KEGG ENZYME: 3.4.13.18

ENZYME: 3.4.13.18

Entry

EC 3.4.13.18                Enzyme

Name

cytosol nonspecific dipeptidase;
N2-beta-alanylarginine dipeptidase;
glycyl-glycine dipeptidase;
glycyl-leucine dipeptidase;
iminodipeptidase;
peptidase A;
Pro-X dipeptidase;
prolinase;
prolyl dipeptidase;
prolylglycine dipeptidase;
L-prolylglycine dipeptidase;
diglycinase;
Gly-Leu hydrolase;
glycyl-L-leucine dipeptidase;
glycyl-L-leucine hydrolase;
glycyl-L-leucine peptidase;
L-amino-acyl-L-amino-acid hydrolase;
glycylleucine peptidase;
glycylleucine hydrolase;
glycylleucine dipeptide hydrolase;
non-specific dipeptidase;
human cytosolic non-specific dipeptidase

Class

Hydrolases;
Acting on peptide bonds (peptidases);
Dipeptidases

Reaction(IUBMB)

Hydrolysis of dipeptides, preferentially hydrophobic dipeptides including prolyl amino acids

Reaction(KEGG)

(other) R01166 R01992

Comment

A zinc enzyme with broad specificity, varying somewhat with source species. Activated and stabilized by dithiothreitol and Mn2+. Inhibited by bestatin and leucine.

History

EC 3.4.13.18 created 1961 as EC 3.4.3.1 and EC 3.4.3.2, transferred 1972 to EC 3.4.13.1 and EC 3.4.13.2, transferred 1978 to EC 3.4.13.11, part transferred 1992 to EC 3.4.13.18, modified 2000 (EC 3.4.13.15 created 1989, incorporated 1992)

Pathway

ec00330

Arginine and proline metabolism

ec00340

Histidine metabolism

ec00410

beta-Alanine metabolism

ec01100

Metabolic pathways

Orthology

K08660

cytosolic nonspecific dipeptidase

Genes

HSA:	55748(CNDP2)

PTR:	455473(CNDP2)

PPS:	117974220(CNDP2)

GGO:	101126755(CNDP2)

PON:	100174694(CNDP2)

NLE:	100583155(CNDP2)

HMH:	116468466(CNDP2)

MCC:	114675568 695080(CNDP2)

MCF:	101865174(CNDP2)

MTHB:

126941534 126946239

MNI:	105489330(CNDP2)

CSAB:

103244083(CNDP2)

CATY:

105596473(CNDP2)

PANU:

101015344(CNDP2)

TGE:	112611594(CNDP2)

MLEU:

105536504(CNDP2)

RRO:	104656990(CNDP2)

RBB:	108525047(CNDP2)

TFN:	117062392(CNDP2)

PTEH:

111550642(CNDP2)

CANG:

105516657(CNDP2)

CJC:	100393355(CNDP2)

SBQ:	101053821(CNDP2)

CIMI:

108303617(CNDP2)

CSYR:

103276517(CNDP2)

MMUR:

105880288(CNDP2)

LCAT:

123621854(CNDP2)

PCOQ:

105814014(CNDP2)

OGA:	100949445(CNDP2)

MMU:	66054(Cndp2)

MCAL:

110284520(Cndp2)

MPAH:

110332928(Cndp2)

RNO:	291394(Cndp2)

MCOC:

116087432(Cndp2)

ANU:	117719866(Cndp2)

MUN:	110555521(Cndp2)

CGE:	100760626(Cndp2)

MAUA:

101843184(Cndp2)

PROB:

127234938(Cndp2)

PLEU:

114696266(Cndp2)

MORG:

121440171(Cndp2)

MFOT:

126507749

AAMP:

119815020(Cndp2)

NGI:	103748118(Cndp2)

HGL:	101709694(Cndp2)

CPOC:

100735444(Cndp2)

CCAN:

109700927(Cndp2)

DORD:

105993010(Cndp2)

DSP:	122119438(Cndp2)

PLOP:

125364009(Cndp2)

NCAR:

124965597

MMMA:

107153990(Cndp2)

OCU:

100347984

OPI:	101532506(CNDP2)

TUP:	102489914(CNDP2)

