KEGG   ENZYME: 3.4.22.47
Entry
EC 3.4.22.47                Enzyme                                 
Name
gingipain K;
Lys-gingipain;
PrtP proteinase
Class
Hydrolases;
Acting on peptide bonds (peptidases);
Cysteine endopeptidases
Reaction(IUBMB)
Endopeptidase with strict specificity for lysyl bonds
Comment
Activity is stimulated by glycine. Known from the bacterium Porphyromonas gingivalis and contributes to the pathogenicity of the organism. In peptidase family C25.
History
EC 3.4.22.47 created 2003
Orthology
K19237  gingipain K
Genes
PGN: PGN_1728(kgp)
PGT: PGTDC60_1418(kgp)
PNI: J5A59_02450
PHIS: J5A62_08895 J5A62_08905
Reference
1  [PMID:8276827]
  Authors
Pike R, McGraw W, Potempa J, Travis J.
  Title
Lysine- and arginine-specific proteinases from Porphyromonas gingivalis. Isolation, characterization, and evidence for the existence of complexes with hemagglutinins.
  Journal
J Biol Chem 269:406-11 (1994)
Reference
2  [PMID:12438376]
  Authors
Curtis MA, Aduse Opoku J, Rangarajan M, Gallagher A, Sterne JA, Reid CR, Evans HE, Samuelsson B.
  Title
Attenuation of the virulence of Porphyromonas gingivalis by using a specific synthetic Kgp protease inhibitor.
  Journal
Infect Immun 70:6968-75 (2002)
DOI:10.1128/IAI.70.12.6968-6975.2002
Other DBs
ExplorEnz - The Enzyme Database: 3.4.22.47
IUBMB Enzyme Nomenclature: 3.4.22.47
ExPASy - ENZYME nomenclature database: 3.4.22.47
BRENDA, the Enzyme Database: 3.4.22.47
CAS: 159745-69-4

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Gene (6)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (5)   
Protein sequence (84)   
   UniProt (56)   
   SWISS-PROT (4)   
   RefSeq(pep) (17)   
   PDBSTR (7)   
DNA sequence (39)   
   RefSeq(nuc) (19)   
   GenBank (10)   
   EMBL (10)   
3D Structure (5)   
   PDB (5)   
Protein domain (10)   
   InterPro (10)   
All databases (144)   

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