KEGG ENZYME: 3.1.2.21

ENZYME: 3.1.2.21

Entry

EC 3.1.2.21                 Enzyme

Name

dodecanoyl-[acyl-carrier-protein] hydrolase;
lauryl-acyl-carrier-protein hydrolase;
dodecanoyl-acyl-carrier-protein hydrolase;
dodecyl-acyl-carrier protein hydrolase;
dodecanoyl-[acyl-carrier protein] hydrolase;
dodecanoyl-[acyl-carrier-protein] hydrolase

Class

Hydrolases;
Acting on ester bonds;
Thioester hydrolases

Sysname

dodecanoyl-[acyl-carrier protein] hydrolase

Reaction(IUBMB)

a dodecanoyl-[acyl-carrier protein] + H2O = an [acyl-carrier protein] + dodecanoate [RN:R04014]

Reaction(KEGG)

R04014;
(other) R08157 R08158 R12329

Substrate

dodecanoyl-[acyl-carrier protein] [CPD:C05223];
H2O [CPD:C00001]

Product

[acyl-carrier protein] [CPD:C00229];
dodecanoate [CPD:C02679]

Comment

Acts on the acyl-carrier-protein thioester of C12 and, with a much lower activity, C14 fatty acids. The derivative of oleic acid is hydrolysed very slowly (cf. EC 3.1.2.14, oleoyl-[acyl-carrier-protein] hydrolase).

History

EC 3.1.2.21 created 1999

Pathway

ec00061

Fatty acid biosynthesis

ec01100

Metabolic pathways

Orthology

K01071

medium-chain acyl-[acyl-carrier-protein] hydrolase

K10781

fatty acyl-ACP thioesterase B

Genes

HSA:	55301(OLAH)

PTR:	450320(OLAH)

PPS:	100969629(OLAH)

PON:	100441345(OLAH)

NLE:	100601676(OLAH)

HMH:	116473822(OLAH)

MCC:

697753

MCF:	102142933(OLAH)

MTHB:

126962398 126962958

MNI:	105468343 105490647(OLAH)

CSAB:

103237931(OLAH)

CATY:

105583885(OLAH) 105584580

PANU:

101003297(OLAH)

TGE:	112631348(OLAH)

MLEU:

105530558(OLAH)

RRO:	104664475(OLAH)

RBB:	108530852(OLAH)

TFN:	117082669(OLAH)

PTEH:

111550042(OLAH)

CANG:

105506223(OLAH)

CJC:	100402846(OLAH)

SBQ:	101043966(OLAH)

CIMI:

108305185(OLAH)

CSYR:

103267724(OLAH)

MMUR:

105856354(OLAH)

LCAT:

123625433(OLAH)

PCOQ:

105823702(OLAH)

OGA:	100963077(OLAH)

MMU:	99035(Olah)

MCAL:

110290252(Olah)

MPAH:

110334162(Olah)

RNO:	64669(Olah)

MCOC:

116082275(Olah)

ANU:	117714040(Olah)

MUN:	110564304(Olah)

CGE:	100755723(Olah)

MAUA:

101830993(Olah)

PROB:

127237520(Olah)

PLEU:

114710817(Olah)

MORG:

121432539(Olah)

MFOT:

126506768

AAMP:

119817836(Olah)

NGI:	103735189(Olah)

HGL:	101699165(Olah)

CPOC:

100730585(Olah)

DORD:

105984432(Olah)

DSP:	122113237(Olah)

PLOP:

125367175(Olah)

NCAR:

124962152

MMMA:

107140257(Olah)

OCU:

100349940

OPI:	101536726(OLAH)

TUP:	102488474(OLAH)

GVR:	103608020(OLAH)

BTA:	617347(OLAH)

BOM:	102273387(OLAH)

BIU:	109567605(OLAH)

BBUB:

102413725(OLAH)

BBIS:

105003035(OLAH)

CHX:	102180055(OLAH)

