Entry
Name
N-acetylphosphatidylethanolamine-hydrolysing phospholipase D;
NAPE-PLD;
anandamide-generating phospholipase D;
N-acyl phosphatidylethanolamine phospholipase D;
NAPE-hydrolyzing phospholipase D
Class
Hydrolases;
Acting on ester bonds;
Phosphoric-diester hydrolases
BRITE hierarchy
Sysname
N-acetylphosphatidylethanolamine phosphatidohydrolase
Reaction(IUBMB)
N-acylphosphatidylethanolamine + H2O = N-acylethanolamine + a 1,2-diacylglycerol 3-phosphate
Substrate
N-acylphosphatidylethanolamine;
H2O [CPD:
C00001 ]
Product
N-acylethanolamine;
1,2-diacylglycerol 3-phosphate
Comment
This enzyme is involved in the biosynthesis of anandamide. It does not hydrolyse phosphatidylcholine and phosphatidylethanolamine [1]. No transphosphatidation [1]. The enzyme contains Zn2+ and is activated by Mg2+ or Ca2+ [2].
History
EC 3.1.4.54 created 2011
Orthology
K13985 N-acyl-phosphatidylethanolamine-hydrolysing phospholipase D
Genes
RBB : 108515835(NAPEPLD) 108516781
TFN : 117065567 117073126(NAPEPLD)
MORG : 121434776 121459051
HGL : 101720071 101722949(Napepld)
AJM : 119034686 119065612(NAPEPLD)
PMUR : 107301910 107303260
XLA : 100036998(napepld.L) 100137693(napepld.S)
SGH : 107576752 107590591(napepld)
MSAM : 119917947 119918362
PRET : 103459295(napepld) 103459303 103459307 103459310
PFOR : 103146197 103146501
PLAI : 106940535 106943693
PMEI : 106922250 106924678(napepld) 106926645
SASA : 106592130 106592131 106599773
STRU : 115189937 115189954 115189955 115189958
OMY : 110511372 110511373 110512490 110527029
OGO : 123994349 123995859 124020953
OKE : 118382937(napepld) 127925062
PSPA : 121318371 121319729
ARUT : 117415050 117419443
AJC : 117105251 117105261 117105269
SKO : 100371650 100371802 100371950
CEL : CELE_Y37E11AR.3(nape-2) CELE_Y37E11AR.4(nape-1)
PVUL : 126828285 130010370
BGT : 106051542 106064809 106073108
CVN : 111105892 111106435 111106654 111109926
CANU : 128159345 128159350 128159352
OED : 125653850 125654447 125654448 130048354
MYI : 110442510 110443829 110443904 110443905
PMAX : 117330860 117331405 117331408 117331409
MCAF : 127702472 127728114
MMER : 123529856 123548809
RPHI : 132733469 132750401
DPOL : 127845772 127845830 127874386 127874387 127874390 127882136
ATEN : 116305450 116305457
ADF : 107340107 107341384 107341416
AMIL : 114959129 114959130 114962193
PDAM : 113672521 113672530 113672531
SPIS : 111325046 111325053 111325068
HMG : 100205873 100208076 105846065
SMO : SELMODRAFT_2635 SELMODRAFT_2636
GSL : Gasu_18170 Gasu_61510
NCS : NCAS_0C01900(NCAS0C01900)
NDI : NDAI_0E02620(NDAI0E02620)
TPF : TPHA_0A01240(TPHA0A01240)
TBL : TBLA_0B04420(TBLA0B04420)
TDL : TDEL_0A05260(TDEL0A05260)
KAF : KAFR_0E00700(KAFR0E00700)
KNG : KNAG_0A01730(KNAG0A01730)
CAL : CAALFM_C100470CA(CaO19.6061)
NTE : NEUTE1DRAFT116607(NEUTE1DRAFT_116607)
PAN : PODANS72p122 PODANSg3311
MTM : MYCTH_2065104 MYCTH_2298369
SSCK : SPSK_06335 SPSK_09259
ELA : UCREL1_1018 UCREL1_6338
PFY : PFICI_04456 PFICI_06131
PSCO : LY89DRAFT_578857 LY89DRAFT_601819 LY89DRAFT_602524 LY89DRAFT_721779
GLZ : GLAREA_01828 GLAREA_03112
BZE : COCCADRAFT_8143 COCCADRAFT_85723
BSC : COCSADRAFT_338759 COCSADRAFT_39487
BOR : COCMIDRAFT_32346 COCMIDRAFT_8345
AALT : CC77DRAFT_1028734 CC77DRAFT_1099505
ZTR : MYCGRDRAFT_51107 MYCGRDRAFT_95030
PFJ : MYCFIDRAFT_203906 MYCFIDRAFT_46081
BCOM : BAUCODRAFT_67574 BAUCODRAFT_68318 BAUCODRAFT_76981
CNE : CNA02140 CNC04610 CND01370
CNB : CNBA2030 CNBC2560 CNBD4940 CNBD5270
CNG : CNAG_01008 CNAG_02845 CNAG_07338
CGI : CGB_B2500C CGB_C6720W CGB_D3590W
CDEU : CNBG_0340 CNBG_0588 CNBG_3495
TMS : TREMEDRAFT_29049 TREMEDRAFT_46031 TREMEDRAFT_62255
TASA : A1Q1_05627 A1Q1_08094
CCAC : CcaHIS019_0205080(CcaverHIS019_0205080) CcaHIS019_0505600(CcaverHIS019_0505600) CcaHIS019_0700490(EFM4)
TVS : TRAVEDRAFT_51812 TRAVEDRAFT_51813
PCO : PHACADRAFT_211339 PHACADRAFT_255196 PHACADRAFT_255223 PHACADRAFT_260146
SHS : STEHIDRAFT_120244 STEHIDRAFT_66170
ADL : AURDEDRAFT_115787 AURDEDRAFT_43365
FME : FOMMEDRAFT_153567 FOMMEDRAFT_170545
SCM : SCHCO_02615361(SCHCODRAFT_02615361)
UMA : UMAG_01873 UMAG_02828 UMAG_05349 UMAG_05894
PFP : PFL1_01859 PFL1_02654 PFL1_05388 PFL1_06682
DDI : DDB_G0271270 DDB_G0293392
DPP : DICPUDRAFT_28013 DICPUDRAFT_93840
ACAN : ACA1_062470 ACA1_203030
SMIN : v1.2.018948.t2(symbB.v1.2.018948.t2)
SPAR : SPRG_10673 SPRG_18228 SPRG_18230
GTT : GUITHDRAFT_69665 GUITHDRAFT_93321
NGR : NAEGRDRAFT_75174 NAEGRDRAFT_77977
PLZ : S4054249_02610 S4054249_22745
RHG : EXZ61_01570 EXZ61_07110
SNG : SNE_A04770(napEPLD-A) SNE_A09680(napEPLD-B)
» show all
Taxonomy
Reference
Authors
Okamoto Y, Morishita J, Tsuboi K, Tonai T, Ueda N
Title
Molecular characterization of a phospholipase D generating anandamide and its congeners.
Journal
Sequence
Reference
Authors
Wang J, Okamoto Y, Morishita J, Tsuboi K, Miyatake A, Ueda N
Title
Functional analysis of the purified anandamide-generating phospholipase D as a member of the metallo-beta-lactamase family.
Journal
Sequence
Other DBs
ExplorEnz - The Enzyme Database: 3.1.4.54
ExPASy - ENZYME nomenclature database: 3.1.4.54