KEGG   ENZYME: 3.4.21.63
Entry
EC 3.4.21.63                Enzyme                                 
Name
oryzin;
Aspergillus alkaline proteinase;
aspergillopeptidase B;
API 21;
aspergillopepsin B;
aspergillopepsin F;
Aspergillus candidus alkaline proteinase;
Aspergillus flavus alkaline proteinase;
Aspergillus melleus semi-alkaline proteinase;
Aspergillus oryzae alkaline proteinase;
Aspergillus parasiticus alkaline proteinase;
Aspergillus serine proteinase;
Aspergillus sydowi alkaline proteinase;
Aspergillus soya alkaline proteinase;
Aspergillus melleus alkaline proteinase;
Aspergillus sulphureus alkaline proteinase;
prozyme;
P 5380;
kyorinase;
seaprose S;
semi-alkaline protease;
sumizyme MP;
prozyme 10;
onoprose;
onoprose SA;
protease P;
promelase
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
Reaction(IUBMB)
Hydrolysis of proteins with broad specificity, and of Bz-Arg-OEt > Ac-Tyr-OEt. Does not hydrolyse peptide amides
Comment
A peptidase of family S8 (subtilisin family), not containing cysteine, that is the predominant extracellular alkaline endopeptidase of the mold Aspergillus oryzae. Identical or closely related enzymes are produced by A. flavus and A. sojae [2,3,4]
History
EC 3.4.21.63 created 1992 (EC 3.4.21.14 created 1961 as EC 3.4.4.16, transferred 1972 to EC 3.4.21.14, modified 1986, part incorporated 1992)
Orthology
K18549  oryzin
Genes
LPIC: 129256198 129259979 129262850 129265598 129272300 129272784 129272867 129272868 129272891 129272903 129272908 129272909 129272980 129273147 129273275 129273423 129273425 129273461 129273603 129277727 129277728 129282672
PBEL: QC761_0074380
PPSD: QC762_0074970 QC762_510310(SUB2_3)
PPSP: QC763_0080550 QC763_510310(SUB2_3)
PPSA: QC764_0074120 QC764_510310(SUB2_3)
PGRI: PgNI_00992 PgNI_09125 PgNI_10512
FPOA: FPOAC1_000849 FPOAC1_003675 FPOAC1_004570 FPOAC1_005648 FPOAC1_005685(PRB1_1) FPOAC1_007674(PRB1_2) FPOAC1_010003
FVN: FVRRES_01015 FVRRES_04017 FVRRES_05068 FVRRES_06221 FVRRES_06258 FVRRES_08152 FVRRES_10849
FFC: NCS54_00160300 NCS54_00189200 NCS54_00381600 NCS54_00958500 NCS54_01329600
FKR: NCS57_00157500 NCS57_00187400 NCS57_00387000 NCS57_00979600 NCS57_01316600
FMU: J7337_001591 J7337_001923(PRB1_1) J7337_006142 J7337_006306 J7337_007904 J7337_008478 J7337_010880 J7337_012173 J7337_012662(PRB1_2)
PCHM: VFPPC_01236 VFPPC_05714 VFPPC_06535 VFPPC_06603
AMUS: LMH87_006112 LMH87_010316
PTKZ: JDV02_003813 JDV02_004629 JDV02_006290 JDV02_006357 JDV02_010728(ALP1_2)
ANI: ANIA_05558 ANIA_10030
AFM: AFUA_4G11800 AFUA_5G09210
ACT: ACLA_011360 ACLA_050840
NFI: NFIA_078120 NFIA_104430
AOR: AO090003001036 AO090020000517
ANG: An07g03880(pepC) An09g03780(pepD)
AFV: AFLA_000633 AFLA_010140
ALUC: AKAW2_11802A(SUB8) AKAW2_40417S(ALP1)
ACHE: ACHE_10233S(ALP1) ACHE_50640S(SUB8)
APUU: APUU_11890S(SUB8) APUU_40913S(ALP1)
POU: POX_a00593
TMF: EYB26_003982
TRG: TRUGW13939_10665
ARAB: EKO05_0002227 EKO05_0010779
CBET: CB0940_02328 CB0940_04215
RSX: RhiXN_00065 RhiXN_05399 RhiXN_07378 RhiXN_09136
 » show all
Reference
1
  Authors
Nakagawa, Y.
  Title
Alkaline proteinases from Aspergillus.
  Journal
Methods Enzymol 19:581-591 (1970)
Reference
2
  Authors
Hayashi, K. and Terada, M.
  Title
Some characteristics of hydrolysis of synthetic substrates and proteins by the alkaline proteases from Aspergillus sojae.
  Journal
Agric Biol Chem 36:1755-1765 (1972)
Reference
3  [PMID:4623338]
  Authors
Turkova J, Mikes O, Hayashi K, Danno G, Polgar L.
  Title
Alkaline proteinases of the genus Aspergillus.
  Journal
Biochim Biophys Acta 257:257-63 (1972)
DOI:10.1016/0005-2795(72)90277-2
Reference
4  [PMID:4441086]
  Authors
Morihara K, Oka T, Tsuzuki H.
  Title
Comparative study of various serine alkaline proteinases from microorganisms. Esterase activity against N-acylated peptide ester substrates.
  Journal
Arch Biochem Biophys 165:72-9 (1974)
DOI:10.1016/0003-9861(74)90143-X
Reference
5  [PMID:4859351]
  Authors
Spadari S, Subramanian AR, Kalnitsky G.
  Title
Highly restricted specificity of the serine proteinase aspergillopeptidase B.
  Journal
Biochim Biophys Acta 359:267-72 (1974)
DOI:10.1016/0005-2795(74)90224-4
Other DBs
ExplorEnz - The Enzyme Database: 3.4.21.63
IUBMB Enzyme Nomenclature: 3.4.21.63
ExPASy - ENZYME nomenclature database: 3.4.21.63
BRENDA, the Enzyme Database: 3.4.21.63
CAS: 9074-07-1

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Gene (108)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (107)   
Protein sequence (201)   
   UniProt (164)   
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   RefSeq(pep) (17)   
   PDBSTR (10)   
DNA sequence (63)   
   RefSeq(nuc) (31)   
   GenBank (16)   
   EMBL (16)   
3D Structure (4)   
   PDB (4)   
Protein domain (11)   
   InterPro (10)   
   PROSITE(DOC) (1)   
All databases (387)   

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