KEGG   ENZYME: 3.4.11.3
Entry
EC 3.4.11.3                 Enzyme                                 
Name
cystinyl aminopeptidase;
cystyl-aminopeptidase;
oxytocinase;
cystine aminopeptidase;
L-cystine aminopeptidase;
oxytocin peptidase;
vasopresssinase
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Aminopeptidases
Reaction(IUBMB)
Release of an N-terminal amino acid, Cys!Xaa-, in which the half-cystine residue is involved in a disulfide loop, notably in oxytocin or vasopressin. Hydrolysis rates on a range of aminoacyl arylamides exceed that for the cystinyl derivative, however [4]
Comment
A zinc-containing sialoglycoprotein in peptidase family M1 (membrane alanyl aminopeptidase family)
History
EC 3.4.11.3 created 1972
Orthology
K01257  cystinyl aminopeptidase
Genes
HSA4012(LNPEP)
PTR461960(LNPEP)
PPS100975663(LNPEP)
GGO101139054(LNPEP)
PON100439455(LNPEP)
NLE100603383(LNPEP)
HMH116470981(LNPEP)
MCC703949(LNPEP)
MCF102115644
MTHB126957459
MNI105484008(LNPEP)
CSAB103225023(LNPEP)
CATY105580982(LNPEP)
PANU101013078(LNPEP)
TGE112625855(LNPEP)
MLEU105546279(LNPEP)
RRO104657441(LNPEP)
RBB108519674(LNPEP)
TFN117064881(LNPEP)
PTEH111542652(LNPEP)
CANG105513429(LNPEP)
CJC100391174(LNPEP)
SBQ101040288(LNPEP)
CIMI108288407
CSYR103257321(LNPEP)
MMUR105876112(LNPEP)
LCAT123648582
PCOQ105805875(LNPEP)
OGA100958484(LNPEP)
MMU240028(Lnpep)
MCAL110312590(Lnpep)
MPAH110338032(Lnpep)
RNO171105(Lnpep)
MCOC116078963(Lnpep)
ANU117700191(Lnpep)
MUN110559507(Lnpep)
CGE100759698(Lnpep)
MAUA101826656
PROB127237720(Lnpep)
PLEU114691312
MORG121466643
MFOT126497573
AAMP119820551
NGI103732022(Lnpep)
HGL101709446(Lnpep)
CPOC100718730(Lnpep)
CCAN109695473(Lnpep)
DORD105989819(Lnpep)
DSP122117366
PLOP125339769
NCAR124986562
MMMA107148611
OCU100353022
OPI101528559
TUP102474416(LNPEP)
GVR103605383(LNPEP)
CFA488896(LNPEP)
CLUD112654107
VVP112915468(LNPEP)
VLG121489040
NPO129501615(LNPEP)
AML100473699(LNPEP)
UMR103672209
UAH113255059(LNPEP)
UAR123799294
ELK111148261
LLV125100824
MPUF101682451(LNPEP)
MNP132028816(LNPEP)
MLK131832487(LNPEP)
NVS122917317
ORO101372794(LNPEP)
EJU114200055(LNPEP)
ZCA113929649
MLX118017034(LNPEP)
NSU110590814
LWW102738475
FCA101083321(LNPEP)
PYU121012608
PCOO112860935(LNPEP)
PBG122491501
LRUF124519350
PTG102969445(LNPEP)
PPAD109254719(LNPEP)
PUC125934320
AJU106969070
HHV120236530
BTA521633(LNPEP)
BOM102267303(LNPEP)
BIU109562347(LNPEP)
BBUB102393847
BBIS104982539(LNPEP)
CHX102186394(LNPEP)
OAS101102729(LNPEP)
BTAX128051242(LNPEP)
ODA120863263
CCAD122439506
MBEZ129558371(LNPEP)
SSC100125826(LNPEP)
CFR102509485(LNPEP)
CBAI105064569(LNPEP)
CDK105100897(LNPEP)
VPC102541002(LNPEP)
BACU103014830(LNPEP)
LVE103071064(LNPEP)
OOR101286074(LNPEP)
DLE111184087(LNPEP)
PCAD102992893(LNPEP)
PSIU116750716(LNPEP)
NASI112394747(LNPEP)
ECB100073222(LNPEP)
EPZ103560188(LNPEP)
EAI106847763
MYB102260924(LNPEP)
MYD102768292(LNPEP)
MMYO118656789
MLF102425594(LNPEP)
MNA107539602(LNPEP)
PKL118702709
