KEGG ENZYME: 3.4.21.22

ENZYME: 3.4.21.22

Entry

EC 3.4.21.22                Enzyme

Name

coagulation factor IXa;
activated Christmas factor;
blood-coagulation factor IXa;
activated blood-coagulation factor IX;
autoprothrombin II;
blood platelet cofactor II;
activated blood coagulation factor XI

Class

Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases

Reaction(IUBMB)

Selective cleavage of Arg!Ile bond in factor X to form factor Xa

Comment

A chymotrypsin homologue, and one of the gamma-carboxyglutamic acid-containing blood coagulation factors. The proenzyme factor IX is activated by factor XIa. In peptidase family S1 (trypsin family)

History

EC 3.4.21.22 created 1978

Orthology

K01321

coagulation factor IX (Christmas factor)

Genes

HSA:

2158(F9)

PTR:	465887(F9)

PPS:	100969131(F9)

GGO:	101128865(F9)

PON:	100446459(F9)

NLE:	100598601(F9)

HMH:	116811419(F9)

MCC:	695578(F9)

MCF:	102146175(F9)

MTHB:

126945530

MNI:	105481354(F9)

CSAB:

103232665(F9)

CATY:

105592697(F9)

PANU:

101018592(F9)

TGE:	112615930(F9)

MLEU:

105554958(F9)

RRO:	104682195(F9)

RBB:

108521383

TFN:	117078021(F9)

PTEH:

111536253(F9)

CANG:

105525424(F9)

CJC:	100398468(F9)

SBQ:	101046698(F9)

CIMI:

108283552(F9)

CSYR:

103264135(F9)

MMUR:

105881058(F9)

LCAT:

123628445(F9)

PCOQ:

105827247(F9)

OGA:	100947691(F9)

MMU:

14071(F9)

MCAL:

110286779(F9)

MPAH:

110314135(F9)

RNO:

24946(F9)

MCOC:

116092876(F9)

ANU:	117695296(F9)

MUN:	110539834(F9)

CGE:	100757213(F9)

MAUA:

101824778(F9)

PROB:

127218119(F9)

PLEU:

114681025(F9)

MORG:

121437358(F9) 121437531

MFOT:

126512087

AAMP:

119804637(F9)

NGI:	103724689(F9)

HGL:	101724977(F9)

CPOC:

100135464(F9)

CCAN:

109675816(F9)

DORD:

105992875(F9)

DSP:	122097109(F9)

PLOP:

125343656(F9)

NCAR:

124972665

MMMA:

107152529(F9)

OCU:	100009113(F9)

OPI:	101527566(F9)

TUP:	102484971(F9)

GVR:	103600149(F9)

CFA:	404015(F9)

CLUD:

112668481(F9)

VVP:	112927642(F9)

VLG:	121483470(F9)

NPO:	129517575(F9)

AML:	100468418(F9)

UMR:	103672846(F9)

UAH:	113241876(F9)

UAR:	123797321(F9)

ELK:

111158974

LLV:

125092370

MPUF:

101678344(F9)

MNP:	132007810(F9)

MLK:	131821832(F9)

NVS:	122896441(F9)

ORO:	101385212(F9)

EJU:	114224597(F9)

ZCA:	113930774(F9)

MLX:	118011743(F9)

NSU:	110575603(F9)

LWW:	102737105(F9)

FCA:	493973(F9)

PYU:

121024192

PCOO:

112871089(F9)

PBG:	122477004(F9)

PVIV:

125157756(F9)

LRUF:

124513777

PTG:	102971107(F9)

PPAD:

109250471(F9)

PUC:

125932017

AJU:

106969973

HHV:	120222248(F9)

BTA:	280688(F9)

BOM:	102285916(F9)

BIU:	109555385(F9)

BBUB:

102416666(F9)

BBIS:

104997790

CHX:	102174637(F9)

OAS:	443316(F9)

BTAX:

128070458(F9)

ODA:	120881735(F9)

CCAD:

122435894(F9)

MBEZ:

129535180(F9)

SSC:	397518(F9)

CFR:	102513153(F9)

CBAI:

105067060(F9)

CDK:	105086028(F9)

VPC:	102531998(F9)

BACU:

103020493(F9)

BMUS:

118889143(F9)

LVE:	103090469(F9)

OOR:	101271539(F9)

DLE:	111164550(F9)

PCAD:

102988201(F9)

PSIU:

116747622(F9)

NASI:

112404083(F9)

ECB:	100054449(F9)

EPZ:	103567516(F9)

EAI:	106840103(F9)

MYB:	102257875(F9)

MYD:	102757434(F9)

MMYO:

118654725(F9)

MLF:	102429338(F9)

PKL:	118722147(F9)

