KEGG ENZYME: 3.4.17.20

ENZYME: 3.4.17.20

Entry

EC 3.4.17.20                Enzyme

Name

carboxypeptidase U;
arginine carboxypeptidase;
carboxypeptidase R;
plasma carboxypeptidase B (misleading, since the term carboxypeptidase B is used for other enzymes);
thrombin-activatable fibrinolysis inhibitor

Class

Hydrolases;
Acting on peptide bonds (peptidases);
Metallocarboxypeptidases

Reaction(IUBMB)

Release of C-terminal Arg and Lys from a polypeptide

Comment

Pro-carboxypeptidase U in (human) plasma is activated by thrombin or plasmin during clotting to form the unstable carboxypeptidase U, with activity similar to that of the more stable lysine carboxypeptidase, except that no preference is shown for Lys over Arg. A zinc enzyme, in peptidase family M14 (carboxypeptidase A family)

History

EC 3.4.17.20 created 1997

Orthology

K01300

carboxypeptidase B2

Genes

HSA:	1361(CPB2)

PTR:	452582(CPB2)

PPS:	100993828(CPB2)

GGO:	101153798(CPB2)

PON:	100452501(CPB2)

NLE:	100582393(CPB2)

HMH:	116467479(CPB2)

MCC:	703317(CPB2)

MCF:	102132600(CPB2)

MTHB:

126940373

MNI:	105490665(CPB2)

CSAB:

103214382(CPB2)

CATY:

105587782(CPB2)

PANU:

101009284(CPB2)

TGE:	112610806(CPB2)

MLEU:

105535486(CPB2)

RRO:	104658149(CPB2)

RBB:	108528946(CPB2)

TFN:	117063285(CPB2)

PTEH:

111522998(CPB2)

CANG:

105510229(CPB2)

CJC:	100411115(CPB2)

SBQ:	101041667(CPB2)

CIMI:

108309486(CPB2)

CSYR:

103264476(CPB2)

MMUR:

105881162(CPB2)

LCAT:

123649276(CPB2)

PCOQ:

105813572(CPB2)

MMU:	56373(Cpb2)

MCAL:

110309374(Cpb2)

MPAH:

110325644(Cpb2)

RNO:	113936(Cpb2)

MCOC:

116084081(Cpb2)

ANU:	117705889(Cpb2)

MUN:	110547470(Cpb2)

CGE:	100754304(Cpb2)

MAUA:

101832358(Cpb2)

PROB:

127230178(Cpb2)

PLEU:

114699220(Cpb2)

MORG:

121461115(Cpb2)

AAMP:

119800387(Cpb2)

NGI:	103726752(Cpb2)

HGL:	101712343(Cpb2)

CPOC:

100736054(Cpb2)

CCAN:

109698557(Cpb2)

DORD:

105981839(Cpb2)

DSP:	122112732(Cpb2)

PLOP:

125347582(Cpb2)

NCAR:

124984469

MMMA:

107141051(Cpb2)

OCU:

100341346

OPI:	101536220(CPB2)

TUP:	102473098(CPB2)

GVR:	103591895(CPB2)

CFA:	608910(CPB2)

CLUD:

112678877(CPB2)

VVP:	112933941(CPB2)

VLG:	121476871(CPB2)

NPO:	129516303(CPB2)

AML:	100482734(CPB2)

UMR:	103677685(CPB2)

UAH:	113251347(CPB2)

UAR:	123791831(CPB2)

ELK:

111147094

LLV:

125096446

MPUF:

101693960(CPB2)

MNP:	132002470(CPB2)

MLK:	131813929(CPB2)

NVS:	122907852(CPB2)

ORO:	101370239(CPB2)

EJU:	114212061(CPB2)

ZCA:	113920041(CPB2)

MLX:	118009180(CPB2)

NSU:	110587683(CPB2)

LWW:	102726651(CPB2)

FCA:	101082116(CPB2)

PYU:	121012974(CPB2)

PCOO:

112861051(CPB2)

PBG:	122482654(CPB2)

PVIV:

125169498(CPB2)

LRUF:

124511153

PTG:	102952076(CPB2)

PPAD:

109265929(CPB2)

PUC:

125933793

AJU:

106972009

HHV:	120246731(CPB2)

BTA:	508222(CPB2)

BOM:	102285531(CPB2)

BIU:	109566696(CPB2)

BBUB:

102390937(CPB2)

BBIS:

104999147(CPB2)

CHX:	102181135(CPB2)

OAS:	101112329(CPB2)

BTAX:

128057795(CPB2)

ODA:	120883212(CPB2)

CCAD:

122447320(CPB2)

MBEZ:

129556597(CPB2)

SSC:	100155038(CPB2)

CFR:	102509764(CPB2)

CBAI:

105066131(CPB2)

CDK:	105089749(CPB2)

VPC:	102530988(CPB2)

BACU:

103010017(CPB2)

BMUS:

118884013(CPB2)

LVE:	103075780(CPB2)

OOR:	101269719(CPB2)

DLE:	111175334(CPB2)

PCAD:

102985818(CPB2)

PSIU:

116742987(CPB2)

NASI:

112406639(CPB2)

ECB:	100058534(CPB2)

EPZ:	103548935(CPB2)

EAI:	106829669(CPB2)

MYB:	102250791(CPB2)

MYD:	102755974(CPB2)

MMYO:

118651919(CPB2)

MLF:	102429248(CPB2)

PKL:	118730773(CPB2)

EFUS:

103295599(CPB2)

MNA:	107542259(CPB2)

DRO:	112310676(CPB2)

SHON:

118994837(CPB2)

AJM:	119037366(CPB2)

PDIC:

114508873(CPB2)

PHAS:

123818757(CPB2)

MMF:	118622819(CPB2)

PPAM:

129080962(CPB2)

HAI:	109391288(CPB2)

RFQ:	117021276(CPB2)

PALE:

102878653(CPB2)

PGIG:

120583898(CPB2)

PVP:	105298906(CPB2)

RAY:	107505990(CPB2)

MJV:	108407588(CPB2)

TOD:	119258511(CPB2)

SARA:

101550576(CPB2)

SETR:

126016325(CPB2)

LAV:	100662006 100662575

TMU:	101350804 101351060

ETF:	101639359(CPB2)

DNM:	101429335(CPB2)

MDO:	100016398(CPB2)

GAS:	123240070(CPB2)

SHR:	100928968(CPB2)

AFZ:

127557042

PCW:	110197346(CPB2)

OAA:	100083738(CPB2)

GGA:	418851(CPB2)

PCOC:

116244214(CPB2)

MGP:	100545409(CPB2)

CJO:	107308136(CPB2)

TPAI:

128071650(CPB2)

LMUT:

125698779(CPB2)

NMEL:

110387568(CPB2)

APLA:

101791007(CPB2)

ACYG:

106035057(CPB2)

CATA:

118251331(CPB2)

AFUL:

116500497(CPB2)

TGU:	100229153(CPB2)

LSR:	110469572(CPB2)

SCAN:

103827416(CPB2)

PMOA:

120505867(CPB2)

OTC:	121337305(CPB2)

PRUF:

121353298(CPB2)

GFR:	102041508(CPB2)

FAB:	101808771(CPB2)

OMA:	130255350(CPB2)

PHI:	102107395(CPB2)

PMAJ:

107199992(CPB2)

CCAE:

111937540(CPB2)

CCW:	104689980(CPB2)

CBRC:

103615151(CPB2)

ETL:	114059887(CPB2)

ZAB:	102063880(CPB2)

ACHL:

103799533(CPB2)

SVG:	106848706(CPB2)

MMEA:

130578543(CPB2)

HRT:	120748982(CPB2)

FPG:	101919154(CPB2)

FCH:	102052809(CPB2)

CLV:	102085489(CPB2)

EGZ:	104131617(CPB2)

NNI:	104010961(CPB2)

PCRI:

104035897(CPB2)

PLET:

104614601(CPB2)

PCAO:

104039840

ACUN:

113481749(CPB2)

TALA:

104360053(CPB2)

PADL:

103915914(CPB2)

AFOR:

103903665(CPB2)

ACHC:

115350569(CPB2)

HALD:

104316719(CPB2)

HLE:	104841642(CPB2)

AGEN:

126045121

GCL:

127024593

CCRI:

104164172(CPB2)

CSTI:

104560652

CMAC:

104484836(CPB2)

MUI:	104537650(CPB2)

BREG:

104638181(CPB2)

FGA:	104084406(CPB2)

GSTE:

104251360(CPB2)

LDI:	104346210(CPB2)

OHA:	104336972(CPB2)

