KEGG   ENZYME: 3.2.2.19
Entry
EC 3.2.2.19                 Enzyme                                 
Name
[protein ADP-ribosylarginine] hydrolase;
ADP-ribose-L-arginine cleavage enzyme;
ADP-ribosylarginine hydrolase;
Nomega-(ADP-D-ribosyl)-L-arginine ADP-ribosylhydrolase;
protein-omega-N-(ADP-D-ribosyl)-L-arginine ADP-ribosylhydrolase
Class
Hydrolases;
Glycosylases;
Hydrolysing N-glycosyl compounds
Sysname
protein-Nomega-(ADP-D-ribosyl)-L-arginine ADP-ribosylhydrolase
Reaction(IUBMB)
(1) protein-Nomega-(ADP-D-ribosyl)-L-arginine + H2O = ADP-D-ribose + protein-L-arginine [RN:R07626];
(2) Nomega-(ADP-D-ribosyl)-L-arginine + H2O = ADP-D-ribose + L-arginine [RN:R01886]
Reaction(KEGG)
R01886 R07626
Substrate
protein-Nomega-(ADP-D-ribosyl)-L-arginine [CPD:C16011];
H2O [CPD:C00001];
Nomega-(ADP-D-ribosyl)-L-arginine [CPD:C01201]
Product
ADP-D-ribose [CPD:C00301];
protein-L-arginine [CPD:C00613];
L-arginine [CPD:C00062]
Comment
The enzyme will remove ADP-D-ribose from arginine residues in ADP-ribosylated proteins.
History
EC 3.2.2.19 created 1989, modified 2004
Orthology
K01245  ADP-ribosylarginine hydrolase
Genes
HSA141(ADPRH)
PTR470893(ADPRH)
PPS100968536(ADPRH)
GGO101150307(ADPRH)
PON100440790(ADPRH)
NLE100602502(ADPRH)
HMH116466906(ADPRH)
MCC712562(ADPRH)
MCF102138957(ADPRH)
MTHB126947746
MNI105470337(ADPRH)
CSAB103228225(ADPRH)
CATY105589730(ADPRH)
PANU101022390(ADPRH)
TGE112619716(ADPRH)
MLEU105544622(ADPRH)
RRO104657619(ADPRH)
RBB108541872(ADPRH)
TFN117083467(ADPRH)
PTEH111543816(ADPRH)
CANG105510731(ADPRH)
CJC100391892(ADPRH)
SBQ101054411(ADPRH)
CIMI108296455(ADPRH)
CSYR103254572(ADPRH)
MMUR105879922(ADPRH)
LCAT123630512(ADPRH)
PCOQ105806300(ADPRH)
OGA100963855(ADPRH)
MMU11544(Adprh)
MCAL110311490(Adprh)
MPAH110329643(Adprh)
RNO25371(Adprh)
MCOC116085900(Adprh)
ANU117718235(Adprh)
MUN110555394(Adprh)
CGE100761196(Adprh)
MAUA101842244(Adprh)
PROB127227165(Adprh)
PLEU114701487(Adprh)
MORG121461960(Adprh)
MFOT126505595
AAMP119825642(Adprh)
NGI103741941(Adprh)
HGL101705433(Adprh)
CPOC100713280(Adprh)
CCAN109694540(Adprh)
DORD105987933(Adprh)
DSP122097939(Adprh)
PLOP125351732(Adprh)
NCAR124993324
MMMA107136289(Adprh)
OCU100354201
OPI101534352(ADPRH)
TUP102473277(ADPRH)
GVR103595385(ADPRH)
CFA100855709(ADPRH)
CLUD112677714(ADPRH)
VVP112913462(ADPRH)
VLG121484441(ADPRH)
NPO129503623(ADPRH)
AML100479971(ADPRH)
UMR103678790(ADPRH)
UAH113251889(ADPRH)
UAR123784030(ADPRH)
ELK111151469
LLV125097753
MPUF101672105(ADPRH)
MNP132012199(ADPRH)
MLK131825088(ADPRH)
NVS122908534(ADPRH)
ORO101363531(ADPRH)
EJU114214719(ADPRH)
ZCA113916213(ADPRH)
MLX118007065(ADPRH)
NSU110582030(ADPRH)
LWW102742050(ADPRH)
PCOO112850327(ADPRH)
LRUF124526447
PUC125917706 125917711
HHV120225968(ADPRH)
BTA525738(ADPRH)
BOM102277051(ADPRH)
BIU109577238(ADPRH)
BBUB102404516(ADPRH)
BBIS104992478(ADPRH)
CHX102168665(ADPRH)
OAS101106222(ADPRH)
BTAX128057364(ADPRH)
ODA120871264(ADPRH)
CCAD122445583(ADPRH)
MBEZ129560890(ADPRH)
SSC100153158(ADPRH)
CFR102524560(ADPRH)
CBAI105081594(ADPRH)
CDK105090325(ADPRH)
VPC102538613(ADPRH)
BACU103002571(ADPRH)
LVE103086426(ADPRH)
OOR101281103(ADPRH)
DLE111167283(ADPRH)
