Entry |
|
Name |
picornain 2A;
picornavirus endopeptidase 2A;
poliovirus protease 2A;
rhinovirus protease 2A;
2A protease;
2A proteinase;
protease 2A;
proteinase 2Apro;
picornaviral 2A proteinase;
Y-G proteinase 2A;
poliovirus proteinase 2A;
poliovirus protease 2Apro
|
Class |
Hydrolases;
Acting on peptide bonds (peptidases);
Cysteine endopeptidases
|
Reaction(IUBMB) |
Selective cleavage of Tyr!Gly bond in picornavirus polyprotein
|
Comment |
From entero-, rhino-, aphto- and cardioviruses. Smaller than the homologous picornain 3C, which is also in peptidase family C3 (picornain 3C family)
|
History |
EC 3.4.22.29 created 1992
|
Orthology |
K25293 | Enterovirus protease 2A |
|
Reference |
|
Authors |
Bazan JF, Fletterick RJ. |
Title |
Viral cysteine proteases are homologous to the trypsin-like family of serine proteases: structural and functional implications. |
Journal |
|
Reference |
|
Authors |
Konig H, Rosenwirth B. |
Title |
Purification and partial characterization of poliovirus protease 2A by means of a functional assay. |
Journal |
|
Reference |
|
Authors |
Krausslich HG, Wimmer E. |
Title |
Viral proteinases. |
Journal |
|
Other DBs |
ExPASy - ENZYME nomenclature database: | 3.4.22.29 |
|