KEGG   ENZYME: 3.4.11.26
Entry
EC 3.4.11.26                Enzyme                                 
Name
intermediate cleaving peptidase 55;
Icp55;
mitochondrial intermediate cleaving peptidase 55 kDa
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Aminopeptidases
Reaction(IUBMB)
The enzyme cleaves the Pro36-Pro37 bond of cysteine desulfurase (EC 2.8.1.7) removing three amino acid residues (Tyr-Ser-Pro) from the N-terminus after cleavage by mitochondrial processing peptidase.
Comment
Icp55 removes the destabilizing N-terminal amino acid residues that are left after cleavage by the mitochondrial processing peptidase, leading to the stabilisation of the substrate. The enzyme can remove single amino acids or a short peptide, as in the case of cysteine desulfurase (EC 2.8.1.7), where three amino acids are removed.
History
EC 3.4.11.26 created 2011
Orthology
K18573  intermediate cleaving peptidase 55
Genes
BPGBathy01g04420
SCEYER078C(ICP55)
SEUBDI49_1483
SPAOSPAR_E01550
AGOAGOS_ACL028W
ERCEcym_8027
KLAKLLA0_C07645g
KMXKLMA_40410(ICP55)
LTHKLTH0A04950g
VPOKpol_411p9
ZROZYRO0C08822g
CGRCAGL0J03300g
NCSNCAS_0E03450(NCAS0E03450)
NDINDAI_0A03130(NDAI0A03130)
TPFTPHA_0P00720(TPHA0P00720)
TBLTBLA_0F01960(TBLA0F01960)
TGBHG536_0C05170
TDLTDEL_0H01760(TDEL0H01760)
KAFKAFR_0L01090(KAFR0L01090)
KNGKNAG_0L01730(KNAG0L01730)
ZMKHG535_0E03330
PPAPAS_chr1-4_0468
DHADEHA2B13750g
PICPICST_67038
PGUPGUG_01816
SPAASPAPADRAFT_141091
LELPVL30_003526(ICP55)
CALCAALFM_C303560WA(CaO19.354)
CTPCTRG_02467
COTCORT_0C03790
CDUCD36_83570
CTENCANTEDRAFT_107785
YLIYALI0B20394g
CLUCLUG_01193
CLUSA9F13_09g02596
CAURCJI96_0004241
SLBAWJ20_1960(ICP55)
PKZC5L36_0A11900
BNNFOA43_000088
BBRXBRETT_001012
OPAHPODL_05013
SLUDSCDLUD_000319
NCRNCU05971
NTENEUTE1DRAFT124894(NEUTE1DRAFT_124894)
SMPSMAC_07000
PANPODANSg3115
PBELQC761_407480(ICP55)
PPSDQC762_407480(ICP55)
PPSPQC763_407480(ICP55)
PPSAQC764_407480(ICP55)
TTTTHITE_2142112
MTMMYCTH_2127963
CTHRCTHT_0040650
MGRMGG_00596
PPEIPpBr36_08571
PGRIPgNI_08742
TMNUCRPA7_2733
SSCKSPSK_00770
FGRFGSG_09309
FPUFPSE_09708
FPOAFPOAC1_012382
FVNFVRRES_13462
FVRFVEG_03796
FOXFOXG_05925
NHENECHADRAFT_76810
FFCNCS54_00299100
FKRNCS57_00294300
FMUJ7337_003804
TRETRIREDRAFT_29108
TRRM419DRAFT_9997
MAWMAC_02737
MAJMAA_02070
PCHMVFPPC_01620
CMTCCM_04066
AMUSLMH87_009204
PLJVFPFJ_04033
PTKZJDV02_004490(ICP55)
VALVDBG_08169
CFJCFIO01_05130
CLUPCLUP02_16445
CHIGCH63R_14111
SAPOSAPIO_CDS5427
ELAUCREL1_6641
