KEGG   ENZYME: 3.4.17.22
Entry
EC 3.4.17.22                Enzyme                                 
Name
metallocarboxypeptidase D;
carboxypeptidase D (cattle, human, mouse, rat);
gp180 (duck)
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Metallocarboxypeptidases
Reaction(IUBMB)
Releases C-terminal Arg and Lys from polypeptides
Comment
Activated by Co2+; inhibited by [(2-guanidinoethyl)sulfanyl]butanedioate. Large molecule (180 kDa) because of presence of three copies of metallopeptidase domain. The product of the silver gene (Drosophila) is similar. A zinc metallopeptidase in peptidase family M14 (carboxypeptidase A family)
History
EC 3.4.17.22 created 1997
Orthology
K07752  carboxypeptidase D
Genes
HSA1362(CPD)
PTR454557(CPD)
PPS100977539(CPD)
GGO101128462(CPD)
PON100436717(CPD)
NLE100597052(CPD)
HMH116474564(CPD)
MCC712407(CPD)
MCF102135486(CPD)
MTHB126938976
MNI105476838(CPD)
CSAB103242665(CPD)
CATY105591562(CPD)
PANU101016026(CPD)
TGE112609145(CPD)
MLEU105547020(CPD)
RRO104665980(CPD)
RBB108517294(CPD)
TFN117067645(CPD)
PTEH111520767(CPD)
CANG105510869
CJC100394725(CPD)
SBQ101034539(CPD)
CIMI108313607(CPD)
CSYR103258388(CPD)
MMUR105857947(CPD)
LCAT123620235(CPD)
PCOQ105820758(CPD)
OGA100941711(CPD)
MMU12874(Cpd)
MCAL110304688(Cpd)
MPAH110331499(Cpd)
RNO25306(Cpd)
MCOC116079227(Cpd)
ANU117710211(Cpd)
MUN110559449(Cpd)
CGE100757331(Cpd)
MAUA101825460(Cpd)
PROB127218882(Cpd)
PLEU114691458(Cpd)
MORG121456201(Cpd)
MFOT126492453
AAMP119812396(Cpd)
NGI103730489(Cpd)
HGL101707145(Cpd)
CPOC100716995(Cpd)
CCAN109695996(Cpd)
DORD105985666(Cpd)
DSP122120384(Cpd)
PLOP125366051(Cpd)
NCAR124979971
MMMA107155146(Cpd)
OCU100339843
OPI101524900(CPD)
TUP102482407(CPD)
GVR103597134(CPD)
CFA480636(CPD)
CLUD112677611(CPD)
VVP112933188(CPD)
VLG121473071(CPD)
NPO129509758(CPD)
AML100476363(CPD)
UMR103667395(CPD)
UAH113269090(CPD)
UAR123776845(CPD)
ELK111151441
LLV125087174
MPUF101691841(CPD)
MNP132003947(CPD)
MLK131815597(CPD)
NVS122906372(CPD)
ORO101378469(CPD)
EJU114213800(CPD)
ZCA113939480(CPD)
MLX118025245(CPD)
NSU110593312(CPD)
LWW102730240(CPD)
FCA101081771(CPD)
PYU121017273(CPD)
PCOO112855038(CPD)
PBG122486068(CPD)
LRUF124512996
PTG102964772(CPD)
PPAD109255186(CPD)
PUC125927519
AJU106968721
HHV120246157(CPD)
BTA532189(CPD)
BOM102274420(CPD)
BIU109573746(CPD)
BBUB102405741(CPD)
BBIS105004143(CPD)
CHX102173329(CPD)
OAS101122802(CPD)
BTAX128065685(CPD)
ODA120866240(CPD)
CCAD122448007(CPD)
MBEZ129541102(CPD)
SSC100517495(CPD)
CFR102509584(CPD)
CBAI105071627(CPD)
CDK105088145(CPD)
VPC102526219(CPD)
BACU103018688(CPD)
LVE103070181(CPD)
OOR101288119(CPD)
DLE111186020(CPD)
PCAD102996164(CPD)
PSIU116744987(CPD)
NASI112394518(CPD)
ECB100072234(CPD)
EPZ103555366(CPD)
