KEGG   ENZYME: 2.8.2.35
Entry
EC 2.8.2.35                 Enzyme                                 
Name
dermatan 4-sulfotransferase;
dermatan-specific N-acetylgalactosamine 4-O-sulfotransferase;
dermatan-4-sulfotransferase-1;
dermatan-4-sulfotransferase 1;
D4ST-1;
dermatan N-acetylgalactosamine 4-O-sulfotransferase;
CHST14 protein;
CHST14;
3'-phospho-5'-adenylyl sulfate:[dermatan]-N-acetyl-D-galactosamine 4-sulfotransferase
Class
Transferases;
Transferring sulfur-containing groups;
Sulfotransferases
Sysname
3'-phospho-5'-adenylyl sulfate:[dermatan]-N-acetyl-D-galactosamine 4-sulfonotransferase
Reaction(IUBMB)
3'-phospho-5'-adenylyl sulfate + [dermatan]-N-acetyl-D-galactosamine = adenosine 3',5'-bisphosphate + [dermatan]-4-O-sulfo-N-acetyl-D-galactosamine [RN:R10873]
Reaction(KEGG)
R10873
Substrate
3'-phospho-5'-adenylyl sulfate [CPD:C00053];
[dermatan]-N-acetyl-D-galactosamine
Product
adenosine 3',5'-bisphosphate [CPD:C00054];
[dermatan]-4-O-sulfo-N-acetyl-D-galactosamine
Comment
The sulfation takes place at the 4-position of N-acetyl-D-galactosamine residues of dermatan. D4ST-1 shows a strong preference in vitro for sulfate transfer to IdoUAalpha(1,3)GalNAcbeta(1,4) that is flanked by GlcUAbeta(1,3)GalNAcbeta(1,4) as compared with IdoUAalpha(1,3)GalNAcbeta(1,4) flanked by IdoUAalpha(1,3)GalNAcbeta(1,4) [1].
History
EC 2.8.2.35 created 2010
Pathway
ec00532  Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate
Orthology
K08105  dermatan 4-sulfotransferase 1
Genes
HSA113189(CHST14)
PTR453336(CHST14)
PPS100974168(CHST14)
GGO101144190(CHST14)
PON100460562(CHST14)
NLE100582723(CHST14)
HMH116482153(CHST14)
MCC703115(CHST14)
MCF102144190(CHST14)
MTHB126959850
MNI105492211(CHST14)
CSAB103245830(CHST14)
CATY105574261(CHST14)
PANU101013593(CHST14)
TGE112628077(CHST14)
MLEU105546222(CHST14)
RRO104659660(CHST14)
RBB108523421(CHST14)
TFN117070867(CHST14)
PTEH111524264(CHST14)
CANG105504964(CHST14)
CJC100414908(CHST14)
SBQ101050993(CHST14)
CIMI108306151(CHST14)
CSYR103275311(CHST14)
MMUR105872445(CHST14)
LCAT123625427(CHST14)
PCOQ105814278(CHST14)
OGA100955240(CHST14)
MMU72136(Chst14)
MCAL110289629(Chst14)
MPAH110318491(Chst14)
RNO691394(Chst14)
MCOC116090705(Chst14)
ANU117702605(Chst14)
MUN110550582(Chst14)
CGE100753239(Chst14)
MAUA101840762(Chst14)
PROB127221638(Chst14)
PLEU114704635(Chst14)
MORG121465760(Chst14)
MFOT126496824
AAMP119814881(Chst14)
NGI103744909(Chst14)
HGL101712567(Chst14)
CPOC100715537(Chst14)
CCAN109700142(Chst14)
DORD105981015(Chst14)
DSP122114424(Chst14)
PLOP125340608(Chst14)
NCAR124976917
MMMA107137652(Chst14)
OCU100347170
OPI101519482(CHST14)
TUP102491092(CHST14)
GVR103588525(CHST14)
CFA608435(CHST14)
CLUD112676117(CHST14)
VVP112919859(CHST14)
VLG121476964(CHST14)
NPO129504188(CHST14)
AML100474523(CHST14)
UMR103673547(CHST14)
UAH113242031(CHST14)
UAR123775483(CHST14)
ELK111162118
LLV125105485
MPUF101677286(CHST14)
MNP131998700(CHST14)
MLK131836114(CHST14)
NVS122893733(CHST14)
ORO101371480(CHST14)
EJU114221268(CHST14)
