Entry
Name
sedolisin;
Pseudomonas sp. pepstatin-insensitive carboxyl proteinase;
pseudomonapepsin;
pseudomonalisin;
sedolysin
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Hydrolysis of the B chain of insulin at -Glu13!Ala-, -Leu15!Tyr- and -Phe25!Tyr-, and angiotensin I at -Tyr4!Ile-. A good synthetic substrate is Lys-Pro-Ile-Glu-Phe!Phe(NO2)-Arg-Leu.
Comment
An enzyme secreted by Pseudomonas sp. No. 101. Optimum pH is 4. It is distinguished from xanthomonapepsin by its insensitivity to EPNP and from scytalidopepsin B by this property and by its unrelated amino-acid sequence. Inhibited by tyrostatin, a peptide aldehyde [2]. Type example of peptidase family S53.
History
EC 3.4.21.100 created 1995 as EC 3.4.23.37, transferred 2001 to EC 3.4.21.100, modified 2003
Orthology
Genes
MBAH : HYN46_00900 HYN46_13560 HYN46_13605 HYN46_14550
CVC : BKX93_23225 BKX93_23230
CHRO : CXB49_09385 CXB49_12540 CXB49_12545
BPM : BURPS1710b_2563 BURPS1710b_A0811(scpB)
BPL : BURPS1106A_2473 BURPS1106A_A2358
BPD : BURPS668_2417 BURPS668_A2497
BPSE : BDL_3405(pcp) BDL_5091(pcp)
BPSM : BBQ_1194(pcp) BBQ_4404(pcp)
BPSU : BBN_1320(pcp) BBN_5191(pcp)
BPSD : BBX_1806(pcp) BBX_4257(pcp)
BPZ : BP1026B_I1253 BP1026B_II1859
BPQ : BPC006_I2516 BPC006_II2327
BPK : BBK_2822(pcp) BBK_4455(pcp)
BPSH : DR55_2441(pcp) DR55_3532(pcp)
BPSA : BBU_19(pcp) BBU_4289(pcp)
BPSO : X996_2028(pcp) X996_5809(pcp)
BUT : X994_446(pcp) X994_5370(pcp)
BTE : BTH_I2044 BTH_II0646
BTQ : BTQ_1866(pcp) BTQ_3938(pcp)
BTJ : BTJ_489(pcp) BTJ_4970(pcp)
BTZ : BTL_1729(pcp) BTL_3439(pcp)
BTV : BTHA_1883(pcp) BTHA_4447(pcp)
BTHE : BTN_3039(pcp) BTN_5425(pcp)
BTHM : BTRA_2009(pcp) BTRA_5700(pcp)
BTHA : DR62_3185 DR62_5603
BTHL : BG87_1953(pcp) BG87_3393(pcp)
BOK : DM82_1726(pcp) DM82_5981(pcp)
BOC : BG90_2994(pcp) BG90_4659(pcp)
BUU : WS70_06955 WS70_26085
BSAV : WS86_07790 WS86_27570
BUR : Bcep18194_B2163 Bcep18194_B2199
BCM : Bcenmc03_3604 Bcenmc03_3636
BCH : Bcen2424_3891 Bcen2424_3924
BCEW : DM40_1558(pcp) DM40_3906(pcp) DM40_3931(pcp)
BAM : Bamb_0766 Bamb_3272 Bamb_3301
BAC : BamMC406_0777 BamMC406_3792 BamMC406_3817
BCT : GEM_2636 GEM_4830 GEM_4861
BCED : DM42_4129(pcp) DM42_4164(pcp)
BCEP : APZ15_19665 APZ15_19805
BPYR : ABD05_17015 ABD05_17175
BCON : NL30_07585 NL30_07735 NL30_11310
BDF : WI26_03970 WI26_18245 WI26_18360
BLAT : WK25_04155 WK25_22080 WK25_22215
BTEI : WS51_02945 WS51_03055
BSEM : WJ12_24855 WJ12_25020
BMEC : WJ16_23575 WJ16_23720
BSTL : BBJ41_32380 BBJ41_32545
BANN : JFN94_04270 JFN94_22335
BARI : NLX30_33665 NLX30_33845
BAEN : L3V59_34425 L3V59_34580
BURK : DM992_30315 DM992_30465
PMEG : FNZ07_11670 FNZ07_31260
CARE : LT85_0470 LT85_1767 LT85_2482 LT85_2972
CPRA : CPter91_0553(pcp) CPter91_1734(pcp) CPter91_2251(pcp)
» show all
Taxonomy
Reference
Authors
Oda K, Sugitani M, Fukuhara K, Murao S.
Title
Purification and properties of a pepstatin-insensitive carboxyl proteinase from a gram-negative bacterium.
Journal
Reference
Authors
Oda K, Nakatani H, Dunn BM.
Title
Substrate specificity and kinetic properties of pepstatin-insensitive carboxyl proteinase from Pseudomonas sp. No. 101.
Journal
Reference
Authors
Wlodawer A, Li M, Dauter Z, Gustchina A, Uchida K, Oyama H, Dunn BM, Oda K
Title
Carboxyl proteinase from Pseudomonas defines a novel family of subtilisin-like enzymes.
Journal
Sequence
Reference
Authors
Wlodawer A, Li M, Gustchina A, Oyama H, Dunn BM, Oda K.
Title
Structural and enzymatic properties of the sedolisin family of serine-carboxyl peptidases.
Journal
Acta Biochim Pol 50:81-102 (2003)
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