Entry |
|
Name |
N-sulfoglucosamine-3-sulfatase;
chondroitinsulfatase
|
Class |
Hydrolases;
Acting on ester bonds;
Sulfuric-ester hydrolases
|
Sysname |
N-sulfo-3-sulfoglucosamine 3-sulfohydrolase
|
Reaction(IUBMB) |
Hydrolysis of the 3-sulfate groups of the N-sulfo-D-glucosamine 3-O-sulfate units of heparin
|
Comment |
The enzyme from Flavobacterium heparinum also hydrolyses N-acetyl-D-glucosamine 3-O-sulfate; the mammalian enzyme acts only on the disulfated residue.
|
History |
EC 3.1.6.15 created 1984, modified 1989
|
Reference |
|
Authors |
Bruce JS, McLean MW, Long WF, Williamson FB. |
Title |
Flavobacterium heparinum 3-O-sulphatase for N-substituted glucosamine 3-O-sulphate. |
Journal |
|
Reference |
|
Authors |
Leder IG. |
Title |
A novel 3-O sulfatase from human urine acting on methyl-2-deoxy-2-sulfamino-alphs-D-glucopyranoside 3-sulfate. |
Journal |
|
Other DBs |
ExplorEnz - The Enzyme Database: | 3.1.6.15 |
ExPASy - ENZYME nomenclature database: | 3.1.6.15 |
|