EAI106822001(CPD)
MYB102248065(CPD)
MYD102770691(CPD)
MMYO118671874(CPD)
MLF102441134(CPD)
MNA107528806(CPD)
PKL118702572(CPD)
EFUS103291747(CPD)
HAI109386883(CPD)
DRO112308708(CPD)
SHON119003732(CPD)
AJM119061988(CPD)
PDIC114503948(CPD)
PHAS123816717(CPD)
MMF118635075(CPD)
RFQ117013109(CPD)
PPAM129070330(CPD)
PALE102882023(CPD)
PGIG120621008(CPD)
PVP105291883(CPD)
RAY107507748(CPD)
MJV108404052(CPD)
TOD119232899(CPD)
SARA101543287(CPD)
LAV100656143(CPD)
TMU101345198
ETF101645738(CPD)
DNM101447175(CPD)
MDO100015882(CPD)
GAS123246807(CPD)
SHR100923705(CPD)
AFZ127558870
PCW110192185(CPD)
OAA100078830(CPD)
GGA417590(CPD)
PCOC116228028(CPD)
MGP100545345(CPD)
CJO107322671(CPD)
TPAI128083408(CPD)
LMUT125703132(CPD)
NMEL110407962(CPD)
APLA101802114(CPD)
ACYG106045786(CPD)
CATA118255079(CPD)
AFUL116497243(CPD)
TGU100219416(CPD) 116809159
LSR110467714(CPD)
SCAN103820140(CPD)
PMOA120507687(CPD)
OTC121345743(CPD)
PRUF121361624(CPD)
GFR102042306(CPD)
FAB101810441(CPD)
OMA130260735(CPD)
PHI102109483(CPD)
PMAJ107212948(CPD)
CCAE111937954(CPD)
CCW104691182(CPD)
CBRC103613357(CPD)
ETL114061228(CPD)
ZAB102068901(CPD)
ACHL103799743(CPD)
SVG106853366(CPD)
MMEA130576960(CPD)
HRT120761252(CPD)
FPG101913850(CPD)
FCH102048834(CPD)
CLV102093976(CPD)
EGZ104121866(CPD)
NNI104012208(CPD)
PCRI104035640(CPD)
PLET104618008(CPD)
EHS104513023(CPD)
PCAO104045542(CPD)
ACUN113487075(CPD)
TALA104362808(CPD)
PADL103920816(CPD)
AFOR103898116(CPD)
ACHC115347176(CPD)
HALD104320315(CPD)
HLE104835606(CPD)
AGEN126039387
GCL127024257
CSTI104552602(CPD)
CMAC104479925(CPD)
MUI104542044(CPD)
BREG104638854(CPD)
FGA104079447(CPD)
GSTE104256931(CPD)
LDI104346364(CPD)
MNB103776437(CPD)
OHA104327170(CPD)
NNT104399864(CPD)
SHAB115601913(CPD)
DPUB104302784(CPD)
PGUU104471453(CPD)
ACAR104522975(CPD)
CPEA104384828(CPD)
AVIT104272035(CPD)
CVF104282144(CPD)
RTD128912550(CPD)
CUCA104057180(CPD)
TEO104370009(CPD)
BRHI104500311(CPD)
AAM106493764
AROW112960690(CPD)
NPD112945375(CPD)
TGT104576798(CPD)
DNE112983953(CPD)
SCAM104142849(CPD)
ASN102370437(CPD)
AMJ102566010(CPD)
CPOO109317227(CPD)
GGN109293358(CPD)
PSS102462593(CPD)
CMY102937712(CPD)
CCAY125623856(CPD)
DCC119844614(CPD)
CPIC101930837(CPD)
TST117867384(CPD)
CABI116829764(CPD)
MRV120387219(CPD)
ASAO132763418(CPD)
PVT110084275(CPD)
SUND121917004(CPD)
PBI103063983(CPD)
PMUR107298419(CPD)
CTIG120318842(CPD)
TSR106545879(CPD)
PGUT117658188(CPD)
APRI131188612(CPD)
PTEX113451668(CPD)
NSS113427583(CPD)
VKO123023347(CPD)
PMUA114585585(CPD)
PRAF128402437(CPD)
ZVI118097044(CPD)
HCG128335986(CPD)
GJA107119558(CPD)
STOW125445579(CPD)
EMC129344651(CPD)
XLA108707943(cpd.L) 108708851(cpd.S)
XTR100135269(cpd)
NPR108800486(CPD)
RTEM120927723(CPD)
