_04935(bioB)
COD : Cp106_0060(bioB) Cp106_0891(bioB2)
COS : Cp4202_0060(bioB) Cp4202_0896(bioB2)
COI : CPCIP5297_00365(bioB) CPCIP5297_04725(bioB)
COE : CP258_00365(bioB) CP258_04720(bioB)
COU : CP162_00375(bioB) CP162_06550(bioB)
CPSE : CPTA_00585 CPTA_01471
CPSU : CPTB_00061 CPTB_00947
CPSF : CPTC_00609 CPTC_01463
CUL : CULC22_00089(bioB1) CULC22_00977(bioB2)
CUC : CULC809_00092(bioB1) CULC809_00962(bioB2)
CUE : CULC0102_0083(bioB1) CULC0102_1082(bioB2)
CUN : Cul210932_0094 Cul210932_1010(bioB)
CUQ : Cul210931_0091 Cul210931_0968(bioB)
CUZ : Cul05146_0088 Cul05146_1035(bioB)
CUJ : CUL131002_0085 CUL131002_0992c(bioB)
CUS : CulFRC11_0086 CulFRC11_0980(bioB)
CMIN : NCTC10288_02481(bioB)
CRF : FRC0190_00112 FRC0190_01094
CRL : NCTC7448_01590(bioB)
CSIL : CBE74_00420 CBE74_05500
NFR : ERS450000_02281(bioB)
NTP : CRH09_13065 CRH09_33985
NAH : F5544_15740(bioB) F5544_19340(bioB)
NAD : NCTC11293_02890(bioB)
NWL : NWFMUON74_47370(bioB)
NIE : KV110_12105(bioB) KV110_35625(bioB)
NSPU : IFM12276_43770(bioB)
RCR : NCTC10994_00124(bioB)
RANT : RHODO2019_09660(bioB)
TPUL : TPB0596_25930(bioB)
SLC : SL103_20855 SL103_22230
SAMB : SAM23877_1333(bioB)
SLE : sle_58320(sle_58320)
SGM : GCM10017557_71470(bioB)
SALJ : SMD11_5834(bioB) SMD11_6634(bioB)
STRO : STRMOE7_33185 STRMOE7_34885
STUI : GCM10017668_05690(bioB) GCM10017668_08420(bioB)
SGOB : test1122_26115(bioB)
SXT : KPP03845_101468(bioB)
SYUN : MOV08_05815(bioB) MOV08_24680 MOV08_33795
SCT : SCAT_0347(bioB) SCAT_p1299(bioB)
SCY : SCATT_03600 SCATT_p04250
PSUL : AU252_00610 AU252_22650
GCR : GcLGCM259_2432(bioB)
MICK : B1A86_00000875(bioB)
DCO : SAMEA4475696_1717(bioB)
PAK : HMPREF0675_4461(bioB)
CGRN : 4412665_01526(bioB)
PPC : HMPREF9154_1002(bioB)
RAIN : Rai3103_02665(bioB)
AGRA : AGRA3207_000632(bioB) AGRA3207_006021(bioB)
AMAZ : LUW76_05045(bioB) LUW76_37740(bioB)
ACIR : OG979_00265(bioB) OG979_08280(bioB)
ACTQ : OG417_14740(bioB) OG417_18695(bioB) OG417_42695
FRA : Francci3_3763 Francci3_4187
PBRO : HOP40_29340(bioB) HOP40_30210(bioB)
PPEL : H6H00_07130(bioB) H6H00_27310(bioB)
KPHY : AOZ06_06120 AOZ06_43530
MSAG : GCM10017556_42110(bioB)
ACTR : Asp14428_64390(bioB)
DROS : Drose_26230(bioB) Drose_29080(bioB)
GLY : K3N28_00490(bioB) K3N28_20705
BALA : DSM104299_04782(bioB)
PARN : NBH00_05530(bioB) NBH00_08295(bioB)
SBAE : DSM104329_05483(bioB)
SYR : SynRCC307_0793(bioB)
SYX : SynWH7803_1530(bioB)
SYH : Syncc8109_0995(BioB)
SYNW : SynWH8103_01067(bioB)
TVN : NIES2134_105760(bioB)
LET : O77CONTIG1_02427(bioB)
CHON : NIES4102_16750(bioB)
SYP : SYNPCC7002_A0309(bioB)
SYNN : NIES970_08690(bioB)
MVZ : myaer102_35240(bioB)
CYJ : Cyan7822_0260 Cyan7822_0356
PRUN : PCC7821_02086(bioB)
NPU : Npun_F6343 Npun_R5730
