KEGG ENZYME: 3.4.22.49

ENZYME: 3.4.22.49

Entry

EC 3.4.22.49                Enzyme

Name

separase;
separin

Class

Hydrolases;
Acting on peptide bonds (peptidases);
Cysteine endopeptidases

Reaction(IUBMB)

All bonds known to be hydrolysed by this endopeptidase have arginine in P1 and an acidic residue in P4. P6 is often occupied by an acidic residue or by an hydroxy-amino-acid residue, the phosphorylation of which enhances cleavage

Comment

In both budding yeast and human cells, cleavage of the cohesin subunit Scc1 by separase is required for sister chromatid separation in mitosis. Budding yeast separase is also known to cleave the Rec8 subunit of a meiotic cohesin complex and the kinetochore protein Slk19. Type example of peptidase family C50.

History

EC 3.4.22.49 created 2003

Orthology

K02365

separase

Genes

HSA:	9700(ESPL1)

PTR:	451937(ESPL1)

PPS:	100986315(ESPL1)

GGO:	101147294(ESPL1)

PON:	100444516(ESPL1)

NLE:	100589406(ESPL1)

HMH:	116481009(ESPL1)

MCC:	702136(ESPL1)

MCF:	102144900(ESPL1)

MTHB:

126931096

MNI:	105474391(ESPL1)

CSAB:

103238388 103238391(ESPL1)

CATY:

105580273(ESPL1)

PANU:

101019541(ESPL1)

TGE:	112634147(ESPL1)

MLEU:

105528263(ESPL1)

RRO:	104670601(ESPL1)

RBB:	108521614(ESPL1)

TFN:	117090041(ESPL1)

PTEH:

111541935(ESPL1)

CANG:

105503575(ESPL1)

CJC:	100404434(ESPL1)

SBQ:	101048054(ESPL1)

CIMI:

108284855(ESPL1)

CSYR:

103250910(ESPL1)

MMUR:

105870726(ESPL1)

LCAT:

123639770(ESPL1)

PCOQ:

105817396(ESPL1)

OGA:	100964680(ESPL1)

MMU:	105988(Espl1)

MCAL:

110310439(Espl1)

MPAH:

110334838(Espl1)

RNO:	315330(Espl1)

MCOC:

116080433(Espl1)

ANU:	117718844(Espl1)

MUN:	110552298(Espl1)

CGE:	100768842(Espl1)

MAUA:

101841056(Espl1)

PROB:

127226138(Espl1)

PLEU:

114696628(Espl1)

MORG:

121444236(Espl1) 121459432

MFOT:

126493608

AAMP:

119822827(Espl1)

NGI:	103738516(Espl1)

HGL:	101723260(Espl1)

CPOC:

100733255(Espl1)

CCAN:

109684045(Espl1)

DORD:

105997880(Espl1)

DSP:	122124210(Espl1)

PLOP:

125364055(Espl1)

NCAR:

124983017

MMMA:

107148806(Espl1)

OCU:

100356105

OPI:	101534121(ESPL1)

TUP:	102498926(ESPL1)

GVR:	103592226(ESPL1)

CFA:	607879(ESPL1)

CLUD:

112667190(ESPL1)

VVP:	112921175(ESPL1)

VLG:	121479643(ESPL1)

NPO:	129517362(ESPL1)

AML:	100467596(ESPL1)

UMR:	103675668(ESPL1)

UAH:	113257561(ESPL1)

UAR:	123794703(ESPL1)

ELK:

111157921

LLV:

125106438

MPUF:

101682674(ESPL1)

MNP:	132019726(ESPL1)

MLK:	131838700(ESPL1)

NVS:	122891326(ESPL1)

ORO:	101369929(ESPL1)

EJU:	114225726(ESPL1)

ZCA:	113922576(ESPL1)

MLX:	118008799(ESPL1)

NSU:	110577440(ESPL1)

LWW:	102748877(ESPL1)

FCA:	101084118(ESPL1)

PYU:	121038492(ESPL1)

PCOO:

112867453(ESPL1)

PBG:	122473473(ESPL1)

PVIV:

125170723(ESPL1)

LRUF:

124502024

PTG:	102954819(ESPL1)

PPAD:

109249194(ESPL1)

PUC:

125919117

AJU:

106986457

HHV:	120247237(ESPL1)

