| Entry |
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| Name |
exodeoxyribonuclease (lambda-induced);
lambda exonuclease;
phage lambda-induced exonuclease;
Escherichia coli exonuclease IV;
E. coli exonuclease IV;
exodeoxyribonuclease IV;
exonuclease IV
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| Class |
Hydrolases;
Acting on ester bonds;
Exodeoxyribonucleases producing 5'-phosphomonoesters
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| Reaction(IUBMB) |
Exonucleolytic cleavage in the 5'- to 3'-direction to yield nucleoside 5'-phosphates
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| Comment |
Preference for double-stranded DNA. Does not attack single-strand breaks.
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| History |
EC 3.1.11.3 created 1972 as EC 3.1.4.28, transferred 1978 to EC 3.1.11.3
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| Orthology |
| K01143 | Enterobacteriaceae phage exonuclease |
| K21526 | Autographiviridae exonuclease |
| K27376 | Demerecviridae flap endonuclease |
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| Reference |
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| Authors |
Lindahl T, Gally JA, Edelman GM. |
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| Title |
Deoxyribonuclease IV: a new exonuclease from mammalian tissues. |
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| Journal |
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| Reference |
|
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| Authors |
Little JW. |
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| Title |
An exonuclease induced by bacteriophage lambda. II. Nature of the enzymatic reaction. |
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| Journal |
J Biol Chem 242:679-86 (1967) |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 3.1.11.3 |
| ExPASy - ENZYME nomenclature database: | 3.1.11.3 |
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