| Entry |
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| Name |
oligopeptidase B;
protease II;
Escherichia coli alkaline proteinase II
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| Class |
Hydrolases;
Acting on peptide bonds (peptidases);
Serine endopeptidases
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| Reaction(IUBMB) |
Hydrolysis of -Arg!, -Lys! bonds in oligopeptides, even when P1' residue is proline
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| Comment |
Known from Escherichia coli. Inhibited by Tos-Lys-CH2Cl. In peptidase family S9 (prolyl oligopeptidase family)
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| History |
EC 3.4.21.83 created 1993
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| Orthology |
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| Genes |
| CSAT: | 104744019 104777969 |
| BNA: | 106405980 106416868 106439033 125610103 |
| RSZ: | 108812428 108852304 130499233 |
| CIC: | CICLE_v10014380mg CICLE_v100182222m |
| HSYR: | 120167888 120188457 |
| LJA: | Lj5g3v2263920.1(Lj5g3v2263920.1) |
| LANG: | 109336282 109354489 |
| PMUM: | 103321112 103321115 |
| PDUL: | 117635044 117635054 |
| CMAX: | 111466641 111493518 |
| CMOS: | 111449474 111458824 |
| CPEP: | 111780697 111801801 |
| MESC: | 110613237 110626459 |
| QLO: | 115967469 115967838 115968949 115975293 |
| SSTN: | 125847223 125869755 |
| NTA: | 107785566 107802307 107828831 |
| SSPL: | 121801948 121807631 |
| SMIL: | 130993249 131012924 |
| ECAD: | 122581822 122581830 |
| CSIN: | 114257432 114301368 |
| PSOM: | 113284462 113355603 |
| DOSA: | Os06t0730600-01(Os06g0730600) |
| TDC: | 119317126 119323832 119334169 119336442 |
| TAES: | 123127763 123137477 123144839 123149893 123156904 123168707 |
| LPER: | 127293766 127295173 127313926 |
| LRD: | 124691518 124699464 124702898 124703722 |
| SITA: | 101757448 101762449 |
| MSIN: | 131236805 131236807 |
| SMO: | SELMODRAFT_173264 SELMODRAFT_175705 |
| VCN: | VOLCADRAFT_73990 VOLCADRAFT_92828 |
| MNG: | MNEG_0612 MNEG_4568 MNEG_4759 MNEG_4760 |
| CSL: | COCSUDRAFT_13807 COCSUDRAFT_42729 |
| CVR: | CHLNCDRAFT_144964 CHLNCDRAFT_58163 |
| MPP: | MICPUCDRAFT_59545(JGI:MicpuC2_59545) |
| MBR: | MONBRDRAFT_25175 MONBRDRAFT_37688 |
| SRE: | PTSG_11373 PTSG_12836 |
| SMIN: | v1.2.032252.t1(symbB.v1.2.032252.t1) |
| TPS: | THAPSDRAFT_31242 THAPSDRAFT_41892 |
| AAF: | AURANDRAFT_59283 AURANDRAFT_65044 |
| SPAR: | SPRG_05201 SPRG_08765 |
| EHX: | EMIHUDRAFT_106837 EMIHUDRAFT_458072 EMIHUDRAFT_465719 EMIHUDRAFT_471180 EMIHUDRAFT_69975 |
| NGR: | NAEGRDRAFT_38762 NAEGRDRAFT_52886 |
| ECOO: | ECRM13514_2353(ptrB) |
| ECOH: | ECRM13516_2256(ptrB) |
| ECW: | EcE24377A_2073(prtB) |
| EDJ: | ECDH1ME8569_1791(ptrB) |
| ECOI: | ECOPMV1_01938(ptrB) |
| ECAN: | CWI88_04185 CWI88_09155 |