BTA:	506740(ESPL1)

BOM:	102284437(ESPL1)

BIU:	109559041(ESPL1)

BBUB:

102401554(ESPL1)

BBIS:

105001575(ESPL1)

CHX:	102177959(ESPL1)

OAS:	101105898(ESPL1)

BTAX:

128048511(ESPL1)

ODA:	120858293(ESPL1)

CCAD:

122427561(ESPL1)

MBEZ:

129537046(ESPL1)

SSC:	100153121(ESPL1)

CFR:	102522390(ESPL1)

CBAI:

105076279(ESPL1)

CDK:	105094570(ESPL1)

VPC:	102526528(ESPL1)

BACU:

103008542(ESPL1)

BMUS:

118902411(ESPL1)

LVE:	103076864(ESPL1)

OOR:	101286713(ESPL1)

DLE:	111173946(ESPL1)

PCAD:

102974477 114486511(ESPL1)

PSIU:

116760526(ESPL1)

NASI:

112394344(ESPL1)

ECB:	100063779(ESPL1)

EPZ:	103559419(ESPL1)

EAI:	106835283(ESPL1)

MYB:	102259018(ESPL1)

MYD:	102752810(ESPL1)

MMYO:

118651695(ESPL1)

MLF:	102417742(ESPL1)

PKL:	118729068(ESPL1)

EFUS:

103285342(ESPL1)

MNA:	107528301(ESPL1)

DRO:	112318617(ESPL1)

AJM:	119043512(ESPL1)

PDIC:

114513150(ESPL1)

PHAS:

123813111(ESPL1)

MMF:	118624167(ESPL1)

PPAM:

129084557(ESPL1)

HAI:	109391774(ESPL1)

RFQ:	117029415(ESPL1)

PALE:

102895542(ESPL1)

PGIG:

120602112(ESPL1)

PVP:	105302660(ESPL1)

RAY:	107509850(ESPL1)

MJV:	108405368(ESPL1)

TOD:	119247985(ESPL1)

SARA:

101546252(ESPL1)

SETR:

126022452(ESPL1)

LAV:	100671244(ESPL1)

TMU:

101351580

ETF:	101651389(ESPL1)

DNM:	101439768(ESPL1)

MDO:	100032809(ESPL1)

GAS:	123250223(ESPL1)

SHR:

100921010

AFZ:

127538318

PCW:	110194100(ESPL1)

OAA:	103169813(ESPL1)

GGA:	425536(ESPL1)

PCOC:

116234926(ESPL1)

MGP:	104916907(ESPL1)

CJO:	107306949(ESPL1)

LMUT:

125685495(ESPL1)

NMEL:

110390892(ESPL1)

APLA:

119715384(ESPL1)

ACYG:

106029392(ESPL1)

CATA:

118261562(ESPL1)

AFUL:

116501724(ESPL1)

TGU:	115491336(ESPL1)

PMOA:

120500677(ESPL1)

OTC:	121333706(ESPL1)

PRUF:

121363968

GFR:	102044437(ESPL1)

OMA:	130265836(ESPL1)

PHI:	102109021(ESPL1)

ETL:	114070102(ESPL1)

HRT:	120764372(ESPL1)

FPG:	101919296(ESPL1)

FCH:	102059227(ESPL1)

EGZ:	104132781(ESPL1)

NNI:	104009170(ESPL1)

PLET:

104618942

ACHC:

115350895(ESPL1)

HLE:	104830294(ESPL1)

AGEN:

126046659

BREG:

104638330

OHA:

104329060

SHAB:

115618608(ESPL1)

CPEA:

104396549(ESPL1)

CVF:	104282021(ESPL1)

RTD:	128903827(ESPL1)

CUCA:

104055654(ESPL1)

AAM:	106488008(ESPL1)

AROW:

112961067(ESPL1)

NPD:	112952278(ESPL1)

TGT:	104575510(ESPL1)

DNE:	112996065(ESPL1)

SCAM:

104152524(ESPL1)

ASN:	102377591(ESPL1)

AMJ:	102574406(ESPL1)

CPOO:

109323407(ESPL1)

PSS:	102455533(ESPL1)

CMY:	102933417(ESPL1)

CCAY:

125629332(ESPL1)

DCC:	119846052(ESPL1)

CPIC:

101941011(ESPL1)

