KEGG ENZYME: 3.4.15.1

ENZYME: 3.4.15.1

Entry

EC 3.4.15.1                 Enzyme

Name

peptidyl-dipeptidase A;
dipeptidyl carboxypeptidase I;
peptidase P;
dipeptide hydrolase (ambiguous);
peptidyl dipeptidase;
angiotensin converting enzyme;
kininase II;
angiotensin I-converting enzyme;
carboxycathepsin;
dipeptidyl carboxypeptidase;
peptidyl dipeptidase I;
peptidyl-dipeptide hydrolase;
peptidyldipeptide hydrolase;
endothelial cell peptidyl dipeptidase;
ACE;
peptidyl dipeptidase-4;
PDH;
peptidyl dipeptide hydrolase;
DCP

Class

Hydrolases;
Acting on peptide bonds (peptidases);
Peptidyl-dipeptidases

Reaction(IUBMB)

Release of a C-terminal dipeptide, oligopeptide!Xaa-Yaa, when Xaa is not Pro, and Yaa is neither Asp nor Glu. Thus, conversion of angiotensin I to angiotensin II, with increase in vasoconstrictor activity, but no action on angiotensin II

Comment

A Cl--dependent, zinc glycoprotein that is generally membrane-bound. A potent inhibitor is captopril. Important in elevation of blood pressure, through formation of angiotensin II (vasoconstrictor) and destruction of bradykinin (vasodilator). Two molecular forms exist in mammalian tissues, a widely-distributed somatic form of 150- to 180-kDa that contains two non-identical catalytic sites, and a testicular form of 90- to 100-kDa that contains only a single catalytic site. Type example of peptidase family M2

History

EC 3.4.15.1 created 1972, modified 1981, modified 1989, modified 1996, modified 2011

Orthology

K01283

peptidyl-dipeptidase A

Genes

HSA:

1636(ACE)

PTR:	107969298 449567(ACE)

PPS:	100980711(ACE) 100981368

GGO:	101139668 101145787

PON:	100453403(ACE) 100453767

NLE:	100592115 105737894

HMH:	116458382 116458677

MCC:	100428661(ACE)

MCF:	102127700 102128376

MTHB:

126938330 126939540

MNI:	105483045 105483150

CSAB:

103243232 103243233

CATY:

105590725(ACE)

PANU:

101020307

TGE:	112609814(ACE)

MLEU:

105551749 105551750 105551751

RRO:	104675473 104675505

RBB:	108536241 108536285

TFN:

117067444

PTEH:

111527592 111527614

CANG:

105515963(ACE)

CJC:	100408147(ACE) 100408518

SBQ:	101052117(ACE)

CIMI:

108318275

CSYR:

103265660

MMUR:

105861642(ACE) 105861733

LCAT:

123620584(ACE) 123621200

PCOQ:

105822587 105825122

OGA:	100945027 100946178

MMU:	11421(Ace) 217246(Ace3)

MCAL:

110304805(Ace) 110305195

MPAH:

110331687(Ace) 110332456

RNO:	24310(Ace) 498012(Ace3)

MCOC:

116077933(Ace) 116078573

ANU:	117710946 117711678

MUN:	110547034 110547055

CGE:	100753209(Ace3) 103158533(Ace)

MAUA:

101824864 101833239

PROB:

127218024(Ace) 127218040

PLEU:

114690399 114690491

MORG:

121436287 121436320(Ace)

MFOT:

126487553

AAMP:

119812098 119812858

NGI:	103744762 103744772

HGL:	101701835(Ace) 101703133

CPOC:

100712658 100714182 100715217(Ace) 100733866 100735910

CCAN:

109703262 109703285

DORD:

105998512(Ace) 105998551

DSP:	122103272 122103576

PLOP:

125365757(Ace) 125366292

NCAR:

124980409 124980587

MMMA:

107158322 107158323

OCU:	100009274(ACE) 103351595

OPI:	101533604(ACE) 101534995

TUP:	102480658 102495265

GVR:	103589236(ACE)

CFA:	100856208 610668(ACE)

CLUD:

112652939 112653001

VVP:	112920644 112920698

VLG:	121473702 121474014

NPO:	129501014 129515675

AML:	100463832 100464084

UMR:	103665896 103665897

UAH:	113265294(ACE) 113265295

UAR:	123803006 123803007

ELK:	111158152 111158167

LLV:	125086844 125086845

MPUF:

101676879 101677359 101677640(ACE)

MNP:	132003318 132004477(ACE)

MLK:	131815943 131816578

NVS:	122906093 122907308

ORO:	101377413 101382544

EJU:	114196714 114196729

ZCA:	113939154 113939873

MLX:	118024390 118024420

NSU:	110570363 110570385(ACE)

LWW:	102733198 102734684

FCA:	101083124 101094061(ACE)

PYU:	121015249(ACE) 121015251

PCOO:

112864456 112864597

PBG:	122485753(ACE) 122485756

PVIV:

125151396 125152104

LRUF:

124512833 124512880

PTG:	102965986 102966279

PPAD:

109277113 109277114

PUC:	125926660 125926662

AJU:	106978669 106978683

HHV:	120234177 120234183

BTA:	100295485(ACE3) 509484(ACE)

BOM:	102266786 102273543

BIU:	109573322 109574310

BBUB:

102392455 102395458

BBIS:

105000614(ACE)

CHX:	102171917 106503207

OAS:	105613829 554335(ACE)

BTAX:

128064606(ACE) 128065386

ODA:	120866953 120866954

CCAD:

122433363 122439786

MBEZ:

129544531(ACE) 129544532

SSC:	100515049 613133(ACE)

CFR:	102505490 102514118

CBAI:

105069792 105069838 105069840

CDK:	105090416 105090499

VPC:

102532894

BACU:

103000257 103017916

BMUS:

118886312 118886658(ACE)

LVE:

103087287

OOR:	101272368 101274195

DLE:	111182603(ACE)

PCAD:

102985025(ACE) 102985307

PSIU:

116745506(ACE)

NASI:

112410212 112410213

ECB:	100064777 100064801(ACE)

EPZ:	103559240 103559241 103559246

EAI:	106835520 106835568

MYB:	102243978(ACE)

MYD:	102756093(ACE)

MMYO:

118671818(ACE)