ZCA113909586(CHST14)
MLX118003279(CHST14)
NSU110585343(CHST14)
LWW102739619(CHST14)
FCA101089445(CHST14)
PYU121024778(CHST14)
PCOO112856370(CHST14)
PBG122468773(CHST14)
LRUF124508094
PTG102960344(CHST14)
PPAD109263156(CHST14)
PUC125909860
AJU106968540
HHV120232194(CHST14)
BTA511245(CHST14)
BOM102276696(CHST14)
BIU109564936(CHST14)
BBUB102393351(CHST14)
BBIS104994405(CHST14)
CHX102171342(CHST14)
OAS101108574(CHST14)
BTAX128054357(CHST14)
ODA120853208(CHST14)
CCAD122443392(CHST14)
MBEZ129563210(CHST14)
SSC100520059(CHST14)
CFR102522609(CHST14)
CBAI105076897(CHST14)
CDK105096881(CHST14)
VPC102542526(CHST14)
BACU103015208(CHST14)
LVE103077004(CHST14)
OOR101279989(CHST14)
DLE111181571(CHST14)
PCAD102987315(CHST14)
PSIU116750008(CHST14)
NASI112391211(CHST14)
ECB100146378(CHST14)
EPZ103564234(CHST14)
EAI106830884(CHST14)
MYB102255542(CHST14)
MYD102756367(CHST14)
MMYO118649875(CHST14)
MLF102418156(CHST14)
MNA107542964(CHST14)
PKL118723572(CHST14)
EFUS103287314(CHST14)
HAI109384001(CHST14)
DRO112311570(CHST14)
SHON118993586(CHST14)
AJM119061311(CHST14)
PDIC114491774(CHST14)
PHAS123808396(CHST14)
MMF118636560(CHST14)
RFQ117022780(CHST14)
PPAM129064065(CHST14)
PALE102895029(CHST14)
PGIG120587183(CHST14)
PVP105288634(CHST14)
RAY107514526(CHST14)
MJV108401640(CHST14)
TOD119237910(CHST14)
SARA101551753(CHST14)
LAV100669698(CHST14)
TMU101348444
ETF101660181(CHST14)
DNM101438812(CHST14)
MDO100027325(CHST14)
GAS123235968(CHST14)
SHR100925127(CHST14)
AFZ127546267
PCW110223711(CHST14)
OAA114815913(CHST14)
GGA770193(CHST14)
PCOC116237815(CHST14)
MGP104910967(CHST14)
CJO107314214(CHST14)
TPAI128086581(CHST14)
LMUT125694317(CHST14)
NMEL110401234(CHST14)
APLA101789722(CHST14)
ACYG106047026(CHST14)
CATA118244768(CHST14)
AFUL116489494(CHST14)
TGU115495449(CHST14)
LSR110485081(CHST14)
SCAN103822305(CHST14)
PMOA120500977(CHST14)
OTC121335700(CHST14)
PRUF121354781(CHST14)
GFR102033127(CHST14)
FAB101817927(CHST14)
OMA130254505(CHST14)
PHI102102390(CHST14)
PMAJ107205280(CHST14)
CCAE111930367(CHST14)
CCW104693010(CHST14)
CBRC103624778(CHST14)
ETL114067990(CHST14)
ZAB102074739(CHST14)
ACHL103805823(CHST14)
SVG106854618(CHST14)
MMEA130583350(CHST14)
HRT120753803(CHST14)
FPG101924189(CHST14)
FCH102048313(CHST14)
CLV102086987(CHST14)
EGZ104130085(CHST14)
NNI104020544(CHST14)
PCRI104033740(CHST14)
PLET104621112(CHST14)
EHS104505933(CHST14)
ACUN113481028(CHST14)
TALA104368999(CHST14)
PADL103925201(CHST14)
AFOR103902632(CHST14)
ACHC115351625(CHST14)
HLE104829885(CHST14)
AGEN126047428 126047565
GCL127016394
CMAC104486694(CHST14)
MUI104541477(CHST14)
FGA104075203(CHST14)
LDI104355045(CHST14)
MNB103781330(CHST14)
SHAB115606968(CHST14)
PGUU104470684(CHST14)
ACAR104527610(CHST14)
CPEA104392101(CHST14)
AVIT104277710(CHST14)
CVF104293010(CHST14)
RTD128909525(CHST14)
CUCA104055687(CHST14)
AAM106486718(CHST14)
AROW112969674(CHST14)
NPD112952064(CHST14)
TGT104580075(CHST14)
DNE112992442(CHST14)
SCAM104141496(CHST14)
ASN102382545(CHST14)
AMJ102567038(CHST14)
CPOO109321487(CHST14)
GGN109299339(CHST14)