PSIU116753673(ADPRH)
NASI112412550(ADPRH)
ECB100070997(ADPRH)
EPZ103547420(ADPRH)
MYB102245153(ADPRH)
MYD102755321(ADPRH)
MMYO118676173(ADPRH)
MLF102426289(ADPRH)
MNA107527215(ADPRH)
PKL118724330(ADPRH)
EFUS103290713(ADPRH)
HAI109388460(ADPRH)
DRO112320614(ADPRH)
SHON118986588(ADPRH)
AJM119059196(ADPRH)
PDIC114490559(ADPRH)
PHAS123826860(ADPRH)
MMF118617150(ADPRH)
RFQ117036413(ADPRH)
PPAM129069645(ADPRH)
PALE102881506(ADPRH)
PGIG120586657(ADPRH)
PVP105301917(ADPRH)
RAY107508368(ADPRH)
MJV108392248(ADPRH)
TOD119257494(ADPRH)
SARA101539676(ADPRH)
LAV100660874(ADPRH)
TMU101350795
ETF101637935(ADPRH)
DNM101434760(ADPRH)
MDO100016348(ADPRH)
GAS123239476(ADPRH)
SHR100927416(ADPRH)
AFZ127554101
PCW110208068(ADPRH)
GGA426545(ADPRHL)
PCOC116238875 116242110(ADPRH)
MGP100540673(ADPRH) 104916026
CJO107322016(ADPRH) 107325783
TPAI128090974(ADPRH)
LMUT125685508 125685783(ADPRH)
NMEL110401341(ADPRH) 110402643
APLA101795135(ADPRH) 119714812
ACYG106039946(ADPRH)
CATA118244909(ADPRH) 118261313 118261315 118261317
AFUL116501476(ADPRH) 116501650
TGU100225609 100226233(ADPRH)
LSR110474901 110476539(ADPRH)
SCAN103818418(ADPRH) 103819895
PMOA120504029(ADPRH) 120505586
OTC121344704(ADPRH) 121348155
PRUF121349252 121360411(ADPRH)
GFR102040950(ADPRH)
FAB101806150(ADPRH) 101808754
OMA130256553(ADPRH) 130260493
PHI102101461(ADPRH) 102112496
PMAJ107209760(ADPRH) 107212272
CCAE111937223 111941677(ADPRH)
CCW104689397(ADPRH) 104695645
CBRC103613724(ADPRH) 103621695
ETL114059619(ADPRH) 114065648
ZAB102069290(ADPRH)
ACHL103801240
SVG106856988(ADPRH) 106858395
MMEA130578175 130588905(ADPRH)
HRT120748433(ADPRH) 120760993
FPG101915329(ADPRH)
FCH102058856(ADPRH)
CLV102084426 102087478(ADPRH)
EGZ104123010(ADPRH)
NNI104014985(ADPRH) 104023367
PCRI104028846(ADPRH)
PLET104619793(ADPRH)
EHS104503408(ADPRH)
PCAO104045584(ADPRH)
ACUN113475984(ADPRH)
TALA104364187(ADPRH) 116962294
PADL103916851(ADPRH) 103925986
AFOR103894075 103894983(ADPRH)
ACHC115337800 115343780(ADPRH)
HALD104324771(ADPRH)
HLE104831586(ADPRH) 104835803
AGEN126034964 126048945
GCL127022565 127028525
CCRI104157627
CSTI104559003(ADPRH) 104560117
CMAC104478363(ADPRH)
MUI104533728(ADPRH)
BREG104635267(ADPRH) 104635367
FGA104074367(ADPRH)
GSTE104258494(ADPRH)
LDI104348492(ADPRH)
MNB103771505(ADPRH)
NNT104403752(ADPRH)
SHAB115601636(ADPRH)
DPUB104299529(ADPRH)
PGUU104461561(ADPRH)
ACAR104529867 104531015(ADPRH)
CPEA104395753(ADPRH)
AVIT104278212(ADPRH)
CVF104290908(ADPRH)
RTD128901543 128903438 128904158(ADPRH)
CUCA104054854 104055985(ADPRH)
TEO104384406(ADPRH)
BRHI104491034(ADPRH)
AAM106490658(ADPRH)
AROW112974426(ADPRH)
NPD112948423(ADPRH)
TGT104577451(ADPRH)
DNE112979286(ADPRH)
SCAM104149205(ADPRH)
ASN102386159(ADPRH)
AMJ102562154(ADPRH) 102567119
CPOO109305674(ADPRH)
GGN109303505(ADPRH)
PSS102452391(ADPRH)
CMY102934922(ADPRH) 119566298
CCAY125637966 125644811(ADPRH)
DCC119856952(ADPRH) 119857896
CPIC101931729(ADPRH) 101936712
TST117888510(ADPRH)
CABI116839122(ADPRH)
MRV120394810(ADPRH) 120404512
ACS100563208(adprh) 100565391
ASAO132771955(ADPRH) 132777968
PVT110078575 110088473(ADPRH)
SUND121926624(ADPRH) 121935601