BBUF120994660(CPD)
BGAR122930408(CPD)
MUO115456542(CPD)
GSH117348966(CPD)
DRE563008(cpda)
SRX107713140 107731961 107743672 107744773
SANH107664935 107675205 107690421
SGH107581996 107585576 107587220 107592607
CCAR109045857 109060340 109083236 109103251(cpd)
CAUA113038153 113058476 113070073 113115031
CGIB127972479 128029201
PTET122326348(cpda)
LROH127177248(cpda)
OMC131520619(cpda)
PPRM120478643(cpda) 120482486(cpdb)
RKG130096773(cpda)
MAMB125248367(cpda) 125252188(cpdb)
CIDE127496061
MASI127421877 127430249
TROS130564733(cpda)
TDW130428533(cpda)
MANU129438056(cpda)
IPU108277877(cpda) 108279099(cpdb)
IFU128621275(cpda)
PHYP113532697(cpd) 113541382
SMEO124394716(cpda)
TFD113643628(cpda)
TVC132857882(cpda)
AMEX103034353(cpd) 103045613
CMAO118801400(cpda)
EEE113569722(cpd) 113582238
CHAR105898219(cpda)
TRU101064552(cpd)
TFS130534944(cpda)
TNGGSTEN00010092G001
LCO104922855(cpd)
NCC104943195(cpd)
TBEN117470281(cpda)
CGOB115017497(cpd)
PGEO117457685(cpda)
GACU117552293(cpda)
ELY117259637(cpda)
EFO125888240(cpda)
PLEP121942848(cpda)
SLUC116048296(cpda)
ECRA117939204(cpda)
ESP116670937(cpd)
PFLV114551262(cpd)
GAT120824433(cpda)
PPUG119193993(cpda)
AFB129096279(cpda)
CLUM117741136(cpda)
MSAM119883582(cpda)
SCHU122878901(cpda)
CUD121518178(cpda)
ALAT119033382(cpda)
MZE101482580(cpd)
ONL100698903(cpd)
OAU116325713(cpda)
OLA101173725(cpd)
OML112149456(cpda)
XMA102218419(cpd)
XCO114133445(cpd)
XHE116708196(cpd)
PRET103474532(cpd)
PFOR103145582(cpd)
PLAI106948051(cpd)
PMEI106927795(cpd)
GAF122832174(cpda)
PPRL129358872(cpda)
CVG107095025(cpd)
CTUL119782805(cpda)
GMU124883995(cpda)
NFU107380397(cpd)
KMR108246050(cpda)
ALIM106534193(cpd)
NWH119410604(cpda)
AOCE111585159(cpd)
MCEP125013322(cpdA)
CSEM103378079(cpd)
POV109630253(cpd)
SSEN122773710(cpda)
HHIP117773396(cpda)
HSP118105974(cpda)
LCF108890362(cpda)
SDU111224052(cpd)
SLAL111668121(cpd)
XGL120791636(cpda)
HCQ109525484(cpd)
SSCV125972809
SBIA133504508(cpda)
PEE133404685(cpda)
PTAO133482500(cpda)
BPEC110174241(cpd)
MALB109960216(cpd)
BSPL114867508(cpda)
SJO128360251(cpda)
SASA106581036 106612847
STRU115163343 115206273
OTW112246916 112267012
OMY110503857 110507689
OGO123992800 124005178
ONE115116537 115141767
OKI109875606 109905656
OKE118372567 118397399
SALP111959355 111982774
SNH120018231 120029108
CCLU121566527 121567898
ELS105007417(cpd)
SFM108932207(cpd)
PKI111860566(cpd)
AANG118210097(cpda)
LOC102692446(cpd)
PSPA121308674(cpda)
ARUT117429629 117430554
PSEX120531472(cpda)
LCM102351860(CPD)
CMK103183365
RTP109918746(cpd)
CPLA122563989
HOC132830595(cpda)
LERI129710884(cpda)
PMRN116958442
BFO118413667 118426111 118427510
BBEL109463160 109463612 109463635
CIN100180843
SCLV120331015 120341665
SPU593440
LPIC129254779
