KEGG   ENZYME: 3.4.21.100
Entry
EC 3.4.21.100               Enzyme                                 
Name
sedolisin;
Pseudomonas sp. pepstatin-insensitive carboxyl proteinase;
pseudomonapepsin;
pseudomonalisin;
sedolysin
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
Reaction(IUBMB)
Hydrolysis of the B chain of insulin at -Glu13!Ala-, -Leu15!Tyr- and -Phe25!Tyr-, and angiotensin I at -Tyr4!Ile-. A good synthetic substrate is Lys-Pro-Ile-Glu-Phe!Phe(NO2)-Arg-Leu.
Comment
An enzyme secreted by Pseudomonas sp. No. 101. Optimum pH is 4. It is distinguished from xanthomonapepsin by its insensitivity to EPNP and from scytalidopepsin B by this property and by its unrelated amino-acid sequence. Inhibited by tyrostatin, a peptide aldehyde [2]. Type example of peptidase family S53.
History
EC 3.4.21.100 created 1995 as EC 3.4.23.37, transferred 2001 to EC 3.4.21.100, modified 2003
Orthology
K05998  pseudomonalisin
Genes
FEDLQ772_11465
LANHKR767_16910
MBAHHYN46_00900 HYN46_13560 HYN46_13605 HYN46_14550
CVICV_1965 CV_1968
CVCBKX93_23225 BKX93_23230
CHROCXB49_09385 CXB49_12540 CXB49_12545
CHRIDK842_16930
CHRBDK843_00055
CRZD1345_08135
CHRMFYK34_04995
CHAECH06BL_17550
RINACS15_5322
RWEKOL96_05355
BMABMA1538
BMVBMASAVP1_A2037
BMLBMA10229_A3274
BMNBMA10247_1309
BMALDM55_186(pcp)
BMAEDM78_1853(pcp)
BMAQDM76_166(pcp)
BMAIDM57_365
BMAFDM51_1239(pcp)
BMAZBM44_1815(pcp)
BMABBM45_1377(pcp)
BPSBPSL2142 BPSS1734
BPMBURPS1710b_2563 BURPS1710b_A0811(scpB)
BPLBURPS1106A_2473 BURPS1106A_A2358
BPDBURPS668_2417 BURPS668_A2497
BPRGBP346_A2543
BPSEBDL_3405(pcp) BDL_5091(pcp)
BPSMBBQ_1194(pcp) BBQ_4404(pcp)
BPSUBBN_1320(pcp) BBN_5191(pcp)
BPSDBBX_1806(pcp) BBX_4257(pcp)
BPZBP1026B_I1253 BP1026B_II1859
BPQBPC006_I2516 BPC006_II2327
BPKBBK_2822(pcp) BBK_4455(pcp)
BPSHDR55_2441(pcp) DR55_3532(pcp)
BPSABBU_19(pcp) BBU_4289(pcp)
BPSOX996_2028(pcp) X996_5809(pcp)
BUTX994_446(pcp) X994_5370(pcp)
BTEBTH_I2044 BTH_II0646
BTQBTQ_1866(pcp) BTQ_3938(pcp)
BTJBTJ_489(pcp) BTJ_4970(pcp)
BTZBTL_1729(pcp) BTL_3439(pcp)
BTDBTI_4244(pcp)
BTVBTHA_1883(pcp) BTHA_4447(pcp)
BTHEBTN_3039(pcp) BTN_5425(pcp)
BTHMBTRA_2009(pcp) BTRA_5700(pcp)
BTHADR62_3185 DR62_5603
BTHLBG87_1953(pcp) BG87_3393(pcp)
BOKDM82_1726(pcp) DM82_5981(pcp)
BOCBG90_2994(pcp) BG90_4659(pcp)
BUUWS70_06955 WS70_26085
BSAVWS86_07790 WS86_27570
BHGI6G56_31835
BUDAQ610_21985
BVIBcep1808_4399
BVEAK36_4409(pcp)
BURBcep18194_B2163 Bcep18194_B2199
BCMBcenmc03_3604 Bcenmc03_3636
BCHBcen2424_3891 Bcen2424_3924
