Entry
Name
dipeptidyl-peptidase III;
dipeptidyl aminopeptidase III;
dipeptidyl arylamidase III;
enkephalinase B;
red cell angiotensinase
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Dipeptidyl-peptidases and tripeptidyl-peptidases
BRITE hierarchy
Reaction(IUBMB)
Release of an N-terminal dipeptide from a peptide comprising four or more residues, with broad specificity. Also acts on dipeptidyl 2-naphthylamides.
Comment
A cytosolic peptidase that is active at neutral pH. It has broad activity on peptides, although it is highly selective for Arg-Arg-2-naphthylamide, at pH 9.2. Active in the hydrolysis of enkephalins. A metallopeptidase, the type example of peptidase family M49.
History
EC 3.4.14.4 created 1981, modified 2001
Orthology
K01277 dipeptidyl-peptidase III
Genes
NLE : 100582608 100595091(DPP3)
CSAB : 103222490(DPP3) 103228650
PANU : 101025917(DPP3) 110742130
RNO : 114591(Dpp3) 678760(Dpp3l1)
ZCA : 113914312(DPP3) 118357179
ASAO : 132764600(DPP3) 132764602
XLA : 394413(dpp3.S) 446491(dpp3.L)
BBUF : 120980169(DPP3) 120983770
SANH : 107669347 107700005
CCAR : 109056653 109056655
CAUA : 113038500 113064156
CGIB : 127941351 127985461
MASI : 127428925 127431008
SASA : 100195375(dpp3) 106602977
STRU : 115154840 115204454(dpp3)
OTW : 112228944 112231170(dpp3)
OGO : 124006222 124007435(dpp3)
ONE : 115101448(dpp3) 115135495
OKI : 109873629(dpp3) 109883621
SALP : 111950262 111964353(dpp3)
SNH : 120021437(dpp3) 120057321
CCLU : 121542102(dpp3) 121579614
ARUT : 117398506 117967830
DSI : Dsimw501_GD18539(Dsim_GD18539)
CQU : CpipJ_CPIJ005356 CpipJ_CPIJ020236
DPL : KGM_207580A KGM_207580B
BROR : 134530842 134532310
PPOI : 119093094 119093102
CSCU : 111619617 111619619
PTEP : 107447605 107447610 107453556
ABRU : 129988286 129988883 129989048
PMEO : 129586218 129594069
RPHI : 132723997 132723999
DPOL : 127843730 127849816 127870751 127870753 127872747
SHX : MS3_00005472(DPP3_1) MS3_00010633(DPP3_2)
AQU : 100634914 100636624 100640601 100641912 105311889
NCS : NCAS_0C03640(NCAS0C03640)
TPF : TPHA_0P00610(TPHA0P00610)
TDL : TDEL_0D04520(TDEL0D04520)
KAF : KAFR_0C00980(KAFR0C00980)
KNG : KNAG_0K01190(KNAG0K01190)
CAL : CAALFM_C603960WA(CaO19.5773)
CDU : CD36_64480 CD36_81860
NTE : NEUTE1DRAFT126368(NEUTE1DRAFT_126368)
PAN : PODANSg2061 PODANSg8339
PBEL : QC761_113370 QC761_205370
PPSA : QC764_113370 QC764_205370
TTT : THITE_2147951 THITE_67951
PPEI : PpBr36_00233 PpBr36_09394
PGRI : PgNI_04892 PgNI_10311
FGR : FGSG_01017 FGSG_11021
FPU : FPSE_00290 FPSE_08592
FKR : NCS57_00081900 NCS57_00983500
PCHM : VFPPC_00559 VFPPC_13377
CMT : CCM_02475 CCM_03673 CCM_05894 CCM_06407 CCM_08520
AMUS : LMH87_005507 LMH87_008040
PLJ : VFPFJ_03651 VFPFJ_08065
PTKZ : JDV02_005031 JDV02_007111
CFJ : CFIO01_04728 CFIO01_11162
CLUP : CLUP02_05445 CLUP02_16241
SAPO : SAPIO_CDS1839 SAPIO_CDS3505
ELA : UCREL1_316 UCREL1_592
SSL : SS1G_01155 SS1G_03755
PSCO : LY89DRAFT_695045 LY89DRAFT_759760
AFM : AFUA_4G06140 AFUA_5G06940
NFI : NFIA_080360 NFIA_110000
APUU : APUU_70345A APUU_70489A
CCAC : CcaHIS019_0410550(YOL057W)
ABP : AGABI1DRAFT118131(AGABI1DRAFT_118131)
ABV : AGABI2DRAFT64000(AGABI2DRAFT_64000)
SCM : SCHCO_02607736(SCHCODRAFT_02607736)
DDI : DDB_G0273471(dpp3-1) DDB_G0273563(dpp3-2)
EHI : EHI_110750(58.t00023)
TET : TTHERM_00011440 TTHERM_00313320
PTM : GSPATT00003396001 GSPATT00007720001 GSPATT00021484001
TVA : TVAG_2v0040270 TVAG_2v0844830
GLA : GL50803_0033689 GL50803_003822
PMUC : ING2E5A_1809(dpp3-1)
» show all
Taxonomy
Reference
1
Authors
McDonald, J.K.
Title
Dipeptidyl-peptidase III.
Journal
In: Barrett, A.J., Rawlings, N.D. and Woessner, J.F. (Eds.), Handbook of Proteolytic Enzymes, Handbook of Proteolytic Enzymes, London, 1998, p. 536-538.
Reference
Authors
Fukasawa K, Fukasawa KM, Iwamoto H, Hirose J, Harada M.
Title
The HELLGH motif of rat liver dipeptidyl peptidase III is involved in zinc coordination and the catalytic activity of the enzyme.
Journal
Sequence
Other DBs
ExplorEnz - The Enzyme Database: 3.4.14.4
ExPASy - ENZYME nomenclature database: 3.4.14.4