EFUS103288756(LNPEP)
HAI109390161(LNPEP)
DRO112307209(LNPEP)
SHON118977438
AJM119055587
PDIC114496094
PHAS123824824
MMF118641862
RFQ117025328(LNPEP)
PPAM129074695(LNPEP)
PALE102892183(LNPEP)
PGIG120612567
PVP105304796(LNPEP)
RAY107518277(LNPEP)
MJV108392001
TOD119260432(LNPEP)
SARA101548854(LNPEP)
LAV100664517(LNPEP)
TMU101354580
ETF101651260
DNM101433270(LNPEP)
MDO100015080(LNPEP)
GAS123236302
SHR100925233(LNPEP)
AFZ127559968
PCW110223535(LNPEP)
OAA100081694
GGA427279(LNPEP)
PCOC116239038(LNPEP)
MGP104915194
CJO107306379(LNPEP)
TPAI128089579(LNPEP)
LMUT125687087
NMEL110389598(LNPEP)
APLA101792280
ACYG106046475
CATA118256857(LNPEP)
AFUL116500756(LNPEP)
TGU100218959(LNPEP)
LSR110473200(LNPEP)
SCAN103821215(LNPEP)
PMOA120509472
OTC121338542
PRUF121355019
GFR102036062(LNPEP)
FAB101815820(LNPEP)
OMA130265072(LNPEP)
PHI102109326(LNPEP)
PMAJ107198251(LNPEP)
CCW104689772
CBRC103616381(LNPEP)
ETL114056953(LNPEP)
ZAB102066074(LNPEP)
ACHL103807397(LNPEP)
SVG106859668(LNPEP)
MMEA130577591(LNPEP)
HRT120765380(LNPEP)
FPG101921722(LNPEP)
FCH102053784(LNPEP)
CLV102089254(LNPEP)
EGZ104135054(LNPEP)
NNI104014064(LNPEP)
PLET104622895
PCAO104053487
ACUN113489982(LNPEP)
TALA104362884
PADL103915039(LNPEP)
AFOR103896078(LNPEP)
ACHC115336548
HLE104830502(LNPEP)
AGEN126036475
GCL127027269
CCRI104165166(LNPEP)
CSTI104560770(LNPEP)
CMAC104478481(LNPEP)
MUI104545691(LNPEP)
LDI104347568(LNPEP)
MNB103782452
OHA104336223(LNPEP)
NNT104411089(LNPEP)
SHAB115600573(LNPEP)
PGUU104469357(LNPEP)
ACAR104523898(LNPEP)
CVF104289558(LNPEP)
RTD128902356(LNPEP)
CUCA104059922(LNPEP)
TEO104382899
AROW112976935(LNPEP)
NPD112951436(LNPEP)
TGT104580399(LNPEP)
DNE112980261(LNPEP)
SCAM104150448(LNPEP)
ASN102376681(LNPEP)
AMJ106736966(LNPEP)
CPOO109308132(LNPEP)
GGN109297449(LNPEP)
PSS102451133
CMY102930761
CCAY125636834
DCC119855860
CPIC101948346
TST117878811(LNPEP)
CABI116835677(LNPEP)
MRV120407783
ACS100565555(lnpep)
ASAO132767167(LNPEP)
PVT110078770(LNPEP)
SUND121920968
PBI103049159(LNPEP)
PMUR107302784(LNPEP)
CTIG120306715
TSR106540963(LNPEP)
PGUT117679086(LNPEP)
APRI131190659(LNPEP)
PTEX113448454(LNPEP)
NSS113415177(LNPEP)
VKO123031173
PMUA114606174(LNPEP)
PRAF128423339(LNPEP)
ZVI118076743(LNPEP)
HCG128344961(LNPEP)
GJA107107285(LNPEP)
STOW125436421
EMC129335075(LNPEP)
XLA379719(lnpep.S) 495293(lnpep.L)
XTR100216271(lnpep)
NPR108790051(LNPEP)
RTEM120931284
BBUF120992535
BGAR122924659
MUO115463162(LNPEP)
GSH117345568(LNPEP)
DRE322814(lnpep)
SRX107720271 107756310
SANH107699734 107703263
SGH107555501 107587503
CCAR109082479
CAUA113049633 113080511
CGIB127957097 127998323
PTET122345207
LROH127165334(lnpep)
OMC131540300(lnpep)
PPRM120472049
RKG130072449(lnpep)
MAMB125267531
CIDE127512717
MASI127430871 127439800
TROS130545099(lnpep)
TDW130419596(lnpep)
MANU129441124(lnpep)
IPU108255525(lnpep)
IFU128625725(lnpep)
PHYP113537004(lnpep)
SMEO124380905
TFD113637661
TVC132855267(lnpep)
AMEX103042675(lnpep)
CMAO118827134