| KMI: | VW41_10355 VW41_13215 |
| REE: | electrica_01880(ptrB) |
| RTG: | NCTC13098_02744(ptrB_1) |
| CNT: | JT31_02080 JT31_21655 |
| CEM: | LH23_16100 LH23_19265 |
| CEN: | LH86_15160 LH86_17990 |
| CLAP: | NCTC11466_01781(ptrB_1) NCTC11466_02387(ptrB_3) |
| KIE: | NCTC12125_00950(ptrB_1) |
| LEF: | LJPFL01_2482 LJPFL01_3371 |
| AHN: | NCTC12129_01998(ptrB) |
| METY: | MRY16398_35520(ptrB) |
| PSHI: | SAMEA2665130_1912(ptrB) |
| YPG: | YpAngola_A1629(ptrB) |
| YPI: | YpsIP31758_2346(ptrB) |
| YEG: | PL78_15900 PL78_18685 |
| SMAR: | SM39_1408(ptrB) SM39_3079 |
| SMAC: | SMDB11_1205(ptrB) SMDB11_2863 |
| SMW: | SMWW4_v1c18970 SMWW4_v1c35780 |
| SLQ: | M495_09360 M495_17865 |
| SERF: | L085_10790 L085_19025 |
| SERS: | SERRSCBI_09135 SERRSCBI_17390 |
| SFG: | AV650_19080 AV650_22780 |
| SQU: | E4343_06460 E4343_23360 |
| SFJ: | SAMEA4384070_1975(ptrB) |
| SOF: | NCTC11214_03987(ptrB_2) |
| SSUR: | ATE40_006325 ATE40_014540 |
| SURI: | J0X03_06115 J0X03_14215 |
| SNEM: | NLX84_09575 NLX84_18000 |
| SNEV: | OI978_14485 OI978_23505 |
| RVC: | J9880_00245 J9880_11650 |
| RBON: | QNM34_04115 QNM34_14800 |
| ERWI: | GN242_11365 GN242_18245 |
| ETO: | RIN69_13225 RIN69_18740 |
| TPTY: | NCTC11468_02110(ptrB) |
| PHEI: | NCTC12003_01829(ptrB) |
| PRJ: | NCTC6933_02093(ptrB_1) |
| HAV: | AT03_11840 AT03_16995 |
| HPAR: | AL518_09660 AL518_14270 |
| OPO: | DSM2777_08230 DSM2777_15865 |
| XFU: | XFF4834R_chr06400(ptrB) |
| XPH: | XppCFBP6546_08475(XppCFBP6546P_08475) |
| XHD: | LMG31886_07430(dapb1) |
| LLZ: | LYB30171_02425(dapb1) |
| XBA: | C7S18_20480 C7S18_21870 |
| VCE: | Vch1786_II0858(ptrB) |
| VPB: | VPBB_A0156 VPBB_A1340 |
| VPK: | M636_00165 M636_06185 |
| VPF: | M634_16805 M634_18930 |
| VPH: | VPUCM_20161 VPUCM_21298 |
| VHA: | VIBHAR_05127 VIBHAR_06740 |
| VCA: | M892_18805 M892_25615 |
| VEX: | VEA_000831 VEA_001256 |
| VDB: | AL552_02425 AL552_04525 |
| VHR: | AL538_17315 AL538_20555 |
| VOW: | A9237_16875 A9237_18095 |
| VRO: | BSZ04_02395 BSZ04_05225 |
| VNL: | D3H41_21805 D3H41_23965 |
| VCC: | FAZ90_05310 FAZ90_19260 |
| VKA: | BTD91_01295 BTD91_18180 |
| VGI: | MID13_10295 MID13_16870 |
| VSL: | LTQ54_14075 LTQ54_23395 |
| VPL: | SA104470976_02818(ptrB) |
| VLE: | ISX51_06675 ISX51_16390 |
| SALY: | E8E00_06375 E8E00_16595 |
| SKS: | FCN78_07040 FCN78_15495 |
| SCOT: | HBA18_07275 HBA18_16320 |
| SPRO: | N7E60_07450 N7E60_15080 |
| PPRC: | PFLCHA0_c15460(ptrB) |
| PMUD: | NCTC8068_01403(ptrB) |
| PFW: | PF1751_v1c15140(ptrB) |
| PTAE: | NCTC10697_03061(ptrB) |
| SCAA: | TUM17387_37080(ptrB) |
| CPS: | CPS_3026(ptrB1) CPS_4644(ptrB2) |
| COM: | CMT41_09290 CMT41_16355 |
| PHA: | PSHAa0069(ptrB) PSHAa2955(ptrB) |
| PTN: | PTRA_a0081(ptrB) PTRA_a3529(ptrB) |
| PSM: | PSM_A0070(ptrB) PSM_A3060(ptrB) |
