KEGG ENZYME: 3.4.19.2

ENZYME: 3.4.19.2

Entry

EC 3.4.19.2                 Enzyme

Name

peptidyl-glycinamidase;
carboxyamidase;
peptidyl carboxy-amidase;
peptidyl-aminoacylamidase;
carboxamidopeptidase;
peptidyl amino acid amide hydrolase

Class

Hydrolases;
Acting on peptide bonds (peptidases);
Omega peptidases

Reaction(IUBMB)

Cleavage of C-terminal glycinamide from polypeptides

Comment

Inactivates vasopressin and oxytocin by splitting off glycinamide. Also cleaves ester substrates of trypsin and chymotrypsin. Although glycinamide is by far the preferred leaving group, other aminoacylamides may also be released, e.g. phenylalaninamide. The toad skin enzyme is inhibited by diisopropyl fluorophosphate.

History

EC 3.4.19.2 created 1978 as EC 3.4.15.2, transferred 1981 to EC 3.4.19.2

Reference

Authors

Fruhaufova, L., Suska-Brezezinska, E., Barth, T. and Rychlik, I.

Title

Rat liver enzyme inactivating oxytocin and its deamino-carba analogues.

Journal

Coll Czech Chem Commun 38:2793-2798 (1973)

Reference

2 [PMID:1122284]

Authors

Nardacci NJ, Mukhopadhyay S, Campbell BJ.

Title

Partial purification and characterization of the antidiuretic hormone-inactivating enzyme from renal plasma membranes.

Journal

Biochim Biophys Acta 377:146-57 (1975)
DOI:10.1016/0005-2744(75)90295-8

Reference

3 [PMID:6766314]

Authors

Simmons WH, Walter R.

Title

Carboxamidopeptidase: purification and characterization of a neurohypophyseal hormone inactivating peptidase from toad skin.

Journal

Biochemistry 19:39-48 (1980)
DOI:10.1021/bi00542a007

Other DBs

ExplorEnz - The Enzyme Database:

3.4.19.2

IUBMB Enzyme Nomenclature:

3.4.19.2

ExPASy - ENZYME nomenclature database:

3.4.19.2

BRENDA, the Enzyme Database:

3.4.19.2

CAS:	94047-14-0

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