Entry
Name
quorum-quenching N-acyl-homoserine lactonase;
acyl homoserine degrading enzyme;
acyl-homoserine lactone acylase;
AHL lactonase;
AHL-degrading enzyme;
AHL-inactivating enzyme;
AHLase;
AhlD;
AhlK;
AiiA;
AiiA lactonase;
AiiA-like protein;
AiiB;
AiiC;
AttM;
delactonase;
lactonase-like enzyme;
N-acyl homoserine lactonase;
N-acyl homoserine lactone hydrolase;
N-acyl-homoserine lactone lactonase;
N-acyl-L-homoserine lactone hydrolase;
quorum-quenching lactonase;
quorum-quenching N-acyl homoserine lactone hydrolase
Class
Hydrolases;
Acting on ester bonds;
Carboxylic-ester hydrolases
BRITE hierarchy
Sysname
N-acyl-L-homoserine-lactone lactonohydrolase
Reaction(IUBMB)
an N-acyl-L-homoserine lactone + H2O = an N-acyl-L-homoserine [RN:
R08970 ]
Reaction(KEGG)
Substrate
Product
N-acyl-L-homoserine [CPD:
C18061 ]
Comment
Acyl-homoserine lactones (AHLs) are produced by a number of bacterial species and are used by them to regulate the expression of virulence genes in a process known as quorum-sensing. Each bacterial cell has a basal level of AHL and, once the population density reaches a critical level, it triggers AHL-signalling which, in turn, initiates the expression of particular virulence genes [5]. Plants or animals capable of degrading AHLs would have a therapeutic advantage in avoiding bacterial infection as they could prevent AHL-signalling and the expression of virulence genes in quorum-sensing bacteria [5]. N-(3-Oxohexanoyl)-L-homoserine lactone, N-(3-oxododecanoyl)-L-homoserine lactone, N-butanoyl-L-homoserine lactone and N-(3-oxooctanoyl)-L-homoserine lactone can act as substrates [5].
History
EC 3.1.1.81 created 2007
Orthology
K13075 N-acyl homoserine lactone hydrolase
Genes
CLAP : NCTC11466_02926(attM)
METY : MRY16398_32520(attM)
PAY : PAU_00481(attM_aiiB)
THIO : AYJ59_03215 AYJ59_04185
HAA : A5892_09070 A5892_17280
OME : OLMES_3818 OLMES_5075
CABA : SBC2_54240(Y2-aiiA)
AXX : ERS451415_03553(aiiA)
PMOB : HG718_00815 HG718_07845
RBS : RHODOSMS8_01313(attM)
ATU : Atu5139(blcC) Atu6071(aiiB)
ASAL : CFBP5507_26510(aiiB)
REI : IE4771_PA00052 IE4771_PA00104
RAD : CO657_23030 CO657_24210
NEN : NCHU2750_42650(ahlD) NCHU2750_56090(ahlD)
BRK : CWS35_03875 CWS35_16040
BGQ : X265_11435 X265_21605
BARH : WN72_05325 WN72_28110
BRAZ : LRP30_08795 LRP30_22805
VGO : GJW-30_1_04057(attM)
LNE : FZC33_12205 FZC33_28280
NOH : G5V57_06135 G5V57_11710
TSV : DSM104635_03525(attM)
RUA : D1823_02475 D1823_15625
RUT : FIU92_00175(Y2-aiiA2)
PARS : DRW48_00680 DRW48_13555
SLUT : H9L13_03565 H9L13_03570 H9L13_03575
BLAS : BSY18_172 BSY18_3630
PARJ : J4G78_13280 J4G78_16865
NAO : Y958_04520 Y958_08145
HTQ : FRZ44_05690(aiiB) FRZ44_30590
HADH : FRZ61_05830(aiiB) FRZ61_16910
DAL : Dalk_4155 Dalk_4159 Dalk_4372