NNT:	104407710(CPB2)

SHAB:

115604369(CPB2)

DPUB:

104306715(CPB2)

PGUU:

104459815(CPB2)

ACAR:

104524048

CPEA:

104391544(CPB2)

AVIT:

104269179(CPB2)

CVF:	104282841(CPB2)

RTD:	128903058(CPB2)

CUCA:

104056527(CPB2)

TEO:

104377233

BRHI:

104501866(CPB2)

AAM:	106489197(CPB2)

AROW:

112969186(CPB2)

NPD:	112950354(CPB2)

TGT:	104580888(CPB2)

DNE:	112988199(CPB2)

SCAM:

104148969(CPB2)

ASN:	102376487(CPB2)

AMJ:	102562517(CPB2)

CPOO:

109306508(CPB2)

GGN:	109303407(CPB2)

PSS:	102448472(CPB2)

CMY:	102946625(CPB2)

CCAY:

125627235(CPB2)

DCC:	119851020(CPB2)

CPIC:

101933938(CPB2)

TST:	117870958(CPB2)

CABI:

116830941(CPB2)

MRV:	120370365(CPB2)

ACS:	100567959(cpb2)

ASAO:

132781910(CPB2)

PVT:	110076120(CPB2)

SUND:

121919080(CPB2)

PBI:	103051972(CPB2)

PMUR:

107289863(CPB2)

CTIG:

120318879(CPB2)

PGUT:

117674319(CPB2)

APRI:

131196966(CPB2)

PTEX:

113442709(CPB2)

NSS:	113412672(CPB2)

VKO:	123030303(CPB2)

PMUA:

114593624(CPB2)

PRAF:

128409953(CPB2)

ZVI:	118082531(CPB2)

HCG:	128340157(CPB2)

GJA:	107110254(CPB2)

STOW:

125439804(CPB2)

EMC:	129338071(CPB2)

XLA:	108708528(cpb2.L) 108709798(cpb2.S)

XTR:	595005(cpb2)

NPR:	108794281(CPB2)

RTEM:

120929623(CPB2)

BBUF:

120995927(CPB2)

BGAR:

122933206(CPB2)

MUO:	115468645(CPB2)

GSH:	117362096(CPB2)

DRE:	100000935(cpb2)

SRX:	107707839(cpb2)

SANH:

107654270(cpb2)

SGH:	107588824(cpb2)

CCAR:

109067316(cpb2)

CAUA:

113044382(cpb2)

CGIB:

127948334

PTET:

122350569(cpb2)

LROH:

127166680(cpb2)

OMC:	131543414(cpb2)

PPRM:

120479668(cpb2)

RKG:	130087832(cpb2)

MAMB:

125272331(cpb2)

CIDE:

127509255

MASI:

127443713

TROS:

130564825(cpb2)

TDW:	130428295(cpb2)

MANU:

129437557(cpb2)

IPU:

108258492

IFU:	128602333(cpb2)

PHYP:

113537361(cpb2)

SMEO:

124377841(cpb2)

TFD:	113648661(cpb2)

TVC:	132839738(cpb2)

AMEX:

103039184(cpb2)

CMAO:

118804389(cpb2)

EEE:	113585022(cpb2)

CHAR:

105890412(cpb2)

TRU:	101063870(cpb2)

TFS:	130522185(cpb2)

TNG:	GSTEN00027145G001

LCO:	104937555(cpb2)

NCC:

104941379

TBEN:

117499017(cpb2)

CGOB:

115016827

PGEO:

117459926(cpb2)

GACU:

117546929(cpb2)

EMAC:

134860926(cpb2)

ELY:	117249807 117249816

EFO:	125884922(cpb2)

PLEP:

121950552 121962801 121962880

SLUC:

116044783(cpb2)

ECRA:

117939427(cpb2)

ESP:	116673913(cpb2)

PFLV:

114551165(cpb2)

GAT:	120821258(cpb2)

PPUG:

119222101(cpb2)

AFB:	129111831(cpb2)

CLUM:

117743717(cpb2)

PSWI:

130204470(cpb2)

MSAM:

119902776(cpb2)

SCHU:

122872377(cpb2)

CUD:	121506353 121506369(cpb2) 121506377 121506387 121506399

ALAT:

119015053(cpb2)

MZE:	101484595 112430744

ONL:

100699903

OAU:	116319211(cpb2)

OLA:	101175299(cpb2)