MLF:	102417726(ACE)

PKL:

118726627

EFUS:

103293154(ACE)

MNA:	107531049(ACE)

DRO:	112316275(ACE)

SHON:

119003488(ACE)

AJM:	119036302(ACE)

PDIC:

114502602(ACE)

PHAS:

123817563(ACE)

MMF:	118634520(ACE)

PPAM:

129071531(ACE)

HAI:	109380275 109380308(ACE)

RFQ:	117012687 117012768(ACE)

PALE:

102880255 102890071(ACE)

PGIG:

120599965 120600373

PVP:	105297764 105297765

RAY:	107501813 107502259

MJV:	108400809 108401348

TOD:	119230616(ACE) 119232510

SARA:

101548258 101548526

SETR:

126001078 126001089

LAV:	100661555 100667696

TMU:	101341729 101341987 101357365

ETF:	101656382 101656494

DNM:	101413042 101420922

MDO:	100025797(ACE)

GAS:	123246196 123247930

SHR:	100932537 100932800

AFZ:

127560404

PCW:	110215741 110215742

OAA:	114815136(ACE)

GGA:	419953(ACE)

PCOC:

116233814(ACE)

MGP:	100542100(ACE)

CJO:	107325232(ACE)

TPAI:

128088718(ACE)

LMUT:

125684637(ACE)

NMEL:

110388589(ACE)

APLA:

101802065(ACE)

ACYG:

106045989(ACE)

CATA:

118258897(ACE)

AFUL:

116498500(ACE)

TGU:	100217841(ACE)

LSR:	110474830(ACE)

SCAN:

103821656(ACE)

PMOA:

120498197(ACE)

OTC:	121347708(ACE)

PRUF:

121352461(ACE)

GFR:	102032473(ACE)

FAB:	101819593(ACE)

OMA:	130264134(ACE)

PHI:	102111483(ACE)

PMAJ:

107215323(ACE)

CCAE:

111940103(ACE)

CCW:	104698643(ACE)

CBRC:

103619910(ACE)

ETL:	114066935(ACE)

ZAB:	102065179(ACE)

ACHL:

103811065(ACE)

SVG:	106861214(ACE)

MMEA:

130582460(ACE)

HRT:	120763794(ACE)

FPG:	101924109(ACE)

FCH:	102048145(ACE)

CLV:	102083877(ACE)

EGZ:	104134883(ACE)

NNI:	104009894(ACE)

PCRI:

104038703(ACE)

PLET:

104618579(ACE)

EHS:	104513983(ACE)

PCAO:

104051561(ACE)

ACUN:

113489137(ACE)

TALA:

104369510(ACE)

PADL:

103913868(ACE)

AFOR:

103906062(ACE)

ACHC:

115345056(ACE)

HALD:

104313802(ACE)

HLE:	104827978(ACE)

AGEN:

126038709

GCL:

127026523

CCRI:

104157279(ACE)

CSTI:

104557834(ACE)

CMAC:

104476826(ACE)

MUI:	104545390(ACE)

BREG:

104639029(ACE)

FGA:	104076621(ACE)

GSTE:

104264711(ACE)

LDI:	104344268(ACE)

OHA:	104338713(ACE)

NNT:	104405844(ACE)

SHAB:

115617938(ACE)

DPUB:

104309240(ACE)

PGUU:

104469594(ACE)

ACAR:

104530793(ACE)

CPEA:

104390241(ACE)

AVIT:

104273835(ACE)

CVF:	104285377(ACE)

RTD:	128919418(ACE)

CUCA:

104054375(ACE)

TEO:	104377133(ACE)

BRHI:

104502331(ACE)

AAM:	106497416(ACE)

AROW:

112962781(ACE)

NPD:	112960180(ACE)

TGT:	104564873(ACE)

DNE:	112982806(ACE)

SCAM:

104144771(ACE)

ASN:	102374457(ACE)

AMJ:	102573284(ACE)

CPOO:

109318963(ACE)

GGN:	109302091(ACE)

PSS:	102443828(ACE)

CMY:	102933955(ACE)

CCAY:

125626761(ACE)

DCC:	119848931(ACE)

CPIC:

101930790(ACE)

TST:	117869220(ACE)

CABI:

116839490(ACE)

MRV:	120392083(ACE)

ACS:	100558092(ace)

ASAO:

132778400(ACE)

PVT:	110080291(ACE)

SUND:

121935169(ACE)

PBI:	103067603(ACE)

PMUR:

107302404(ACE)

CTIG:

120302639(ACE)

TSR:	106545809(ACE)

PGUT:

117664820(ACE)

APRI:

131198534(ACE)

PTEX:

113447248(ACE)

NSS:	113420071(ACE)

VKO:	123031857(ACE)

PMUA:

114581443(ACE)

PRAF:

128401008(ACE)

ZVI:	118095294(ACE)

HCG:	128331749(ACE)

GJA:	107125675(ACE)

STOW:

125444577(ACE)

EMC:	129340516(ACE)

XLA:

108701765

XTR:	100144634(ace)

NPR:	108785994(ACE)

RTEM:

120919027(ACE)

BGAR:

122941140(ACE)

MUO:	115481874(ACE)

GSH:	117347738(ACE)

DRE:	565980(ace)

SRX:	107708876(ace) 107743967

SANH:

107653924 107664635

SGH:	107557358(ace) 107598651

CCAR:

109060366(ace) 109099167

CAUA:

113056340 113111957

CGIB:

127969191 128024991

PTET:

122355822(ace)

LROH:

127173941

OMC:	131550651(ace)

PPRM:

120474469(ace)

RKG:	130080540(ace)

MAMB:

125255089(ace)

CIDE:

127523680

MASI:

127423315 127426732

TROS:

130569206(ace)

TDW:	130439256(ace) 130439451

MANU:

129421044(ace)

IPU:

108274082

IFU:	128616542(ace)

PHYP:

113527416(ace)

SMEO:

124388635(ace)

TFD:	113653553(ace)

TVC:	132841584(ace)

AMEX:

103040258(ace)

CMAO:

118809154(ace)

EEE:	113584762(ace)

CHAR:

105891181(ace)

TRU:	101076790(ace)

TFS:	130528547(ace)

TNG:	GSTEN00024111G001

LCO:	104923252(ace)

