KEGG   ENZYME: 3.4.21.60
Entry
EC 3.4.21.60                Enzyme                                 
Name
scutelarin;
taipan activator;
Oxyuranus scutellatus prothrombin-activating proteinase
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
Reaction(IUBMB)
Selective cleavage of Arg!Thr and Arg!Ile in prothrombin to form thrombin and two inactive fragments
Comment
From the venom of the Taipan snake (Oxyuranus scutellatus). Converts prothrombin to thrombin. Specificity is similar to that of Factor Xa (EC 3.4.21.6). However, unlike Factor Xa this enzyme can cleave its target in the absence of coagulation Factor Va. Activity is potentiated by phospholipid and Ca2+ which binds via gamma-carboxyglutamic acid residues. Similar enzymes are known from the venom of other Australian elapid snakes, including Pseudonaja textilis textilis, Oxyuranus microlepidotus and Demansia nuchalis affinis. A member of peptidase family S1.
History
EC 3.4.21.60 created 1978 as EC 3.4.99.28, transferred 1992 to EC 3.4.21.60, modified 2010, modified 2011
Reference
1  [PMID:6986908]
  Authors
Walker FJ, Owen WG, Esmon CT.
  Title
Characterization of the prothrombin activator from the venom of Oxyuranus scutellatus scutellatus (taipan venom).
  Journal
Biochemistry 19:1020-3 (1980)
DOI:10.1021/bi00546a029
Reference
2  [PMID:3531198]
  Authors
Speijer H, Govers-Riemslag JW, Zwaal RF, Rosing J.
  Title
Prothrombin activation by an activator from the venom of Oxyuranus scutellatus (Taipan snake).
  Journal
J Biol Chem 261:13258-67 (1986)
Other DBs
ExplorEnz - The Enzyme Database: 3.4.21.60
IUBMB Enzyme Nomenclature: 3.4.21.60
ExPASy - ENZYME nomenclature database: 3.4.21.60
BRENDA, the Enzyme Database: 3.4.21.60
CAS: 93389-45-8

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