TST:	117888594(ESPL1)

CABI:

116828489(ESPL1)

MRV:	120390887(ESPL1)

ACS:	100566013(espl1)

ASAO:

132765462(ESPL1)

PVT:	110070448(ESPL1)

SUND:

121921737(ESPL1)

PBI:	103063794(ESPL1)

PMUR:

107288516(ESPL1)

CTIG:

120303304(ESPL1)

TSR:	106550895(ESPL1)

PGUT:

117666488(ESPL1)

APRI:

131193692(ESPL1)

PTEX:

113444843(ESPL1)

NSS:	113416193(ESPL1)

VKO:	123029896(ESPL1)

PMUA:

114586316(ESPL1)

PRAF:

128406024(ESPL1)

ZVI:	118076682(ESPL1)

HCG:	128345454(ESPL1)

GJA:	107118969(ESPL1)

STOW:

125428170(ESPL1)

EMC:	129346258(ESPL1)

XLA:	431925(espl1.S) 733221(espl1.L)

XTR:	100158636(espl1)

NPR:	108786827(ESPL1)

RTEM:

120929323(ESPL1)

BBUF:

120996094(ESPL1)

BGAR:

122933341(ESPL1)

MUO:	115466723(ESPL1)

GSH:	117357444(ESPL1)

DRE:	797406(espl1)

SRX:	107711058 107740575

SANH:

107667390 107673592

SGH:	107582795 107585178

CCAR:

109063482 109091441

CAUA:

113094395(espl1)

CGIB:

127959757

PTET:

122347489(espl1)

LROH:

127167307(espl1)

OMC:	131542846(espl1)

PPRM:

120491369(espl1)

RKG:	130087544(espl1)

MAMB:

125273720(espl1)

CIDE:

127514559

MASI:

127446132 127449376

TROS:

130556889(espl1)

TDW:	130425288(espl1)

MANU:

129449996(espl1)

IPU:

108271745

IFU:	128615001(espl1)

PHYP:

113545840(espl1)

SMEO:

124382852(espl1)

TFD:	113662736(espl1) 125141227

TVC:	132844115(espl1)

AMEX:

103046696(espl1)

CMAO:

118808271(espl1)

EEE:	113575991(espl1)

TRU:	101077884(espl1)

TFS:	130524493(espl1)

TNG:	GSTEN00027237G001

LCO:	104931366(espl1)

NCC:	104967237 104967240

TBEN:

117489633(espl1)

CGOB:

115008801(espl1)

PGEO:

117447403(espl1)

GACU:

117551158(espl1)

EMAC:

134882256(espl1)

ELY:	117256249(espl1)

EFO:	125896120(espl1)

PLEP:

121956374(espl1)

SLUC:

116065562(espl1)

ECRA:

117943793(espl1)

ESP:	116688706(espl1)

PFLV:

114554229(espl1)

GAT:	120834670(espl1)

PPUG:

119194157(espl1)

AFB:	129106018(espl1)

CLUM:

117730883(espl1)

PSWI:

130209032(espl1)

MSAM:

119886141(espl1)

SCHU:

122867223(espl1)

CUD:	121507034(espl1)

ALAT:

119021256(espl1)

MZE:	101471736(espl1)

ONL:	102078894(espl1)

OAU:	116320386(espl1)

OLA:	101174584(espl1)

OML:	112145288(espl1)

CSAI:

133448740(espl1)

XMA:	102232020(espl1)

XCO:	114135107(espl1)

XHE:	116711188(espl1)

PRET:

103465369(espl1)

PFOR:

103147647(espl1)

PLAI:

106954425(espl1)

PMEI:

106924384(espl1)

GAF:	122834239(espl1)

PPRL:

129357583(espl1)

CVG:	107082120(espl1)

CTUL:

119776667(espl1)

GMU:	124856662(espl1)

NFU:	107384036(espl1)

KMR:	108235600(espl1)

ALIM:

106518044(espl1)

NWH:	119412569(espl1)

AOCE:

111588761(espl1)

MCEP:

125007380(espl1)

CSEM:

103385986(espl1)

POV:	109628965(espl1)

SSEN:

122768258(espl1)

HHIP:

117761872(espl1)

HSP:	118104972(espl1)

SMAU:

118309718(espl1)

LCF:

108881443

SDU:	111221621(espl1)

SLAL:

111667822(espl1)

XGL:	120783239(espl1)

HCQ:	109522611(espl1)

SSCV:

125977377

SBIA:

133507700(espl1)

PEE:	133409250(espl1)

PTAO:

133483758(espl1)

BPEC:

110158716(espl1)

MALB:

109956223(espl1)

BSPL:

114855888(espl1)

SJO:	128355452(espl1)

SASA:

106565678(espl1)

STRU:

115207813(espl1)

OTW:	112217676(espl1)

OMY:	110494335(espl1)

OGO:	124003497(espl1)

ONE:	115143182(espl1)

OKI:	109895832(espl1)

OKE:	118388557(espl1)

SALP:

111966917(espl1)

SNH:	120061159(espl1)

CCLU:

121575271

ELS:	105017151(espl1)

SFM:	108918227(espl1)

PKI:	111858657(espl1)

AANG:

118211359(espl1)

LOC:	102696375(espl1)

PSPA:

121308896(espl1)

ARUT:

117400942 117967028

LCM:	102366561(ESPL1)

LRJ:	133358334(ESPL1)

BFO:

118432840

BBEL:

109479122

CIN:

100185242

SCLV:

120343948

SPU:

576865

APLC:

110975876

DME:	Dmel_CG10583(Sse)

DER:

6544672

DSE:

6610899

DSI:	Dsimw501_GD13181(Dsim_GD13181)

DYA:	Dyak_GE20543

DSR:

110176236

DPO:

4812927

DPE:

6600318

DMN:	108151739 108163891 117189158 117189159

DWI:

6639208

DMO:	Dmoj_GI13175

DAZ:

108613082

DNV:

108651051

DHE:

111593099

DVI:

6623931

BDR:

105234066

RZE:

108364332

AOQ:

129242765

TDA:	119672386 119673307

LCQ:

111690719

GFS:

119635782

ECOE:

129945303

CLON:

129607820

AGA:

1281669

ACOZ:

120951549

AARA:

120894961

AMER:

121590949

AFUN:

125764598

AMOU:

128299070

AALI:

118468842

AAG:

5570130

CQU:	CpipJ_CPIJ011580

CPII:

120416142

AME:

100576647

BIM:

100745045

BTER:

100652250

CCAL:

108631249

OBB:

114879196

SOC:

105201909

MPHA:

105828446

AEC:

105151714

ACEP:

105618839

PBAR:

105424685

VEM:

105561977

HST:

105191085

DQU:

106745176

CFO:

105256588

FEX:

115243231

LHU:

105675199

PGC:

109858810

OBO:

105277561

PCF:

106785104

VVE:

124952145

NVI:

100286823

CSOL:

105367898

TCA:

103313682

DPA:

109535482

ATD:

109602160

NVL:

108562643

PMAC:

106713033

PPOT:

106109029

PXU:

106117645

CCRN:

123305694

API:

100162113

DNX:

107171602

AGS:

114131393

RMD:

113557111

BTAB:

109031090

CLEC:

106665082

NLU:

111061611

MQU:	128996274 128997018

PHU:	Phum_PHUM080610

BROR:

134539659

PJA:

122266502

PCHN:

125032966

HAME:

121858770

PCLA:

123761976

PTRU:

123511977

EAF:

111706956

DSV:

119455692

RSAN:

119393682

RMP:

119172785

VDE:

111248630

VJA:

111270901

DPTE:

113792053

PTEP:

107454523

SDM:

118204682

CEL:	CELE_Y47G6A.12(sep-1) CELE_ZK430.5(ZK430.5)

CBR:	CBG_14956(Cbr-sep-1)

CRQ:	GCK72_002117

LOA:	LOAG_04930

TSP:

Tsp_02125

LGI:	LOTGIDRAFT_230378

HRF:

124116111

CRG:

105325911

MYI:

110463375

PMAX:

117343195

MMER:

123559935

OBI:

106869135

OSN:

115209522

LAK:

106162192

SMM:	Smp_167810

OVI:	T265_15152

EGL:

EGR_03600

NVE:

5515603

EPA:

110254628

ATEN:

116288580

AMIL:

114977839

PDAM:

113669626

DGT:

114520908

HMG:

101239166

AQU:

105312138

ATH:	AT4G22970(ESP)

ALY:

9303812

CRB:

17878951

CSAT:

104718008 104727823 104731195

EUS:	EUTSA_v10024187mg EUTSA_v10029518mg

BRP:	103860637 103861751

BNA:	106375763 106398538 106415125 106440466 106440619 111214417 125585778 125595404 125595406 125603850

BOE:	106301587 106316163 106337896 106343049

RSZ:

108842701

THJ:

104814230

CPAP:

110808249

CIT:

102627230

CIC:	CICLE_v10000008mg

PVY:	116123826 116136111

MINC:

123206072 123214667

TCC:

18607368

GRA:

105786009

GHI:	107921536 107925336

GAB:

108466833

HSYR:

120145063

DZI:

111298142

GMX:	100791010 100805306

GSJ:	114385811 114422230

PVU:	PHAVU_006G212000g

VRA:

106775912

VAR:

108343196

VUN:

114188679

CCAJ:

109803269

APRC:

113852013

MTR:	11418825 25497699

TPRA:

123910420 123910680

CAM:

101501526

PSAT:

127085273

VVO:	131623306 131634316 131645137

LJA:	Lj0g3v0225339.1(Lj0g3v0225339.1)

ADU:	107468818 107487547

AIP:

107623888

AHF:	112714932 112784436 112800459

LANG:

109334474

PCIN:

129306986

QSA:	O6P43_012254 O6P43_031553

FVE:

101294643

RCN:	112176206 112176381

PPER:

18791340

PMUM:

103319233

PAVI:

110764872

PDUL:

117615543

MDM:	103425344 114823234

MSYL:

126603255

ZJU:

107427758

MNT:

21406896

CSAV:

115694687

CSV:

101203087

CMO:

103488503

BHJ:

120075849

MCHA:

111017677

CMAX:

111478544

CMOS:

111447831

CPEP:

111795502

RCU:

8277534

JCU:

105628784

HBR:

110633641

MESC:

110618533

POP:

7478128

PEU:

105114008

PALZ:

118029252

JRE:

109007053

CILL:

122309304

CAVE:

132192086

QSU:

111987076

QLO:

115977465

TWL:

119982436

VVI:	100259948 104882073

VRI:

117926741

SLY:

101263947

SPEN:

107008385

SOT:

102604188

SSTN:

125843969

SDUL:

129885817

CANN:

107839972

LBB:

132598730

NTA:	107804022 107828330

NSY:

104227270

NTO:

104086993

NAU:

109243351

INI:

109169153

ITR:

116019743

SIND:

105169434

OEU:

111411489

EGT:

105949607

SSPL:

121753928 121758961

SMIL:

131019378

SHIS:

125218490

APAN:

127262011

HAN:

110884718

ECAD:

122594979

LSV:

111878317

CCAV:

112517090

DCR:

108209499

CSIN:

114268452

RVL:

131308829

AEW:	130755560 130779728

BVG:

104888210

SOE:

110783145

CQI:	110728401 110738838

ATRI:

130802134

MOF:

131164793

NNU:

104589335

MING:

122086603

TSS:

122666187

PSOM:

113346473 113356227

OSA:

4330866

DOSA:

Os02t0770700-01(Os02g0770700)

OBR:

102702071

OGL:

127761172

BDI:

100825113

ATS:

109766103

TDC:	119315995 119322508

TAES:

123128537 123138403 123145658

TUA:

125514802

LPER:

127302599 127305987 127317065

LRD:	124647555 124647960 124681922 124690729

SBI:	8073776 8075210

ZMA:

103654220

SITA:

101777770 101782294

SVS:	117839564 117852376

PVIR:

120643306 120657316

PHAI:

112882964

PDA:

103696471

EGU:

105035069

MUS:	103974999 103998153

ZOF:

121993191

DCT:

110108353

PEQ:

110020186

AOF:

109842386

MSIN:

131236470

NCOL:

116266278

ATR:

18424419

SMO:	SELMODRAFT_405667 SELMODRAFT_442839

PPP:

112285826

CRE:	CHLRE_01g029200v5

VCN:	VOLCADRAFT_96349(espA)

CSL:	COCSUDRAFT_40112

CVR:	CHLNCDRAFT_143874

APRO:

F751_1252

OLU:	OSTLU_119551(cut1)

OTA:	OT_ostta02g00970

GSL:	Gasu_44590

CCP:	CHC_T00004631001

SCE:	YGR098C(ESP1)