| PSEO: | OM33_03095 OM33_03955 |
| PIA: | PI2015_0066 PI2015_2972 |
| PPHE: | PP2015_1407 PP2015_3233 |
| PBW: | D172_000600 D172_017070 |
| PRR: | AT705_11540 AT705_19985 |
| PALN: | B0W48_07735 B0W48_08595 |
| PPIS: | B1L02_17750 B1L02_23155 |
| PEA: | PESP_a0078(ptrB) PESP_a3786(ptrB) |
| PSPO: | PSPO_a0157(ptrB) PSPO_a3256(ptrB) |
| PART: | PARC_a0079(ptrB) PARC_a3869(ptrB) |
| PTU: | PTUN_a3978(ptrB) PTUN_a4111(ptrB) |
| PNG: | PNIG_a0081(ptrB) PNIG_a3752(ptrB) |
| PTD: | PTET_a0075(ptrB) PTET_a3458(ptrB) |
| PSEN: | PNC201_17245(ptrB1) PNC201_22140(ptrB2) |
| PDJ: | D0907_00615 D0907_16075 |
| PAGA: | PAGA_a0085(ptrB) PAGA_a3837(ptrB) |
| PCAR: | PC2016_0065 PC2016_3102 |
| PMAA: | CPA52_00415 CPA52_15685 |
| PVB: | J5X90_04870 J5X90_21910 |
| PSAZ: | PA25_31740 PA25_36650 |
| PDV: | FFU37_15045 FFU37_15815 |
| PFLI: | CTT31_17480 CTT31_18430 |
| PSHO: | KQ246_13795 KQ246_14745 |
| PMAZ: | R5H13_18345 R5H13_24045 |
| RHEI: | ATY27_06030 ATY27_08670 |
| GAI: | IMCC3135_06990(dapb1) |
| AHY: | AHML_01705 AHML_09130 |
| AHD: | AI20_10780 AI20_17720 |
| AHR: | V428_01840 V428_09390 |
| AHP: | V429_01840 V429_09395 |
| AHJ: | V469_14100 V469_21480 |
| AHH: | RY45_02035 RY45_09100 |
| AHI: | VU14_14255 VU14_20745 |
| AAJ: | BOQ57_01655 BOQ57_08080 |
| ASA: | ASA_2696(ptrB) ASA_3983(ptrB) |
| AEO: | O23A_p1903 O23A_p4008 |
| AVO: | AMS64_14475 AMS64_21565 |
| ADH: | CK627_05540 CK627_17705 |
| AEM: | CK911_08830 CK911_15610 |
| AEA: | C2U39_01000 C2U39_07830 |
| ARV: | C7N77_02805 C7N77_17545 |
| AES: | C2U30_05750 C2U30_16050 |
| AEL: | NCTC12917_00270(ptrB_1) NCTC12917_01516(ptrB_2) |
| AALL: | I6G90_03355 I6G90_17595 |
| ARIV: | KYK33_01205 KYK33_12720 |
| AEJ: | E5E97_05985 E5E97_13430 |
| ABES: | IU367_01380 IU367_13650 |
| CHJ: | NCTC10426_01410(ptrB) |
| PLG: | NCTC10937_01584(ptrB) |
| UND: | UNDKW_3907 UNDKW_5353 |
| URU: | DSM104443_00782(dapb1) |
| UPL: | DSM104440_00744(dapb1) |
| BNU: | N3Z17_03735 N3Z17_05040 |
| RBS: | RHODOSMS8_00426(dapb1) |
| SMEL: | SM2011_c00114(ptrB) |
| RHI: | NGR_a01580 NGR_a01920(bxrF) NGR_c07420(ptrB) |
| SFD: | USDA257_c07160(ptrB) |
| SAME: | SAMCFNEI73_Ch1057(ptrB) |
| AGR: | AGROH133_04686(ptrB) |
| AVV: | RvVAT039_25470(ptrB) |
| AVF: | RvVAR031_12720(ptrB) |
| REC: | RHECIAT_CH0001313(ptrB) |
| REL: | REMIM1_CH01229(ptrB) REMIM1_PC00151 REMIM1_PC00162 |
| REP: | IE4803_CH01256(ptrB) |
| REI: | IE4771_CH01299(ptrB) |
| RGA: | RGR602_CH01152(ptrB) |
| RPHA: | AMC79_CH01272(ptrB) |
| RBAN: | J2J98_06130 J2J98_26325 |
| NEN: | NCHU2750_07430(ptrB) |
| BIO: | BR141012304_10020(ptrB2) |
| VGO: | GJW-30_1_03824(ptrB) |
| BEZ: | NCTC12898_00316(ptrB) |
| MAQU: | Maq22A_1p30370(ptrB) |
| FIL: | BN1229_v1_2422(ptrB) |
| FIY: | BN1229_v1_3492(ptrB) |
| PZU: | PHZ_c1071(ptrB) PHZ_c2722 |