CALH : IJ00_18105 IJ00_23190
NSPH : BDGGKGIB_01060(bioB)
STAN : STA3757_46730(bioB)
GCY : LQF76_08225(bioB) LQF76_13235(hydE)
MBF : BHV42_05330 BHV42_08565
TNR : Thena_1513 Thena_1717
TACI : TDSAC_1034 TDSAC_1686
ABIW : Abiwalacus_13560(bioB)
VEG : SAMN05444156_1240 SAMN05444156_1675
MEAP : MTHMO_1126 MTHMO_1156(bioB)
VBS : EGM51_06755(hydE) EGM51_10910(bioB) EGM51_14155(bioB)
LCRE : Pla8534_45590(bioB)
KST : KSMBR1_2003(bioB_1) KSMBR1_3382(bioB_2)
PBAS : SMSP2_00164(bioB_1) SMSP2_02851(bioB_2)
ALUS : STSP2_01437(thiH_3) STSP2_02226(bioB)
VBL : L21SP4_01045(bioB_1) L21SP4_01857(bioB_2)
VBC : C5Q97_09485 C5Q97_15750(bioB)
TPI : TREPR_3668 TREPR_3777
TRC : DYE49_11380(hydE) DYE49_12145(bioB)
SSM : Spirs_2968 Spirs_3470
STA : STHERM_c12140 STHERM_c17990
STQ : Spith_0487 Spith_1256
BHY : BHWA1_00056(bioB) BHWA1_02062(bioB)
BHD : BHYOB78_02705 BHYOB78_05835
BPO : BP951000_0792(bioB) BP951000_2015
BPJ : B2904_orf1819(bioB) B2904_orf2182(bioB)
BPIP : BPP43_05075 BPP43_11165
BPW : WESB_0915(bioB) WESB_2110(bioB1)
BIP : Bint_1945 Bint_2637(bioB)
BHP : BHAMNSH16_01395 BHAMNSH16_08865
TAQU : KDW03_06830(bioB) KDW03_08630(hydE)
GEX : GETHOR_06650(bioB) GETHOR_22100
GEP : Q9293_04020(bioB) Q9293_13395(hydE)
MSIL : METEAL_08710(bioB) METEAL_23260 METEAL_27070
EPO : Epro_0228 Epro_1056(bioB)
FVA : FV113G1_12300 FV113G1_19420
FUL : C4N20_11985 C4N20_12720
FMO : C4N19_07750 C4N19_13060
FGO : C4N16_07300 C4N16_07445(hydE)
FNF : BSQ88_06915(bioB) BSQ88_07100(hydE)
FHO : H9Q81_00895(bioB) H9Q81_01105(hydE)
FPOL : ERS445057_01229(bioB)
IPO : Ilyop_0228 Ilyop_1780 Ilyop_2722
CSOM : MKD34_01990(bioB) MKD34_10700(hydE)
HABY : HLVA_14630(bioB) HLVA_18690
CPOR : BED41_07410 BED41_11485
ARAM : KAR29_00195(hydE) KAR29_12970(bioB)
FSU : Fisuc_0159 Fisuc_0621
FSC : FSU_0562 FSU_1052(bioB)
BTHO : Btheta7330_01175(bioB)
BCEL : BcellWH2_04993(thiH_2)
BFC : BacF7301_24090(hydE)
BDO : EL88_07255 EL88_21190
BDH : GV66_01980 GV66_15180
PCOP : I6J50_05950(hydE) I6J50_15145(bioB)
PAH : Poras_0212 Poras_0730
PCRE : NCTC12858_01239(bioB)
PCAG : NCTC12856_01354(bioB) NCTC12856_01485(thiH_2)
OSP : Odosp_0742 Odosp_2287
BUY : D8S85_03480(bioB) D8S85_08035(hydE)
BVIR : I6J59_12700(bioB) I6J59_16995(hydE)
BFH : F1611_07345(bioB) F1611_10660(hydE)
RBC : BN938_0062 BN938_2396
MCOS : GM418_19525(hydE) GM418_22515(hydE) GM418_29255
MBAS : ALGA_1051 ALGA_2637
PCM : AY601_0888 AY601_1807
SMIZ : 4412673_02528(bioB)
SDJ : NCTC13534_01505(bioB)
STHA : NCTC11429_02555(bioB)
PSEZ : HME7025_00506(bioB)
AALG : AREALGSMS7_00916(bioB)
KOS : KORDIASMS9_00708(bioB)
KAN : IMCC3317_33030(bioB)
SPON : HME9304_01190(bioB)
CGLE : NCTC11432_00684(bioB)
CTAK : 4412677_01526(bioB)
CHRJ : CHRYMOREF3P_0474(bioB)
KFA : Q73A0000_04065(bioB)