PFYPFICI_09832
SSLSS1G_02276
BFUBCIN_16g00690
MBEMBM_06434
PSCOLY89DRAFT_547068
GLZGLAREA_01487
ANIANIA_01780
AFMAFUA_6G09190
ACTACLA_083200
NFINFIA_054880
AORAO090001000597
ANGAn11g06960
AFVAFLA_012730
ALUCAKAW2_80621A
ACHEACHE_80717S
APUUAPUU_21327S
PCSN7525_001752
PDPPDIP_35620
POUPOX_a01223
TMFEYB26_001473
TRGTRUGW13939_05872
CIMCIMG_01195
CPWCPC735_051910
UREUREG_01135
PBLPAAG_01230
PBNPADG_03595
ABEARB_05294
TVETRV_02331
AJEHCAG_05830
BGHBDBG_02164
PNOSNOG_06295
PTEPTT_13396
BZECOCCADRAFT_30228
BSCCOCSADRAFT_40620
BORCOCMIDRAFT_1198
AALTCC77DRAFT_1094573
ARABEKO05_0006035
ZTRMYCGRDRAFT_71838
PFJMYCFIDRAFT_160714
FFUCLAFUR5_00699
CBETCB0940_01761
BCOMBAUCODRAFT_63038
NPAUCRNP2_9365
TMLGSTUM_00000329001
SPOSPAC12B10.05(icp55)
SOMSOMG_03759(icp55)
CNECNC05670
CNBCNBC1520
CNGCNAG_07509
CGICGB_C8230W
CDEUCNBG_3599
TMSTREMEDRAFT_25984
TASAA1Q1_05829
CCACCcaHIS019_0704360(ICP55)
TVSTRAVEDRAFT_70397
DSQDICSQDRAFT_154298
SHSSTEHIDRAFT_122394
HIRHETIRDRAFT_439291
PSQPUNSTDRAFT_64678
ADLAURDEDRAFT_80933
FMEFOMMEDRAFT_157919
GTRGLOTRDRAFT_34532
RSXRhiXN_03685
LBCLACBIDRAFT_303704
CCICC1G_11395
ABPAGABI1DRAFT64099(AGABI1DRAFT_64099)
ABVAGABI2DRAFT219147(AGABI2DRAFT_219147)
PCUBJR316_0005122
MRRMoror_8821
MOREE1B28_003929
SCMSCHCO_02527674(SCHCODRAFT_02527674)
CPUTCONPUDRAFT_143630
SLASERLADRAFT_434905
WSEWALSEDRAFT_61425
WICJ056_002554
UMAUMAG_04738
PFPPFL1_04380
SGRAEX895_000230
MGLMGL_2324
MRTMRET_0188
MSYMMSY001_2032
PGRPGTG_05721
PTRCPtA15_15A33
PSTRPst134EA_028203 Pst134EA_032300
MLRMELLADRAFT_85093
MBRMONBRDRAFT_37508
TVATVAG_2v0182750
 » show all
Reference
1  [PMID:19720832]
  Authors
Naamati A, Regev-Rudzki N, Galperin S, Lill R, Pines O
  Title
Dual targeting of Nfs1 and discovery of its novel processing enzyme, Icp55.
  Journal
J Biol Chem 284:30200-8 (2009)
DOI:10.1074/jbc.M109.034694
  Sequence
[sce:YER078C]
Reference
2  [PMID:19837041]
  Authors
Vogtle FN, Wortelkamp S, Zahedi RP, Becker D, Leidhold C, Gevaert K, Kellermann J, Voos W, Sickmann A, Pfanner N, Meisinger C
  Title
Global analysis of the mitochondrial N-proteome identifies a processing peptidase critical for protein stability.
  Journal
Cell 139:428-39 (2009)
DOI:10.1016/j.cell.2009.07.045
  Sequence
[sce:YER078C]
Other DBs
ExplorEnz - The Enzyme Database: 3.4.11.26
IUBMB Enzyme Nomenclature: 3.4.11.26
ExPASy - ENZYME nomenclature database: 3.4.11.26
BRENDA, the Enzyme Database: 3.4.11.26

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