OAS:	101116669(OLAH)

ODA:	120868612(OLAH)

CCAD:

122448461

MBEZ:

129558232(OLAH)

SSC:	100627446(OLAH)

CFR:	102522778(OLAH)

CBAI:

105072476(OLAH)

VPC:	102529434(OLAH)

BACU:

103001653(OLAH)

PCAD:

102991368(OLAH)

ECB:	100068833(OLAH)

EPZ:	103556832(OLAH)

EAI:	106840468(OLAH)

MYB:	102239550(OLAH)

MYD:	102759672(OLAH)

MMYO:

118655462(OLAH)

MLF:	102436487(OLAH)

PKL:	118719611(OLAH)

EFUS:

103292622(OLAH)

MNA:	107534813(OLAH)

DRO:	112320938(OLAH)

PDIC:

114491925(OLAH)

PHAS:

123831089(OLAH)

MMF:	118643242(OLAH)

PPAM:

129084763(OLAH)

HAI:	109393805(OLAH)

RFQ:	117019110(OLAH)

PGIG:

120614701(OLAH)

PVP:	105291715(OLAH)

RAY:	107504822(OLAH)

TOD:	119245273(OLAH)

SARA:

101551105(OLAH)

LAV:	100675942(OLAH)

TMU:

101361105

ETF:	101651008(OLAH)

DNM:	101415627(OLAH)

MDO:	100027206(OLAH)

GAS:	123249804(OLAH)

SHR:	100914322(OLAH)

AFZ:

127564857

PCW:	110209026(OLAH)

OAA:	100077700(OLAH)

GGA:	420532(OLAH)

PCOC:

116243282(OLAH)

MGP:	100547884(OLAH)

CJO:	107309023(OLAH)

TPAI:

128086388(OLAH)

LMUT:

125695997(OLAH)

NMEL:

110393652(OLAH)

APLA:

101793583(OLAH)

ACYG:

106039692(OLAH)

CATA:

118247444(OLAH)

AFUL:

116485827(OLAH)

TGU:	100224799(OLAH)

LSR:	110482463(OLAH)

SCAN:

103813106(OLAH)

PMOA:

120503875(OLAH)

OTC:	121338143(OLAH)

PRUF:

121353101(OLAH)

GFR:	102031766(OLAH)

FAB:	101815966(OLAH)

OMA:	130248929(OLAH)

PHI:	102106226(OLAH)

PMAJ:

107198685(OLAH)

CCAE:

111924181(OLAH)

CCW:	104689201(OLAH)

CBRC:

103612339(OLAH)

ETL:	114065102(OLAH)

ZAB:	102074087(OLAH)

ACHL:

103804692(OLAH)

SVG:	106852799(OLAH)

MMEA:

130583645(OLAH)

HRT:	120749960(OLAH)

FPG:	101922325(OLAH)

FCH:	102058635(OLAH)

CLV:	102084717(OLAH)

EGZ:	104128444(OLAH)

NNI:	104022905(OLAH)

PCRI:

104026616(OLAH)

PLET:

104625413(OLAH)

EHS:	104502497(OLAH)

PCAO:

104047264(OLAH)

ACUN:

113477405(OLAH)

TALA:

104358957(OLAH)

PADL:

103922402(OLAH)

AFOR:

103895942(OLAH)

ACHC:

115339272(OLAH)

AGEN:

126037952

GCL:

127013650

CCRI:

104158046(OLAH)

CSTI:

104561432(OLAH)

CMAC:

104487451(OLAH)

MUI:	104533426(OLAH)

BREG:

104629022(OLAH)

FGA:	104069112(OLAH)

GSTE:

104258972(OLAH)

LDI:	104339726(OLAH)

MNB:	103776212(OLAH)

OHA:	104332535(OLAH)

NNT:	104412137(OLAH)

SHAB:

115612550(OLAH)

DPUB:

104307001(OLAH)

PGUU:

104467261(OLAH)

