KEGG   ENZYME: 3.1.2.18
Entry
EC 3.1.2.18                 Enzyme                                 
Name
ADP-dependent short-chain-acyl-CoA hydrolase;
short-chain acyl coenzyme A hydrolase;
propionyl coenzyme A hydrolase;
propionyl-CoA hydrolase;
propionyl-CoA thioesterase;
short-chain acyl-CoA hydrolase;
short-chain acyl-CoA thioesterase
Class
Hydrolases;
Acting on ester bonds;
Thioester hydrolases
Sysname
ADP-dependent-short-chain-acyl-CoA hydrolase
Reaction(IUBMB)
acyl-CoA + H2O = CoA + a carboxylate [RN:R00383]
Reaction(KEGG)
R00383
Substrate
acyl-CoA [CPD:C00040];
H2O [CPD:C00001]
Product
CoA [CPD:C00010];
carboxylate [CPD:C00060]
Comment
Requires ADP; inhibited by NADH. Maximum activity is shown with propanoyl-CoA.
History
EC 3.1.2.18 created 1992
Reference
1  [PMID:2901416]
  Authors
Alexson SE, Nedergaard J.
  Title
A novel type of short- and medium-chain acyl-CoA hydrolases in brown adipose tissue mitochondria.
  Journal
J Biol Chem 263:13564-71 (1988)
Reference
2  [PMID:2570608]
  Authors
Alexson SE, Svensson LT, Nedergaard J.
  Title
NADH-sensitive propionyl-CoA hydrolase in brown-adipose-tissue mitochondria of the rat.
  Journal
Biochim Biophys Acta 1005:13-9 (1989)
DOI:10.1016/0005-2760(89)90025-8
Other DBs
ExplorEnz - The Enzyme Database: 3.1.2.18
IUBMB Enzyme Nomenclature: 3.1.2.18
ExPASy - ENZYME nomenclature database: 3.1.2.18
BRENDA, the Enzyme Database: 3.1.2.18
CAS: 117698-16-5

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Chemical substance (4)   
   KEGG COMPOUND (4)   
Chemical reaction (3)   
   KEGG REACTION (1)   
   KEGG RCLASS (2)   
Protein sequence (15)   
   UniProt (14)   
   RefSeq(pep) (1)   
DNA sequence (53)   
   RefSeq(nuc) (1)   
   GenBank (26)   
   EMBL (26)   
All databases (75)   

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