Entry
Name
matriptase;
serine protease 14;
membrane-type serine protease 1;
MT-SP1;
prostamin;
serine protease TADG-15;
tumor-associated differentially-expressed gene 15 protein;
ST14;
breast cancer 80 kDa protease;
epithin;
serine endopeptidase SNC19;
matriptase-1;
matriptase-2;
matriptase-3;
TMPRSS6 (gene name)
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Cleaves various synthetic substrates with Arg or Lys at the P1 position and prefers small side-chain amino acids, such as Ala and Gly, at the P2 position
Comment
This trypsin-like integral-membrane serine peptidase has been implicated in breast cancer invasion and metastasis [1,2]. The enzyme can activate hepatocyte growth factor/scattering factor (HGF/SF) by cleavage of the two-chain forms at an Arg residue to give active alpha- and beta-HGF, but It does not activate plasminogen, which shares high homology with HGF [1]. The enzyme can also activate urokinase plasminogen activator (uPA), which initiates the matrix-degrading peptidase cascade [1,2]. Hemojuvelin has been shown to be a physiological substrate for matriptase-2 [5]. Belongs in peptidase family S1A.
History
EC 3.4.21.109 created 2006, modified 2022
Orthology
K08670 suppressor of tumorigenicity protein 14
Genes
CABI : 116821753 116837763(ST14)
XLA : 394363(st14.L) 494753(st14.S)
MUO : 115476628 115482177(ST14)
GSH : 117347895(ST14) 117369338
DRE : 557248(zmp:0000001114) 678603(st14a)
SRX : 107714535 107715280 107739784 107755384 107756115 107758079
SANH : 107668533 107669406 107670627 107683671 107704733
SGH : 107548197 107554966 107565100 107567179 107582215 107585712
CCAR : 109070750 109103650 109105256 109108527
CAUA : 113061764 113070251 113073169 113095045 113099199 113114944 113118679
CGIB : 127934244 127972919 127977849 127986632 128028981
PTET : 122322972(st14a) 122326373(st14b) 122358862(zmp:0000001114)
LROH : 127152942(st14b) 127176998(st14) 127181043(st14a)
OMC : 131520973(st14) 131524522(st14a) 131529401(st14b)
PPRM : 120459943(st14a) 120478614(zmp:0000001114) 120494712(st14b)
RKG : 130069943(st14a) 130070694(st14) 130072135(st14b)
MAMB : 125249574(st14) 125252803(st14b) 125253747(st14a)
CIDE : 127495105 127500278 127504183
MASI : 127416748 127422470 127428471 127429845 127455723
TROS : 130563169(st14a) 130565001(st14) 130569814(st14b)
TDW : 130407583(st14b) 130429061(st14) 130436024(st14a)
MANU : 129419858(st14a) 129424232(st14b) 129438373(st14)
IPU : 108264634(st14a) 108278113(st14) 108278916(st14b)
IFU : 128606821(st14a) 128621133(st14) 128622455(st14b)
PHYP : 113526776(st14) 113539274 113541721
SMEO : 124394131(zmp:0000001114) 124395575(st14a) 124398421(st14b)
TFD : 113643622(zmp:0000001114) 113649471(st14b) 113660912(st14a)
TVC : 132851072(st14a) 132858255(st14) 132860310(st14b)
AMEX : 103023437 103035661 103037956
CMAO : 118801361(st14a) 118804678(zmp:0000001114) 118820357(st14b)
EEE : 113575109 113585899 113587882
CHAR : 105901269(zmp:0000001114) 105904776(st14a)
TRU : 101064860(st14) 101074247 101074340
TFS : 130530407 130532723(st14) 130535235(st14a)
TNG : GSTEN00003546G001 GSTEN00030210G001 GSTEN00034189G001
LCO : 104925945 104937445 109142308
NCC : 104944245(st14) 104961400
TBEN : 117468839(st14a) 117480185(zmp:0000001114) 117483828
CGOB : 115011242 115017363(st14) 115020969
PGEO : 117449826 117456918(st14a) 117461505(zmp:0000001114)
GACU : 117550593(st14a) 117553900(zmp:0000001114) 117557107
EMAC : 134861542(st14) 134863386 134880547(st14a)
ELY : 117258716 117259575(st14a) 117266415(zmp:0000001114)
EFO : 125889258(st14a) 125892430 125893726(st14)
PLEP : 121943201(st14a) 121946084(zmp:0000001114) 121947401
SLUC : 116041148(st14a) 116049333(zmp:0000001114) 116059191
ECRA : 117941342(st14a) 117946895(zmp:0000001114)
ESP : 116673683(st14) 116691009
PFLV : 114553205 114556545 114558979
GAT : 120811115(zmp:0000001114) 120819859(st14a) 120829850
PPUG : 119197466(zmp:0000001114) 119221884(st14a) 119222841
AFB : 129092924(st14a) 129100011 129110177(st14)
CLUM : 117733075(st14b) 117741887(st14a) 117745267(zmp:0000001114)
PSWI : 130199891 130211129(st14a) 130213318(st14)
MSAM : 119882371(st14a) 119898302(zmp:0000001114) 119906001
SCHU : 122879684(st14a) 122881429(zmp:0000001114) 122882637
CUD : 121513359(zmp:0000001114) 121515285(st14a) 121517274
ALAT : 119005812(zmp:0000001114) 119022950 119031561(st14a)
MZE : 101466688 101466949 101467249 101477872(st14) 101479765
ONL : 100701219 100705591 100705852 100706119 100711707(st14)
