KEGG ENZYME: 3.4.22.48

ENZYME: 3.4.22.48

Entry

EC 3.4.22.48                Enzyme

Name

staphopain;
staphylopain

Class

Hydrolases;
Acting on peptide bonds (peptidases);
Cysteine endopeptidases

Reaction(IUBMB)

Broad endopeptidase action on proteins including elastin, but rather limited hydrolysis of small-molecule substrates. Assays are conveniently made with hemoglobin, casein or Z-Phe-Arg-NHMec as substrate

Comment

Known from species of Staphylococcus. Type example of peptidase family C47.

History

EC 3.4.22.48 created 2003

Orthology

K08258

staphopain A

Genes

SDO:	SD1155_05665

SA1725

SAV:

SAV1909

SAW:

SAHV_1894

SAH:	SaurJH1_1998

SAJ:	SaurJH9_1964

SAM:

MW1850

SAS:

SAS1832

SAR:

SAR2001

SAC:	SACOL1970(sspB2)

SAX:	USA300HOU_1910

SAA:	SAUSA300_1890

SAO:	SAOUHSC_02127

SAE:	NWMN_1847(sspB)

SAD:	SAAV_1975(sspB2) SAAV_c10(scpA)

SUU:	M013TW_1946(scpA)

SUV:	SAVC_08805

SUE:

SAOV_2011

SUJ:	SAA6159_01840(scpA)

SUK:	SAA6008_01930(sspB2)

SUC:	ECTR2_1781

SUT:	SAT0131_02036

SUQ:	HMPREF0772_11233(sspP)

SUZ:	MS7_1944(sspP)

SUD:	ST398NM01_2003

SUX:	SAEMRSA15_18160

SUW:	SATW20_19040(scpA)

SUG:

SAPIG2003

SUF:	SARLGA251_17940(scpA)

SAUA:

SAAG_02428

SAUE:

RSAU_001796(sspA)

SAUN:

SAKOR_01871

SAUS:

SA40_1750(scpA)

SAUU:

SA957_1834(scpA)

SAUG:

SA268_1906(scpA)

SAUZ:

SAZ172_1921(scpA)

SAUT:

SAI1T1_2014480

SAUJ:

SAI2T2_1014490

SAUK:

SAI3T3_1014480

SAUQ:

SAI4T8_1014490

SAUV:

SAI7S6_1014490(sspP)

SAUW:

SAI5S5_1014430(sspP)

SAUX:

SAI6T6_1014450(sspP)

SAUY:

SAI8T7_1014470(sspP)

SAUF:

X998_1964(scpA)

SAB:

SAB1845

SUY:	SA2981_1866

SAUB:

C248_1984

SAUM:

BN843_19480

SAUC:

CA347_1997(sspP)

SAUR:

SABB_02334(sspP)

SAUI:

AZ30_10175

SAUD:

CH52_09380

SER:	SERP2390(sspB)

SEP:

SE_0184

SEPP:

SEB_00115

SEPS:

DP17_1276(sspP)

SWA:	A284_10420

SPAS:

STP1_1663

SHU:	SHYC_10000(sspP)

SAGQ:

EP23_12145

SSIF:

AL483_06970

SCV:	A4G25_04920

SPIC:

SAMEA4384060_1964(sspP)

SSH:	NCTC13712_01929(sspP)

SDB:	CNQ82_04755

SRAI:

LN051_01195

EFT:	M395_04820

ELAC:

I4Q40_10175

RHO:	RHOM_16405

VGU:	HYG85_04020

» show all

Reference

Authors

Hofmann, B., Hecht, H.J., Kiess, M. and Schomburg, D.

Title

Crystal structure of a thiol proteinase from Staphylococcus aureus V8 in the E-64 inhibitor complex.

Journal

Acta Crystallogr Sect A (Suppl) 49:102 (1993)

Reference

Authors

Potempa, J., Dubin, A. and Travis, J.

Title

Staphylopain.

Journal

In: Barrett, A.J., Rawlings, N.D. and Woessner, J.F. (Eds.), Handbook of Proteolytic Enzymes, Handbook of Proteolytic Enzymes, London, 1998, p. 669-671.

Reference

3 [PMID:11767947]

Authors

Dubin G, Chmiel D, Mak P, Rakwalska M, Rzychon M, Dubin A

Title

Molecular cloning and biochemical characterisation of proteases from Staphylococcus epidermidis.

Journal

Biol Chem 382:1575-82 (2001)
DOI:10.1515/BC.2001.192

Sequence

[ag:CAC22343]

Other DBs

ExplorEnz - The Enzyme Database:

3.4.22.48

IUBMB Enzyme Nomenclature:

3.4.22.48

ExPASy - ENZYME nomenclature database:

3.4.22.48

BRENDA, the Enzyme Database:

3.4.22.48

CAS:	347841-89-8

All links

Gene (74)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (73)   
Protein sequence (526)   
   UniProt (41)   
   SWISS-PROT (8)   
   RefSeq(pep) (477)   
DNA sequence (19261)   
   RefSeq(nuc) (16255)   
   GenBank (1551)   
   EMBL (1455)   
Protein domain (6)   
   InterPro (6)   
All databases (19867)   

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