PTAN : CRYO30217_01625(bioB)
CPB : Cphamn1_0208 Cphamn1_2458
PROC : Ptc2401_02213(bioB)
PROS : CHL67_01000 CHL67_11390(bioB)
PROW : OO006_03575 OO006_13630(bioB)
PROI : OO005_03475 OO005_10775 OO005_12555(bioB)
DTE : Dester_0146 Dester_1067 Dester_1506
THR : TRQ7_02945 TRQ7_07995
DAP : Dacet_1024 Dacet_1713
CNI : Calni_0118 Calni_1516
FSI : Flexsi_0607 Flexsi_0782
TYE : THEYE_A0809(bioB) THEYE_A1718
MFE : Mefer_0991 Mefer_1526
MVU : Metvu_0026 Metvu_0267
MFS : MFS40622_0355 MFS40622_1390
MIF : Metin_0082 Metin_0672
MESG : MLAUSG7_0274 MLAUSG7_1346(bioB)
MESA : MLASG1_0955(bioB) MLASG1_1400
MMP : MMP0126(bioB) MMP1238(bioB)
MMQ : MmarC5_0353 MmarC5_1552
MMAK : MMKA1_01310 MMKA1_14130(bioB) MMKA1_14300(bioB) MMKA1_14470(bioB) MMKA1_14640(bioB)
MMAO : MMOS7_01570 MMOS7_13460(bioB)
MMAD : MMJJ_09600(bioB_1) MMJJ_16070(bioB_2)
MVN : Mevan_0552 Mevan_1131
MEIS : PXD04_05385 PXD04_08905(bioB)
MRU : mru_0527(bioB2) mru_2087(bioB1)
HJT : DVR14_17305(bioB) DVR14_21435(bioB)
» show all
Taxonomy
Reference
1
Authors
Trainor, D.A., Parry, R.J. and Gitterman, A.
Title
Biotin biosynthesis. 2. Stereochemistry of sulfur introduction at C-4 of dethiobiotin.
Journal
J Am Chem Soc 102:1467-1468 (1980)
Reference
Authors
Shiuan D, Campbell A.
Title
Transcriptional regulation and gene arrangement of Escherichia coli, Citrobacter freundii and Salmonella typhimurium biotin operons.
Journal
Sequence
Reference
Authors
Zhang S, Sanyal I, Bulboaca GH, Rich A, Flint DH
Title
The gene for biotin synthase from Saccharomyces cerevisiae: cloning, sequencing, and complementation of Escherichia coli strains lacking biotin synthase.
Journal
Sequence
Reference
Authors
Ugulava NB, Gibney BR, Jarrett JT.
Title
Biotin synthase contains two distinct iron-sulfur cluster binding sites: chemical and spectroelectrochemical analysis of iron-sulfur cluster interconversions.
Journal
Reference
Authors
Berkovitch F, Nicolet Y, Wan JT, Jarrett JT, Drennan CL.
Title
Crystal structure of biotin synthase, an S-adenosylmethionine-dependent radical enzyme.
Journal
Sequence
Reference
Authors
Lotierzo M, Tse Sum Bui B, Florentin D, Escalettes F, Marquet A.
Title
Biotin synthase mechanism: an overview.
Journal
Reference
Authors
Taylor AM, Farrar CE, Jarrett JT
Title
9-Mercaptodethiobiotin is formed as a competent catalytic intermediate by Escherichia coli biotin synthase.
Journal
Reference
Authors
Reyda MR, Fugate CJ, Jarrett JT
Title
A complex between biotin synthase and the iron-sulfur cluster assembly chaperone HscA that enhances in vivo cluster assembly.
Journal
Other DBs
ExplorEnz - The Enzyme Database: 2.8.1.6
ExPASy - ENZYME nomenclature database: 2.8.1.6
BRENDA, the Enzyme Database: 2.8.1.6