KEGG ENZYME: 3.4.13.20

ENZYME: 3.4.13.20

Entry

EC 3.4.13.20                Enzyme

Name

beta-Ala-His dipeptidase;
serum carnosinase

Class

Hydrolases;
Acting on peptide bonds (peptidases);
Dipeptidases

Reaction(IUBMB)

Preferential hydrolysis of the beta-Ala!His dipeptide (carnosine), and also anserine, Xaa!His dipeptides and other dipeptides including homocarnosine [RN:R01166 R03288]

Reaction(KEGG)

R01166 R03288 > R01992

Comment

Present in the serum of humans and higher primates, but not in the serum of other mammals. Activated by Cd2+ and citrate. Belongs in peptidase family M20.

History

EC 3.4.13.20 created 1992

Pathway

ec00330

Arginine and proline metabolism

ec00340

Histidine metabolism

ec00410

beta-Alanine metabolism

ec01100

Metabolic pathways

Orthology

K05604

beta-Ala-His dipeptidase

Genes

HSA:	84735(CNDP1)

PTR:	455474(CNDP1)

PPS:	100970514(CNDP1)

GGO:	101127378(CNDP1)

PON:	100172721(CNDP1)

NLE:	100583488(CNDP1)

HMH:	116468465(CNDP1)

MCC:	114675569 695195(CNDP1)

MCF:	102131452(CNDP1)

MTHB:

126941533

MNI:	105489329(CNDP1)

CSAB:

103244082(CNDP1)

CATY:

105596474(CNDP1)

PANU:

101015924(CNDP1)

TGE:	112611596(CNDP1)

MLEU:

105536503(CNDP1)

RRO:	104656992(CNDP1)

RBB:	108525057(CNDP1)

TFN:	117062418(CNDP1)

PTEH:

111550667(CNDP1)

CANG:

105516658(CNDP1)

CJC:	100395623(CNDP1)

SBQ:	101048509(CNDP1)

CIMI:

108303618(CNDP1)

CSYR:

103276518(CNDP1)

MMUR:

105865691(CNDP1)

LCAT:

123621855(CNDP1)

PCOQ:

105814010(CNDP1)

OGA:	100942379(CNDP1)

MMU:	338403(Cndp1)

MCAL:

110284617(Cndp1)

MPAH:

110333472(Cndp1)

RNO:	307212(Cndp1)

MCOC:

116087758(Cndp1)

ANU:	117720154(Cndp1)

MUN:	110555520(Cndp1)

CGE:	100761203(Cndp1)

MAUA:

101843727(Cndp1)

PROB:

127234951(Cndp1)

PLEU:

114696268(Cndp1)

MORG:

121440120(Cndp1)

MFOT:

126496121

AAMP:

119814477(Cndp1)

NGI:	103748140(Cndp1)

HGL:	101707301(Cndp1)

CPOC:

100729620(Cndp1)

CCAN:

109681064(Cndp1)

DORD:

105993016(Cndp1)

DSP:	122119467(Cndp1)

PLOP:

125363952(Cndp1)

NCAR:

124965748

MMMA:

107153992(Cndp1)

OCU:

100345937

OPI:	101520559(CNDP1)

TUP:	102489508(CNDP1)

GVR:	103601403(CNDP1)

CFA:	476165(CNDP1)

CLUD:

112643958(CNDP1)

VVP:	112919334(CNDP1)

VLG:	121482003(CNDP1)

NPO:	129495407 129514441

AML:	100467604(CNDP1)

UMR:	103658416(CNDP1)

UAH:	113253529(CNDP1)

UAR:	123787479(CNDP1)

ELK:

111154244

LLV:

125082265

MPUF:

101693266(CNDP1)

MNP:	132023690(CNDP1)

MLK:	131810850(CNDP1)

NVS:	122902806(CNDP1)

ORO:	101378722(CNDP1)

EJU:	114208805(CNDP1)

ZCA:	113912534(CNDP1)

MLX:	118004601(CNDP1)

NSU:	110576905(CNDP1)

LWW:

102743946

FCA:	101099503(CNDP1)

PYU:	121032788(CNDP1)

PCOO:

112868297(CNDP1)

PBG:	122470869(CNDP1)

PVIV:

125148888(CNDP1)

LRUF:

124517100

PTG:	102964440(CNDP1)

PPAD:

109251775(CNDP1)

PUC:

125914623

AJU:

106982253

HHV:	120234524(CNDP1)

BTA:	614200(CNDP1)

BOM:	102267168(CNDP1)

BIU:	109578014(CNDP1)

BBUB:

102402300(CNDP1)

BBIS:

104999545(CNDP1)

CHX:	102180002(CNDP1)

OAS:	101110987(CNDP1)

BTAX:

128067497(CNDP1)

ODA:	120880845(CNDP1)

CCAD:

122425636(CNDP1)

MBEZ:

129549560(CNDP1)

SSC:	100516053(CNDP1)

CFR:	102512299(CNDP1)

CBAI:

105082224(CNDP1)

CDK:	105105074(CNDP1)

VPC:	102545337(CNDP1)

BACU:

103016948(CNDP1)

BMUS:

118879942(CNDP1)

LVE:	103084929(CNDP1)

OOR:	101281356(CNDP1)

DLE:	111167305(CNDP1)

PCAD:

102991690(CNDP1)

PSIU:

116765104(CNDP1)

NASI:

112406134(CNDP1)

ECB:	100061728(CNDP1)

EPZ:	103544994 103561746

EAI:	106832860(CNDP1)

MYB:	102242328(CNDP1)

MYD:	102767022(CNDP1)

MMYO:

118663607(CNDP1)

MLF:	102441425(CNDP1)

PKL:	118707691(CNDP1)

EFUS:

103303420(CNDP1)

MNA:	107537575(CNDP1)

DRO:	112322841(CNDP1)

SHON:

118979685(CNDP1)

AJM:	119049620(CNDP1)

PDIC:

114506599 114506601

PHAS:

123826383(CNDP1)

MMF:	118619295(CNDP1)

PPAM:

129078923(CNDP1)

HAI:	109383171(CNDP1)

RFQ:	117011739(CNDP1)

PALE:

102890418(CNDP1)

PGIG:

120583410(CNDP1)

PVP:	105296966(CNDP1)

RAY:	107512645(CNDP1)

MJV:	108409039(CNDP1)

TOD:	119243737(CNDP1)

SARA:

101537805(CNDP1)

LAV:	100657615(CNDP1)

TMU:

101356417

ETF:

101638029

DNM:	101419660(CNDP1)

MDO:	100619431(CNDP1)

GAS:	123231803(CNDP1)

SHR:	100922964(CNDP1)

PCW:	110215824(CNDP1)

OAA:	100076860(CNDP1)

GGA:	421012(CNDP1)

PCOC:

116226248(CNDP1)

MGP:	100541194(CNDP1)

CJO:	107309982(CNDP1)

TPAI:

128091189

LMUT:

125691296

NMEL:

110394441(CNDP1)

APLA:

101791863(CNDP1)

ACYG:

106035949(CNDP1)

CATA:

118249976(CNDP1)

AFUL:

116486255(CNDP1)

TGU:

100232073

LSR:	110470903(CNDP1)

SCAN:

103815755(CNDP1)

PMOA:

120503051(CNDP1)

OTC:	121337781(CNDP1)

PRUF:

121362906(CNDP1)

GFR:	102040432(CNDP1)

FAB:	101819344(CNDP1)

OMA:	130248781(CNDP1)

PHI:	102111429(CNDP1)

PMAJ:

107200306(CNDP1)

CCAE:

111925250(CNDP1)

CCW:	104685799(CNDP1)

CBRC:

103623610(CNDP1)

ETL:	114057532(CNDP1)

ZAB:	102061545(CNDP1)

ACHL:

103812090

SVG:	106849974(CNDP1)

MMEA:

130573865(CNDP1)

HRT:	120754069(CNDP1)

FPG:	101915873(CNDP1)

FCH:	102045939(CNDP1)

CLV:

102095516

EGZ:	104128655(CNDP1)

NNI:	104018184(CNDP1)

PCRI:

104038420(CNDP1)

PLET:

104617497(CNDP1)

EHS:	104502793(CNDP1)

PCAO:

104041471(CNDP1)

ACUN:

113476758(CNDP1)

TALA:

104365361(CNDP1)

PADL:

103924881(CNDP1)

AFOR:

103896768(CNDP1)

ACHC:

115340732(CNDP1)

HALD:

104314544(CNDP1)

HLE:	104838324(CNDP1)

AGEN:

126051268

GCL:

127013188

CCRI:

104154684(CNDP1)

CSTI:

104559417(CNDP1)

CMAC:

104473061(CNDP1)

MUI:	104533638(CNDP1)

BREG:

104642495(CNDP1)

FGA:	104083911(CNDP1)

GSTE:

104259881(CNDP1)

LDI:	104352901(CNDP1)

MNB:	103768953(CNDP1)

OHA:

104334065

NNT:	104399359(CNDP1)

SHAB:

115611334(CNDP1)

DPUB:

104302225

PGUU:

104466295(CNDP1)

ACAR:

104518011(CNDP1)

CPEA:

104398695(CNDP1)

AVIT:

104273769(CNDP1)

CVF:	104287197(CNDP1)

RTD:	128905841(CNDP1)

CUCA:

104062209(CNDP1)

TEO:	104374556(CNDP1)

BRHI:

104495049(CNDP1)

AAM:	106482719(CNDP1)

AROW:

112965374(CNDP1)

NPD:	112947652(CNDP1)

TGT:	104576207(CNDP1)

DNE:	112983541(CNDP1)

SCAM:

104141048(CNDP1)

ASN:	102367881(CNDP1)

AMJ:	106737110(CNDP1)

CPOO:

109316708(CNDP1)

GGN:	109302670(CNDP1)

PSS:

102445657

CMY:	102938002(CNDP1)

CCAY:

125632248(CNDP1)

DCC:	119851305(CNDP1)

CPIC:

101937111

TST:	117873297(CNDP1)

CABI:

116819721(CNDP1) 116839990

MRV:

120399587

ACS:	100554161(cndp1)

ASAO:

132774677(CNDP1)

PVT:	110083379(CNDP1)

SUND:

121927603

PMUR:

107291693(CNDP1)

CTIG:

120304164(CNDP1)

TSR:

106550218

PGUT:

117672588(CNDP1)

APRI:

131194781

PTEX:

113435551(CNDP1)

NSS:	113413564(CNDP1)

VKO:

123021584

PMUA:

114600793 114600796

PRAF:

128417668

ZVI:	118089897 118090242

HCG:

128323776

GJA:	107115115(CNDP1)

STOW:

125439529

EMC:

129333683

XLA:	398917(cndp1.L)

XTR:	100135225(cndp1)

NPR:

108799252

RTEM:

120940816

BBUF:

121001433

BGAR:

122937900(CNDP1)

MUO:

115475709

EEE:

113574437

SASA:

100196692(cndp1)

STRU:

115181558

OTW:

112247755

OMY:

110485118

ONE:

115140919

OKI:

109901869

OKE:

118364577

SALP:

111964936 112068906

SNH:

120047676

CCLU:

121586031 123488284

ELS:

105019194

SFM:

108940582

PKI:	111844178 111844287

AANG:

118225539(cndp2)

PSPA:

121313319 121314853

ARUT:

117399795 117435786

PSEX:

120515857

SOY:

115888585

AGRG:

126741962

CSET:

123313278

AGB:

108912082

PPYR:

116177011

» show all

Reference

1 [PMID:7116644]

Authors

Lenney JF, George RP, Weiss AM, Kucera CM, Chan PW, Rinzler GS

Title

Human serum carnosinase: characterization, distinction from cellular carnosinase, and activation by cadmium.

Journal

Clin Chim Acta 123:221-31 (1982)
DOI:10.1016/0009-8981(82)90166-8

Sequence

[hsa:84735]

Reference

2 [PMID:1903095]

Authors

Jackson MC, Kucera CM, Lenney JF.

Title

Purification and properties of human serum carnosinase.

Journal

Clin Chim Acta 196:193-205 (1991)
DOI:10.1016/0009-8981(91)90073-L

Other DBs

ExplorEnz - The Enzyme Database:

3.4.13.20

IUBMB Enzyme Nomenclature:

3.4.13.20

ExPASy - ENZYME nomenclature database:

3.4.13.20

BRENDA, the Enzyme Database:

3.4.13.20

CAS:	525589-43-9

DBGET integrated database retrieval system