PSS102462445(CHST14)
CMY102945000(CHST14)
CCAY125638808(CHST14)
DCC119857923(CHST14)
CPIC101933563(CHST14)
TST117876883(CHST14)
CABI116837818(CHST14)
MRV120402862(CHST14)
ACS100563611(chst14)
ASAO132765087 132778515
PVT110091558(CHST14)
SUND121932534
PBI103049955(CHST14)
PMUR107292485(CHST14)
CTIG120320384(CHST14)
TSR106547025(CHST14)
PGUT117664964(CHST14)
APRI131196914(CHST14)
PTEX113437366(CHST14)
NSS113421525(CHST14)
VKO123035516(CHST14)
PMUA114585558(CHST14)
PRAF128402670(CHST14)
ZVI118097394(CHST14)
HCG128335804(CHST14) 128343038
GJA107113505(CHST14)
STOW125430182(CHST14)
EMC129328800(CHST14)
XLA108699261(chst14.L)
XTR100496179(chst14)
NPR108799094(CHST14)
RTEM120920547(CHST14)
BBUF120981829(CHST14)
BGAR122938443(CHST14)
MUO115480669(CHST14)
GSH117364799(CHST14)
DRE404732(chst14)
SRX107721361 107737336
SANH107665414 107683987
SGH107555762 107556138
CCAR109051416 109051417
CAUA113062921 113063186 113120968
CGIB127938293 127984551
PTET122325391(chst14)
LROH127182539(chst14)
OMC131527256(chst14)
PPRM120493669(chst14)
RKG130091805(chst14)
MAMB125277875(chst14)
CIDE127502153
MASI127415901 127456720
TROS130565832(chst14)
TDW130434358(chst14)
MANU129429333(chst14)
IPU108257907
IFU128601403(chst14)
PHYP113545322(chst14)
SMEO124376685(chst14)
TFD113642561(chst14)
TVC132843447(chst14)
AMEX103039455(chst14)
CMAO118815397(chst14)
EEE113586374(chst14)
CHAR105895060(chst14)
TRU101073313(chst14)
TFS130528966(chst14)
TNGGSTEN00032752G001
LCO104919098(chst14)
NCC104947083(chst14)
TBEN117495942(chst14)
CGOB115007120(chst14)
PGEO117445457(chst14)
GACU117555166(chst14)
ELY117254268(chst14)
EFO125895485(chst14)
PLEP121941051(chst14)
SLUC116058810(chst14)
ECRA117950165(chst14)
ESP116695627(chst14)
PFLV114562009(chst14)
GAT120824172(chst14)
PPUG119216569(chst14)
AFB129094811(chst14)
CLUM117729639(chst14)
MSAM119894649(chst14)
SCHU122877629(chst14)
CUD121511866(chst14)
ALAT119028436(chst14)
MZE101475363(chst14)
ONL109194385(chst14)
OAU116331050(chst14)
OLA101163891(chst14)
OML112136951(chst14)
XMA102234472(chst14)
XCO114151622(chst14)
XHE116726521(chst14)
PRET103463827(chst14)
PFOR103137105(chst14)
PLAI106963401(chst14)
PMEI106924110(chst14)
GAF122838578(chst14)
PPRL129375199(chst14)
CVG107091552(chst14)
CTUL119780626(chst14)
GMU124873308(chst14)
NFU107393406(chst14)
KMR108243380(chst14)
ALIM106533505(chst14)
NWH119430860(chst14)
AOCE111569592(chst14)
MCEP125009109(chst14)
CSEM103376694(chst14)
POV109625798(chst14)
SSEN122762462(chst14)
HHIP117760552(chst14)
HSP118121376(chst14)
LCF108879115
SDU111226386(chst14)
SLAL111644360(chst14)
XGL120790988(chst14)
HCQ109509816(chst14) 109531938
SSCV125994729
SBIA133503160(chst14)
PEE133406782(chst14)
PTAO133480899(chst14)
BPEC110154819(chst14)
MALB109962092(chst14)
BSPL114853054(chst14)
SJO128362116(chst14)
SASA106584126
STRU115192377
OTW112249207(chst14) 112251823
OMY110521680(chst14)
OGO124037866(chst14)
ONE115145140
OKI109898034
OKE118359027(chst14)
SALP111972325(chst14)
SNH120052590(chst14)
CCLU121533959 121540147