EEE113574970(lnpep)
CHAR122130533
TRU101075332(lnpep)
TFS130525544(lnpep)
TNGGSTEN00028656G001
LCO104921214(lnpep)
NCC104943771
TBEN117475964(lnpep)
CGOB115013600(lnpep)
PGEO117442383(lnpep)
GACU117546833(lnpep)
ELY117252398(lnpep)
EFO125889827
PLEP121944168
SLUC116056647
ECRA117945190(lnpep)
ESP116689361
PFLV114555125(lnpep)
GAT120830366
PPUG119225218
AFB129101250(lnpep)
CLUM117736810(lnpep)
MSAM119892233
SCHU122876429
CUD121509809
ALAT119019277
MZE101464558
ONL100692735(lnpep)
OAU116332525
OLA101154957
OML112148247
XMA102233247
XCO114154379
XHE116729613
PRET103470390
PFOR103142937
PLAI106944598(lnpep)
PMEI106920931
GAF122828809
PPRL129372067(lnpep)
CVG107083671(lnpep)
CTUL119786572
GMU124877870
NFU107393919(lnpep)
KMR108234607
ALIM106521748(lnpep)
NWH119413091
AOCE111587793(lnpep)
MCEP125012234
CSEM103398275
POV109638180(lnpep)
SSEN122769635
HHIP117767225(lnpep)
HSP118114816
LCF108878318
SDU111227707(lnpep)
SLAL111660327(lnpep)
XGL120804849
HCQ109514097
SSCV125994498
SBIA133499700(lnpep)
PEE133399820(lnpep)
PTAO133475357(lnpep)
BPEC110156743(lnpep)
MALB109956957(lnpep)
BSPL114862642(lnpep)
SJO128365338(lnpep)
SASA106580282(lnpep) 106585016
STRU115164396 115200251(lnpep)
OTW112248569 112262802
OMY110525774(lnpep) 110535084
OGO124034239 124036411
ONE115117285 115117953
OKI109880995 109895999(lnpep)
OKE118374175 118393305(lnpep)
SALP111958167 111974780
SNH120029584 120062898
CCLU121573642 121584938
ELS105007007
SFM108938375(lnpep)
PKI111839226(lnpep)
AANG118206239(lnpep)
LOC102683571(lnpep)
PSPA121299611 121313833
ARUT117403961(lnpep)
PSEX120532402
LCM102360095(LNPEP)
CMK103178390
RTP109933513(lnpep)
CPLA122559783
HOC132823281
LERI129695873(lnpep)
PMRN116950706
LRJ133354243
BBEL109468396
AARA120898825
ASTE118502692
AFUN125765870
AMOU128304963
SOY115886622
MSEX115449147
TNL113500536
DSV119463958
 » show all
Reference
1  [PMID:6041057]
  Authors
Sjoholm I.
  Title
Biochemical studies on oxytocin and oxytocinase.
  Journal
Acta Pharm Suec 4:81-96 (1967)
Reference
2  [PMID:4292447]
  Authors
Sjoholm I, Yman L.
  Title
Degradation of oxytocin, lysine-vasopressin, angiotensin II and angiotensin-II-amide by oxytocinase (cystine aminopeptidase).
  Journal
Acta Pharm Suec 4:65-76 (1967)
Reference
3  [PMID:5421622]
  Authors
Yman L.
  Title
Studies on human serum aminopeptidases. Some properties of oxytocinase, human serum aminopeptidase A and leucine aminopeptidase and their purification from retroplacental serum.
  Journal
Acta Pharm Suec 7:75-86 (1970)
Reference
4
  Authors
Sakura, H., Lin, T.Y., Doi, M., Mizutani, S. and Kawashima, Y.
  Title
Purification and properties of oxytocinase, a metalloenzyme.
  Journal
Biochem Int 2:173-179 (1981)
Other DBs
ExplorEnz - The Enzyme Database: 3.4.11.3
IUBMB Enzyme Nomenclature: 3.4.11.3
ExPASy - ENZYME nomenclature database: 3.4.11.3
BRENDA, the Enzyme Database: 3.4.11.3
CAS: 9031-41-8

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