SEUB:

DI49_2057

SPAO:

SPAR_G03190

AGO:	AGOS_AAR089C

KLA:	KLLA0_D15136g

KMX:	KLMA_50439(ESP1)

LTH:	KLTH0E05478g

ZRO:	ZYRO0C12672g

CGR:	CAGL0G03223g

NCS:	NCAS_0E01080(NCAS0E01080)

NDI:	NDAI_0G01210(NDAI0G01210)

TPF:	TPHA_0D04010(TPHA0D04010)

TBL:	TBLA_0C02250(TBLA0C02250)

TGB:	HG536_0G01540

TDL:	TDEL_0F03240(TDEL0F03240)

KAF:	KAFR_0K01610(KAFR0K01610)

KNG:	KNAG_0B01060(KNAG0B01060)

ZMK:	HG535_0B06080

PPA:	PAS_chr1-4_0541

DHA:	DEHA2D01958g

PIC:	PICST_28228(ESP1)

PGU:	PGUG_04920

SPAA:

SPAPADRAFT_132760

LEL:	PVL30_001409(ESP1)

CAL:	CAALFM_C101670CA(ESP1)

CTP:	CTRG_04463

COT:	CORT_0B10500

CDU:	CD36_01530

CTEN:

CANTEDRAFT_94478

YLI:	YALI0C08960g

CLU:	CLUG_00834

CLUS:

A9F13_10g01056 A9F13_10g01067

SLB:	AWJ20_4184(ESP1)

PKZ:	C5L36_0B04650

BNN:	FOA43_003297

BBRX:

BRETT_004142

OPA:	HPODL_00833

NCR:

NCU00205

NTE:	NEUTE1DRAFT146400(NEUTE1DRAFT_146400)

SMP:	SMAC_02224(putative_esp1)

PAN:	PODANSg5443

PBEL:

QC761_710410(ESP1)

PPSD:

QC762_710410(ESP1)

PPSP:

QC763_710410(ESP1)

PPSA:

QC764_0105660(ESP1_1)

TTT:	THITE_2146478

MTM:	MYCTH_2117988

CTHR:

CTHT_0070540

MGR:

MGG_06245

PPEI:

PpBr36_06738

PGRI:

PgNI_10009

TMN:	UCRPA7_6398

SSCK:

SPSK_08265

FGR:	FGSG_05504

FPU:	FPSE_03499

FPOA:

FPOAC1_008159

FVN:	FVRRES_08714

FVR:	FVEG_07021

FOX:	FOXG_09389

NHE:	NECHADRAFT_46823

FFC:	NCS54_01040800

FKR:	NCS57_01034300

FMU:	J7337_009642

TRE:	TRIREDRAFT_50913

TRR:	M419DRAFT_26189

MAW:

MAC_02527

MAJ:

MAA_03454

PCHM:

VFPPC_04332

CMT:

CCM_07539

AMUS:

LMH87_009867

PLJ:	VFPFJ_01244

PTKZ:

JDV02_007433(ESP1)

VAL:	VDBG_06747

VDA:	VDAG_05810

CFJ:	CFIO01_11437

CLUP:

CLUP02_03331

CHIG:

CH63R_02448

SAPO:

SAPIO_CDS5673

ELA:	UCREL1_8234

PFY:	PFICI_08012

SSL:	SS1G_07342

BFU:	BCIN_10g02490(Bcesp1)

MBE:

MBM_02389

PSCO:

LY89DRAFT_778661

GLZ:	GLAREA_11949

ANI:	ANIA_08783

AFM:	AFUA_5G09710

ACT:	ACLA_012860

NFI:	NFIA_077600

AOR:	AO090005000276

ANG:	An07g03090

AFV:	AFLA_003064

ALUC:

AKAW2_11864A

ACHE:

ACHE_60910S

APUU:

APUU_70349A

PCS:	N7525_001962

PDP:	PDIP_54810

POU:	POX_a00830

TMF:	EYB26_008469

TRG:	TRUGW13939_00088

CIM:	CIMG_04712

CPW:	CPC735_071130

URE:	UREG_01885

PBL:	PAAG_05691

PBN:	PADG_07698

ABE:

ARB_01287

TVE:

TRV_01158

AJE:	HCAG_04674

BGH:	BDBG_04545

PNO:	SNOG_00996

PTE:

PTT_18381

BZE:	COCCADRAFT_3922

BSC:	COCSADRAFT_189437

BOR:	COCMIDRAFT_105691

AALT:

CC77DRAFT_979400

ARAB:

EKO05_0004355

ZTR:	MYCGRDRAFT_92316

PFJ:	MYCFIDRAFT_213087

FFU:	CLAFUR5_01701

CBET:

CB0940_01623

BCOM:

BAUCODRAFT_149939

NPA:	UCRNP2_1130

TML:	GSTUM_00009703001

SPO:	SPCC5E4.04(cut1)

SOM:	SOMG_04321(cut1)

CNE:

CNB00660

CNB:	CNBB5030 CNBB5040

CNG:	CNAG_07463

CGI:	CGB_B9070W CGB_B9080W

CDEU:

CNBG_6117

TMS:	TREMEDRAFT_29861

TASA:

A1Q1_05076

CCAC:

CcaHIS019_0507290(ESP1)

TVS:	TRAVEDRAFT_41033

DSQ:	DICSQDRAFT_163077

PCO:	PHACADRAFT_203784

SHS:	STEHIDRAFT_76141

HIR:	HETIRDRAFT_56130

PSQ:	PUNSTDRAFT_102931

ADL:	AURDEDRAFT_170753

FME:	FOMMEDRAFT_171563

GTR:	GLOTRDRAFT_80657

RSX:	RhiXN_00146

LBC:	LACBIDRAFT_297425 LACBIDRAFT_307095 LACBIDRAFT_307111 LACBIDRAFT_317505 LACBIDRAFT_317635 LACBIDRAFT_317789

CCI:	CC1G_02409

ABP:	AGABI1DRAFT80074(AGABI1DRAFT_80074)

ABV:	AGABI2DRAFT208386(AGABI2DRAFT_208386)

MRR:	Moror_3206

E1B28_006233

SCM:	SCHCO_01122301(SCHCODRAFT_01122301)

CPUT:

CONPUDRAFT_138600

SLA:	SERLADRAFT_445696

WSE:	WALSEDRAFT_60488

WIC:	J056_003644

UMA:	UMAG_03262

PFP:	PFL1_06503

MGL:

MGL_1370

MRT:

MRET_3990

PGR:	PGTG_03501

PTRC:

PtA15_2A385

MLR:	MELLADRAFT_36075

EIN:	Eint_070290

EHE:	EHEL_070310

ERO:	EROM_070280

MBR:	MONBRDRAFT_33070

SRE:	PTSG_11533

EHI:	EHI_120330(182.t00017)

EDI:	EDI_265930

EIV:	EIN_059330

ACAN:

ACA1_053220

CPV:

cgd7_2760

CHO:	Chro.70313

TET:	TTHERM_00297160

PTM:	GSPATT00003810001

SMIN:

v1.2.024604.t1(symbB.v1.2.024604.t1)

FCY:	FRACYDRAFT_178623

TPS:	THAPSDRAFT_260749

AAF:	AURANDRAFT_72664

PIF:	PITG_03497

PSOJ:

PHYSODRAFT_471658

EHX:	EMIHUDRAFT_451944

GTT:	GUITHDRAFT_148744

TBR:	TB927.1.3120

TBG:	TbgDal_I1900

TCR:	507837.10 508405.80

LMA:	LMJF_20_1680

LIF:	LINJ_20_1650

LDO:	LDBPK_201650

LMI:	LMXM_20_1680

LBZ:	LBRM_20_5840

LPAN:

LPMP_205780

TVA:	TVAG_2v0956510

» show all

Reference

1 [PMID:12194817]

Authors

Waizenegger I, Gimenez-Abian JF, Wernic D, Peters JM

Title

Regulation of human separase by securin binding and autocleavage.

Journal

Curr Biol 12:1368-78 (2002)
DOI:10.1016/S0960-9822(02)01073-4

Sequence

[hsa:9700]

Other DBs

ExplorEnz - The Enzyme Database:

3.4.22.49

IUBMB Enzyme Nomenclature:

3.4.22.49

ExPASy - ENZYME nomenclature database:

3.4.22.49

BRENDA, the Enzyme Database:

3.4.22.49

CAS:	351527-77-0

DBGET integrated database retrieval system