Entry
Name
furin;
prohormone convertase;
dibasic processing enzyme;
PACE;
paired basic amino acid cleaving enzyme;
paired basic amino acid converting enzyme;
serine proteinase PACE;
PC1;
SPC3;
proprotein convertase
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
BRITE hierarchy
Reaction(IUBMB)
Release of mature proteins from their proproteins by cleavage of -Arg-Xaa-Yaa-Arg! bonds, where Xaa can by any amino acid and Yaa is Arg or Lys. Releases albumin, complement component C3 and von Willebrand factor from their respective precursors
Comment
One of a group of peptidases in peptidase family S8 (subtilisin family) that is structurally and functionally similar to kexin. All are activated by Ca2+, contain Cys near the active site His, and are inhibited by p-mercuribenzoate. At least three related enzymes are recognized in mammals: PC2, PC3 and PC4, which have somewhat different specificities
History
EC 3.4.21.75 created 1993
Orthology
Genes
AAM : 106491445(FURIN) 106491446 106498806(DHODH)
XLA : 397747(furin.S) 398345(furin.L)
DRE : 566557(furina) 566591(furinb)
SRX : 107720773 107733942 107737005 107750721
SANH : 107662279 107670216 107673235(furin) 107685214
SGH : 107564611 107578911 107581806 107594731 107600744
CCAR : 109045813 109051091 109058346
CAUA : 113051979 113066714 113098354 113105574
CGIB : 127946830 127961282 128014542 128017345
PTET : 122330520(furinb) 122348362(furina)
LROH : 127156871(furinb) 127168464(furina)
OMC : 131534206(furinb) 131543649(furina)
PPRM : 120468220(furinb) 120469859(furina)
RKG : 130073722(furinb) 130091338(furina)
MAMB : 125246722(furinb) 125264432(furina)
CIDE : 127506524 127515609
MASI : 127435898 127437293 127445520 127450832
TROS : 130551830(furinb) 130566199(furina)
TDW : 130414511(furinb) 130429494(furina)
MANU : 129428132(furina) 129433050(furinb)
IPU : 108270701(furina) 108274716(furinb)
IFU : 128614105(furina) 128618606(furinb)
PHYP : 113529949 113536428
SMEO : 124391538(furina) 124392804(furinb)
TFD : 113653066(furina) 113660005(furinb)
TVC : 132855509(furina) 132856546(furinb)
AMEX : 103024357 103043208
CMAO : 118811583(furinb) 118818635(furina)
EEE : 113573922 113588517 113589159
CHAR : 105900767(furinb) 105908088(furina)
TFS : 130518178(furina) 130536876(furinb)
TNG : GSTEN00017671G001 GSTEN00022836G001
LCO : 104925266(furin) 104927319
TBEN : 117471797(furina) 117491586(furinb)
CGOB : 115004588 115009375(furin)
PGEO : 117448469(furinb) 117468297(furina)
GACU : 117533346(furina) 117545789(furinb)
ELY : 117254385(furina) 117262740(furinb)
EFO : 125887441(furinb) 125898783(furina)
PLEP : 121950052(furinb) 121957430(furina)
SLUC : 116038294(furinb) 116060658(furina)
ECRA : 117948702(furinb) 117949039(furina)
PFLV : 114554240 114559648(furin)
GAT : 120809446(furinb) 120833511(furina)
PPUG : 119195579(furinb) 119199036(furina)
AFB : 129099584(furina) 129107916(furinb)
CLUM : 117731982(furinb) 117747828(furina)
MSAM : 119890467(furina) 119893111(furinb)
SCHU : 122875585(furinb) 122881109(furina)
CUD : 121510938(furina) 121514668(furinb)
ALAT : 119017797(furina) 119024920(furinb)
MZE : 101479014 101482852(furin)
ONL : 100705046 100709405(furin)
OAU : 116335380(furinb) 116335756(furina)
OLA : 100049240 101158353(furin)
OML : 112152324(furinb) 112161061(furina)
XMA : 102222459 102231939(furin)
XCO : 114142600 114155117(furin)
XHE : 116718381 116733882(furin)
PRET : 103462559 103466119(furin)
PFOR : 103133656(furin) 103136585
PLAI : 106945049(furin) 106948985
PMEI : 106921969 106927547(furin)
GAF : 122835572(furinb) 122843218(furina)
PPRL : 129362982(furinb) 129364013(furina)
CVG : 107095805 107104466(furin)
CTUL : 119793084(furinb) 119798957(furina)
GMU : 124859063(furinb) 124866765(furina)
NFU : 107381331 107388981(furin)
KMR : 108228577(furina) 108239969(furinb)
ALIM : 106515632(furin) 106532108
NWH : 119415568(furinb) 119422415(furina)
AOCE : 111563041(furin) 111587677
MCEP : 125005793(furina) 125014493(furinb)
CSEM : 103378886 103380512(furin)
POV : 109624036 109636815(furin)
SSEN : 122772274(furina) 122775878(furinb)
HHIP : 117759251(furina) 117762836(furinb)
HSP : 118109760(furina) 118110055(furinb)
LCF : 108875306(furinb) 108877754(furina)
SDU : 111221567 111228587(furin)
SLAL : 111646277 111655357(furin)
XGL : 120793159(furinb) 120794708(furina)
HCQ : 109525872 109530490(furin)
SSCV : 125967598 125970349
SBIA : 133497897(furina) 133502201(furinb)
PEE : 133396187(furina) 133403079(furinb)
PTAO : 133474415(furina) 133477763(furinb)
BPEC : 110165934(furin) 110175436
MALB : 109962881 109968745(furin)
BSPL : 114852747(furina) 114857048(furinb)
SJO : 128358419(furinb) 128362631(furina)
