KEGG ENZYME: 3.4.21.34

ENZYME: 3.4.21.34

Entry

EC 3.4.21.34                Enzyme

Name

plasma kallikrein;
serum kallikrein;
kininogenin;
kallikrein I;
kallikrein II;
kininogenase;
kallikrein;
callicrein;
glumorin;
padreatin;
padutin;
kallidinogenase;
bradykininogenase;
panceatic kallikrein;
onokrein P;
dilminal D;
depot-Padutin;
urokallikrein;
urinary kallikrein

Class

Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases

Reaction(IUBMB)

Selective cleavage of some Arg! and Lys! bonds, including Lys!Arg and Arg!Ser in (human) kininogen to release bradykinin

Comment

Formed from plasma prokallikrein (Fletcher factor) by factor XIIa. Activates coagulation factors XII, VII and plasminogen. Selective for Arg > Lys in P1, in small molecule substrates.

History

EC 3.4.21.34 created 1965 as EC 3.4.4.21, transferred 1972 to EC 3.4.21.8, part transferred 1981 to EC 3.4.21.34

Orthology

K01324

plasma kallikrein

Genes

HSA:	3818(KLKB1)

PTR:	471375(KLKB1)

PPS:	100985593(KLKB1)

GGO:	101142617(KLKB1)

PON:	100172926(KLKB1)

NLE:	100594044 115835879

HMH:	116466086(KLKB1)

MCC:	696639(KLKB1)

MCF:	102142369(KLKB1)

MTHB:

126955234

MNI:	105466552(KLKB1)

CSAB:

103236637(KLKB1)

CATY:

105594265(KLKB1)

PANU:

101004320(KLKB1)

TGE:	112624825(KLKB1)

MLEU:

105540242(KLKB1)

RRO:	104673817(KLKB1)

RBB:	108522428(KLKB1)

TFN:	117086226(KLKB1)

PTEH:

111548503(KLKB1)

CANG:

105524322(KLKB1)

CJC:	100409572(KLKB1)

SBQ:	101048983(KLKB1)

CIMI:

108288135(KLKB1)

CSYR:

103271965(KLKB1)

MMUR:

105882474(KLKB1)

LCAT:

123638620(KLKB1)

PCOQ:

105810082(KLKB1)

OGA:	100950732(KLKB1)

MMU:	16621(Klkb1)

MCAL:

110299702(Klkb1)

MPAH:

110336817(Klkb1)

RNO:	25048(Klkb1)

MCOC:

116071383(Klkb1)

ANU:	117721641(Klkb1)

MUN:	110558008(Klkb1)

CGE:	100767873(Klkb1)

MAUA:

101827641(Klkb1)

PROB:

127220497(Klkb1)

PLEU:

114701164(Klkb1)

MORG:

121433832(Klkb1)

MFOT:

126504788

AAMP:

119811369(Klkb1)

NGI:	103750509(Klkb1)

HGL:	101719264(Klkb1)

CPOC:

100715794(Klkb1)

CCAN:

109684302(Klkb1)

DORD:

105991332(Klkb1)

DSP:	122127383(Klkb1)

PLOP:

125339581(Klkb1)

NCAR:

124983746

MMMA:

107142650(Klkb1)

OCU:

100356267

OPI:	101523823(KLKB1)

TUP:	102485674(KLKB1)

GVR:	103581445(KLKB1)

CFA:	475624(KLKB1)

VVP:	112934777(KLKB1)

NPO:	129503582(KLKB1)

AML:	100468355(KLKB1)

UMR:	103680968(KLKB1)

UAH:	113262285(KLKB1)

UAR:	123784492(KLKB1)

ELK:

111144530

LLV:

125093973

MPUF:

101689429(KLKB1)

MNP:	132006307(KLKB1)

MLK:	131820617(KLKB1)

NVS:	122919283(KLKB1)

ORO:	101379313(KLKB1)

EJU:	114206167(KLKB1)

ZCA:	113924887(KLKB1)

MLX:	118010046(KLKB1)

NSU:	110584170(KLKB1)

LWW:	102726728(KLKB1)

FCA:	101094092(KLKB1)

PYU:	121039709(KLKB1)

PCOO:

112869962(KLKB1)

PBG:	122470993(KLKB1)

PVIV:

125163419(KLKB1)

LRUF:

124520854

PTG:	102971874(KLKB1)

PPAD:

109250991(KLKB1)

PUC:

125923456

AJU:

106982221

HHV:	120237791(KLKB1)

BTA:	533547(KLKB1)

BOM:	102270694(KLKB1)

BIU:	109553560(KLKB1)

BBUB:

102396882(KLKB1)

BBIS:

104985562(KLKB1)

CHX:	102184030(KLKB1)

OAS:

101116376

BTAX:

128068326(KLKB1)

ODA:	120865743(KLKB1)

CCAD:

122432375(KLKB1)

MBEZ:

129549324(KLKB1)

SSC:	397144(KLKB1)

CFR:	102512343(KLKB1)

CBAI:

105067666(KLKB1)