PBI103049757(ADPRH) 103050993
PMUR107282553 107289021(ADPRH)
CTIG120303882(ADPRH) 120304568
TSR106557080 106557382(ADPRH)
PGUT117663793(ADPRH) 117669151
APRI131198605 131200282(ADPRH)
PTEX113436334(ADPRH) 113443700
NSS113409822(ADPRH) 113418573
VKO123029470(ADPRH) 123032210
PMUA114582790 114595963(ADPRH)
PRAF128400974 128412895(ADPRH)
ZVI118085653(ADPRH) 118095262
HCG128331547 128350761(ADPRH)
GJA107117555(ADPRH) 107122687
STOW125430542(ADPRH) 125445296
EMC129325432(ADPRH) 129338674
XLA108704185 432184(adprh.L) 447554(adprh.S) 495095(adprh)
XTR100135190(adprh) 493544(adprh)
NPR108784947 108784953 108789187
RTEM120943082 120943841(ADPRH)
BBUF121007570 121007979(ADPRH)
BGAR122944489 122945050(ADPRH)
MUO115473919(ADPRH) 115474170
GSH117360968(ADPRH) 117361301
DRE445059(adprh)
SRX107726130
SANH107704615(adprh)
SGH107571852
CCAR109110344
CAUA113112133
CGIB127969173
PTET122355059 122355417
LROH127173935 127173936(adprh)
OMC131527044 131550953
MAMB125260965(adprh)
CIDE127523546
MASI127421955 127427134
TROS130569229(adprh)
TDW130438706(adprh)
MANU129420274(adprh)
IPU100528393(adprh) 108274007
IFU128617239 128617240
PHYP113547472 113547477
SMEO124388883 124388884
TFD113650622 113650623
TVC132841471 132841473
AMEX103037544 111192396
CMAO118809711 118809712 118809713
EEE113576880
CHAR105894051(adprh) 105900953
TRU101073656 101076629
TFS130522348 130522365
TNGGSTEN00035061G001 GSTEN00035062G001
LCO109141701(adprh)
NCC104947179(adprh)
TBEN117473576(adprh)
CGOB115024306(adprh)
PGEO117445003 117464680(adprh)
GACU117545015(adprh)
ELY117247246(adprh)
EFO125880885(adprh)
PLEP121959068(adprh)
SLUC116060957(adprh)
ECRA117937315(adprh)
ESP116671313(adprh)
PFLV114548095
GAT120819115(adprh)
PPUG119212659(adprh)
AFB129091539(adprh)
CLUM117749040(adprh)
MSAM119915760(adprh)
SCHU122867957(adprh)
CUD121528113(adprh)
ALAT119009492(adprh)
MZE101482423(adprh)
ONL100711972(adprh)
OAU116327642(adprh)
OLA101172847(adprh)
OML112153970(adprh)
XMA102216979 102225753
XCO114133640 114136652
XHE116727404 116727496
PRET103481379 103481399
PFOR103152333 103152348
PLAI106934950 106956260
PMEI106904148(adprh) 106924693
GAF122823533(adprh) 122823567
PPRL129377840(adprh) 129377866
CVG107094293 107094305
CTUL119777812(adprh) 119796759
GMU124874862(adprh) 124875567
NFU107387950 107387955
KMR108249548 108249559(adprh)
ALIM106521401 106535168
NWH119423604 119423619
AOCE111568801 111574344
CSEM103381590
POV109641266(adprh)
SSEN122759594(adprh)
HHIP117752751(adprh)
HSP118100484(adprh)
LCF108890419
SDU111219950(adprh)
SLAL111652249(adprh)
XGL120794853(adprh)
SSCV125991555
SBIA133495281(adprh)
PEE133418223(adprh)
PTAO133469795(adprh)
BPEC110170987 110171022
MALB109973617(adprh)
BSPL114846085(adprh)
SJO128381011(adprh)
SASA100194575(adprh) 106579059 106586332(adprh)
STRU115160839 115160840 115162372
OTW112223322(adprh) 112237465 112237501
OMY110492864(adprh) 110520181 110520182
OGO124043928 124043931
ONE115109915 115109924(adprh)
OKI109867332 109867342
OKE118366996 118366997
SALP111976284
SNH120045812(adprh) 120058290 120058293
CCLU121536716 121536718 121572470(adprh)
ELS105016254 105024377
SFM108930637(adprh) 108933024