APLC110980715
SKO100367428 100372562
DMEDmel_CG4122(svr)
DER6555783
DSE6615869
DSIDsimw501_GD16509(Dsim_GD16509)
DYADyak_GE16618
DAN6504608
DSR110183075
DPO6901408
DPE6598149
DMN108159252
DWI6644767
DGR6565846
DMODmoj_GI15159
DAZ108618259
DNV108656323
DHE111593082
DVI6636081
CCAT101462369
BOD106625782
BDR105226175
RZE108377769
AOQ129236896
TDA119669508
MDE101900836 109613934 131800864
SCAC106093712
LCQ111676751
LSQ119609294
GFS119644672
ECOE129953783
CLON129607804
HIS119655560
AGA1273549
ACOZ120948991
AARA120894160
AMER121590406
ASTE118506890
AFUN125764912
AMOU128299864
AALI118461494
AAG23687919
AALB109422660 115260168
CQUCpipJ_CPIJ009464 CpipJ_CPIJ009465
CPII120414381
CNS116348711
BCOO119084248
AME724816
ACER107993797
ALAB122719329
ADR102673328
AFLR100863850
BIM100749957
BBIF117213585
BVK117234262
BVAN117163196
BTER100651403
BAFF126915560
BPYO122568609
BPAS132908691
FVI122532251
CCAL108630368
OBB114874739
OLG117611932
MGEN117221903
NMEA116430378
CGIG122399407
SOC105199087
MPHA105833089
AEC105152604
ACEP105617236
PBAR105433737
VEM105564077
HST105184921
DQU106747187
CFO105251427
FEX115244802
LHU105668319
PGC109863141
OBO105280420
PCF106783784
PFUC122520066
VPS122631503
VCRB124426535
VVE124952258
NVI100122498
CSOL105365417
TPRE106653140
LBD127286726
MDL103571699
CGLO123271762
FAS105273111
DAM107039422
AGIF122854974
VCAN122406694
CCIN107266632
DSM124404882
NPT124212973
NFB124174829
NLO107221357
NVG124297239
AROA105683922
TCA655207
DPA109540038
SOY115876489
AGRG126733570
ATD109602651
CSET123320609
AGB108910193
LDC111505211
NVL108563176
APLN108735792
PPYR116162581
OTU111420598
BMOR101735927
MSEX115455674
DPLKGM_206855
BANY112045921
MJU123871210
NIQ126775417
VCD124532697
MCIX123663282
PMAC106712962
PPOT106106028
PXU106117845
PRAP110997051
PBX123712916
PNAP125056147
ZCE119833882
CCRC123700061
LSIN126969719
HAW110382679
HZE124639344
TNL113502763
SLIU111360061
OFU114352896 114360848
PXY105384432 105391574 105394772
PGW126376194
CFEL113369781
CCRN123300977
API100161290
DNX107164754
AGS114119778
RMD113550382
ACOO126845936
DVT126894344
BTAB109033499 109034391
DCI103513394
CLEC106664715
HHAL106681823 106691197
NLU111050394
HVI124369207
MQU128984518 128999160
PHUPhum_PHUM392810
FOC113207213
TPAL117642553
ZNE110826868
CSEC111870064
IEL124155937
FCD110850729
DPXDAPPUDRAFT_250728
DMK116927841
DPZ124325965
PVM113813967 113827202
PJA122260287
PCHN125029297
PMOO119574485
HAME121879405
PCLA123763619
CQD128694145
PTRU123516951
ESN126999945
HAZT108678957
EAF111698819 111709190 111716650
LSM121124750
TCF131884828 131887637
PPOI119111851
DSV119446686
RSAN119389501 119389506
VDE111253535
VJA111266374 111273015
TUT107369162
DPTE113799761
DFR124499813
CSCU111622109
