KEGG   ENZYME: 3.4.21.38
Entry
EC 3.4.21.38                Enzyme                                 
Name
coagulation factor XIIa;
Hageman factor (activated);
blood-coagulation factor XIIf;
activated beta blood-coagulation factor XII;
prealbumin activator;
Hageman factor beta-fragment;
Hageman factor fragment HFf;
blood-coagulation factor XIIabeta;
prekallikrein activator;
kallikreinogen activator
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
Reaction(IUBMB)
Selective cleavage of Arg!Ile bonds in factor VII to form factor VIIa and factor XI to form factor XIa
Comment
Also activates plasminogen and plasma prokallikrein. Formed from the proenzyme, factor XII, by plasma kallikrein or factor XIIa. In peptidase family S1 (trypsin family)
History
EC 3.4.21.38 created 1981
Orthology
K01328  coagulation factor XII (Hageman factor)
Genes
HSA2161(F12)
PTR462304(F12)
PPS100995209(F12)
GGO101125814(F12)
PON100434389(F12)
NLE100586368(F12)
HMH116471892(F12)
MCC699875(F12)
MCF101925781(F12)
MTHB126956331
MNI105484051(F12)
CSAB103245055(F12)
CATY105581726(F12)
PANU100999329(F12)
TGE112626332(F12)
MLEU105546704(F12)
RRO104680459(F12)
RBB108544775(F12)
TFN117065332(F12)
PTEH111521616(F12)
CANG105515134(F12)
CJC100412907(F12)
SBQ101051215(F12)
CIMI108292162(F12)
MMUR105883825(F12)
LCAT123623454(F12)
PCOQ105823511(F12)
OGA100960869(F12)
MMU58992(F12)
MCAL110308153(F12)
MPAH110334054(F12)
RNO306761(F12)
MCOC116081647(F12)
ANU117714186(F12)
CGE100764143(F12)
MAUA101827943(F12)
PROB127229418(F12)
PLEU114689206(F12)
MORG121453467(F12)
MFOT126502886
AAMP119817505(F12)
NGI103732377(F12)
HGL101720589(F12)
CPOC100728720(F12)
CCAN109685737(F12)
DORD105985443(F12)
DSP122096537(F12)
PLOP125341958(F12)
NCAR124987089
MMMA107144723(F12)
OCU100351481
OPI101523368(F12)
TUP102472619(F12)
GVR103594909(F12)
CFA489090(F12)
CLUD112651364(F12)
VVP112927944(F12)
VLG121487275(F12)
NPO129509839(F12)
AML100475269(F12)
UMR103664758
UAH113264151(F12)
UAR123791509(F12)
ELK111141160
LLV125100999
MPUF101686585(F12)
MNP132028473(F12)
MLK131831976(F12)
NVS122901773(F12)
ORO101377877(F12)
EJU114208722(F12)
ZCA113929206(F12)
MLX118017315(F12)
NSU110588475(F12)
LWW102734552(F12)
FCA100313488(F12)
PYU121011726(F12)
PCOO112860979(F12)
PBG122489877(F12)
LRUF124520001
PTG102968089(F12)
PPAD109267582(F12)
PUC125934392
AJU106975412
HHV120236803(F12)
BTA280789(F12)
BOM102271184(F12)
BIU109561902(F12)
BBUB102411763(F12)
BBIS104993332(F12)
CHX102178999(F12)
OAS101106770(F12)
BTAX128051527(F12)
ODA120863853(F12)
CCAD122440034(F12)
MBEZ129559436(F12)
SSC397474(F12)
CFR102509848(F12)
CBAI105062036(F12)
CDK105099592(F12)
VPC102528574(F12)
BACU103008303(F12)
LVE103090424(F12)
OOR101286772(F12)
DLE111169857(F12)
PCAD102988028(F12)
PSIU116750993(F12)