DWD : DSCW_00660 DSCW_20330(attM) DSCW_45610
DTI : Desti_1606 Desti_4075
TAV : G4V39_09295 G4V39_10870
MSD : MYSTI_04124 MYSTI_07968
MFB : MFUL124B02_22285 MFUL124B02_42265
CCX : COCOR_00758(attM) COCOR_02803
AVM : JQX13_05950 JQX13_42120 JQX13_44885 JQX13_45550
MBD : MEBOL_005799 MEBOL_006523
CFUS : CYFUS_001667 CYFUS_001972 CYFUS_005958
VIN : AKJ08_2026 AKJ08_2865
SCU : SCE1572_13090 SCE1572_29490
CCRO : CMC5_044670 CMC5_056820(attM)
MRM : A7982_02369 A7982_02843 A7982_07123
BMYO : BG05_2551(aiiA) BG05_5611(aiiA)
PARG : PspKH34_20780(aiiB)
BSJ : UP17_03120 UP17_10830
SPAS : STP1_1768 STP1_1900
SXO : SXYL_00255 SXYL_00306
SKL : C7J89_00500 C7J89_03140
SPIC : SAMEA4384060_0114(aiiB)
SSIM : SAMEA4384339_1823(attM)
SPSD : JMB28_01800 JMB28_02030
PPM : PPSC2_13265(hagH) PPSC2_17265
PPO : PPM_2544(hagH) PPM_3486(M1_3854)
PPQ : PPSQR21_026340 PPSQR21_026350 PPSQR21_034830
PPOY : RE92_19835 RE92_23535
PPEO : ABE82_13725 ABE82_14430
PNP : IJ22_27240 IJ22_49610
PPAB : KET34_18105 KET34_18655
AFX : JZ786_15010 JZ786_19905 JZ786_21015 JZ786_22095 JZ786_22580
AACO : K1I37_05175 K1I37_10865
ACUR : JZ785_22200 JZ785_24190
ADAU : NZD86_00495 NZD86_04955
AFAS : NZD89_12260 NZD89_12285
EFF : skT53_05220(aiiB) skT53_05940(attM) skT53_09640
PMAR : B0X71_08685 B0X71_18390 B0X71_20035
CBEI : LF65_02416 LF65_02694
CSR : Cspa_c42350 Cspa_c54480
CDY : F3K33_10500 F3K33_14035
CGAS : J1C67_08845 J1C67_16375
OBJ : EIO64_15410 EIO64_15415
PETR : QKW49_15715 QKW49_20625
DKU : Desku_0586 Desku_3080
CBOL : CGC65_04025 CGC65_23690
ETM : CE91St48_33730(aiiB)
MPHL : MPHLCCUG_01980(aiiA_2)
MAUU : NCTC10437_01927(aiiA_1) NCTC10437_02782(aiiA_2)
NFR : ERS450000_04269(attM)
NIE : KV110_16495 KV110_40815
ROA : Pd630_LPD07236 Pd630_LPD07276 Pd630_LPD07368 Pd630_LPD07369
SVL : Strvi_4414 Strvi_6072
SCI : B446_00045 B446_35245
SCAD : DN051_08200 DN051_39300
CPHY : B5808_17390 B5808_20135
ARZ : AUT26_08450 AUT26_19585
ALX : LVQ62_00795 LVQ62_13030
MICG : GJV80_07140 GJV80_19510
NMES : H9L09_10940 H9L09_15815
MMAR : MODMU_1792 MODMU_2622(attM)
PDX : Psed_2242 Psed_5982 Psed_6016 Psed_6463
PSEE : FRP1_08015 FRP1_11665
PSEQ : AD006_15575 AD006_19305
PECQ : AD017_23415 AD017_27145
ACTY : OG774_05405 OG774_14465
ACTN : L083_6939 L083_8055
PSUU : Psuf_061570 Psuf_067510
RXY : Rxyl_0540 Rxyl_2378 Rxyl_3043
RUB : GBA63_04295 GBA63_04620
BSOL : FSW04_00045 FSW04_25385
BALA : DSM104299_02114(attM)
KBS : EPA93_02005 EPA93_03205 EPA93_04185 EPA93_06405 EPA93_07275 EPA93_15680 EPA93_34155 EPA93_34565 EPA93_39080
KBB : ccbrp13_00520 ccbrp13_19580 ccbrp13_46690 ccbrp13_48900
PMET : G4Y79_06015 G4Y79_09250
TACI : TDSAC_0048 TDSAC_1688
GPH : GEMMAAP_00645 GEMMAAP_17005
SDJ : NCTC13534_03077(attM)
TYE : THEYE_A1583 THEYE_A1635
HJE : HacjB3_03490 HacjB3_04910