GVR:	103601401(CNDP2)

CFA:	476166(CNDP2)

CLUD:

112643962(CNDP2)

VVP:	112919332(CNDP2)

VLG:	121482006(CNDP2)

NPO:	129495536 129514581

AML:	100466673(CNDP2)

UMR:	103658414(CNDP2)

UAH:	113253527(CNDP2)

UAR:	123787478(CNDP2)

ELK:

111154262

LLV:

125082182

MPUF:

101692016(CNDP2)

MNP:	132023687(CNDP2)

MLK:	131810851(CNDP2)

NVS:	122902808(CNDP2)

ORO:	101378244(CNDP2)

EJU:	114208836(CNDP2)

ZCA:	113912663(CNDP2)

MLX:	118004423(CNDP2)

NSU:	110577182(CNDP2)

LWW:	102733124(CNDP2)

FCA:	101095774(CNDP2)

PYU:	121032792(CNDP2)

PCOO:

112868116(CNDP2)

PBG:	122470868(CNDP2)

PVIV:

125149167(CNDP2)

LRUF:

124517054

PTG:	102964722(CNDP2)

PPAD:

109251777(CNDP2)

PUC:

125914362

AJU:

106982249

HHV:	120234517(CNDP2)

BTA:	512626(CNDP2)

BOM:	102267439(CNDP2)

BIU:	109577882(CNDP2)

BBUB:

102400679(CNDP2)

BBIS:

104999517(CNDP2)

CHX:	102189261(CNDP2)

OAS:	101111244(CNDP2)

BTAX:

128067413(CNDP2)

ODA:	120880941(CNDP2)

CCAD:

122425597(CNDP2)

MBEZ:

129549662(CNDP2)

SSC:	100158127(CNDP2)

CFR:	102510239(CNDP2)

CBAI:

105082250(CNDP2)

CDK:	105105096(CNDP2)

VPC:	102541579(CNDP2)

BACU:

103016660(CNDP2)

BMUS:

118879902(CNDP2)

LVE:	103085206(CNDP2)

OOR:	101280936(CNDP2)

DLE:	111167306(CNDP2)

PCAD:

102990839(CNDP2)

PSIU:

116765186(CNDP2)

NASI:

112406116(CNDP2)

ECB:	100061697(CNDP2)

EPZ:	103561747(CNDP2)

EAI:	106832864(CNDP2)

MYB:	102242032(CNDP2)

MYD:	102767302(CNDP2)

MMYO:

118663332(CNDP2)

MLF:	102441120(CNDP2)

PKL:	118707692(CNDP2)

EFUS:

103303431(CNDP2)

MNA:	107537573(CNDP2)

DRO:	112322720(CNDP2)

SHON:

118979672(CNDP2)

AJM:	119049609(CNDP2)

PDIC:

114506625(CNDP2)

PHAS:

123826394(CNDP2)

MMF:	118618814(CNDP2)

PPAM:

129078776(CNDP2)

HAI:	109383204(CNDP2)

RFQ:	117011740(CNDP2)

PALE:

102880342(CNDP2)

PGIG:

120584024(CNDP2)

PVP:	105296956(CNDP2)

RAY:	107512646(CNDP2)

MJV:	108409041(CNDP2)

TOD:	119242968(CNDP2)

SARA:

101538070(CNDP2)

LAV:	100668146(CNDP2)

TMU:

101353090

ETF:	101661056(CNDP2)

DNM:	101417455(CNDP2)

MDO:	100016094(CNDP2)

GAS:	123231802(CNDP2)

SHR:	100920874(CNDP2)

PCW:	110215842(CNDP2)

OAA:	100076899 100076934

GGA:	421013(CNDP2)

PCOC:

116226247(CNDP2)

MGP:	100541349(CNDP2)

CJO:	107309961(CNDP2)

TPAI:

128091192

LMUT:

125691295(CNDP2)

NMEL:

110394204(CNDP2)

APLA:

101791366(CNDP2)

ACYG:

106036016(CNDP2)

CATA:

118249970(CNDP2)

AFUL:

116486302(CNDP2)

TGU:	100229152(CNDP2)

LSR:	110470875(CNDP2)

SCAN:

103826354(CNDP2)