ELS105011847(chst14)
SFM108922740(chst14)
PKI111834745(chst14)
AANG118226546(chst14)
LOC102685514(chst14)
PSPA121298231(chst14) 121321872
ARUT117408979 117962415 117964072
PSEX120527458(chst14)
LCM102352110(CHST14)
CMK103178176(chst14)
RTP109932081
CPLA122550064(chst14)
HOC132819250(chst14)
LERI129697348(chst14)
PMRN116944660(CHST14)
LRJ133340504(CHST14)
BFO118418852 118418914 118419511
BBEL109470576 109477578 109487724
SCLV120345748
SPU115918502 594830
LPIC129260684 129272558 129280509 129280687 129281244
APLC110982416 110984100
AJC117102660
SKO100369274 100377013
PJA122251701 122267253
PCHN125029590 125044089
CQD128702778
PTRU123513250
HAZT108677641
GAE121375076 121375996 121387646
HRF124122293 124122331
HRJ124270120 124284355 124286545
CANU128160118
PMAX117330379 117331116 117331261 117331861
MMER123525561 123530092 123543360 123545014 123548793 123548795 123549850 123550094 123550468 123551983 123551993 123554238 123559763 123559814
OSN115214151
NVE116607440 116609250 5507697 5510750 5521879
EPA110238992
ATEN116288437
ADF107332762
AMIL114955404 114955419
PDAM113664665 113665176
SPIS111334426
DGT114523817 114524044 114524489 114524510
XEN124434836 124445724 124446126
AQU100635685
SPIZGJ672_00745
NAXHC341_17670
DAKDaAHT2_1087
SYESyncc9902_0456
SYNKKR100_13715
SYNRKR49_06610 KR49_06620
SYNDKR52_04975
SYWSYNW0391
 » show all
Reference
1  [PMID:11470797]
  Authors
Evers MR, Xia G, Kang HG, Schachner M, Baenziger JU
  Title
Molecular cloning and characterization of a dermatan-specific N-acetylgalactosamine 4-O-sulfotransferase.
  Journal
J Biol Chem 276:36344-53 (2001)
DOI:10.1074/jbc.M105848200
  Sequence
[hsa:113189]
Reference
2  [PMID:12847091]
  Authors
Mikami T, Mizumoto S, Kago N, Kitagawa H, Sugahara K
  Title
Specificities of three distinct human chondroitin/dermatan N-acetylgalactosamine 4-O-sulfotransferases demonstrated using partially desulfated dermatan sulfate as an acceptor: implication of differential roles in dermatan sulfate biosynthesis.
  Journal
J Biol Chem 278:36115-27 (2003)
DOI:10.1074/jbc.M306044200
  Sequence
[hsa:113189]
Reference
3  [PMID:19661164]
  Authors
Pacheco B, Maccarana M, Malmstrom A
  Title
Dermatan 4-O-sulfotransferase 1 is pivotal in the formation of iduronic acid blocks in dermatan sulfate.
  Journal
Glycobiology 19:1197-203 (2009)
DOI:10.1093/glycob/cwp110
  Sequence
[hsa:113189]
Reference
4  [PMID:16702220]
  Authors
Mitsunaga C, Mikami T, Mizumoto S, Fukuda J, Sugahara K
  Title
Chondroitin sulfate/dermatan sulfate hybrid chains in the development of cerebellum. Spatiotemporal regulation of the expression of critical disulfated disaccharides by specific sulfotransferases.
  Journal
J Biol Chem 281:18942-52 (2006)
DOI:10.1074/jbc.M510870200
  Sequence
[mmu:72136]
Other DBs
ExplorEnz - The Enzyme Database: 2.8.2.35
IUBMB Enzyme Nomenclature: 2.8.2.35
ExPASy - ENZYME nomenclature database: 2.8.2.35
BRENDA, the Enzyme Database: 2.8.2.35

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