| BVY: | NCTC9239_01694(ptrB) |
| TSV: | DSM104635_02553(ptrB) |
| LVS: | LOKVESSMR4R_03312(dapb1) |
| HNE: | HNE_1167 HNE_2146(ptrB) |
| SPHK: | SKP52_06815(ptrB) SKP52_21205 |
| SPHP: | LH20_09335 LH20_21330 |
| SPHQ: | BWQ93_08455 BWQ93_16410 |
| SPHX: | E5675_08130 E5675_20450 |
| SPHU: | SPPYR_2273(ptrB) SPPYR_3738 |
| SKR: | BRX40_05435 BRX40_17760 |
| SPLK: | AV944_01405 AV944_07050 |
| SPAP: | H3Z74_01155 H3Z74_01545 H3Z74_19970 |
| SSAU: | H8M03_05940 H8M03_10245 |
| SARI: | H5J25_01240 H5J25_18500 |
| SSUA: | FPZ54_06425 FPZ54_12310 |
| SBIN: | SBA_ch1_04830(ptrB) |
| SRAD: | LLW23_05370 LLW23_10395 |
| SSAG: | KV697_10655 KV697_18220 |
| SYA: | A6768_08860 A6768_23455 |
| SFLA: | SPHFLASMR4Y_01766(dapb1) |
| BLAS: | BSY18_2296 BSY18_903 |
| BFW: | B5J99_03045 B5J99_13695 |
| AMX: | AM2010_1241 AM2010_2469 |
| PMAS: | NCF86_07750 NCF86_13820 |
| EBLA: | JGUZn3_16310(dapb1) |
| LCK: | HN018_11380 HN018_16710 |
| NCB: | C0V82_01550 C0V82_11565 |
| BDC: | DOE51_14595 DOE51_15795 |
| BSTO: | C0V70_15545 C0V70_15555 |
| STHO: | QNH10_06910 QNH10_08780 |
| MTUB: | MT7199_0802(ptrA_B) |
| MMAE: | MMARE11_47180(ptrB) |
| MSHG: | MSG_01904(ptrB_1) MSG_04415(ptrB_2) |
| MBAI: | MB901379_04299(ptrB) |
| MHEK: | JMUB5695_00623(ptrB) |
| MSPG: | F6B93_08160 F6B93_19780 |
| MKY: | IWGMT90018_55870(ptrB) |
| MPHL: | MPHLCCUG_00676(ptrB) |
| MTHN: | 4412656_03967(ptrB) |
| MAUU: | NCTC10437_04896(ptrB) |
| MSAR: | MSAR_09810(ptrB) MSAR_22410 |
| MFLV: | NCTC10271_00629(ptrB) |
| MSAL: | DSM43276_00605(ptrB) |
| MTER: | 4434518_03559(ptrB) |
| CDIP: | ERS451417_01948(ptrB) |
| CUN: | Cul210932_1924(ptrB) |
| CUQ: | Cul210931_1816(ptrB) |
| CUJ: | CUL131002_1840c(ptrB) |
| CCG: | CCASEI_11520 CCASEI_12275 |
| CMIN: | NCTC10288_00390(ptrB) |
| CRL: | NCTC7448_00397(ptrB) |
| CCYS: | SAMEA4530656_0228(ptrB) |
| NFR: | ERS450000_03660(ptrB) |
| NAD: | NCTC11293_01329(ptrB) |
| NWL: | NWFMUON74_05690(ptrB) |
| NSPU: | IFM12276_02720(ptrB) |
| RCR: | NCTC10994_01978(ptrB) |
| AMAU: | DSM26151_00990(dapb1) |
| AAGI: | NCTC2676_1_02522(ptrB) |
| KVR: | CIB50_0001426(dapb1) |
| BFA: | Bfae_03460 Bfae_03470 |
| BRX: | BH708_15075 BH708_15080 |
| BRV: | CFK39_09785 CFK39_09790 |
| BGG: | CFK41_15535 CFK41_15540 |
| BRZ: | CFK38_00970 CFK38_00975 |
| BSAU: | DWV08_15775 DWV08_15780 |
| DCO: | SAMEA4475696_1183(ptrB) |
| PRV: | G7070_08715 G7070_15510 |
| NOY: | EXE57_00470 EXE57_00895 |
| NANO: | G5V58_07635 G5V58_18080 |
| NAQU: | ENKNEFLB_03131(dapb1) |
| NCQ: | K6T13_08165 K6T13_10260 |
| PSIM: | KR76_11805 KR76_26935 |
| MSAG: | GCM10017556_28960(ptrB) |
| VER: | HUT12_01460 HUT12_02165 |
| ACTR: | Asp14428_44280(ptrB) |
| CATI: | CS0771_15780 CS0771_26490 |
| TBW: | NCTC13354_01087(ptrB) |
| BBRN: | B2258_0436 B2258_1556 |
