KEGG ENZYME: 3.4.21.82

ENZYME: 3.4.21.82

Entry

EC 3.4.21.82                Enzyme

Name

glutamyl endopeptidase II;
GluSGP

Class

Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases

Reaction(IUBMB)

Preferential cleavage: -Glu! >> -Asp! . Preference for Pro or Leu at P2 and Phe at P3. Cleavage of -Glu!Asp- and -Glu!Pro- bonds is slow

Comment

From Streptomyces griseus. A peptidase of family S1 (trypsin family). Inhibited by [Leu18->Glu]-modified turkey ovomucoid third domain

History

EC 3.4.21.82 created 1993

Orthology

K18548

glutamyl endopeptidase II

Genes

SGR:	SGR_1986(sprE)

SGB:

WQO_25535

SFI:

SFUL_5378

SANL:

KZO11_27065

SCYE:

R2B67_08775

STRC:

AA958_25625

SPRI:

SPRI_1032

SCZ:	ABE83_09780

SRN:	A4G23_04080

SCLF:

BB341_02930

SVU:	B1H20_26095

SLK:	SLUN_33990

SQZ:	FQU76_29180

SCAV:

CVT27_24925

STSU:

B7R87_29305

SSPB:

CP982_07905

SCAL:

I6J39_25790

SFB:	CP974_22050

SPEU:

CGZ69_31675

SGJ:	IAG43_28255

STRY:

EQG64_25935

SAOV:

G3H79_38370

SJN:	RI060_36965

SFIY:

F0344_09210

SFP:	QUY26_00565

KAB:	B7C62_26810

PLK:	CIK06_11400

» show all

Reference

1 [PMID:3149277]

Authors

Yoshida N, Tsuruyama S, Nagata K, Hirayama K, Noda K, Makisumi S.

Title

Purification and characterization of an acidic amino acid specific endopeptidase of Streptomyces griseus obtained from a commercial preparation (Pronase).

Journal

J Biochem (Tokyo) 104:451-6 (1988)
DOI:10.1093/oxfordjournals.jbchem.a122488

Reference

2 [PMID:1674942]

Authors

Komiyama T, Bigler TL, Yoshida N, Noda K, Laskowski M Jr.

Title

Replacement of P1 Leu18 by Glu18 in the reactive site of turkey ovomucoid third domain converts it into a strong inhibitor of Glu-specific Streptomyces griseus proteinase (GluSGP).

Journal

J Biol Chem 266:10727-30 (1991)

Reference

3 [PMID:1794975]

Authors

Nagata K, Yoshida N, Ogata F, Araki M, Noda K.

Title

Subsite mapping of an acidic amino acid-specific endopeptidase from Streptomyces griseus, GluSGP, and protease V8.

Journal

J Biochem (Tokyo) 110:859-62 (1991)
DOI:10.1093/oxfordjournals.jbchem.a123679

Reference

4 [PMID:1959600]

Authors

Svendsen I, Jensen MR, Breddam K

Title

The primary structure of the glutamic acid-specific protease of Streptomyces griseus.

Journal

FEBS Lett 292:165-7 (1991)
DOI:10.1016/0014-5793(91)80859-2

Sequence

[sgr:SGR_1986]

Reference

5 [PMID:1587264]

Authors

Breddam K, Meldal M.

Title

Substrate preferences of glutamic-acid-specific endopeptidases assessed by synthetic peptide substrates based on intramolecular fluorescence quenching.

Journal

Eur J Biochem 206:103-7 (1992)
DOI:10.1111/j.1432-1033.1992.tb16906.x

Sequence

[sgr:SGR_1986]

Other DBs

ExplorEnz - The Enzyme Database:

3.4.21.82

IUBMB Enzyme Nomenclature:

3.4.21.82

ExPASy - ENZYME nomenclature database:

3.4.21.82

BRENDA, the Enzyme Database:

3.4.21.82

CAS:	137010-42-5

All links

Gene (28)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (27)   
Protein sequence (9)   
   UniProt (6)   
   SWISS-PROT (1)   
   PDBSTR (2)   
DNA sequence (3)   
   GenBank (2)   
   EMBL (1)   
3D Structure (1)   
   PDB (1)   
Protein domain (6)   
   InterPro (6)   
All databases (47)   

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