KEGG   ENZYME: 3.2.2.22
Entry
EC 3.2.2.22                 Enzyme                                 
Name
rRNA N-glycosylase;
ribosomal ribonucleate N-glycosidase;
nigrin b;
RNA N-glycosidase;
rRNA N-glycosidase;
ricin;
momorcochin-S;
Mirabilis antiviral protein;
momorcochin-S;
gelonin;
saporins
Class
Hydrolases;
Glycosylases;
Hydrolysing N-glycosyl compounds
Sysname
rRNA N-glycohydrolase
Reaction(IUBMB)
Hydrolysis of the N-glycosylic bond at A-4324 in 28S rRNA from rat ribosomes
Comment
Ricin A-chain and related toxins show this activity. Naked rRNA is attacked more slowly than rRNA in intact ribosomes. Naked rRNA from Escherichia coli is cleaved at a corresponding position.
History
EC 3.2.2.22 created 1990, modified 2000
Reference
1  [PMID:3288622]
  Authors
Endo Y, Tsurugi K
  Title
The RNA N-glycosidase activity of ricin A-chain. The characteristics of the enzymatic activity of ricin A-chain with ribosomes and with rRNA.
  Journal
J Biol Chem 263:8735-9 (1988)
Other DBs
ExplorEnz - The Enzyme Database: 3.2.2.22
IUBMB Enzyme Nomenclature: 3.2.2.22
ExPASy - ENZYME nomenclature database: 3.2.2.22
BRENDA, the Enzyme Database: 3.2.2.22
CAS: 113756-12-0

  All links  
Protein sequence (2923)   
   UniProt (2283)   
   SWISS-PROT (88)   
   RefSeq(pep) (15)   
   PDBSTR (500)   
   PMD (37)   
DNA sequence (715)   
   RefSeq(nuc) (15)   
   GenBank (356)   
   EMBL (344)   
3D Structure (259)   
   PDB (259)   
Protein domain (18)   
   InterPro (18)   
All databases (3915)   

Download RDF
DBGET integrated database retrieval system