OAU : 116319791(zmp:0000001114) 116335434 116335451 116335452 116336482(st14a)
OLA : 101155223 101159080 101167722
OML : 112140850(st14b) 112143284 112148988(st14a)
CSAI : 133428371(st14) 133441971(st14a) 133456937(st14b)
XCO : 114133486 114140995 114142073
XHE : 116707790 116716285 116722865
PRET : 103460238 103475070 103478525
PFOR : 103130751 103138218(st14) 103143098
PLAI : 106936792(st14) 106941993 106945868
PMEI : 106907691 106916987(st14) 106930620
GAF : 122831346(zmp:0000001114) 122832595(st14a) 122842906
PPRL : 129359116(st14a) 129371386(st14)
CVG : 107086094 107086126 107090648 107097008
CTUL : 119771544(zmp:0000001114) 119778314 119786503 119786520 119792000
GMU : 124864496(zmp:0000001114) 124868487 124883455(st14a)
NFU : 107378656 107380617 107391481
KMR : 108241995(zmp:0000001114) 108248801(st14a)
ALIM : 106517708 106522742 106532781
NWH : 119409487(zmp:0000001114) 119410741(st14a) 119417382
AOCE : 111577072 111577347(st14) 111586977
MCEP : 125009082 125014048(st14a) 125015950(zmp:0000001114)
CSEM : 103377975 103384408 103388506
POV : 109630036(st14) 109633031 109643192
SSEN : 122773898(st14a) 122774544(zmp:0000001114) 122776619
HHIP : 117764643 117773256(st14a) 117777149(zmp:0000001114)
HSP : 118106611(st14a) 118111624 118114213(zmp:0000001114)
SMAU : 118299607(st14a) 118300385(zmp:0000001114) 118316951
LCF : 108876125(st14a) 108879524(st14b) 108881772 108890744(st14)
SDU : 111221013 111233649(st14) 111234044 111235457
SLAL : 111662282 111662879 111664983 111673355
XGL : 120783768(zmp:0000001114) 120792473(st14a) 120803752
HCQ : 109510401 109510847 109517617
SSCV : 125972836 125975519 125988043
SBIA : 133500577(st14) 133504958(st14a) 133510393
PEE : 133401747(st14) 133405291(st14a) 133406703
PTAO : 133479262(st14) 133481901(st14a) 133484603
BPEC : 110157936 110163592(st14) 110171801
MALB : 109968489 109968626 109971701
BSPL : 114843368(st14) 114858630(st14b) 114868097(st14a)
SJO : 128357745 128360369(st14a) 128366752(st14)
SASA : 106563416 106577854 106579543 106605621 106613383(st14)
STRU : 115164224 115176413 115204350 115206717
OTW : 112222738(zmp:0000001114) 112226793 112231264(st14b) 112267508(st14a)
OMY : 110503277(st14a) 110510036(st14b) 110510471 110536557 110538136(zmp:0000001114)
OGO : 123998002 124005099(st14a) 124005467 124006818(st14b)
ONE : 115101379 115101482 115140829
OKI : 109874109 109885994 109901662 109906905
OKE : 118364088 118367647 118374866(st14b) 118383691(st14a)
SALP : 111958944 111958965 111964244
SNH : 120021589(st14b) 120031354 120048555
CCLU : 121541226(st14b) 121556970 121567854(st14a) 121586103
ELS : 105010839 105019120 105021946 105029604
SFM : 108924830(st14) 108930336 108939600 108942054
PKI : 111836275 111837950 111840267 111841510
AANG : 118208793(st14a) 118233057(zmp:0000001114) 118235964(st14b)
LOC : 102691172 102697193(st14)
PSPA : 121298948(zmp:0000001114) 121302857 121302859 121304205 121309541(st14a)
ARUT : 117397427 117434051 117966500 117971981
LCM : 102354865 102356973(ST14)
CPLA : 122540761 122555251 122555509
LERI : 129702563 129712471
BFO : 118404120 118404123 118405051 118406282 118407090 118409130 118412355 118426067
BBEL : 109462101 109464386 109467565 109476243 109476314 109479646
SCLV : 120335342 120339087 120339088
SPU : 105440151 105442296 115926792 115928530 115929048 373199(CGSP1) 582875 584950 588863
LPIC : 129253669 129256764
APLC : 110978654 110980664 110981982 110985421
SKO : 100366428 100367524 100370651 100373316
» show all
Taxonomy
Reference
Authors
Lee SL, Dickson RB, Lin CY.
Title
Activation of hepatocyte growth factor and urokinase/plasminogen activator by matriptase, an epithelial membrane serine protease.
Journal
Reference
Authors
Lin CY, Anders J, Johnson M, Sang QA, Dickson RB.
Title
Molecular cloning of cDNA for matriptase, a matrix-degrading serine protease with trypsin-like activity.
Journal
Sequence
Reference
Authors
Ramsay AJ, Reid JC, Velasco G, Quigley JP, Hooper JD.
Title
The type II transmembrane serine protease matriptase-2--identification, structural features, enzymology, expression pattern and potential roles.
Journal
Reference
Authors
Kojima K, Tsuzuki S, Fushiki T, Inouye K.
Title
The activity of a type II transmembrane serine protease, matriptase, is dependent solely on the catalytic domain.
Journal
Reference
Authors
Wysocka M, Gruba N, Miecznikowska A, Popow-Stellmaszyk J, Gutschow M, Stirnberg M, Furtmann N, Bajorath J, Lesner A, Rolka K.
Title
Substrate specificity of human matriptase-2.
Journal
Other DBs