NASI112400091(F12)
ECB100068589(F12)
EPZ103539971(F12)
EAI106827197(F12)
MYB102263500(F12)
MYD102764826(F12)
MMYO118657566(F12)
MLF102422821(F12)
MNA107529736(F12)
PKL118711279(F12)
EFUS103287365(F12)
HAI109389742(F12)
DRO112320387(F12)
SHON118999765(F12)
AJM119035154(F12)
PDIC114509956(F12)
PHAS123813235(F12)
MMF118643761(F12)
RFQ117016472(F12)
PPAM129066463(F12)
PALE102877694(F12)
PGIG120616565(F12)
PVP105293507(F12)
RAY107517529(F12)
MJV108406369(F12)
TOD119235734(F12)
SARA101538105(F12)
LAV100663101(F12)
TMU101342146
ETF101646298(F12)
DNM101431380(F12)
MDO100031953(F12)
GAS123235484(F12)
SHR100922168(F12)
AFZ127550286
PCW110216837(F12)
OAA100087798(F12)
AMJ102570409(F12)
CPIC101953082(F12)
TST117882018(F12)
CABI116833290(F12)
MRV120370460(F12)
ACS100555717(f12)
ASAO132769057(F12)
PVT110077399(F12)
SUND121920360(F12)
PBI112540271(F12)
PMUR114922858(F12)
CTIG120304035(F12)
TSR106553235(F12)
PGUT117679805(F12)
APRI131191897(F12)
PTEX113454960(F12)
NSS113415808(F12)
VKO123034027(F12)
PMUA114591453(F12)
PRAF128408075(F12)
ZVI118080515(F12)
HCG128341619(F12)
GJA107111529(F12)
STOW125427670(F12)
EMC129328981(F12)
XLA100037012(f12.L)
XTR100493769(f12)
NPR108783741(F12)
RTEM120932213(F12)
BBUF120977540(F12)
BGAR122928204(F12)
MUO115476690(F12)
GSH117351817(F12)
SCHU122884470
PPOT106109596
PXU106124100
SLIU111354867
OFU114365944
PCHN125048206
PPOI119096711 119097148 119097150
 » show all
Reference
1  [PMID:6918768]
  Authors
Fujikawa K, Davie EW.
  Title
Human factor XII (Hageman factor).
  Journal
Methods Enzymol 80 Pt C:198-211 (1981)
DOI:10.1016/s0076-6879(81)80018-3
Reference
2  [PMID:6370301]
  Authors
Cho K, Tanaka T, Cook RR, Kisiel W, Fujikawa K, Kurachi K, Powers JC.
  Title
Active-site mapping of bovine and human blood coagulation serine proteases using synthetic peptide 4-nitroanilide and thio ester substrates.
  Journal
Biochemistry 23:644-50 (1984)
DOI:10.1021/bi00299a009
Reference
3  [PMID:3011063]
  Authors
Que BG, Davie EW
  Title
Characterization of a cDNA coding for human factor XII (Hageman factor).
  Journal
Biochemistry 25:1525-8 (1986)
DOI:10.1021/bi00355a009
  Sequence
[hsa:2161]
Reference
4  [PMID:3237089]
  Authors
Fujikawa K.
  Title
Bovine Hageman factor and its fragments.
  Journal
Methods Enzymol 163:54-68 (1988)
DOI:10.1016/0076-6879(88)63007-2
Reference
5  [PMID:3237092]
  Authors
Silverberg M, Kaplan AP.
  Title
Human Hageman factor and its fragments.
  Journal
Methods Enzymol 163:68-80 (1988)
DOI:10.1016/0076-6879(88)63008-4
Other DBs
ExplorEnz - The Enzyme Database: 3.4.21.38
IUBMB Enzyme Nomenclature: 3.4.21.38
ExPASy - ENZYME nomenclature database: 3.4.21.38
BRENDA, the Enzyme Database: 3.4.21.38
CAS: 75216-42-1

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