NCC:	104966409(ace)

TBEN:

117473838(ace)

CGOB:

115024501(ace)

PGEO:

117464370(ace) 117464404

GACU:

117545140(ace)

EMAC:

134870693(ace)

ELY:	117247632(ace)

EFO:	125881066(ace)

PLEP:

121959090

SLUC:

116044258(ace)

ECRA:

117936645(ace)

ESP:	116671151(ace)

PFLV:

114547837(ace)

GAT:	120819300(ace)

PPUG:

119212747(ace)

AFB:	129091090(ace)

CLUM:

117749244(ace)

PSWI:

130203567(ace)

MSAM:

119915522(ace)

SCHU:

122868105(ace)

CUD:	121528232(ace)

ALAT:

119009665(ace)

MZE:	101470840(ace)

ONL:	100712518(ace)

OAU:	116320154(ace)

OLA:	101172772(ace) 101173018 111946416

OML:	112154380 112154658(ace)

CSAI:

133419459(ace)

XMA:	102221242(ace) 102238075

XCO:	114151374(ace) 114151607

XHE:	116727094(ace) 116727735

PRET:

103481980(ace) 103482159

PFOR:

103142748 103143124(ace)

PLAI:

106958690(ace) 106964438

PMEI:

106904713 106923296

GAF:	122823727(ace)

PPRL:

129352312

CVG:	107100492(ace)

CTUL:

119792874(ace)

GMU:	124875539(ace)

NFU:	107373324 107374473 107374589 107388107(ace)

KMR:	108237275(ace)

ALIM:

106517337(ace) 106535188

NWH:	119423934(ace) 119424168 119424170 119424171

AOCE:

111570427(ace)

MCEP:

125022266(ace)

CSEM:

103382106(ace)

POV:	109626948(ace)

SSEN:

122759089(ace)

HHIP:

117752627(ace)

HSP:	118100408(ace)

SMAU:

118287466(ace)

LCF:

108875837

SDU:	111220374(ace)

SLAL:

111672022(ace)

XGL:	120794236(ace)

HCQ:	109515983(ace)

SSCV:

125991473

SBIA:

133495195(ace)

PEE:	133395188(ace)

PTAO:

133468927(ace)

BPEC:

110159607(ace)

MALB:

109963664

BSPL:

114845366(ace)

SJO:	128381218(ace)

SASA:

106578314 106579262

STRU:

115159185 115200950

OTW:	112223647 112224096

OMY:	110491548 110498835

OGO:	124039909 124048311

ONE:	115106521 115143921

OKI:	109865702 109875695

OKE:	118357611 118366329

SALP:

111977173 111978277

SNH:	120045381 120060851

CCLU:

121547240 121567975

ELS:	105024522(ace)

SFM:	108928079(ace)

PKI:	111848632(ace)

AANG:

118217282 118221799

LOC:	102692099(ace)

PSPA:

121301717(ace)

ARUT:

117433335 117433482

PSEX:

120517329(ace)

LCM:	102356679 102358151

CMK:	103187713(ace)

CPLA:

122540046(ace)

HOC:	132830710(ace)

LERI:

129710228(ace)

PMRN:

116941101(ACE) 116948568

LRJ:	133344722 133349797

BFO:	118403150 118403314 118403321 118403506 118403507 118403682 118409681 118417365 118418232 118427679

BBEL:

109475027 109483872 109483913 109486676

CIN:	100177115 100180899

SCLV:

120342655 120343110

SPU:	100889485 574921 577312 578277 582767 593501 593516 593528

LPIC:

129255513 129257065 129265776 129272603 129274309 129274312

APLC:

110973283 110975980 110975981 110976389 110977723

AJC:

117122612

SKO:	100369495 100371822 100373236 100375424

DME:	Dmel_CG10142(Ance-5) Dmel_CG10593(Acer) Dmel_CG16869(Ance-2) Dmel_CG17988(Ance-3) Dmel_CG8196(Ance-4) Dmel_CG8827(Ance)

DER:	6540862 6540890 6540915 6540929 6541763 6548439

DSE:	6608276 6611222 6611716 6618900

DSI:	Dsimw501_GD10112(Dsim_GD10112) Dsimw501_GD23554(Dsim_GD23554) Dsimw501_GD23936(Dsim_Ance) Dsimw501_GD23937(Dsim_GD23937) Dsimw501_GD23939(Dsim_GD23939) Dsimw501_GD24910(Dsim_GD24910)

DYA:	Dyak_GE11404 Dyak_GE18694 Dyak_GE18695 Dyak_GE18785 Dyak_GE19012 Dyak_GE22653

DAN:	6494396 6495564 6497098 6498342

DSR:	110183874 110184068 110185592 110185727 110185942 110188985

DPO:	26533284 4803547 4804566 6902705 6902708 6902709 6903376 6903759 6904117

DPE:	113565405 113565453 6590076 6593017 6593982 6598001 6598003 6598005 6598006 6598008

DMN:	108158036 108158876 108161508 108162090 108163596 108163597 108163732 108163743 117187828 117190445

DWI:	26530341 6638145 6642187 6642191 6642421 6646754

DGR:	6559713 6560506 6561537 6561617 6562450 6562612

DMO:	Dmoj_GI10464 Dmoj_GI12636 Dmoj_GI12647 Dmoj_GI19428 Dmoj_GI19680

DAZ:	108609920 108611024 108611131 108616015 108616775

DNV:	108649360 108649398 108653177 108653430 115564748

DHE:	111597732 111600312 111600323 111603917 111604554

DVI:	6627173 6628146 6634022 6635836

CCAT:

101448622 101453723 101454020 101461472 101461648 101463032 101463213

BOD:	106621484 106621485 106623515 106623751 106624532 106625490 106625552

BDR:	105229109 105229185 105232276 105232277 105232278 105232282 105232878

RZE:	108359735 108365732 108370741 108370742 108374079 108377844

AOQ:	129245412 129245834 129246194 129247260 129248407 129249237

TDA:	119661821 119661822 119662562 119662563 119674729 119675003 119675112 119680982 119681344 119681345 119681346 119681347 119682066 119683681 119684307 119684788

MDE:	101890617 101891220 101891395 101891581 101891754 101892102 101897093 101897276 101897451 101898307

SCAC:

106080891 106080905 106080907 106085079 106085086 106085098 106085099 106085974 106085977 106085978

LCQ:	111675739 111677496 111677497 111677527 111677534 111678184 111678189 111682932

LSQ:	119606338 119606339 119606341 119606342 119606343 119606347 119608604 119612463

GFS:	119636392 119641085 119641093 119641102 119642189

ECOE:

129938852 129939024 129939207 129940625 129940643 129940854 129940856 129940879 129941328 129941604 129941711 129941719 129941737 129942113 129942669 129950246 129951086 129951348 129951999 129952061 129953541

CLON:

129606085 129606118 129606157 129606158 129607400 129607401 129607402 129607455 129607472 129615721

AGA:	1269607 1274704 1277966 1279158 1279159 1279162 1279163 4578145 4578342

ACOZ:

120953578 120955931 120955932 120955933 120955934 120956039 120956879 120959551 120959553 120961606

AARA:

120897794 120898219 120901409 120901935 120902104 120902105 120902106 120904353 120904355 120904356

AMER:

121594754 121596079 121597596 121597597 121597598 121597600 121603425

ASTE:

118507469 118508806 118508810 118508811 118508812 118512071 118513872 118517090

AFUN:

125764117 125766232 125768683

AMOU:

128298922 128301554 128303355 128304586 128305673 128305716

AALI:

118458092 118459167 118460981 118460982 118460983

AAG:	23687871 23687880 5564488 5571787 5571788 5575537 5576926

AALB:

109410834 109418632 109421171 109429410 109430368

CQU:	CpipJ_CPIJ004086 CpipJ_CPIJ008037 CpipJ_CPIJ009106 CpipJ_CPIJ009107 CpipJ_CPIJ009108 CpipJ_CPIJ016658

CPII:

120413133 120416008 120426646 120426647 120426648 120428353

CNS:	116339244 116341227 116343859 116350667

BCOO:

119066100 119073255 119076261 119076263 119076813

AME:	408536 726599

ACER:

107996204 107996328 108003297 108003669

ALAB:

122710834 122713950 122715300 122716150

ADR:	102671470 102673616

AFLR:

100863229 100872843 105736298

BIM:	100741044 100741573 100741589 100746911

BBIF:

117206929 117212154 117214692 117216376

BVK:	117231635 117235883 117240133 117240379

BVAN:

117153818 117162749 117164332 117166272

BTER:

100643830 100648126 100648879

BAFF:

126916340 126922538 126924262

BPYO:

122566225 122567048 122574032 122575560

BPAS:

132905276 132911315 132912227

FVI:	122531146 122533058 122533781

CCAL:

108630018 108630781

OBB:	114874107 114878974 114879032

OLG:	117603599 117603905 117605636

MGEN:

117225107 117226508

NMEA:

116424047 116424874 116432458

CGIG:

122394838 122402087 122404689

SOC:	105194681 105205562 105205813 105205851

MPHA:

105832049 105836394 105838565 105838648

AEC:	105146699 105149150 105151359

ACEP:

105618474 105625639 105626741

PBAR:

105422935 105423690 105427913

VEM:	105559190 105560169 105564404 105565736

HST:	105187836 105188756 105190423 105191653

DQU:	106743048 106743873 106744872

CFO:	105255379 105255596 105258144 105258735

FEX:	115236437 115241566 115241625 115241911 115242370

LHU:	105675528 105676522 105677666 105677771

PGC:	109852369 109852448 109860351

OBO:	105277505 105281342 105282107 105285556

PCF:	106786393 106788340 106792150

PFUC:

122515598 122517743 122521062

VPS:	122635661 122637716 122637840

VCRB:

124425713 124428494

VVE:	124956377 124957766

NVI:	100118011 100123549 100678623

CSOL:

105359611 105362386 105363868

TPRE:

106655001 106657748 106659265

LHT:	122498256 122498617 122501603

LBD:	127279834 127286008 127287682 127288007 127288239 127289306

MDL:	103572600 103576800 103578115

CGLO:

123263450 123264111 123265901 123268254

FAS:	105264884 105270777 105272583 105273275

DAM:	107036997 107040031 107040810 107041713 107043007

AGIF:

122848189 122850001 122852042 122855726

CINS:

118067673 118068109 118071774

VCAN:

122409888 122413929 122416845 122417924 122419109

CCIN:

107268193 107268194 107268195 107270864 107272995

DSM:	124407938 124408058 124409425 124409746 124416683

NPT:	124216501 124216581 124217354 124217537

NFB:	124179963 124180838 124181269 124185962

NLO:	107216843 107221160 107225344 107226576

NVG:	124302364 124302529 124303235 124305410

AROA:

105683636 105684950 105687164 105690357

TCA:	658047 658170(Ance-3) 658335 661107 663638

DPA:	109536526 109537454 109540808 109541221

SOY:	115879137 115879437 115881981 115889039

AGRG:

126742681 126745096 126748108 126748254

ATD:	109597090 109598516 109600257 109601515

CSET:

123307879 123308603 123315439 123315989 123323008

AGB:	108911069 108913027 108915521 108915563

LDC:	111502912 111506207

NVL:	108561359 108561583 108561585 108564313 108565889 108566579 108566581 108567239

APLN:

108738961 108741626 108742521

PPYR:

116158674 116158950 116163731 116163992 116177180 116178976 116179795 116181619

OTU:	111413086 111414514 111415386 111417926 111428233 111428427 111428456

BMOR:

101735566 101742492 101744965 101745756 692400

BMAN:

114241873 114245203 114245204 114245205 114246475 114247916 114252658

MSEX:

115439786 115441665 115444071 115446281 115446292 115446294 115450478

DPL:	KGM_205558 KGM_205559 KGM_205560 KGM_206216 KGM_210755

BANY:

112042963 112046929 112050032 112050069 112052643 112053787 128198547

MJU:	123867372 123867375 123867376 123869176 123878962

NIQ:	126769120 126769124 126769126 126772795 126779067 126779179

VCD:	124532359 124532538 124532604 124535369 124541139 124541274

MCIX:

123657695 123667695 123667948

PMAC:

106715187 106715578 106716199 106718138 106718792 106720249 106720307

PPOT:

106101419 106101799 106103673 106103675 106103677 106106263 106106309

PXU:	106115749 106115842 106115843 106122395 106122579 106123783 106123803

PRAP:

110993956 110996458 110996459 110996460 110997231 110998898 111001332

PBX:	123713941 123715605 123715825 123715982 123717416

PNAP:

125055585 125060457 125063168 125063287 125063288

ZCE:	119836512 119836545 119837036 119837439 119840590

CCRC:

123693142 123693330 123693399 123694819 123704135

LSIN:

126964982 126964995 126964998 126965784 126968308

AAGE:

121726979 121726980 121726981 121736241 121739574 121740192 121740308

HAW:	110373323 110374317 110374326 110374328 110375642 110383602 110384674

HZE:	124631666 124631881 124631926 124634336 124634559 124643347 124643445

TNL:	113496423 113496652 113500811 113504235 113504281 113504317

SLIU:

111349922 111350104 111355492 111355493 111355494 111355961 111356205

OFU:	114351429 114352780 114355895 114357873 114361744 114365464 114365468 114366264

PXY:	105379965 105381320 105381904 105383330 105383331 105385122 105392336 105393255 105396664

PGW:	126369378 126369379 126369381 126370218 126378313 126378378

CFEL:

113388422

CCRN:

123294364 123297842 123299969

API:	100164692 100166321 100166890 100168185(Ance-like) 100569104 100575164

DNX:	107162312 107162900 107163154 107169470

AGS:	114120823 114120839 114125644 114129465

RMD:	113551300 113552529 113554090 113558567

ACOO:

126834798 126836730 126840544 126844611

DVT:	126898091 126900063 126904424 126905726

BTAB:

109031665 109037939 109037940 109042582

DCI:	103506926 103508843

CLEC:

106661523 106664466 106672168 106672985

HHAL:

106679626 106685585 106690221

NLU:	111044873 111050316 111055718 111059211 120352840

HVI:	124368681 124368715 124369568 124369814

MQU:	128985544 128996745 128998498

PHU:	Phum_PHUM034490 Phum_PHUM207460 Phum_PHUM522390 Phum_PHUM522500 Phum_PHUM522520

FOC:	113202759 113203185 113208755 113212059 113217743 113217744

TPAL:

117640983 117646256 117649397 117649398 117649875 117651373

ZNE:	110829908 110829909 110830098 110837138 110840923 110840973 110840990

CSEC:

111864141 111865324 111865329 111865333 111871771 111873661

SGRE:

126293252 126293313

BROR:

134527682 134527872 134534321 134535180 134535263

IEL:	124158588 124159602 124169233

FCD:	110842890 110845544 110851052 110852103 110856071 110858388

DPX:	DAPPUDRAFT_214350 DAPPUDRAFT_243454 DAPPUDRAFT_304127 DAPPUDRAFT_306022 DAPPUDRAFT_307230 DAPPUDRAFT_307838 DAPPUDRAFT_307858

DMK:	116922832 116923675 116923750 116923970 116926869 116929694

DPZ:	124320229 124320727 124324598 124340951 124342211 124342622

PVM:	113799967 113802353 113803188 113803786 113808966 113823712 113827588

PJA:	122246699 122249106 122254117 122259272 122264891

PCHN:

125035166 125035831 125039179 125041905 125042113

PMOO:

119571016 119571025 119571691 119581705 119582350 119586536

HAME:

121854067 121855324 121857197 121866016 121879054

PCLA:

123747242 123747373 123747374 123757374 123757692 123764501 123773274

CQD:	128689434 128694438 128695775 128699171 128700584

PTRU:

123504193 123504222 123504280 123507320 123507408 123507448 123520204

ESN:	126982361 126988495 126991683 126992797 126994387 126995123 127006147 127009800

MNZ:	135196555 135200224 135200466 135201842 135201843 135216844 135217183

HAZT:

108664804 108680274

EAF:	111695006 111695390 111697618

LSM:	121114739 121119666

TCF:	131880635 131880636 131889215

PPOI:

119097286 119100896 119103205 119111444 119111448

DSV:	119455430 119455496 119455499

RSAN:

119393732 119394328 119395013 119395038 119395040 119399541

RMP:	119172337 119172924 119179835

VDE:

111244364

VJA:

111271363

TUT:

107368139

DPTE:

113789144 113797912 113798300

DFR:	124490609 124493918

CSCU:

111612383 111622279 111622286 111641467

PTEP:

107441685 107444143 107445552 107445555 107448934

ABRU:

129960278 129961822 129962309 129962313 129962314 129962315

UDV:	129216798 129216861 129218266

SDM:	118184501 118195242 118205234

LPOL:

106458754 106462698 106472652 111089490

PMEO:

129583358 129583460 129585927 129590456 129593261 129595571

CEL:	CELE_C42D8.5(acn-1)

CBR:	CBG_14607(Cbr-acn-1)

CRQ:	GCK72_024363

NAI:	NECAME_01815

BMY:	BM_BM2712(Bma-acn-1)

LOA:	LOAG_08740

TSP:

Tsp_01435

HRO:	HELRODRAFT_111546 HELRODRAFT_191596 HELRODRAFT_76483 HELRODRAFT_98522

LGI:	LOTGIDRAFT_115941 LOTGIDRAFT_118685 LOTGIDRAFT_161404 LOTGIDRAFT_215685 LOTGIDRAFT_215695

PVUL:

126821332 126821402 126821689 126822356

PCAN:

112557226 112557507 112573688

BGT:	106055618 106055619 106059089 106063041

GAE:

121371990

HRF:	124116125 124116126 124122559

HRJ:	124283354 124284705

CRG:	105325056 105337281(Ace) 117686524

CVN:	111101340 111107787 111137463

CANU:

128162585 128175297 128189996

OED:	125645421 125681449

MYI:	110442410 110457180 110457181 110457194

PMAX:

117320026

MCAF:

127727919 127729297

MMER:

123560737 123561361

RPHI:

132718045 132720609 132735588

DPOL:

127831950 127851278 127860088 127882306 127882468

OBI:	106868111 106869868

OSN:

115213195

LAK:	106150791 106161991 106171935

NVE:	116614488 5498715 5500329 5505310 5507095 5509484

EPA:	110236601 110246046 110246825

ATEN:

116295303 116302489 116307529

ADF:	107352074 107352075

AMIL:

114953923 114953924 114956778

PDAM:

113671633 113676309

SPIS:

111331992 111339682

DGT:	114523571 114536140 114536149 114536865

XEN:	124446807 124446969

HMG:	100202515 100206770 100210213

HSY:	130636604 130636605

TAD:	TRIADDRAFT_37492

XCC:

XCC1116

XCB:

XC_3130

XCA:	xcc-b100_3225

XCP:

XCR_1338

XCV:

XCV1249

XAX:

XACM_1192

XAC:

XAC1217

XCI:	XCAW_03136

XCT:	J151_01358

XCJ:	J158_01355

XCU:	J159_01355

XCN:	J169_01354

XCW:	J162_01354

XCR:	J163_01354

XCM:	J164_01354

XCF:	J172_01349

XFU:	XFF4834R_chr33230

XOM:	XOO3345(XOO3345)

XOO:

XOO3539

XOP:

PXO_04473

XOY:	AZ54_06030

XOR:

XOC_1282

XOZ:	BE73_16985

XAL:

XALC_0887

XSA:	SB85_07140

XTN:	FD63_04890

XVE:	BJD12_19380

XPE:	BJD13_10575

XHR:	XJ27_09090

XGA:	BI317_07085

XVA:	C7V42_06590

XAR:	XB05_00855

XHY:	FZ025_04405

XCZ:	EBN15_04890

XTH:	G4Q83_00820

XEU:	XSP_001239

XHD:	LMG31886_31180

XPR:	MUG10_03740

XAG:	HEP73_03127

XDY:	NYR95_06770

XAS:	HEP74_02944

SML:

Smlt3574

SMT:

Smal_2996

BUJ:	BurJV3_3026

SMZ:

SMD_3147

SACZ:

AOT14_25770

STEK:

AXG53_03980

SRH:	BAY15_2755

SLM:	BIZ42_04585

STEN:

CCR98_15585

STEM:

CLM74_15910

STES:

MG068_15480

SINC:

DAIF1_31200

SPAQ:

STNY_R31680

STEQ:

ICJ04_12855

SGEN:

RKE57_15600

PSU:	Psesu_2161

PSUW:

WQ53_02775

PSD:

DSC_06070

PMEX:

H4W19_00850

PJP:	LAG73_11460

PDD:	MNQ95_01770

PWI:	MWN52_13440

LAB:	LA76x_3622(ace)

LAQ:	GLA29479_777

LCP:	LC55x_3591(ace)

LGU:	LG3211_1594

LEZ:

GLE_1570

LEM:

LEN_3391

LMB:	C9I47_2124

LYT:	DWG18_08965

LUE:	DCD74_05720

LYJ:	FKV23_05785

LSOL:

GOY17_13295

LSX:	H8B22_11340

LARE:

HIV01_001405

LHX:	LYSHEL_03330

LCAS:

LYSCAS_03330

LCIC:

INQ41_10210

LAVI:

INQ42_09655

LLZ:	LYB30171_01879

LAUX:

LA521A_25620

LYA:	RDV84_24365

LUM:	CNR27_11825

LUG:	FPZ22_03155

THES:

FHQ07_04020

THEH:

G7079_10405

TCN:	H9L16_10100

TBV:	H9L17_04115

XBC:	ELE36_13190

DKO:

I596_1523

XBA:	C7S18_07225

TAMN:

N4264_18640

PAGR:

E2H98_02665

SON:

SO_2494

SDN:

Sden_2117

SFR:

Sfri_1887

SAZ:

Sama_1817

SBL:	Sbal_2246 Sbal_4532

SBM:	Shew185_2125

SBN:	Sbal195_2170

SBP:	Sbal223_2259

SBT:	Sbal678_2173

SBS:	Sbal117_2369

SBB:	Sbal175_2295

SLO:

Shew_2053

SSE:

Ssed_2057

SPL:

Spea_2340

SHE:	Shewmr4_2051

SHM:	Shewmr7_1924

SHN:	Shewana3_2156

SWD:

Swoo_2544

SWP:

swp_2383

SVO:

SVI_2322

SHF:	CEQ32_05285

SJA:	SJ2017_1962

SPSW:

Sps_01127

SBJ:	CF168_09980

SMAV:

CFF01_09060

SHEW:

CKQ84_19515

SLJ:	EGC82_12125

SBK:	SHEWBE_2612

SKH:	STH12_01499

SLIT:

JQC75_09180

SPSH:

FM037_15145

SEUR:

FM038_011230

SCYP:

JYB88_08570

SSEM:

JYB85_08750

SINV:

K8B83_11905

SXM:	MKD32_09470

SSEH:

N7V09_12600

SACH:

K0H61_08630

SAEG:

K0H80_10425

SDEO:

D0436_09730

SMES:

K0I73_08945

SHAO:

K0H81_09440

SZH:	K0H63_10145

SSPA:

K0I31_10725

SHNS:

K0J45_10475

SRHS:

K0I63_10620

SPSJ:

K0I62_10580

SMAY:

K0H60_10825

SOG:	RA178_11875

SPSR:

EGC80_16935

CPS:

CPS_1585

COM:	CMT41_06100

COZ:	A3Q34_17145

COLW:

A3Q33_14855

COLA:

DBO93_12445

COV:	EKO29_06035

CBER:

B5D82_14950

LSD:	EMK97_00060

THT:	E2K93_01060

THAB:

LP316_07465

THAT:

H3N35_10905

TACT:

SG35_011485

TVD:	SG34_017930

PSEO:

OM33_11595

PPHE:

PP2015_1416

PRR:	AT705_01040

PLZ:	S4054249_13475

PALN:

B0W48_14515

PPIS:

B1L02_09310

PEA:	PESP_a1448

PSPO:

PSPO_a1844

PART:

PARC_a2553

PTU:	PTUN_a1759

PSEN:

PNC201_09645

PDJ:	D0907_06655

PAGA:

PAGA_a2437

PCAR:

PC2016_1992

PVB:	J5X90_13405

PSAZ:

PA25_13420

PDV:	FFU37_04500

PFLI:

CTT31_09990

PMAZ:

R5H13_10550

PSYM:

J1N51_01100

AMC:	MADE_1008755

AMAA:

amad1_09155

AMAL:

I607_08070

AMAE:

I876_08335

AMAO:

I634_08440

AMAD:

I636_08870

AMAI:

I635_09140

AMAG:

I533_08380

AMAC:

MASE_07965

AMB:	AMBAS45_08550

AMG:	AMEC673_08055

AMK:	AMBLS11_07960

ALT:	ambt_09930

ASP:	AOR13_1841

ASQ:	AVL57_07945

AAW:	AVL56_06825

ALE:	AV939_06955

ALZ:	AV940_06800

GAG:	Glaag_2085

GNI:

GNIT_1032

PMES:

FX988_00392

LAL:	AT746_11700

SALH:

HMF8227_01715

PAEW:

KIH87_07760

ALII:

QR722_10900

PMAW:

MACH26_22220

FES:	HER31_05360

CEG:	D0C16_22100

TTU:	TERTU_2099

SAGA:

M5M_17395

MTHD:

A3224_10760

MICC:

AUP74_01978

MAGA:

Mag101_12285

MII:	BTJ40_05910

MICT:

FIU95_05705

MHYD:

GTQ55_05640

MCEL:

LPW13_03655

MICZ:

GL2_26280

MVB:	MJO52_05910

MPAF:

R5R33_16005

MBRG:

PVT68_04250

HJA:	BST95_03020

LLO:

LLO_1982

LSH:	CAB17_11125

RHH:	E0Z06_04410

RHEI:

ATY27_02330

WOC:	BA177_18120

PLEI:

Q9312_03850

KKO:

Kkor_1388

KGE:

TQ33_1115

KSD:	KS2013_1165

KPD:	CW740_06445

KAM:	SR900_07790

SINI:

GT972_12445

FCE:	JN531_008905

RDP:	RD2015_4513

MNR:	ACZ75_24275

MASW:

AM586_19455

MASY:

DPH57_25595

MENY:

LSQ66_16495

MASZ:

C9I28_23710

MALI:

EYF70_03655

MUM:	FCL38_14990

MFLA:

GO485_10495

MPLI:

E1742_10800

TCT:	PX653_27205

DUG:	HH213_05255

DZO:	SR858_04140

TMJ:	P0M04_18625

RUG:	QC826_04380

EHB:	E7V67_021505

UPV:	EJN92_15280

UPI:	EJG51_017610

MESP:

C1M53_16790

NOH:	G5V57_17615

PSF:

PSE_0360

CAK:

Caul_0184

CMB:	CSW64_01790

CAUL:

KCG34_14895

PZU:

PHZ_c0316

BRD:	JL11_03565

BRG:	A4249_13230

BVC:	CEP68_07990

BREV:

E7T10_02090

BMED:

GYM46_07230

BND:	KWG56_14555

BGOE:

IFJ75_15565

BVIT:

JIP62_11915

BALB:

M8231_13525

BFQ:	JX001_02250

BRES:

E4341_02170

AEX:	Astex_0409

ASTI:

Q1W73_03935

TSV:	DSM104635_02591

APAH:

KB221_14555

TMD:	KUV46_02265

MMR:	Mmar10_1467

HYT:	HXX25_04825

HNE:

HNE_1947

HBA:

Hbal_0598

CBOT:

ATE48_16515

NPP:	PP1Y_AT21138

NPN:	JI59_18910

NRE:	BES08_01765

NOV:	TQ38_007125

NOR:	FA702_00395

NGF:	FRF71_10415

NOG:	GKE62_17420

NDR:	HT578_20545

SAL:

Sala_0456

SPHK:

SKP52_18105

SPHP:

LH20_16505

SMAG:

AN936_01840

SMAZ:

LH19_18700

STER:

AOA14_08370

SGI:	SGRAN_3476(ace)

SPHQ:

BWQ93_13185

SPHO:

C3E99_12185

SPHX:

E5675_21165

SINA:

KNJ79_15915

SPHU:

SPPYR_0141

SWI:

Swit_2667

SPHD:

HY78_12175

RDI:	CMV14_02435

SPHM:

G432_00930

STAX:

MC45_04745

SPHI:

TS85_09285

SSAN:

NX02_12980

SNJ:	A7E77_13945

SMY:	BJP26_07295

SPAN:

AWL63_17445

SKR:	BRX40_16375

SPLM:

BXU08_02065

SPLK:

AV944_12650

SPKC:

KC8_02095

SPHC:

CVN68_01590

SPHF:

DM480_12300

SPHA:

D3Y57_06525

SPAU:

DRN02_005555

SLUT:

H9L13_07350

SRHI:

H9L12_04455

SLAN:

GV829_11605

SSED:

H9L14_06860

SPAP:

H3Z74_07680

SXA:	FMM02_01480

SPAI:

FPZ24_09425

SSIN:

G7078_07485

SSAU:

H8M03_01745

SARI:

H5J25_06730

SSUA:

FPZ54_01585

SBIN:

SBA_ch1_24530

SAER:

NEF64_12015

SGLC:

M1K48_02300

SRAD:

LLW23_14455

SNAP:

PQ455_01345

SDON:

M9980_03475

SSAG:

KV697_03910

SSY:

SLG_23650

SBD:	ATN00_13785

SPHR:

BSY17_2968

SHYD:

CJD35_13065

SYA:	A6768_08710

SCLO:

SCLO_1007070

SPYG:

YGS_C1P1114

SAMI:

SAMIE_1012830

SPPH:

KFK14_11620

CIJ:	WG74_13430

SPHG:

AZE99_07535

SFLA:

SPHFLASMR4Y_00851

SPHY:

CHN51_15470

SPHL:

LPB140_08200

SLAA:

EUU25_05170

BLAS:

BSY18_285

BFW:	B5J99_10435

BMAA:

T8S45_03050

SPHJ:

BSL82_07970

SPZR:

G5C33_09835

PALG:

HFP57_04005

PARP:

HFP51_04950

PARJ:

J4G78_01540

PHAO:

HF685_02525

ACOB:

P0Y56_03035

SMIC:

SmB9_12650

SPHS:

ETR14_20580

SFLV:

IC614_04155

SAND:

H3309_06305 H3309_08985

AEP:	AMC99_01399

ALB:

AEB_P1567

ALH:	G6N82_14755

AAY:

WYH_00229

AMX:	AM2010_648

PMAS:

NCF86_06735

ANH:	A6F65_01468

ADO:	A6F68_02380

TFV:	IDJ81_10300

EFV:	CHH26_07135

QCI:	NCF85_07375

QSP:	L1F33_10545

QSO:	IRL76_06865

QAR:	K3148_13395

QGE:	K3136_00420

QPS:	K3166_05150

ELI:

ELI_07405

ERK:	CD351_11280

ERR:	DVR09_10985

ERF:	FIU90_11345

EMV:	HQR01_10725

PNS:	A9D12_13260

PORL:

BG023_112159

PHZ:	CHX26_12030

POT:	E2E27_10180

AFLV:

QQW98_10550

NCB:	C0V82_09325

HFL:	PUV54_06355

ECOG:

FIV45_00315

GSO:	PH603_00975

ADE:

Adeh_2024

ACP:	A2cp1_1939

AFW:	Anae109_1785

ANK:	AnaeK_1854

AORY:

AMOR_58830

MXA:

MXAN_3581

MSD:	MYSTI_04371

MYM:	A176_003327

MFB:	MFUL124B02_23325

MYX:	QEG98_19195

CCX:	COCOR_04454

MFU:	LILAB_25885

MMAS:

MYMAC_003522

SUR:	STAUR_4119

AGE:	AA314_05130

AVM:	JQX13_40170

MBD:	MEBOL_006925

CFUS:

CYFUS_004661

VIN:	AKJ08_2640

SCL:	sce3979 sce5088

SCU:	SCE1572_23880 SCE1572_30910

CCRO:

CMC5_062220

PAUU:

E8A73_002045 E8A73_002935

MRM:	A7982_03788

SAMY:

DB32_002593

LLU:	AKJ09_11323

HOH:

Hoch_6422

NANN:

O0S08_45825

TUM:	CBW65_02160

TAB:	CIG75_04395

NTR:	B0W44_04260

KPUL:

GXN76_05880

PABS:

JIR001_09640

AFT:	BBF96_12400

RXY:

Rxyl_3178

RRD:	RradSPS_2735

RMAR:

GBA65_00355

GVI:

gll3143

GLJ:

GKIL_2224

GML:	ISF26_16250

CCZ:	CCALI_02788

OBG:	Verru16b_00408

OLE:	K0B96_06360

PLH:	VT85_17175

GES:	VT84_35045

GOG:	C1280_16165

GMS:	SOIL9_09640

TIM:	GMBLW1_51560

LRS:	PX52LOC_01185

FTJ:

FTUN_6918

ULI:	ETAA1_12270

TSPH:

KIH39_12285

SACI:

Sinac_2369

PBOR:

BSF38_03282

AGV:	OJF2_77400

UAM:	UABAM_06068

ABA:	Acid345_4468

TSA:	AciPR4_3174

TRS:	Terro_0304

TALB:

FTW19_25615

ORP:	MOP44_05415

SUS:

Acid_4844

PFER:

IRI77_16265

ABAC:

LuPra_00431

LUB:	TBR22_A04050

THYD:

TTHT_1108

SCOR:

J3U87_18375

GEX:	GETHOR_01160

GEP:	Q9293_00650

MSIL:

METEAL_42020

MSEA:

METESE_38350

GBA:

J421_0092

BACC:

BRDCF_p1005

CBAE:

COR50_08685

CSAC:

SIO70_15955

RHOZ:

GXP67_07405

DPF:	ON006_13200

HSW:

Hsw_1814

HYM:	N008_16255

HYD:	PK28_11185

HYE:	AM218_05305

HYG:	AUC43_18185

HYP:	A0257_04740

HYH:	D3Y59_03365

HYJ:	FHG12_17000

HBN:	GUY19_02110

HTS:	HMJ29_19055

HTB:	MTX78_12980

HYK:	O9Z63_09205

HSK:	H4317_08270

HCW:	O3303_07370

HSB:	MWH26_09860

HAEI:

MUN82_05390

HVL:	MUN86_13330

HCF:	MUN80_19835

PKO:	PKOR_00660

PACT:

CA264_06060

ADD:	HUW48_10730

ASWU:

HUW51_18300

FBT:	D770_19145

FUV:	JR347_03315

FMM:	LVD15_06245

FLW:	LVD16_04745

FPAL:

HYN49_09910

FMG:	HYN48_09400

LUL:	LPB138_13980

PPON:

MUN68_003705

MANG:

RBH95_11290

FBU:	UJ101_00896(ACE)

OHO:	Oweho_1053

CABY:

Cabys_1631

» show all

Reference

1 [PMID:2849100]

Authors

Soubrier F, Alhenc-Gelas F, Hubert C, Allegrini J, John M, Tregear G, Corvol P

Title

Two putative active centers in human angiotensin I-converting enzyme revealed by molecular cloning.

Journal

Proc Natl Acad Sci U S A 85:9386-90 (1988)
DOI:10.1073/pnas.85.24.9386

Sequence

[hsa:1636]

Reference

2 [PMID:2554286]

Authors

Ehlers MR, Fox EA, Strydom DJ, Riordan JF.

Title

Molecular cloning of human testicular angiotensin-converting enzyme: the testis isozyme is identical to the C-terminal half of endothelial angiotensin-converting enzyme.

Journal

Proc Natl Acad Sci U S A 86:7741-5 (1989)
DOI:10.1073/pnas.86.20.7741

Sequence

[hsa:1636]

Reference

3 [PMID:1320019]

Authors

Wei L, Clauser E, Alhenc-Gelas F, Corvol P

Title

The two homologous domains of human angiotensin I-converting enzyme interact differently with competitive inhibitors.

Journal

J Biol Chem 267:13398-405 (1992)

Reference

4 [PMID:7674927]

Authors

Corvol P, Williams TA, Soubrier F.

Title

Peptidyl dipeptidase A: angiotensin I-converting enzyme.

Journal

Methods Enzymol 248:283-305 (1995)
DOI:10.1016/0076-6879(95)48020-x

Other DBs

ExplorEnz - The Enzyme Database:

3.4.15.1

IUBMB Enzyme Nomenclature:

3.4.15.1

ExPASy - ENZYME nomenclature database:

3.4.15.1

BRENDA, the Enzyme Database:

3.4.15.1

CAS:

9015-82-1

DBGET integrated database retrieval system