PKI111833209(adprh)
AANG118220254(adprh)
LOC102692964(adprh)
PSPA121307308(adprh) 121322949
ARUT117399057(adprh) 117402915
PSEX120531144 120531145 120536480(adprh)
LCM102353586 102354521(ADPRH)
CMK103176834
RTP109926461(adprh)
CPLA122561943(adprh)
HOC132827877(adprh)
LERI129714392(adprh)
PMRN116936989 116943767(ADPRH)
LRJ133357247(ADPRH) 133362082
BFO118404985 118425262
BBEL109462731 109482741 109485214
SPU577960 578587
LPIC129273705 129273706 129276724
APLC110980273 110983402
AJC117105666 117120575
SKO100373408 100373742
HROHELRODRAFT_161549 HELRODRAFT_184901 HELRODRAFT_65081 HELRODRAFT_65129
LGILOTGIDRAFT_170414
PCAN112556689
BGT106056268
GAE121378956
HRF124131820
OED125669599
MYI110453922
PMAX117337337
MCAF127736034 127736036
MMER123530266 123561984 123563285 123564832 123564841
RPHI132712761 132712762 132727360 132732520 132735432 132735435 132740105 132755056
DPOL127866562 127866565 127866567 127866568 127872552 127873588
LAK106157901 106158834 106174255
NVE5499174 5504669 5504679
EPA110239995
ATEN116298878
ADF107341614
AMIL114957647
SPIS111328293
DGT114539455
XEN124440981 124447726 124448018 124448032 124448139 124448144 124448145 124448183 124448191 124448195 124448819 124448820 124448855 124456687 124456688 124457245 124457248 124457255 124457603 124457942 124459019
HSY130641301
AQU100637875
DDIDDB_G0289675(adprh)
DPPDICPUDRAFT_34975
DFADFA_04483(adprh)
ACANACA1_020140 ACA1_147520
NGRNAEGRDRAFT_31389 NAEGRDRAFT_33467(AM35b) NAEGRDRAFT_54990(AM35a) NAEGRDRAFT_80552
 » show all
Reference
1  [PMID:2994036]
  Authors
Moss J, Jacobson MK, Stanley SJ.
  Title
Reversibility of arginine-specific mono(ADP-ribosyl)ation: identification in erythrocytes of an ADP-ribose-L-arginine cleavage enzyme.
  Journal
Proc Natl Acad Sci U S A 82:5603-7 (1985)
DOI:10.1073/pnas.82.17.5603
Reference
2  [PMID:1375222]
  Authors
Moss J, Stanley SJ, Nightingale MS, Murtagh JJ Jr, Monaco L, Mishima K, Chen HC, Williamson KC, Tsai SC.
  Title
Molecular and immunological characterization of ADP-ribosylarginine hydrolases.
  Journal
J Biol Chem 267:10481-8 (1992)
  Sequence
[rno:25371]
Reference
3  [PMID:10358013]
  Authors
Konczalik P, Moss J.
  Title
Identification of critical, conserved vicinal aspartate residues in mammalian and bacterial ADP-ribosylarginine hydrolases.
  Journal
J Biol Chem 274:16736-40 (1999)
DOI:10.1074/jbc.274.24.16736
Reference
4  [PMID:8349667]
  Authors
Takada T, Iida K, Moss J.
  Title
Cloning and site-directed mutagenesis of human ADP-ribosylarginine hydrolase.
  Journal
J Biol Chem 268:17837-43 (1993)
  Sequence
[hsa:141] [mmu:11544]
Reference
5  [PMID:8678289]
  Authors
Ohno T, Tsuchiya M, Osago H, Hara N, Jidoi J, Shimoyama M.
  Title
Detection of arginine-ADP-ribosylated protein using recombinant ADP-ribosylarginine hydrolase.
  Journal
Anal Biochem 231:115-22 (1995)
DOI:10.1006/abio.1995.1510
Other DBs
ExplorEnz - The Enzyme Database: 3.2.2.19
IUBMB Enzyme Nomenclature: 3.2.2.19
ExPASy - ENZYME nomenclature database: 3.2.2.19
BRENDA, the Enzyme Database: 3.2.2.19
CAS: 98668-52-1

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