PMOA:

120503028(CNDP2)

OTC:	121337801(CNDP2)

PRUF:

121362908(CNDP2)

GFR:	102034558(CNDP2)

FAB:	101807367(CNDP2)

OMA:	130248780(CNDP2)

PHI:	102114713(CNDP2)

PMAJ:

107200307(CNDP2)

CCAE:

111925251(CNDP2)

CCW:	104685798(CNDP2)

CBRC:

103623591(CNDP2)

ETL:	114057531(CNDP2)

ZAB:	102061994(CNDP2)

ACHL:

103811014(CNDP2)

SVG:	106849964(CNDP2)

MMEA:

130573866(CNDP2)

HRT:	120754188(CNDP2)

FPG:	101914717(CNDP2)

FCH:	102052576(CNDP2)

CLV:	102092467(CNDP2)

EGZ:	104128656(CNDP2)

NNI:	104018185(CNDP2)

PCRI:

104028924(CNDP2)

PLET:

104614746(CNDP2)

EHS:	104503949(CNDP2)

PCAO:

104039532(CNDP2)

ACUN:

113477172(CNDP2)

TALA:

104365362(CNDP2)

PADL:

103924880(CNDP2)

AFOR:

103896769(CNDP2)

ACHC:

115340615(CNDP2)

HALD:

104314543(CNDP2)

HLE:	104838276(CNDP2)

AGEN:

126051262

GCL:

127012998

CCRI:

104155598(CNDP2)

CSTI:

104559416(CNDP2)

CMAC:

104473956(CNDP2)

MUI:

104543041

BREG:

104632378(CNDP2)

FGA:	104082053(CNDP2)

GSTE:

104259882(CNDP2)

LDI:	104352900(CNDP2)

MNB:	103768952(CNDP2)

OHA:	104334047(CNDP2)

NNT:	104400171(CNDP2)

SHAB:

115613590(CNDP2)

DPUB:

104302219(CNDP2)

PGUU:

104458898(CNDP2)

ACAR:

104518733(CNDP2)

CPEA:

104398683(CNDP2)

AVIT:

104273767(CNDP2)

CVF:	104287196(CNDP2)

RTD:	128906115(CNDP2)

CUCA:

104062193(CNDP2)

TEO:	104374557(CNDP2)

BRHI:

104495048(CNDP2)

AAM:	106484108(CNDP2)

AROW:

112965382(CNDP2)

NPD:	112947629(CNDP2)

TGT:	104578055(CNDP2)

DNE:	112983543(CNDP2)

SCAM:

104141049(CNDP2)

ASN:

102368140

AMJ:	102560010 102563504(CNDP2)

CPOO:

109316734(CNDP2)

GGN:	109302685(CNDP2)

PSS:	102446043(CNDP2)

CMY:	102938228(CNDP2)

CCAY:

125632247 125632251

DCC:	119851962(CNDP2)

CPIC:

101937378(CNDP2)

TST:	117873296 117873299(CNDP2)

CABI:

116819716(CNDP2) 116833078

MRV:	120396881 120397455

ACS:	100553967(cndp2) 100556028

ASAO:

132771668 132774676 132774678(CNDP2)

PVT:	110083373 110083377(CNDP2)

SUND:

121927606 121929703

PBI:	103052866(CNDP2)

PMUR:

107291689(CNDP2)

CTIG:

120304161(CNDP2)

TSR:	106538260(CNDP2)

PGUT:

117672589(CNDP2)

APRI:

131195512(CNDP2)

PTEX:

113435550(CNDP2)

NSS:	113413563(CNDP2)

VKO:	123021603(CNDP2)

PMUA:

114600794(CNDP2)

PRAF:

128417667(CNDP2) 128417670

ZVI:	118089898(CNDP2)

HCG:	128322834 128324974

GJA:	107115121(CNDP2)

STOW:

125439063 125439208(CNDP2)

EMC:	129333156(CNDP2) 129333810

XLA:	108695220 380001(cndp2.S) 398689(darmin.L) 446978(cndp2.L)

XTR:	394903(darmin) 394907(cndp2)

NPR:

108799251

RTEM:

120940814 120940817

BBUF:

121001372(CNDP2) 121002463

BGAR:

122938492 122938927(CNDP2)

MUO:

115475702

GSH:	117355570(CNDP2)

DRE:	327288(cndp2)

SRX:	107739559 107748690

SANH:

107688323 107696911

SGH:	107579761 107592070 107593602(cndp2)

CCAR:

109057850 109066328

CAUA:

113062240 113120098

CGIB:

127935903 127979408

PTET:

122324144(cndp2)

LROH:

127182255(cndp2)

OMC:	131525934(cndp2)

PPRM:

120483687(cndp2)

RKG:	130085136(cndp2)

MAMB:

125275430(cndp2)

CIDE:

127501285

MASI:

127421410 127425338

TROS:

130567245(cndp2)

TDW:	130415990(cndp2)

MANU:

129455653(cndp2)

IPU:

108257136

IFU:	128600542(cndp2)

PHYP:

113536259(cndp2)

SMEO:

124376309(cndp2)

TFD:	113661599(cndp2)

TVC:	132864094(cndp2)

AMEX:

103024590(cndp2)

CMAO:

118806188(cndp2)

EEE:	113585121(cndp2)

CHAR:

105892098(cndp2)

TRU:

101066809

TFS:	130518583(cndp2)

TNG:	GSTEN00032549G001

LCO:	104927574(cndp2)

NCC:	104962947(cndp2)

TBEN:

117477704(cndp2)

CGOB:

115016153(cndp2)

PGEO:

117455138(cndp2)

GACU:

117542652(cndp2)

EMAC:

134875101(cndp2)

ELY:	117264148(cndp2)

EFO:	125904988(cndp2)

PLEP:

121958078(cndp2)

SLUC:

116047369 116052110

ECRA:

117957039(cndp2)

ESP:	116701665(cndp2)

PFLV:

114546188 114568612

GAT:	120826290 120826292

PPUG:

119219246(cndp2)

AFB:	129097162(cndp2)

CLUM:

117739426(cndp2)

PSWI:

130207528(cndp2)

MSAM:

119907110(cndp2)

SCHU:

122864926(cndp2)

CUD:	121523195(cndp2)

ALAT:

119016670(cndp2)

MZE:	101468473 101468783 101469064 106676710

ONL:	100534585(cndp2) 109196322 109196637

OAU:	116319991 116320001 120432687

OLA:	101158501(cndp2)

OML:	112148383(cndp2)

CSAI:

133461450 133461452

XMA:

102232950

XCO:

114156569

XHE:	116731800 116731801

PRET:

103472482 103472483(cndp2)

PFOR:

103146841 103146842

PLAI:

106958621 106958632

PMEI:

106916860 106916861(cndp2)

GAF:	122843118(cndp2)

PPRL:

129375182(cndp2)

CVG:	107103163 107103164

CTUL:

119779647 119779674

GMU:

124878784

NFU:	107394616(cndp2)

KMR:	108237889(cndp2)

ALIM:

106536426

NWH:	119425656(cndp2)

AOCE:

111585218(cndp2)

MCEP:

125020538(cndp2)

CSEM:

103394277(cndp2)

POV:	109638787 109638844

SSEN:

122786844(cndp2)

HHIP:

117770608 117770609

HSP:	118125040 118125041

SMAU:

118292079(cndp2)

LCF:

108879475

SDU:	111223447(cndp2)

SLAL:

111657615(cndp2)

XGL:	120786914(cndp2)

HCQ:	109512013(cndp2)

SSCV:

125986737

SBIA:

133497994(cndp2)

PEE:	133395847(cndp2)

PTAO:

133470853(cndp2)

BPEC:

110161127(cndp2)

MALB:

109958636(cndp2)

BSPL:

114865954(cndp2)

SJO:	128374263(cndp2)

SASA:

106569863 106579285 106579306 106588296(CNDP2) 106605538

STRU:

115173661

OTW:	112227796 112247756 112264696(cndp2)

OMY:	110485134 110488252 110496332 110511684

OGO:

124012566

ONE:

115128481

OKI:	109903118 109907431

OKE:	118399418(cndp2)

SALP:

111955262 111955733

SNH:

120022716

CCLU:

121559773 121586920(cndp2)

