KEGG   ENZYME: 3.2.1.144
Entry
EC 3.2.1.144                Enzyme                                 
Name
3-deoxyoctulosonase;
alpha-Kdo-ase
Class
Hydrolases;
Glycosylases;
Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds
Sysname
3-deoxyoctulosonyl-lipopolysaccharide hydrolase
Reaction(IUBMB)
3-deoxyoctulosonyl-lipopolysaccharide + H2O = 3-deoxyoctulosonic acid + lipopolysaccharide [RN:R06054]
Reaction(KEGG)
R06054;
(other) R12219
Substrate
3-deoxyoctulosonyl-lipopolysaccharide [CPD:C06744];
H2O [CPD:C00001]
Product
3-deoxyoctulosonic acid [CPD:C01187];
lipopolysaccharide [CPD:C00338]
Comment
Releases Kdo (alpha- and beta-linked 3-deoxy-D-manno-octulosonic acid) from different lipopolysaccharides, including Re-LPS from Escherichia coli and Salmonella, Rd-LPS from S. minnesota, and de-O-acyl-re-LPS. 4-Methylumbelliferyl-alpha-Kdo (alpha-Kdo-OMec) is also a substrate.
History
EC 3.2.1.144 created 2000
Pathway
ec00540  Lipopolysaccharide biosynthesis
ec01100  Metabolic pathways
Orthology
K23082  3-deoxy-D-manno-octulosonic acid-hydrolase
Genes
HPY: HP_0579
HEO: C694_02985
HPJ: jhp_0526
HPA: HPAG1_0558
HPS: HPSH_03980
HHP: HPSH112_04135
HHQ: HPSH169_02980
HHR: HPSH417_02780
HPG: HPG27_538
HPP: HPP12_0585
HPB: HELPY_0797
HPL: HPB8_775
HPC: HPPC_02870
HCA: HPPC18_02780
HPM: HPSJM_02930
HPE: HPELS_03675
HPO: HMPREF4655_21022
HPI: hp908_0586
HPQ: hp2017_0566
HPW: hp2018_0568
HPU: HPCU_03160
HEF: HPF16_0780
HPF: HPF30_0748
HEQ: HPF32_0554
HEX: HPF57_0604
HPT: HPSAT_03910
HPZ: HPKB_0765
HPV: HPV225_0585
HPX: HMPREF0462_0837
HEN: HPSNT_02975
HPH: HPLT_02875
HEG: HPGAM_02980
HPN: HPIN_03980
HEP: HPPN120_02850
HEU: HPPN135_02855
HES: HPSA_02680
HPYS: HPSA20_0593
HCN: HPB14_03795
HPD: KHP_0739
HEY: MWE_0938
HER: C695_02990
HEI: C730_02990
HPYA: HPAKL117_02735
HPYK: HPAKL86_01955
HPYO: HPOK113_0595
HPYL: HPOK310_0757
HPYB: HPOKI102_04120
HPYC: HPOKI112_04150
HPYD: HPOKI128_02750
HPYE: HPOKI154_02970
HPYF: HPOKI422_04120
HPYG: HPOKI673_02945
HPYH: HPOKI828_02950
HPYJ: HPOKI898_04120
HPYR: K747_06965
HPYI: K750_05175
HPYU: K751_03515
HPYM: K749_01605
HEM: K748_00100
HEB: U063_0884
HEZ: U064_0888
HAC: Hac_1433
HFE: HFELIS_01180
HBI: HBZC1_15940
HCE: HCW_06240
HCM: HCD_01360
HHM: BN341_10740
 » show all
Reference
1  [PMID:9334217]
  Authors
Li YT, Wang LX, Pavlova NV, Li SC, Lee YC.
  Title
alpha-KDOase activity in oyster and synthesis of alpha- and beta-4-methylumbelliferyl ketosides of 3-deoxy-D-manno-octulosonic acid.
  Journal
J Biol Chem 272:26419-24 (1997)
DOI:10.1074/jbc.272.42.26419
Other DBs
ExplorEnz - The Enzyme Database: 3.2.1.144
IUBMB Enzyme Nomenclature: 3.2.1.144
ExPASy - ENZYME nomenclature database: 3.2.1.144
BRENDA, the Enzyme Database: 3.2.1.144
CAS: 199128-67-1

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Pathway (5)   
   KEGG PATHWAY (4)   
   KEGG MODULE (1)   
Chemical substance (6)   
   KEGG COMPOUND (6)   
Chemical reaction (4)   
   KEGG REACTION (2)   
   KEGG RCLASS (2)   
Gene (68)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (67)   
All databases (83)   

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