SSAI : N0B31_04330 N0B31_10095
HGI : ABY42_05455 ABY42_06705
HAQ : DU484_01940 DU484_14995
HAJ : DU500_02345 DU500_15025
SRUB : C2R22_08740 C2R22_10895 C2R22_24295
HSAL : JMJ58_01085 JMJ58_02230
NOU : Natoc_0585 Natoc_4249
HLR : HALLA_07525 HALLA_11185
NAJ : B1756_05050 B1756_18310
NAG : AArcMg_0836 AArcMg_1223
NAN : AArc1_2394 AArc1_2747
TVO : TVG1350001(TVG1350001)
SCAS : SACC_13970 SACC_26990
SIM : M1627_0473 M1627_0845
SIN : YN1551_2055 YN1551_2106
SULO : GFS33_10715 GFS33_10760
SACD : HS1genome_1991 HS1genome_2193
» show all
Taxonomy
Reference
Authors
Thomas PW, Stone EM, Costello AL, Tierney DL, Fast W.
Title
The quorum-quenching lactonase from Bacillus thuringiensis is a metalloprotein.
Journal
Reference
Authors
Dong YH, Gusti AR, Zhang Q, Xu JL, Zhang LH
Title
Identification of quorum-quenching N-acyl homoserine lactonases from Bacillus species.
Journal
Sequence
Reference
Authors
Wang LH, Weng LX, Dong YH, Zhang LH.
Title
Specificity and enzyme kinetics of the quorum-quenching N-Acyl homoserine lactone lactonase (AHL-lactonase).
Journal
Reference
Authors
Dong YH, Xu JL, Li XZ, Zhang LH.
Title
AiiA, an enzyme that inactivates the acylhomoserine lactone quorum-sensing signal and attenuates the virulence of Erwinia carotovora.
Journal
Reference
Authors
Dong YH, Wang LH, Xu JL, Zhang HB, Zhang XF, Zhang LH.
Title
Quenching quorum-sensing-dependent bacterial infection by an N-acyl homoserine lactonase.
Journal
Reference
Authors
Lee SJ, Park SY, Lee JJ, Yum DY, Koo BT, Lee JK.
Title
Genes encoding the N-acyl homoserine lactone-degrading enzyme are widespread in many subspecies of Bacillus thuringiensis.
Journal
Sequence
Reference
Authors
Park SY, Lee SJ, Oh TK, Oh JW, Koo BT, Yum DY, Lee JK
Title
AhlD, an N-acylhomoserine lactonase in Arthrobacter sp., and predicted homologues in other bacteria.
Journal
Sequence
Reference
Authors
Ulrich RL.
Title
Quorum quenching: enzymatic disruption of N-acylhomoserine lactone-mediated bacterial communication in Burkholderia thailandensis.
Journal
Reference
Authors
Kim MH, Choi WC, Kang HO, Lee JS, Kang BS, Kim KJ, Derewenda ZS, Oh TK, Lee CH, Lee JK.
Title
The molecular structure and catalytic mechanism of a quorum-quenching N-acyl-L-homoserine lactone hydrolase.
Journal
Sequence
Reference
Authors
Liu D, Lepore BW, Petsko GA, Thomas PW, Stone EM, Fast W, Ringe D.
Title
Three-dimensional structure of the quorum-quenching N-acyl homoserine lactone hydrolase from Bacillus thuringiensis.
Journal
Sequence
Reference
Authors
Yang F, Wang LH, Wang J, Dong YH, Hu JY, Zhang LH.
Title
Quorum quenching enzyme activity is widely conserved in the sera of mammalian species.
Journal
Other DBs
ExplorEnz - The Enzyme Database: 3.1.1.81
ExPASy - ENZYME nomenclature database: 3.1.1.81