CDK:	105102384(KLKB1)

VPC:	102526079(KLKB1)

ECB:	100056650(KLKB1)

EAI:	106840366(KLKB1)

MYB:	102247445(KLKB1)

MYD:	102764838(KLKB1)

MMYO:

118652088(KLKB1)

MLF:	102426918(KLKB1)

PKL:	118730055(KLKB1)

EFUS:

103290370

MNA:	107534033(KLKB1)

DRO:	112306752(KLKB1)

SHON:

118993096(KLKB1)

AJM:	119036873(KLKB1)

PDIC:

114508386(KLKB1)

PHAS:

123807510(KLKB1)

PPAM:

129064872(KLKB1)

HAI:	109395838(KLKB1)

RFQ:	117021760(KLKB1)

PALE:

102883484(KLKB1)

PGIG:

120618463(KLKB1)

PVP:	105294687(KLKB1)

RAY:	107510433(KLKB1)

MJV:	108396405(KLKB1)

TOD:	119230348 119257004(KLKB1)

SARA:

101551391(KLKB1)

LAV:

100660779

TMU:

101358166

ETF:	101648903(KLKB1)

DNM:	101423717(KLKB1)

MDO:	100013981(KLKB1)

GAS:	123253136(KLKB1)

SHR:	100917450(KLKB1)

AFZ:

127541438

PCW:	110204309 110204628

OAA:

100086786

GGA:	422723(F11)

PCOC:

116238902

MGP:

100549617

CJO:

107313680

TPAI:

128080587

LMUT:

125691632

NMEL:

110397297

APLA:

101805242

ACYG:

106035178

AFUL:

116488670

TGU:

100228027

LSR:

110474988

SCAN:

103826205

PMOA:

120498052

OTC:

121348392

PRUF:

121360367

GFR:	102045543(F11)

FAB:	101814154(KLKB1)

OMA:

130252715

PHI:

102108065

PMAJ:

107203558

CCAE:

111927976

CCW:	104690592(KLKB1)

CBRC:

103622482

ETL:

114067778

ZAB:	102073697(KLKB1)

ACHL:

103809042

SVG:

106861361

MMEA:

130575960(KLKB1)

HRT:

120753014

FPG:	101918416(F11)

FCH:

102054661

CLV:

102094577

EGZ:

104129485

NNI:

104021299

PCRI:

104029039

PLET:

104623403

EHS:

104514970

PCAO:

104047316

ACUN:

113479233

TALA:

104364370

PADL:

103922514

AFOR:

103897379

ACHC:

115341152

HALD:

104322979

HLE:

104833396

AGEN:

126037302

GCL:

127015861

CCRI:

104158114

CSTI:

104560594

CMAC:

104485911

MUI:

104546960

BREG:

104637415

FGA:

104078586

GSTE:

104254684

LDI:

104354850

MNB:

103772976

OHA:

104334543

NNT:

104410570

SHAB:

115610814

DPUB:

104301811

PGUU:

104462377

ACAR:

104518261

CPEA:

104393018

AVIT:

104278421

CVF:

104285446

RTD:

128910092

CUCA:

104063496

TEO:

104376291

BRHI:

104499248

AAM:

106484024

AROW:

112965854

NPD:

112949925

TGT:

104575322

DNE:

112986089

SCAM:

104145249(KLKB1)

ASN:	102385242(KLKB1)

AMJ:	102566272(KLKB1)

CPOO:

109322021

GGN:	109303759(KLKB1)

PSS:

102455335

CCAY:

125636019

CPIC:

101952530(KLKB1)

TST:	117878095(KLKB1)

CABI:

116835912

MRV:

120406388

ACS:	100557428(klkb1)

ASAO:

132776686(KLKB1)

PVT:	110077890(KLKB1)

SUND:

121931138(KLKB1)

PBI:	103051995(KLKB1)

PMUR:

107302682

CTIG:

120316639(KLKB1)

TSR:	106542021(KLKB1)

PGUT:

117680187(KLKB1)

APRI:

131203421(KLKB1)

PTEX:

113434569(KLKB1)

NSS:

113411769

VKO:	123036510(KLKB1)

PMUA:

114604642(KLKB1)

PRAF:

128420683(KLKB1)

ZVI:	118084140(KLKB1)

HCG:

128328487

GJA:	107121980(KLKB1)

STOW:

125440103(KLKB1)

EMC:	129336665(KLKB1)

XLA:	446603(klkb1.L)

XTR:	100486524(klkb1)

NPR:

108784940

RTEM:

120921901

BBUF:

120990165(KLKB1)

BGAR:

122934952(KLKB1)

MUO:	115462197(KLKB1)

GSH:

117366873

IPU:

108257413

IFU:

128600665

PHYP:

113536237

SMEO:

124376377

TFD:

113661525

TVC:

132837578

CMAO:

118804887

CHAR:

105910278 122129143

TNG:	GSTEN00017543G001

PFLV:

114568223

SCHU:

122864163

MZE:

101476310

ONL:	100691143 100711845 100712382

OLA:

101167304

OML:

112136310

XMA:	102235514 102236020 111610402

XCO:	114155410 114155689 114156653

XHE:	116730704 116731571

PRET:

103472119 103472120 103472122

GAF:

122843703

PPRL:

129376300 129376381

CVG:

107092604

CTUL:

119784643

GMU:	124878882 124879615

NFU:

107374492

AOCE:

111572227

MCEP:

125019440

HHIP:

117770686

HSP:

124851080

LCF:

108893006

SDU:

111223201

SLAL:

111673270

XGL:

120786050

HCQ:

109519192

ELS:

105027740

SFM:

108938912

PKI:

111854240

LOC:	102685657 107077276

LCM:	102361209(KLKB1)

LERI:

129697020

CIN:	100176588 100182205

SCLV:

120327917 120334500 120342435 120342461

APLC:

110973868 110984589

AAG:	5570931 5575054 5575060

AALB:

109426188

CQU:	CpipJ_CPIJ016225

CPII:

120419921

BIM:

100740887

BTER:

100644527

SOC:	105193897 105196026 105196044 105196739 105200420

MPHA:

105831007 105832984 114253741

AEC:	105151207 105151375

ACEP:

105617847 105619958

PBAR:

105424748

VEM:

105568413

HST:	105186338 109503706

CFO:	105249589 105251050 105251056 105255493 105257558

LHU:

105671298

PGC:	109852197 109853791

NVI:	100114471(SP16)

CSOL:

105362138 105366751

ATD:

109602881

NVL:	108559693 108563022 108565242

BMOR:

100862834 101740247

BMAN:

114246163 114251826

MSEX:

115446368 115455935

BANY:

112047014

HAW:

110374025

TNL:	113499223 113500559 113505544 113505545

PXY:

105385426

API:

100160497

AGS:

114121009

RMD:

113548576

BTAB:

109030011

CLEC:

106664815

BROR:

134534436

FCD:	110842752 110858603

DPX:	DAPPUDRAFT_241460

PVM:	113802726 113807483 113811866 113819716

PJA:

122246632

PCHN:

125038135

HAME:

121870979

PCLA:

123760876 123765977

PPOI:

119101902

VDE:

111249763

VJA:

111266457

TUT:

107364976

DPTE:

113796590 113797445

DFR:	124493637 124498460

CSCU:

111620528 111638398

PTEP:

107440325 107442445

ABRU:

129960180

SDM:

118195904

LGI:	LOTGIDRAFT_153888

PCAN:

112554714 112571496

HRJ:	124289327 124291123

MYI:

110443096

PMAX:

117329014

OBI:	106870435 106877341

OSN:

115217699

LAK:

106151350

OVI:	T265_14457

NVE:

5502645

AMIL:

114955798

PDAM:

113670584 113685551

SPIS:

111344747

NGR:	NAEGRDRAFT_65585

» show all

Reference

1 [PMID:6918767]

Authors

Heimark RL, Davie EW.

Title

Bovine and human plasma prekallikrein.

Journal

Methods Enzymol 80 Pt C:157-72 (1981)
DOI:10.1016/s0076-6879(81)80016-x

Reference

2 [PMID:6976185]

Authors

McRae BJ, Kurachi K, Heimark RL, Fujikawa K, Davie EW, Powers JC.

Title

Mapping the active sites of bovine thrombin, factor IXa, factor Xa, factor XIa, factor XIIa, plasma kallikrein, and trypsin with amino acid and peptide thioesters: development of new sensitive substrates.

Journal

Biochemistry 20:7196-206 (1981)
DOI:10.1021/bi00528a022

Reference

3 [PMID:3237096]

Authors

Silverberg M, Kaplan AP.

Title

Prekallikrein.

Journal

Methods Enzymol 163:85-95 (1988)
DOI:10.1016/0076-6879(88)63010-2

Reference

4 [PMID:2598771]

Authors

Seidah NG, Ladenheim R, Mbikay M, Hamelin J, Lutfalla G, Rougeon F, Lazure C, Chretien M.

Title

The cDNA structure of rat plasma kallikrein.

Journal

DNA 8:563-74 (1989)
DOI:10.1089/dna.1989.8.563

Sequence

[rno:25048]

Reference

5 [PMID:2534361]

Authors

Tsuda Y, Teno N, Okada Y, Wanaka K, Bohgaki M, Hijikata-Okunomiya A, Okamoto U, Naito T, Okamoto S.

Title

Synthesis of tripeptide chloromethyl ketones and examination of their inhibitory effects on plasmin and plasma kallikrein.

Journal

Chem Pharm Bull (Tokyo) 37:3108-11 (1989)
DOI:10.1248/cpb.37.3108

Other DBs

ExplorEnz - The Enzyme Database:

3.4.21.34

IUBMB Enzyme Nomenclature:

3.4.21.34

ExPASy - ENZYME nomenclature database:

3.4.21.34

BRENDA, the Enzyme Database:

3.4.21.34

CAS:	410538-33-9

DBGET integrated database retrieval system