KEGG ENZYME: 3.1.7.10

ENZYME: 3.1.7.10

Entry

EC 3.1.7.10                 Enzyme

Name

(13E)-labda-7,13-dien-15-ol synthase;
labda-7,13E-dien-15-ol synthase

Class

Hydrolases;
Acting on ester bonds;
Diphosphoric-monoester hydrolases

Sysname

geranylgeranyl-diphosphate diphosphohydrolase [(13E)-labda-7,13-dien-15-ol-forming]

Reaction(IUBMB)

geranylgeranyl diphosphate + H2O = (13E)-labda-7,13-dien-15-ol + diphosphate [RN:R09874]

Reaction(KEGG)

R09874

Substrate

geranylgeranyl diphosphate [CPD:C00353];
H2O [CPD:C00001]

Product

(13E)-labda-7,13-dien-15-ol [CPD:C20158];
diphosphate [CPD:C00013]

Comment

The enzyme from the lycophyte Selaginella moellendorffii is bifunctional, initially forming (13E)-labda-7,13-dien-15-yl diphosphate, which is hydrolysed to the alcohol.

History

EC 3.1.7.10 created 2012

Pathway

ec00904

Diterpenoid biosynthesis

ec01110

Biosynthesis of secondary metabolites

Orthology

K16086

(13E)-labda-7,13-dien-15-ol synthase

Genes

SMO:	SELMODRAFT_112927 SELMODRAFT_120716

Reference

1 [PMID:21751328]

Authors

Mafu S, Hillwig ML, Peters RJ

Title

A novel labda-7,13e-dien-15-ol-producing bifunctional diterpene synthase from Selaginella moellendorffii.

Journal

Chembiochem 12:1984-7 (2011)
DOI:10.1002/cbic.201100336

Sequence

[smo:SELMODRAFT_120716]

Other DBs

ExplorEnz - The Enzyme Database:

3.1.7.10

IUBMB Enzyme Nomenclature:

3.1.7.10

ExPASy - ENZYME nomenclature database:

3.1.7.10

BRENDA, the Enzyme Database:

3.1.7.10

DBGET integrated database retrieval system