| LET: | O77CONTIG1_00396(ptrB) |
| CALT: | Cal6303_0719 Cal6303_4060 |
| NSPH: | BDGGKGIB_01720(ptrB) |
| OBG: | Verru16b_00712(ptrB) |
| UAM: | UABAM_00734 UABAM_03026 |
| HHY: | Halhy_4541 Halhy_5400 |
| SMIZ: | 4412673_03316(ptrB) |
| SDJ: | NCTC13534_04711(ptrB_1) |
| STHA: | NCTC11429_00977(ptrB) |
| RSI: | Runsl_0016 Runsl_2201 |
| RUN: | DR864_19270 DR864_20205 |
| RUP: | DTQ70_11555 DTQ70_26510 |
| HTB: | MTX78_08510 MTX78_08520 |
| FLL: | EI427_15260 EI427_24265 |
| ATK: | AUTU_04510(ptrB_1) AUTU_27340(ptrB_2) |
| FOK: | KK2020170_20650(ptrB) |
| CGH: | CGC50_01475 CGC50_04380 |
| RBI: | RB2501_07190 RB2501_15554 |
| CBAL: | M667_14000 M667_15910 |
| PHG: | KCTC32516_01818(dapb1) |
| FOP: | FNB79_12985 FNB79_14110 |
| AALG: | AREALGSMS7_04519(dapb1) |
| KOS: | KORDIASMS9_04202(dapb1) |
| KAN: | IMCC3317_12630(dapb1) |
| AQB: | D1818_02455 D1818_03975 |
| AQA: | D1815_03625 D1815_04950 |
| AFLA: | FHG64_01905 FHG64_03150 |
| ANP: | FK178_02490 FK178_03555 |
| OCI: | FEZ18_00595 FEZ18_14440 |
| SPON: | HME9304_02984(ptrB) |
| HWS: | RNZ46_13705 RNZ46_15590 |
| EMN: | M876_04125 M876_18150 |
| EEN: | BBD30_00625 BBD30_05835 |
| ELB: | VO54_01350(ptrB_1) VO54_02431(ptrB_2) |
| EMG: | BBD33_02520 BBD33_15255 |
| EGO: | BBD34_10210 BBD34_15260 |
| EGM: | AYC65_11390 AYC65_16360 |
| ELZ: | FCS00_04485 FCS00_09875 |
| ELIZ: | JCR23_03620 JCR23_09330 |
| CGN: | OK18_09125 OK18_13920 |
| CHRY: | CEY12_15725 CEY12_21035 |
| CARH: | EGY05_04325 EGY05_23195 |
| CNK: | EG343_15415 EG343_22225 |
| CJT: | EG359_15865 EG359_21310 |
| CBEN: | EG339_06845 EG339_13400 |
| CGLE: | NCTC11432_03579(ptrB) |
| CTAI: | NCTC12078_01957(ptrB) |
| CTAK: | 4412677_01711(ptrB) |
| CBP: | EB354_12320 EB354_18815 |
| CCAO: | H5J24_14735 H5J24_21285 |
| CRHI: | KB553_17110 KB553_22450 |
| CDAE: | MUU74_03965 MUU74_16825 |
| CTUR: | LNP04_12465 LNP04_18530 |
| CHRJ: | CHRYMOREF3P_3138(ptrB) |
| CFLU: | ODZ84_15285 ODZ84_20805 |
| CJG: | NCTC13459_01915(ptrB) |
| CANT: | NCTC13489_01986(ptrB) |
| CFAE: | LL667_01485 LL667_06185 |
| PTAN: | CRYO30217_00951(dapb1) |
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| Reference |
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| Authors |
Kanatani A, Masuda T, Shimoda T, Misoka F, Lin XS, Yoshimoto T, Tsuru D |
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| Title |
Protease II from Escherichia coli: sequencing and expression of the enzyme gene and characterization of the expressed enzyme. |
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| Journal |
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| Sequence |
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| Other DBs |
| ExPASy - ENZYME nomenclature database: | 3.4.21.83 |
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