EFUS:

103298450(F9)

MNA:	107532746(F9)

DRO:	112300060(F9)

SHON:

118991400(F9)

AJM:	119035951 119035956(F9)

PDIC:

114505075(F9)

PHAS:

123819095(F9)

MMF:	118635992(F9)

PPAM:

129075486(F9)

HAI:	109388665(F9)

RFQ:	117028021(F9)

PALE:

102881862(F9)

PGIG:

120612376(F9)

PVP:	105303800(F9)

RAY:	107503214(F9)

MJV:	108386638(F9)

TOD:	119246507(F9)

SARA:

101549359(F9)

LAV:	100663465(F9)

TMU:

101352726

ETF:	101650690(F9)

DNM:	101418669(F9)

MDO:	100012394(F9)

GAS:	123253283(F9)

SHR:	100921381(F9)

AFZ:

127542449

PCW:	110197732(F9)

OAA:	100082935(F9)

GGA:	374258(F9)

PCOC:

116229652(F9)

MGP:	100551218(F9)

CJO:	107312750(F9)

TPAI:

128076228(F9)

LMUT:

125699676(F9)

NMEL:

110403425(F9)

APLA:

101804105(F9)

ACYG:

106037454(F9)

CATA:

118245506(F9)

AFUL:

116494587(F9)

TGU:	100225886(F9)

LSR:	110482933(F9)

SCAN:

103816587(F9)

PMOA:

120508761(F9)

OTC:	121331811(F9)

PRUF:

121349130(F9)

GFR:	102038061(F9)

FAB:	101810173(F9)

OMA:	130252963(F9)

PHI:	102114302(F9)

PMAJ:

107203652(F9)

CCAE:

111928537(F9)

CCW:	104691321(F9)

CBRC:

103622503(F9)

ETL:	114060716(F9)

ZAB:	102061407(F9)

ACHL:

103809982(F9)

SVG:	106858383(F9)

MMEA:

130584875(F9)

FPG:	101924325(F9)

FCH:	102052819(F9)

CLV:	102088048(F9)

EGZ:	104130320(F9)

NNI:	104012866(F9)

PCRI:

104029717(F9)

PLET:

104625891

EHS:	104512332(F9)

PCAO:

104051284

ACUN:

113480064(F9)

TALA:

104362475(F9)

PADL:

103917338(F9)

AFOR:

103901279(F9)

ACHC:

115333694(F9)

HALD:

104324538

HLE:	104834823(F9)

AGEN:

126050002

GCL:

127019715

CCRI:

104163119(F9)

CSTI:

104563531(F9)

CMAC:

104481118(F9)

MUI:	104548810(F9)

BREG:

104636356(F9) 104636704

FGA:

104074542

GSTE:

104259558

LDI:	104353070(F9)

MNB:	103781648(F9)

OHA:	104335683(F9)

NNT:	104402361(F9)

SHAB:

115612960(F9)

DPUB:

104303620(F9)

PGUU:

104468901(F9)

ACAR:

104531259

CPEA:

104388304(F9)

AVIT:

104271260(F9)

CVF:	104283516(F9)

RTD:	128915257(F9)

CUCA:

104059300(F9)

TEO:	104382269(F9)

BRHI:

104499629(F9)

AAM:	106484761(F9)

AROW:

112974089(F9)

NPD:	112944472(F9)

TGT:	104565111(F9)

DNE:	112989701(F9)

SCAM:

104150553(F9)

ASN:	102384799(F9)

AMJ:	102565567(F9)

CPOO:

109310845(F9)

GGN:	109300611(F9)

PSS:	102463532(F9)

CMY:	102938403(F9)

CCAY:

125642518(F9)

DCC:	119861496(F9)

CPIC:

101937636(F9)

TST:	117882789(F9)

CABI:

116820597(F9)

MRV:	120372101(F9)

ACS:	100563567(f9)

PVT:	110084962(F9) 110084966

SUND:

121936404 121936945

PBI:	103058462 112540883

PMUR:

107303228(F9) 114922195

CTIG:

120313156(F9) 120313157

TSR:	106538358(F9)

PGUT:

117679567 117679568

APRI:

131205096 131205191

PTEX:

113446853(F9)

NSS:	113423773(F9) 113423775

VKO:	123021890(F9) 123021893

PMUA:

114589339 114589340

PRAF:

128406976 128406977

ZVI:	118089875 118090360

HCG:	128335733(F9)

GJA:	107116105(F9)

STOW:

125442688(F9)

EMC:	129341527(F9)

XLA:	100049721(f9.S) 108698922(f9.L)

XTR:	496659(f9)

NPR:	108793198(F9)

RTEM:

120913655(F9)

BBUF:

120977643(F9)