SASA : 106561302 106562248 106573344 106587394
STRU : 115152133(furin) 115167187 115197322 115203143
OTW : 112218687(furinb) 112249199 112251547 112253271 112253480 112263744
OMY : 110497223(furinb) 110506586 110522396 110526458 110531970
OGO : 123989578 123996879 124002179 124033706(furina) 124035603 124035687
ONE : 115109520 115109771(pcsk4) 115112301 115134149
OKI : 109867753 109888393 109888537(pcsk4) 109889492 109895236
OKE : 118362490 118393914 118395756(furinb) 118397387 118400667 118401133
SALP : 111952700 111952767(furin) 111962447 111969435 111974070 111975923
SNH : 120024852 120047639 120054033 120054034 120066383(furinb)
CCLU : 121532212(furinb) 121548261 121558019 121576850 121577037
ELS : 105016086 105018383(furin)
SFM : 108941070 108942037(furin)
PKI : 111845104 111846807(furin)
PSPA : 121304121 121304423 121309276
ARUT : 117428137 117429744
PMRN : 116942023 116955056
LRJ : 133343729 133344925 133360702
BBEL : 109462116 109471859
SCLV : 120330211 120330340 120343553
LPIC : 129261778 129261927
DME : Dmel_CG10772(Fur1) Dmel_CG18734(Fur2)
DSI : Dsimw501_GD18200(Dsim_GD18200)
CCAT : 101451553 101460139
TDA : 119669036 119669037 119675719
MDE : 101889562 101890230 131800680
SCAC : 106087875 106090602
ECOE : 129942321 129946942
CLON : 129609774 129618581
AMER : 121589521 121590582
ASTE : 118505159 118507665
AFUN : 125764278 125775235
AMOU : 128299376 128304751
BCOO : 119067665 119075946
ACER : 107994951 108004424
LHT : 122502460 122505755 122512283
LBD : 127278228 127287188 127287744
AROA : 105684095 105688046
AGRG : 126739140 126749097
CSET : 123314742 123322070
APLN : 108739285 108741866
PPYR : 116163062 116165621
OTU : 111414549 111421751 111428320
PPOT : 106110216 106111512
CFEL : 113364322 113366380
CCRN : 123292827 123298680
ACOO : 126836185 126838172 126847150
HHAL : 106690541 106692106
FOC : 113202058 113209561 113213681
TPAL : 117644727 117645278 117645572
SGRE : 126281630 126281686 126281749
IEL : 124166899 124167131 124169105
DPX : DAPPUDRAFT_126713 DAPPUDRAFT_306271
DMK : 116917232 116925194 116931035
DPZ : 124313930 124344544 124348392
PJA : 122248384 122254218 122262593 122267606
PCHN : 125037293 125043103 125047190 125048037
PMOO : 119585036 119594556 119595044
HAME : 121857898 121868704 121873204 121876390
PCLA : 123765522 123768377 123770315
PTRU : 123507880 123512313 123515370 123515847
ESN : 127002135 127004066 127008713
HAZT : 108671426 108676954
EAF : 111698254 111700110 111700479 111708112
LSM : 121116754 121119030 121119337 121126132 121129007
TCF : 131877949 131886204 131888966 131890248
PPOI : 119100534 119100535 119100859
RSAN : 119387287 119387718
CSCU : 111619913 111638182
UDV : 129218398 129223976 129230130
SDM : 118184093 118185709 118188184
LPOL : 106460561 106468227
PMEO : 129588027 129599114
CBR : CBG_15803(Cbr-kpc-1)
BMY : BM_BM3293(Bma-kpc-1)
LOA : LOAG_03049 LOAG_04307
HRO : HELRODRAFT_105284 HELRODRAFT_107946 HELRODRAFT_170307 HELRODRAFT_72480 HELRODRAFT_82350 HELRODRAFT_82977 HELRODRAFT_84740
CRG : 105320244 105323116 105337580 105346909 117690912 117691566
CVN : 111105159 111123992 111128997
CANU : 128176426 128184631 128184696 128186001
MMER : 123528967 123533308 123534165 123534595 123545805 123560080 123563904 123563905 123566363
RPHI : 132721318 132742356 132743047 132751180 132752714
DPOL : 127838225 127839832 127849512 127849517 127877616
LAK : 106154677 106156258 106159649 106170020 106173945
SHX : MS3_00007487(FUR1_1)
AMIL : 114954185 114954192 114977448
PDAM : 113670141 113678907
SPIS : 111330827 111335101 111335105 111342661 111346486
» show all
Taxonomy
Reference
Authors
van de Ven WJ, Voorberg J, Fontijn R, Pannekoek H, van den Ouweland AM, van Duijnhoven HL, Roebroek AJ, Siezen RJ.
Title
Furin is a subtilisin-like proprotein processing enzyme in higher eukaryotes.
Journal
Reference
Authors
Van de Ven WJ, Creemers JW, Roebroek AJ.
Title
Furin: the prototype mammalian subtilisin-like proprotein-processing enzyme. Endoproteolytic cleavage at paired basic residues of proproteins of the eukaryotic secretory pathway.
Journal
Reference
Authors
Hatsuzawa K, Murakami K, Nakayama K.
Title
Molecular and enzymatic properties of furin, a Kex2-like endoprotease involved in precursor cleavage at Arg-X-Lys/Arg-Arg sites.
Journal
Reference
Authors
Seidah NG, Chretien M
Title
Proprotein and prohormone convertases of the subtilisin family Recent developments and future perspectives.
Journal
Reference
Authors
Steiner DF, Smeekens SP, Ohagi S, Chan SJ.
Title
The new enzymology of precursor processing endoproteases.
Journal
J Biol Chem 267:23435-8 (1992)
Other DBs
ExPASy - ENZYME nomenclature database: 3.4.21.75