OML:	112160012(cpb2)

CSAI:

133425019(cpb2)

XMA:	102234292(cpb2)

XCO:	114138216(cpb2)

XHE:

116715788

PRET:

103475539(cpo)

PFOR:

103147128

PLAI:

106950966

PMEI:

106905192(cpb2)

GAF:	122827454(cpb2)

PPRL:

129379098(cpb2)

CVG:	107093726(cpb2)

CTUL:

119784424(cpb2)

GMU:	124861754(cpb2)

NFU:	107381108(cpb2)

KMR:	108246710(cpb2)

ALIM:

106529640(cpb2)

NWH:	119429107(cpb2)

AOCE:

111580792(cpb2)

MCEP:

125000609(cpb2)

CSEM:

103389881(cpb2)

POV:

109643485

SSEN:

122765173(cpb2)

HHIP:

117777455(cpb2)

HSP:	118103143(cpb2)

SMAU:

118301373(cpb2)

LCF:

108872994

SDU:	111238723(cpb2)

SLAL:

111644417(cpb2)

XGL:	120797961(cpb2)

HCQ:	109520860(cpb2)

SSCV:

125988585

SBIA:

133492128(cpb2)

PEE:	133414146(cpb2)

PTAO:

133489847(cpb2)

BPEC:

110168983(cpb2)

BSPL:

114870192(cpb2)

SJO:	128354382(cpb2)

SASA:

106574315(cpb2) 106575090(cpo)

STRU:

115179320 115195939

OTW:	112266587(cpb2)

OMY:	110495951(cpb2)

OGO:	124008022 124010502(cpb2)

ONE:	115129625 115144654

OKI:

109906656

OKE:	118363677(cpb2)

SALP:

111953182 111953547(cpb2)

SNH:	120051231(cpb2)

CCLU:

121554179

ELS:	105023706(cpo)

PKI:

111860687

AANG:

118222270(cpb2)

LOC:	102697256(cpb2)

PSPA:

121320685 121327503

ARUT:

117405533 117406811

PSEX:

120523699(cpb2)

LCM:	102355283(CPB2)

CMK:	103177537(cpb2)

CPLA:

122554928

HOC:

132820896

LERI:

129702819

PMRN:

116954429

AAG:

5572629

FEX:

115240213

NLU:

111047712

PCLA:

123749699

VDE:

111243188

VJA:	111259794 111266533

HRO:	HELRODRAFT_185234

EPA:

110245430

SPIS:

111335355

PIF:	PITG_00756

» show all

Reference

1 [PMID:1939207]

Authors

Eaton DL, Malloy BE, Tsai SP, Henzel W, Drayna D.

Title

Isolation, molecular cloning, and partial characterization of a novel carboxypeptidase B from human plasma.

Journal

J Biol Chem 266:21833-8 (1991)

Sequence

[hsa:1361]

Reference

2 [PMID:8130654]

Authors

Shinohara T, Sakurada C, Suzuki T, Takeuchi O, Campbell W, Ikeda S, Okada N, Okada H.

Title

Pro-carboxypeptidase R cleaves bradykinin following activation.

Journal

Int Arch Allergy Immunol 103:400-4 (1994)
DOI:10.1159/000236661

Reference

3 [PMID:8195249]

Authors

Wang W, Hendriks DF, Scharpe SS.

Title

Carboxypeptidase U, a plasma carboxypeptidase with high affinity for plasminogen.

Journal

J Biol Chem 269:15937-44 (1994)

Reference

4 [PMID:7727441]

Authors

Tan AK, Eaton DL.

Title

Activation and characterization of procarboxypeptidase B from human plasma.

Journal

Biochemistry 34:5811-6 (1995)
DOI:10.1021/bi00017a012

Reference

5 [PMID:8916945]

Authors

Broze GJ Jr, Higuchi DA.

Title

Coagulation-dependent inhibition of fibrinolysis: role of carboxypeptidase-U and the premature lysis of clots from hemophilic plasma.

Journal

Blood 88:3815-23 (1996)

Other DBs

ExplorEnz - The Enzyme Database:

3.4.17.20

IUBMB Enzyme Nomenclature:

3.4.17.20

ExPASy - ENZYME nomenclature database:

3.4.17.20

BRENDA, the Enzyme Database:

3.4.17.20

CAS:	156621-18-0

DBGET integrated database retrieval system