BCJBCAM0922 BCAM0957
BCENDM39_3999(pcp)
BCEWDM40_1558(pcp) DM40_3906(pcp) DM40_3931(pcp)
BCEOI35_4841 I35_4877
BAMBamb_0766 Bamb_3272 Bamb_3301
BACBamMC406_0777 BamMC406_3792 BamMC406_3817
BMJBMULJ_03854
BMUBmul_4660
BMKDM80_3859(pcp)
BMULNP80_3915(pcp)
BCTGEM_2636 GEM_4830 GEM_4861
BCEDDM42_4129(pcp) DM42_4164(pcp)
BCEPAPZ15_19665 APZ15_19805
BDLAK34_4498(pcp)
BPYRABD05_17015 ABD05_17175
BCONNL30_07585 NL30_07735 NL30_11310
BUBBW23_4683(pcp)
BDFWI26_03970 WI26_18245 WI26_18360
BLATWK25_04155 WK25_22080 WK25_22215
BTEIWS51_02945 WS51_03055
BSEMWJ12_24855 WJ12_25020
BPSLWS57_09010
BMECWJ16_23575 WJ16_23720
BSTGWT74_23965
BSTLBBJ41_32380 BBJ41_32545
BANNJFN94_04270 JFN94_22335
BARINLX30_33665 NLX30_33845
BAENL3V59_34425 L3V59_34580
BGLbglu_2g07550
BGUKS03_5159(pcp)
BGDbgla_2g18790
BGOBM43_5602(pcp)
BUKMYA_0783 MYA_4042
BULBW21_3784(pcp)
BGPBGL_2c18980
BPLAbpln_2g19480
BURKDM992_30315 DM992_30465
PCAFDSC91_000952
PMEGFNZ07_11670 FNZ07_31260
PBRYNDK50_25690
TVLFAZ95_33335
TCARU0034_22585
CFUCFU_2834
CARELT85_0470 LT85_1767 LT85_2482 LT85_2972
CPRACPter91_0553(pcp) CPter91_1734(pcp) CPter91_2251(pcp)
ACYCJI721_10935
VABWPS_04890
 » show all
Reference
1  [PMID:3548827]
  Authors
Oda K, Sugitani M, Fukuhara K, Murao S.
  Title
Purification and properties of a pepstatin-insensitive carboxyl proteinase from a gram-negative bacterium.
  Journal
Biochim Biophys Acta 923:463-9 (1987)
DOI:10.1016/0304-4165(87)90055-9
Reference
2  [PMID:1562589]
  Authors
Oda K, Nakatani H, Dunn BM.
  Title
Substrate specificity and kinetic properties of pepstatin-insensitive carboxyl proteinase from Pseudomonas sp. No. 101.
  Journal
Biochim Biophys Acta 1120:208-14 (1992)
DOI:10.1016/0167-4838(92)90272-F
Reference
3  [PMID:11323721]
  Authors
Wlodawer A, Li M, Dauter Z, Gustchina A, Uchida K, Oyama H, Dunn BM, Oda K
  Title
Carboxyl proteinase from Pseudomonas defines a novel family of subtilisin-like enzymes.
  Journal
Nat Struct Biol 8:442-6 (2001)
DOI:10.1038/87610
  Sequence
Reference
4  [PMID:12673349]
  Authors
Wlodawer A, Li M, Gustchina A, Oyama H, Dunn BM, Oda K.
  Title
Structural and enzymatic properties of the sedolisin family of serine-carboxyl peptidases.
  Journal
Acta Biochim Pol 50:81-102 (2003)
Other DBs
ExplorEnz - The Enzyme Database: 3.4.21.100
IUBMB Enzyme Nomenclature: 3.4.21.100
ExPASy - ENZYME nomenclature database: 3.4.21.100
BRENDA, the Enzyme Database: 3.4.21.100
CAS: 848318-58-1

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