BGAR:

122919645(F9)

MUO:	115474433(F9)

GSH:	117360947(F9) 117366428

DRE:	100004411 359826(f9a) 678552(f9b)

SRX:	107718750 107720621 107725753 107744572 107752055 107752057

SANH:

107658031 107665423 107693933 107701106 107705017

SGH:	107548854 107551862 107555166 107601103

CCAR:

109052316 109097646 109101831

CAUA:

113054325 113058792 113074406 113081131 113109828 113113961

CGIB:

127966822 127971705 128021163 128029091

PTET:

122332961 122352633(f9b) 122357932(f9a)

LROH:

127171814(f9b) 127175782(f9a) 127177761

OMC:	131520567 131548350(f9b) 131553344(f9a)

PPRM:

120470818 120474441(f9a) 120476467(f9b)

RKG:	130069660(f9a) 130082805(f9b) 130089389

MAMB:

125248956 125259379(f9a) 125260815(f9b)

CIDE:

127494393 127495179 127520167

MASI:

127413254 127418322 127422599 127432866 127433732

TROS:

130546321(f9b) 130563404(f9a) 130565187

TDW:	130411574(f9b) 130428564 130437722(f9a)

MANU:

129422212(f9a) 129438705 129446924 129446925

IPU:	108268424(f9a) 108276806(f9b) 108277713

IFU:	128611397(f9a) 128620199(f9b) 128621863

PHYP:

113529026 113538408(f9) 113544655

SMEO:

124386197(f9a) 124393102(f9b) 124394151

TFD:	113635590(f9a) 113637905 113650395(f9b)

TVC:	132856247(f9a) 132858080 132863337(f9b)

AMEX:

103022627(f9) 103033862 103041525

CMAO:

118798569 118807185(f9a) 118824414(f9b)

EEE:	113574745 113576276(f9) 113583063

CHAR:

105907419(f9b) 105909308 105911766(f9a)

TRU:	101064607 101068927(f9) 445943(f9)

TFS:	130531323(f9a) 130535456 130538133(f9b)

TNG:	GSTEN00012000G001 GSTEN00021128G001 GSTEN00031251G001

LCO:	104923492(f9) 104933045 104934181

NCC:	104958005(f9) 104966981

TBEN:

117474436 117489236(f9a) 117490239(f9b)

CGOB:

115014925(f9) 115017358 115018674

PGEO:

117443417 117453514(f9a) 117458136(f9b)

GACU:

117537616(f9a) 117540102(f9b)

EMAC:

134859853(f9a) 134871745(f9b) 134880417

ELY:	117259475 117260738(f9a) 117263254(f9b)

EFO:	125888443 125894968(f9a) 125898498(f9b)

PLEP:

121944792 121947762(f9a) 121952108(f9b)

SLUC:

116037008(f9b) 116052318(f9a) 116058414

ECRA:

117952317(f9a) 117955774(f9b)

ESP:	116679434 116696315(f9) 116700694

PFLV:

114553065 114563384(f9) 114566228

GAT:	120816259 120817387(f9a) 120821765(f9b)

PPUG:

119210652(f9a) 119215010(f9b) 119219178

AFB:	129089049 129089700(f9a) 129113167(f9b)

CLUM:

117738001(f9a) 117741454 117742862(f9b)

PSWI:

130209557(f9a) 130209949 130210685(f9b) 130210694

MSAM:

119883019 119888354(f9a) 119896138(f9b)

SCHU:

122878610 122879908(f9a) 122888044(f9b)

CUD:	121516494(f9a) 121518348 121518745(f9b)

ALAT:

119004656 119007505(f9a) 119030677(f9b)

MZE:	101464969 101466133 101487720

ONL:	100694381 100704957 100710669

OAU:	116319684 116322509(f9a) 116335354

OLA:

111948660

OML:	112142967(f9b) 112149281

CSAI:

133447621(f9a) 133459515(f9b)

XMA:	102218647 102223546 102232890

XCO:	114139367 114153445 114161730

XHE:	116707484 116714655 116728004

PRET:

103471616(f9) 103475255(proc) 103475699

PFOR:

103138877 103140167(f9) 103152964(proc)

PLAI:

106940167 106941078 106945726(f9) 106951497(proc)

PMEI:

106914303(proc) 106916355(f9) 106917156 106926451

GAF:	122832819 122837096(f9a) 122845323

PPRL:

129359431 129360452 129360457 129373518(f9b)

CVG:	107084182 107089261 107103483

CTUL:

119786309(f9a) 119791588 119795204

GMU:	124860629(f9a) 124876095(f9b) 124884100

NFU:	107386752(f9)

KMR:	108238908(f9b) 108250981

ALIM:

106524024(f9) 106534439

NWH:	119411452 119419953(f9b)

AOCE:

111567418 111579637 111583320

MCEP:

125008173(f9a) 125013724 125021693(f9b)

CSEM:

103378120 103390768(f9) 103395530

POV:	109635678(f9) 109643586

SSEN:

122760751 122773154 122778257(f9a) 122779212(f9b)

HHIP:

117768879(f9a) 117772464 117774356(f9b)

HSP:	118105997 118112359(f9a) 118122015(f9b)

SMAU:

118297752 118300433(f9b) 118319200(f9a)

LCF:	108872530(f9a) 108893791(f9b) 108902924

SDU:	111216838 111217075 111232459(f9)

SLAL:

111646698 111666341 111672128

XGL:	120785141(f9a) 120791817 120802120(f9b)

HCQ:	109510358 109511925(f9)

SSCV:

125982268 125982327 125988050

SBIA:

133492048(f9b) 133509030(f9a) 133510528

PEE:	133408100(f9a) 133413998 133416515(f9b)

PTAO:

133467233 133484673(f9a) 133484951

BPEC:

110155882 110158837(f9) 110174768

MALB:

109955339 109959991

BSPL:

114863862(f9a) 114868003 114869145(f9b)

SJO:	128362908(f9a) 128371145(f9b)

SASA:

100380442(fa9) 106602969(f9) 106611733 106612366

STRU:

115154847(f9) 115162857 115205279 115205815

OTW:	112216678 112228949(f9b) 112256184(f9a) 112265006

OMY:	110490052 110504952(f9a) 110507316 110534144(f9b)

OGO:	123993164 123994829 124006117(f9b) 124011005

ONE:	115106768 115129409 115135497(f9) 115137179

OKI:	109864473 109883606(f9) 109905138 109906297

OKE:	118363426 118366006 118390511(f9b) 118397029

SALP:

111949682 111951166 111960637 111967439

SNH:	120018467 120028772 120057325(f9b) 120062323

CCLU:

121532151(f9a) 121541383 121567286 121579623

ELS:	105029672 105029823 109614554

SFM:	108922151 108922945 108929003

PKI:	111835018 111837223 111859692

AANG:

118210210 118224271(f9a) 118236647

LOC:	102691633 102698954(f9)

PSPA:

121317879(f9b) 121322738

ARUT:

117412272 117430184

PSEX:

120535044 120537308

LCM:	102357491(F9)

CMK:	103178220(f9) 103179434

RTP:

109929282

CPLA:

122555773 122557440

HOC:	132820285 132821359

LERI:

129703554

PMRN:

116954510

LRJ:

133357564

BFO:

118406418

BBEL:

109483133

MDE:	105262172 131800573

MPHA:

105831068

PFUC:

122520349

HHAL:

106689756

FCD:

110842688

PJA:

122244892

PCHN:

125044487

HAME:

121859461

RSAN:

119379359 119396908

RMP:

119174990

VDE:

111248144

VJA:

111261258

SDM:	118188966 118193394

NVE:

5510641

ATEN:

116287514

TAD:	TRIADDRAFT_26286

» show all

Reference

1 [PMID:1012029]

Authors

Fujikawa K, Davie EW.

Title

Bovine factor IX (Christmas factor).

Journal

Methods Enzymol 45:74-83 (1976)
DOI:10.1016/S0076-6879(76)45011-5

Reference

2 [PMID:367103]

Authors

Davie EW, Fujikawa K, Kurachi K, Kisiel W.

Title

The role of serine proteases in the blood coagulation cascade.

Journal

Adv Enzymol Relat Areas Mol Biol 48:277-318 (1979)
DOI:10.1002/9780470122938.ch6

Reference

3 [PMID:6412750]

Authors

Link RP, Castellino FJ.

Title

Kinetic comparison of bovine blood coagulation factors IXa alpha and IXa beta toward bovine factor X.

Journal

Biochemistry 22:4033-41 (1983)
DOI:10.1021/bi00286a007

Reference

4 [PMID:6370301]

Authors

Cho K, Tanaka T, Cook RR, Kisiel W, Fujikawa K, Kurachi K, Powers JC.

Title

Active-site mapping of bovine and human blood coagulation serine proteases using synthetic peptide 4-nitroanilide and thio ester substrates.

Journal

Biochemistry 23:644-50 (1984)
DOI:10.1021/bi00299a009

Other DBs

ExplorEnz - The Enzyme Database:

3.4.21.22

IUBMB Enzyme Nomenclature:

3.4.21.22

ExPASy - ENZYME nomenclature database:

3.4.21.22

BRENDA, the Enzyme Database:

3.4.21.22

CAS:	37316-87-3

DBGET integrated database retrieval system