ACAR:

104528435(OLAH)

CPEA:

104394074(OLAH)

AVIT:

104267019(OLAH)

CVF:	104289933(OLAH)

RTD:	128905594(OLAH)

TEO:	104383546(OLAH)

AAM:	106483605(OLAH)

AROW:

112967012(OLAH)

NPD:	112947374(OLAH)

TGT:	104580897(OLAH)

DNE:	112982319(OLAH)

SCAM:

104144105(OLAH)

ASN:	102386110(OLAH)

AMJ:	102557880(OLAH)

CPOO:

109308412(OLAH)

GGN:	109291372(OLAH)

PSS:	102454966(OLAH)

CMY:	102930778(OLAH)

CCAY:

125630824(OLAH)

DCC:	119852288(OLAH)

CPIC:

101937274(OLAH)

CABI:

116840020(OLAH)

MRV:	120397059(OLAH)

XLA:	108718823(olah.L)

XTR:	407865(olah)

NPR:	108795592(OLAH)

RTEM:

120939957(OLAH)

BBUF:

121002900(OLAH)

BGAR:

122939021(OLAH)

MUO:	115460090 115468269

GSH:	117354191(OLAH)

DRE:	568096(olah)

SRX:	107739590 107748745

SANH:

107656617 107693288

SGH:	107589366 107599545

CCAR:

109111875

CAUA:

113120148(olah)

CGIB:

127979255

PTET:

122323400(olah)

LROH:

127181777(olah)

OMC:	131525541(olah)

PPRM:

120483503(olah)

RKG:	130097357(olah)

MAMB:

125275314(olah)

CIDE:

127500761

MASI:

127421544 127424983

TROS:

130566826(olah)

TDW:	130416077(olah)

MANU:

129455720(olah)

IPU:	100528864(olah)

IFU:	128616237(olah)

PHYP:

113534943(olah)

SMEO:

124382229(olah)

TFD:	113641319(olah)

TVC:	132842898(olah)

AMEX:

103035172(olah)

CMAO:

118806058(olah)

EEE:	113578374(olah)

CHAR:

105902009(olah)

TRU:	101061874(olah)

TFS:	130518146(olah)

TNG:	GSTEN00003671G001

LCO:	104928057(olah)

TBEN:

117477937(olah)

CGOB:

115015784(olah)

PGEO:

117455010(olah)

GACU:

117559292(olah)

EMAC:

134874876(olah)

ELY:	117263941(olah)

EFO:	125904844(olah)

PLEP:

121958300(olah)

SLUC:

116047173(olah)

ECRA:

117957244(olah)

ESP:	116702048(olah)

PFLV:

114567813(olah)

GAT:	120826636(olah)

PPUG:

119218896(olah)

AFB:	129097144(olah)

CLUM:

117739549(olah)

PSWI:

130208926(olah)

MSAM:

119908035(olah)

SCHU:

122864998(olah)

CUD:	121524056(olah)

ALAT:

119016758(olah)

MZE:	101474377(olah)

ONL:	100691905(olah)

OAU:	116318887(olah)

OLA:	101160493(olah)

OML:	112161056(olah)

CSAI:

133460604 133460605

XMA:	102216960(olah)

XCO:	114155297(olah)

XHE:	116730514(olah)

PRET:

103473026(olah)

PFOR:

103143486(olah)

PLAI:

106946895(olah)

PMEI:

106927639(olah)

GAF:	122844276(olah)

PPRL:

129375918(olah)

CVG:	107098937(olah)

CTUL:

119771383(olah)

GMU:	124879812(olah)

NFU:	107394887(olah)

KMR:	108228836(olah)

ALIM:

106530105(olah)

NWH:	119425964(olah)

AOCE:

111586624(olah)

MCEP:

125020273(olaH)

CSEM:

103393954(olah)

POV:	109643703(olah)

SSEN:

122786240(olah)

HHIP:

117770252(olah)