ELS:	105012659(cndp2) 105019195

SFM:	108933337 108940590

PKI:	111852260(cndp2)

AANG:

118234299

LOC:

102691691

PSPA:

121313318(cndp2)

ARUT:

117400499

PSEX:

120515471

LCM:	102355182(CNDP2)

CMK:	103184951(cndp2)

RTP:	109926834 109930436(cndp2)

CPLA:

122549127 122563238

HOC:	132815406 132828412

LERI:

129696656(cndp2) 129696749

PMRN:

116952102 116952170 116957063(CNDP2)

LRJ:	133354783 133354921

BFO:	118413259 118413263

BBEL:

109475613

SCLV:

120343814 120343815

SPU:

594228

LPIC:

129268451

APLC:

110975407 110975526

AJC:

117108254

DME:	Dmel_CG17337(Cndp2)

DER:	6541545 6542112

DSE:

6619122

DSI:	Dsimw501_GD10382(Dsim_GD10382)

DYA:	Dyak_GE20538

DAN:

6496679

DSR:

110189385

DPO:	4803334 6900685 6903574 6903577

DPE:	6590913 6593962 6601359

DMN:	108160511 108164327 108165321 117191695

DWI:	26529072 6637975 6642226

DGR:	122322429 6559591 6562652

DMO:	Dmoj_GI19613 Dmoj_GI21918 Dmoj_GI26928

DAZ:	108609647 108616326

DNV:	108649470 108653630 108658188 115562763

DHE:	111599124 111600877 115483170 115483411

DVI:	6635996 6636375

CCAT:

101459287

BOD:

106619861

BDR:

105225790

RZE:	108361204 108373660 108378449

AOQ:

129244763

TDA:	119679077 119679918

MDE:

101898638

SCAC:

106088768

LCQ:	111678523 111683225 111685089

LSQ:	119611244 119611245 119614572 119616105 119616106

GFS:

119636071

ECOE:

129942971

CLON:

129607628 129617506

HIS:	119649821 119660005

AGA:

1269609

ACOZ:

120961493

AARA:

120894521

AMER:

121594757

ASTE:

118512085

AFUN:

125768687

AMOU:

128304877

AALI:

118465945

AAG:

5571265

AALB:

109423371

CQU:	CpipJ_CPIJ017373

CPII:

120419737 120426984

CNS:

116347018

BCOO:

119083552 119083678

AME:

412393

ACER:

107994223

ALAB:

122719680

ADR:

102679602

AFLR:

100871423

BIM:

100743679

BBIF:

117210351

BVK:

117242103

BVAN:

117159367

BTER:

100648827

BAFF:

126916108

BPYO:

122569277

BPAS:

132916261

FVI:

122532872

CCAL:

108633094

OBB:

114878059

OLG:

117602111

MGEN:

117221549

NMEA:

116424237

CGIG:

122402713

SOC:

105196148

MPHA:

105834920

AEC:

105147021

ACEP:

105622856

PBAR:

105423960

VEM:

105564520

HST:

105184854

DQU:

106745289

CFO:

105259365

FEX:

115239176

LHU:

105675762

PGC:

109859585

OBO:

105278212

PCF:

106789699

PFUC:

122516150

VPS:

122637264

VCRB:

124432454

VVE:

124957391

NVI:	100120037 100121200 103316591

CSOL:

105365033 105366448

TPRE:

106654916 106658410 106659291

LHT:	122497935 122507754

LBD:	127282657 127283587

MDL:

103573504

CGLO:

123267416

FAS:

105264324

DAM:

107044678

AGIF:

122856964

CINS:

118072197

VCAN:

122413683 122417547

CCIN:

107263402 107268682 112494062

DSM:	124404772 124406381

NPT:	124212931 124213523

NFB:

124176450

NLO:	107216710 107217505

NVG:

124298765

AROA:

105686542

TCA:	660098 660961

DPA:	109537684 109538891 109539660 125502409

SOY:	115878971 115888352 115888372

AGRG:

126735780 126739725

ATD:	109598646 109598719

CSET:

123320860 123322814

AGB:	108907429 108910451

LDC:	111509700 111516518

NVL:	108560640 108566235

APLN:

108737344 108742348 112906241

PPYR:

116167140 116169822 116174314 116175071 116177587 116182436

OTU:	111413998 111416335

BMOR:

101736010

BMAN:

114249371

MSEX:

115445769

DPL:	KGM_204431

BANY:

112043314

MJU:

123864470

NIQ:

126779909

VCD:

124537797

MCIX:

123664955

PMAC:

106712293

PPOT:

106108116

PXU:

106117384

PRAP:

111003138

PBX:

123717760

PNAP:

125061807

ZCE:

119830040

CCRC:

123704033

LSIN:

126971387

HAW:	110371138(Cndp2)

HZE:

124637477

TNL:

113492664

SLIU:

111353944

OFU:

114356650

PXY:	105387002 105392064

PGW:

126381828

CFEL:

113376566

CCRN:

123290432 123296921

API:	100166238 100168968

DNX:	107164375 107164376

AGS:	114126248 114126249

RMD:	113553511 113553512

ACOO:

126833669

DVT:

126906814

BTAB:

109044429

DCI:	103517369 103517370

CLEC:

106663411

HHAL:

106688063

NLU:

111052840

HVI:

124365709

MQU:	128995019 128996959

PHU:	Phum_PHUM537060

FOC:

113203520

TPAL:

117653507

ZNE:

110827434

CSEC:

111863503

SGRE:

126267504

BROR:

134541416

IEL:

124159081

FCD:	110845061 110850716

DPX:	DAPPUDRAFT_303911

DMK:	116923712 123466513

DPZ:

124343665

PVM:	113817185 113817189

PJA:

122259274

PCHN:

125028999

PMOO:

119574574

HAME:

121878563

PCLA:

123756117

CQD:

128690851

PTRU:

123516830

ESN:	126999698 126999699

HAZT:

108673169

EAF:

111718405

LSM:	121115275 121116157 121125662

TCF:

131880309

PPOI:

119092052

DSV:	119448131 119448629 119448660 119450066 119450350

RSAN:

119374986 119383068 119383227 119383499

RMP:	119169521 119170266 119170479

VDE:

111245322

VJA:

111268095

DPTE:

113795765 113797587

DFR:	124492451 124492527

CSCU:

111636340

PTEP:

107451720

ABRU:

129981659

UDV:

129222670

SDM:

118199316

LPOL:

106464998

NAI:	NECAME_06866 NECAME_13889

TSP:

Tsp_11047

LGI:	LOTGIDRAFT_224093

PVUL:

126823500 126823732

PCAN:

112560591

BGT:

106050636

GAE:

121382039

HRF:

124149788

HRJ:

124288318

CRG:	105342026 105342027

CVN:	111109369 111109392 111115386

CANU:

128176850 128176866

OED:

125683452

MYI:

110440951

PMAX:

117336170

MCAF:

127705692

MMER:

123537357

RPHI:

132746753

DPOL:

127870035

OBI:	106883127 106883205

OSN:	115213823 115213824

LAK:

106176476

OVI:	T265_06073

EGL:

EGR_00983

NVE:

5515142

EPA:

110248653

ATEN:

116307316

ADF:

107348131

AMIL:

114951152 114951153

PDAM:

113664778

SPIS:

111320177

DGT:

114517120

XEN:	124442687 124442688 124442689

HMG:	100210621 100211929

HSY:

130612663

GSL:	Gasu_32150

CCP:	CHC_T00002877001

MBR:	MONBRDRAFT_37652

SRE:	PTSG_10206

FCY:	FRACYDRAFT_236083

AAF:	AURANDRAFT_29643

GTT:	GUITHDRAFT_84281

» show all

Reference

Authors

Bauer, K.

Title

Cytosol non-specific dipeptidase.

Journal

In: Barrett, A.J., Rawlings, N.D. and Woessner, J.F. (Eds.), Handbook of Proteolytic Enzymes, Academic Press, London, 1998, p. 1520-1522.

Other DBs

ExplorEnz - The Enzyme Database:

3.4.13.18

IUBMB Enzyme Nomenclature:

3.4.13.18

ExPASy - ENZYME nomenclature database:

3.4.13.18

BRENDA, the Enzyme Database:

3.4.13.18

CAS:

9025-31-4

DBGET integrated database retrieval system