UDV129223868
SDM118184900
LPOL106468988
CELCELE_F59A3.1(cpd-1)
CBRCBG_12487
CRQGCK72_002607
BMYBM_BM11935(Bma-cpd-1)
LOALOAG_08391
TSPTsp_00258
LGILOTGIDRAFT_226642
PCAN112561933
BGT106059226
GAE121368157
HRF124119271
HRJ124259925
CRG105333147 105343166
CVN111134706
CANU128187970 128190375
OED125674336
MYI110446872
PMAX117332640
MMER123533958
RPHI132749630
DPOL127865161
OBI106880679
OSN115224523
LAK106176567
SMMSmp_159890
SHXMS3_00010665
OVIT265_14579
NVE5502924 5513076 5513584 5518577 5519099
EPA110236473 110240551 110243944 110247075
ATEN116289641 116296036
ADF107334139 107334491 107353995
AMIL114948211 114957509 114957926 114976312
PDAM113666372 113681020 113684813 113685986
SPIS111324602 111327875 111336557 111342677
DGT114520353 114525020 114526262
XEN124433673 124435258
HMG100208105 100208464 100213926
HSY130623445
TADTRIADDRAFT_28479 TRIADDRAFT_32385 TRIADDRAFT_36680
AQU100636145
GMX100775772 100779927
GSJ114371992 114403285
PVUPHAVU_007G083600g
VRA106772299
VAR108326385
VUN114192081
VUM124821109
CCAJ109805851
APRC113872012
MTR25485045
TPRA123903794
CAM101510794
PSAT127092517
VVO131631807 131643650
LJALj5g3v1914090.1(Lj5g3v1914090.1)
ADU107467853
AIP107617945
AHF112712476 112775617
LANG109335576 109346745
PCIN129311462
QSAO6P43_004149 O6P43_008065
PPER18767851
PMUM103336220
PAVI110760284
MSYL126621008
MNT21384369
CSAV115708757
CILL122296472
CAVE132184697
SOT102582791
CANN107856023
NTA107809795
NSY104240271
NTO104087394
NAU109236874
MBRMONBRDRAFT_27454
SREPTSG_06583
DDIDDB_G0288963
DFADFA_04675
NGRNAEGRDRAFT_79374
LACICW733_02530
WINWPG_1411
LUTLupro_08720
AQAD1815_13320
MESQC7H62_0045
 » show all
Reference
1  [PMID:9525948]
  Authors
Eng FJ, Novikova EG, Kuroki K, Ganem D, Fricker LD
  Title
gp180, a protein that binds duck hepatitis B virus particles, has metallocarboxypeptidase D-like enzymatic activity.
  Journal
J Biol Chem 273:8382-8 (1998)
DOI:10.1074/jbc.273.14.8382
  Sequence
[apla:101802114]
Reference
2  [PMID:7559630]
  Authors
Song L, Fricker LD.
  Title
Purification and characterization of carboxypeptidase D, a novel carboxypeptidase E-like enzyme, from bovine pituitary.
  Journal
J Biol Chem 270:25007-13 (1995)
DOI:10.1074/jbc.270.42.25007
Reference
3  [PMID:8910535]
  Authors
Song L, Fricker LD.
  Title
Tissue distribution and characterization of soluble and membrane-bound forms of metallocarboxypeptidase D.
  Journal
J Biol Chem 271:28884-9 (1996)
DOI:10.1074/jbc.271.46.28884
Other DBs
ExplorEnz - The Enzyme Database: 3.4.17.22
IUBMB Enzyme Nomenclature: 3.4.17.22
ExPASy - ENZYME nomenclature database: 3.4.17.22
BRENDA, the Enzyme Database: 3.4.17.22
CAS: 153967-26-1

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