HSP:	118124551(olah)

SMAU:

118291619(olah)

LCF:

108899375

SDU:	111230514(olah)

SLAL:

111661082(olah)

XGL:	120786826(olah)

HCQ:	109513606(olah)

SSCV:

125987375

SBIA:

133492458(olah)

PEE:	133395360(olah)

PTAO:

133470835(olah)

BPEC:

110168928(olah)

MALB:

109958738(olah)

BSPL:

114865427(olah)

SJO:	128373769(olah)

SASA:

100196232(olah)

STRU:

115173388(olah)

OTW:	112264938(olah)

OMY:	100301766(olah)

OGO:	124013211(olah)

ONE:	115128270(olah)

OKI:	109907629(olah)

OKE:	118399180(olah)

SALP:

111956208(olah)

SNH:	120022734(olah)

CCLU:

121586277(olah)

ELS:	105009858(olah)

SFM:	108933393(olah)

PKI:	111834098(olah)

AANG:

118234258(olah)

LOC:	102684274(olah)

PSPA:

121313185(olah)

ARUT:

117400293(olah)

PSEX:

120515463(olah)

LCM:	102354603(OLAH)

CMK:	103181559(olah)

CPLA:

122549991

HOC:	132816103(olah)

LERI:

129709353(olah)

BFO:

118407981

BBEL:

109478146

SPU:

582714

LPIC:

129275205

APLC:

110974650 110977368

AJC:

117109975

LGI:	LOTGIDRAFT_184680

PVUL:

126815866

PCAN:

112565315

BGT:

106061994

GAE:

121384619

HRF:

124138500

HRJ:

124267554

CRG:

105339010

CVN:

111124570

CANU:

128191508

OED:

125678620

MYI:

110445787

PMAX:

117329480

MCAF:

127714981

MMER:

123557628

RPHI:

132734153

DPOL:

127877749

LAK:	106152278 106181168

NVE:

5513765

EPA:

110234691

ATEN:

116297757

PDAM:

113679240

SPIS:

111321809

ATH:	AT1G08510(FATB)

ALY:

9325763

CRB:

17897852

CSAT:

104739442 104755032 104766704

EUS:	EUTSA_v10007761mg

BRP:	103836386 103843393 103871592

BNA:	106346329 106362292 106377030 106383116 106415535 106420175

BOE:	106295830 106312522 106312734

RSZ:	108805233 108823083 108861314 130509222

THJ:	104809019 104826529

CPAP:

110823017

CIT:	102577983(FATB) 102623135

CIC:	CICLE_v10008435mg CICLE_v100336872m

PVY:	116105440 116118105 116118107 116121683 116121693 116121983 116124154 116143815

MINC:

123195058 123217660 123218962 123227893

TCC:	18588657 18595859 18605136

GRA:	105765848 105771957 105773608 105781329 105792884

GHI:	107901209 107902762 107930856 107932089 107932873 107933005 107938815 107939491 107962656

GAB:	108451200 108461691 108470202 108473564 108486625

HSYR:

120117613 120144613 120144624 120144661 120149811 120149877 120159265 120164707 120166267 120176735 120197279 120211819

DZI:	111284999 111290330 111299072 111303232 111303822

EGR:	104416677 104436629 104438474

GMX:	100170693(FAT1) 100781381 100787680(FATB1B) 100791281 100791811 100795014 100797796 100814191

GSJ:	114393555 114408211 114409600 114409960 114411725 114414050 114416123 114416682

PVU:	PHAVU_003G176200g PHAVU_009G164200g PHAVU_009G164800g PHAVU_009G200200g

VRA:	106756605 106760302 106761669 106768841

VAR:	108320727 108330264 108330613 108331107

VUN:	114162762 114163002 114178102 114196246

VUM:	124820729 124834898 124840550 124840552

CCAJ:

109792425 109796024 109808042 109813179 109818220

APRC:

113845895 113845962 113868476 113868495 113868516

MTR:	112419006 11419965 11445423

TPRA:

123884572 123918013 123921695

CAM:	101502796 101506785 101507613

PSAT:

127073633 127085613 127086354 127093886

VVO:	131599190 131631392 131634168 131655406

LJA:	Lj0g3v0119999.1(Lj0g3v0119999.1) Lj1g3v1498440.1(Lj1g3v1498440.1)

ADU:	107463448 107469463 107470945 107471251 107471935

AIP:	107611783 107623121 107626543 107626553 107630423 107633058 107634421

AHF:	112708367 112708432 112708494 112716234 112717838 112729053 112729098 112729101 112735907 112738250 112738255 112761935 112772103 112782702

LANG:

109327356 109327494 109328449 109336962 109343614 109345129 109354183 109362625

PCIN:

129299538 129309387 129320796 129320873

QSA:	O6P43_002312 O6P43_023022 O6P43_023547

FVE:	101292829 101297137

RCN:	112180142 112187492

PPER:

18770729 18776586 18781921 18782856

PMUM:

103338095 103340987

PAVI:

110760089 110760376 110771268

PDUL:

117612679 117622644 117628034 117633951

MDM:	103400481 103437519 103448739 103455000

MSYL:

126583057 126593952 126599568 126601588 126626891

PXB:	103936166 103949986 103960678 103962990 103964031

ZJU:	107406654 107406660 107406718 107418024 107435376 125420663

MNT:	112094260 21393434 21408286

CSAV:

115705304 115706172 115708944

CSV:	101206509 101210955 101218502

CMO:	103484573 103497577 103501532

BHJ:	120071362 120080246 120083717

MCHA:

111012889 111014514 111025297

CMAX:

111465562 111485199 111493525 111495310 111497736

CMOS:

111431501 111440932 111444205 111450443 111461080 111461803

CPEP:

111778784 111780651 111783499 111793517 111798693 111806062

RCU:	8269197 8271338 8278580

JCU:	105634942(FAT-L2) 105634943(FAT-L3) 105639285

HBR:	110631965 110645490 110655148 110659295

MESC:

110600334 110603870 110607705 110625829 110625830 110626527 110631177

POP:	112327864 7458749 7463140 7484691 7484856 7490983 7490985

PEU:	105109650 105115906 105119571 105125284 105139390

PALZ:

118031742 118044656 118047982 118050679 118054123 118057544

JRE:	108992677 108997545 109004120 109011019

CILL:

122280875 122305060 122308327

CAVE:

132165515 132176275 132188490

QSU:	111992796 112027571 112028149

QLO:	115962879 115976982

TWL:	119986193 119992857 119995911 120005081

VVI:	100254336 100257579

VRI:	117904960 117925270

SLY:	101245130 101261397

SPEN:

107007182 107013824

SOT:	102584501 102595208

SSTN:

125858467 125861909

SDUL:

129870130 129895229

CANN:

107841760 107862897

LBB:	132634111 132636768 132640966

NTA:	107758962(NtTE) 107770446 107785685 107789402 107793720 107816769 107824843

NSY:	104213511 104235585

NTO:	104090382 104106300 104120713

NAU:	109209927 109237319

INI:	109148196 109168713 109186555

ITR:	115999631 116012017 116030155

SIND:

105158149 105162096

OEU:	111380614 111411282 111412963 111412964

EGT:	105951633 105974064

SSPL:

121747436 121748446 121751285 121753332 121764974 121805566 121808565

SMIL:

130987839 130988320 131020157

SHIS:

125188909 125191012 125197186 125206644

APAN:

127239166 127239789 127254816

HAN:	110865595 110877217 110883188 110883191 110886372 110886373 110886378 110886379 110940305

ECAD:

122592278 122597131 122597133 122597659 122597666 122599234 122608756 122610689

LSV:	111877545 111877561 111882802 111883800 111885680 111891607 111897937 111897947 111897954 111897955 111897957

CCAV:

112500834 112506644 112514238 112516804 112516805

DCR:	108199923 108215198 108221107 108222429

CSIN:

114264135 114292046 114322109

RVL:	131301689 131320198 131335183

AEW:	130757322 130767422 130779627 130788993 130796192

BVG:	104900372 104902140 104908278

SOE:	110785861 110786001 110800859

CQI:	110684304 110707842 110719839 110723382 110729089 110739680

ATRI:

130798165 130812636 130815246 130824560

MOF:	131158108 131161006

NNU:

104592290

MING:

122057040 122057929 122062163 122075561 122080762 122080975 122082115

TSS:	122645079 122645080 122646643 122652359 122671710 122671761

PSOM:

113271692 113277242 113277794 113279584 113279586 113281006 113282666 113299722 113303627 113347984 113351354 113351356 113351359 113352148 113354080 113355955 113359337 113361171

OSA:	4340093 4341431 4351056

DOSA:

Os02t0644700-01(Os02g0644700) Os06t0143400-01(Os06g0143400) Os06t0596300-01(Os06g0596300) Os11t0659500-01(Os11g0659500)

OBR:	102700717 102709182 102714591

OGL:	127754549 127762308 127777096 127777753

BDI:	100821684 100827301

ATS:	109747972 109761208

TDC:	119287811 119329540 119330094 119337588

TAES:

123087981 123147228 123148128 123156838 123164387 123168027

TUA:	125521347 125525935

LPER:

127311338 127313445 127332012

LRD:	124672830 124684860 124685045 124694876 124695069

SBI:	8065057 8070721 8082941 8084639

ZMA:	100281497 100283590 100284647 100284999 103638097

SITA:

101757281 101770614 101775948

SVS:	117842871 117852738 117852979

PVIR:

120655062 120658086 120668927 120669896 120671047 120686506 120702572 120703818

PHAI:

112878804 112882401 112889102 112889420

PDA:	103697375 103704422 103720846 103720983 120111519

EGU:	105040257 105047747 105047881(PTE) 105049016

MUS:	103975330 103986019 103986595 103992592 103999297

ZOF:	121967815 121973049 121974354 121991719 121995611 122027139 122029552 122031787 122034220 122036776 122038760 122053036

DCT:	110093301 110102359 110106288 110106936 110108241 110111960

PEQ:	110025999 110027988 110039424

AOF:	109822131 109825405 109826182 109835670 109844902

MSIN:

131239447 131255145

NCOL:

116256015 116264416

ATR:	18434274 18434284

SMO:	SELMODRAFT_103466 SELMODRAFT_13356 SELMODRAFT_15558 SELMODRAFT_15559 SELMODRAFT_233217 SELMODRAFT_425816

PPP:	112274563 112274729 112292328 112294324 112295522

» show all

Reference

1 [PMID:1989513]

Authors

Pollard MR, Anderson L, Fan C, Hawkins DJ, Davies HM.

Title

A specific acyl-ACP thioesterase implicated in medium-chain fatty acid production in immature cotyledons of Umbellularia californica.

Journal

Arch Biochem Biophys 284:306-12 (1991)
DOI:10.1016/0003-9861(91)90300-8

Reference

2 [PMID:1898097]

Authors

Davies HM, Anderson L, Fan C, Hawkins DJ.

Title

Developmental induction, purification, and further characterization of 12:0-ACP thioesterase from immature cotyledons of Umbellularia californica.

Journal

Arch Biochem Biophys 290:37-45 (1991)
DOI:10.1016/0003-9861(91)90588-A

Other DBs

ExplorEnz - The Enzyme Database:

3.1.2.21

IUBMB Enzyme Nomenclature:

3.1.2.21

ExPASy - ENZYME nomenclature database:

3.1.2.21

BRENDA, the Enzyme Database:

3.1.2.21

CAS:	137903-37-8

DBGET integrated database retrieval system