KEGG ENZYME: 2.8.2.32

ENZYME: 2.8.2.32

Entry

EC 2.8.2.32                 Enzyme

Name

scymnol sulfotransferase;
3'-phosphoadenylyl sulfate:5beta-scymnol sulfotransferase

Class

Transferases;
Transferring sulfur-containing groups;
Sulfotransferases

Sysname

3'-phosphoadenylyl sulfate:5beta-scymnol sulfonotransferase

Reaction(IUBMB)

3'-phosphoadenylyl sulfate + 5beta-scymnol = adenosine 3',5'-bisphosphate + 5beta-scymnol sulfate [RN:R07798]

Reaction(KEGG)

R07798

Substrate

3'-phosphoadenylyl sulfate [CPD:C00053];
5beta-scymnol [CPD:C16260]

Product

adenosine 3',5'-bisphosphate [CPD:C00054];
5beta-scymnol sulfate [CPD:C16261]

Comment

The enzyme from the shark Heterodontus portusjacksoni is able to sulfate the C27 bile salts 5beta-scymnol (the natural bile salt) and 5alpha-cyprinol (the carp bile salt). Enzyme activity is activated by Mg2+ but inhibited by the product 5beta-scymnol sulfate.

History

EC 2.8.2.32 created 2005

Reference

1 [PMID:7749614]

Authors

Macrides TA, Faktor DA, Kalafatis N, Amiet RG.

Title

Enzymic sulfation of bile salts. Partial purification and characterization of an enzyme from the liver of the shark Heterodontus portusjacksoni that catalyses the sulfation of the shark bile steroid 5 beta-scymnol.

Journal

Comp Biochem Physiol Biochem Mol Biol 107:461-9 (1994)
DOI:10.1016/0305-0491(94)90212-7

Reference

Authors

Pettigrew, N.E., Wright, P.F.A. and Macrides, T.A.

Title

Investigation of 5beta-scymnol sulfotransferase from the kidney and testes of Heterodontus portusjacksoni.

Journal

Comp Biochem Physiol 121:243-249 (1998)

Reference

Authors

Pettigrew, N.E., Wright, P.F.A. and Macrides, T.A.

Title

5beta-Scymnol sulfotransferase isolated from the tissues of an Australian shark species.

Journal

Comp Biochem Physiol 121:299-307 (1998)

Reference

Authors

Pettigrew, N.E., Wright, P.F.A. and Macrides, T.A.

Title

5beta-scymnol sulfotransferase isolated from the liver of two Australian ray species.

Journal

Comp Biochem Physiol 121:341-348 (1998)

Other DBs

ExplorEnz - The Enzyme Database:

2.8.2.32

IUBMB Enzyme Nomenclature:

2.8.2.32

ExPASy - ENZYME nomenclature database:

2.8.2.32

BRENDA, the Enzyme Database:

2.8.2.32

CAS:	220581-70-4

All links

Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (3)   
   KEGG REACTION (1)   
   KEGG RCLASS (2)   
All databases (7)   

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